hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06757.1
Complex Portal: CPX-15783
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RTL9 | Retrotransposon Gag-like protein 9 (Retrotransposon gag domain-containing protein 1) (Tumor antigen BJ-HCC-23) | 2 | UniProt NCBI |
| UGT1A8 | UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H) | 5 | UniProt NCBI |
| UGT1A10 | UDP-glucuronosyltransferase 1A10 (UGT1A10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-10) (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J) | 5 | UniProt NCBI |
| ESYT1 | Extended synaptotagmin-1 (E-Syt1) (Membrane-bound C2 domain-containing protein) | 5 | UniProt NCBI |
| UGT1A7 | UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP698 | 9.83834482812e-07 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Glucuronidation |
| KEGG:00053 | 1.43433291444e-06 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Ascorbate and aldarate metabolism |
| REAC:R-HSA-156588 | 1.74530562074e-06 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Glucuronidation |
| KEGG:00040 | 2.14152523635e-06 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Pentose and glucuronate interconversions |
| GO:0051552 | 3.84440695359e-06 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | flavone metabolic process |
| KEGG:00860 | 5.07589472875e-06 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Porphyrin metabolism |
| KEGG:00140 | 9.18507275524e-06 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Steroid hormone biosynthesis |
| KEGG:00830 | 1.9338342299e-05 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Retinol metabolism |
| KEGG:05204 | 2.17491853578e-05 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 2.30261795237e-05 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Drug metabolism - cytochrome P450 |
| KEGG:04976 | 2.86326141069e-05 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Bile secretion |
| KEGG:00980 | 3.01633992163e-05 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Metabolism of xenobiotics by cytochrome P450 |
| GO:0009812 | 3.362820138e-05 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | flavonoid metabolic process |
| KEGG:00983 | 4.44119474406e-05 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Drug metabolism - other enzymes |
| WP:WP5224 | 0.000224001431405 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | 2q37 copy number variation syndrome |
| REAC:R-HSA-156580 | 0.000254380816813 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Phase II - Conjugation of compounds |
| REAC:R-HSA-9748784 | 0.000264137476094 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Drug ADME |
| WP:WP1604 | 0.000264396631677 | 0.4 | UGT1A10 UGT1A8 | Codeine and morphine metabolism |
| GO:0052695 | 0.000349481973524 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | cellular glucuronidation |
| KEGG:01240 | 0.000360991485359 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Biosynthesis of cofactors |
| GO:0019585 | 0.000436807598019 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | glucuronate metabolic process |
| GO:0006063 | 0.000436807598019 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | uronic acid metabolic process |
| WP:WP691 | 0.000534376000489 | 0.4 | UGT1A10 UGT1A8 | Tamoxifen metabolism |
| KEGG:05207 | 0.000650418791408 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Chemical carcinogenesis - receptor activation |
| WP:WP5276 | 0.00123199381981 | 0.4 | UGT1A10 UGT1A8 | Estrogen metabolism |
| GO:0015020 | 0.00194127795747 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | glucuronosyltransferase activity |
| REAC:R-HSA-211859 | 0.00217510180244 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | Biological oxidations |
| REAC:R-HSA-9749641 | 0.0065872694687 | 0.4 | UGT1A8 UGT1A7 | Aspirin ADME |
| GO:0001889 | 0.00744248347584 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | liver development |
| GO:0061008 | 0.00807957978043 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | hepaticobiliary system development |
| GO:0042440 | 0.019918492568 | 0.6 | UGT1A10 UGT1A8 UGT1A7 | pigment metabolic process |
| GO:0052696 | 0.0280843539964 | 0.4 | UGT1A8 UGT1A7 | flavonoid glucuronidation |
| GO:0009698 | 0.0468008499735 | 0.4 | UGT1A8 UGT1A7 | phenylpropanoid metabolic process |
| GO:0009804 | 0.0468008499735 | 0.4 | UGT1A8 UGT1A7 | coumarin metabolic process |
| CORUM:7314 | 0.0498708842806 | 0.2 | ESYT1 | ESYT1-ESYT3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| UGT1A7 | UGT1A10 | 1.0 |
mutually_exclusive (O60656)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RTL9 | UGT1A7 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UGT1A7 | ESYT1 | 0.996 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UGT1A8 | UGT1A7 | 0.972 |
mutually_exclusive (Q9HAW8)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RTL9 | UGT1A8 | 0.415 | bioplex3_WMM WMM_only | ||
| UGT1A8 | UGT1A10 | 0.415 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only | |
| RTL9 | UGT1A10 | 0.415 | bioplex3_WMM WMM_only | ||
| UGT1A8 | ESYT1 | 0.206 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| UGT1A10 | ESYT1 | 0.049 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RTL9 | ESYT1 | 0.037 | bioplex3_WMM gupta_WMM WMM_only |
Related Complexes