hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06763.1

Complex Portal: CPX-19885

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
ARHGAP11A	Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A)	4	UniProt NCBI
PPP1R12A	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)	5	UniProt NCBI
MYL6B	Myosin light chain 6B (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa) (Smooth muscle and nonmuscle myosin light chain alkali 6B)	5	UniProt NCBI
SPECC1L	Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein)	5	UniProt NCBI
CGN	Cingulin	5	UniProt NCBI
SPECC1	Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1)	5	UniProt NCBI
PLEKHG3	Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3)	5	UniProt NCBI
MYO5B	Unconventional myosin-Vb	5	UniProt NCBI
MPRIP	Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)	5	UniProt NCBI
COBL	Protein cordon-bleu	5	UniProt NCBI
KCTD10	BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (hBACURD3) (BTB/POZ domain-containing protein KCTD10) (Potassium channel tetramerization domain-containing protein 10)	5	UniProt NCBI
LRCH3	DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3)	5	UniProt NCBI
TPM4	Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)	5	UniProt NCBI
DOCK7	Dedicator of cytokinesis protein 7	5	UniProt NCBI
TPM2	Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)	5	UniProt NCBI
LMO7	LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP)	5	UniProt NCBI
NEXN	Nexilin (F-actin-binding protein) (Nelin)	5	UniProt NCBI
PPP1R9A	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0015629	9.34591604933e-08	0.588235294118	SPECC1L NEXN SPECC1 TPM4 COBL MPRIP PPP1R9A TPM2 PPP1R12A MYO5B	actin cytoskeleton
GO:0003779	2.85736335182e-07	0.529411764706	TPM4 NEXN PLEKHG3 COBL MPRIP PPP1R9A TPM2 CGN MYO5B	actin binding
GO:0007010	6.9195378161e-06	0.705882352941	SPECC1L NEXN SPECC1 DOCK7 TPM4 COBL PPP1R9A TPM2 CGN PPP1R12A MYO5B LRCH3	cytoskeleton organization
CORUM:817	5.44233315652e-05	0.117647058824	PPP1R12A MPRIP	MRIP-MBS complex
CORUM:815	0.000163158265417	0.117647058824	PPP1R12A MPRIP	MRIP-MBS-RHOA complex
GO:0051015	0.00121808345907	0.352941176471	TPM4 NEXN TPM2 MPRIP MYO5B PPP1R9A	actin filament binding
GO:0008092	0.00122648037853	0.529411764706	TPM4 NEXN PLEKHG3 COBL MPRIP PPP1R9A TPM2 CGN MYO5B	cytoskeletal protein binding
GO:0005884	0.0025813923743	0.294117647059	TPM4 SPECC1L TPM2 SPECC1 COBL	actin filament
HPA:0031323	0.0106033907039	0.176470588235	CGN MYO5B COBL	appendix; enterocytes - Microvilli[High]
HPA:0131323	0.0125509433138	0.176470588235	CGN MYO5B COBL	colon; enterocytes - Microvilli[High]
HPA:0401323	0.0184084093266	0.176470588235	CGN MYO5B COBL	rectum; enterocytes - Microvilli[High]
HPA:0481323	0.0226546380262	0.176470588235	CGN MYO5B COBL	small intestine; enterocytes - Microvilli[High]
HPA:0220053	0.0278176163018	0.588235294118	TPM4 SPECC1 COBL MPRIP LMO7 PPP1R9A CGN KCTD10 PPP1R12A MYO5B	gallbladder; glandular cells[High]
KEGG:04814	0.0489120633125	0.176470588235	TPM4 MYO5B TPM2	Motor proteins

Edges

Protein 1	Protein 2	Score	ProteomeHD
DOCK7	LRCH3	1.0
TPM4	TPM2	0.997	0.146
CGN	LMO7	0.995	0.142
PPP1R9A	NEXN	0.995
MPRIP	MYO5B	0.995
PPP1R12A	MYO5B	0.995	0.104
NEXN	LMO7	0.994
MPRIP	SPECC1L	0.994
SPECC1L	MYO5B	0.993	0.14
PPP1R9A	PLEKHG3	0.992	0.134
PPP1R12A	MYL6B	0.992	0.1
PPP1R12A	LRCH3	0.992	0.07
PLEKHG3	DOCK7	0.992
MPRIP	NEXN	0.991
MPRIP	PPP1R9A	0.991
SPECC1L	NEXN	0.991
NEXN	TPM4	0.991
SPECC1L	LMO7	0.99	0.106
SPECC1L	SPECC1	0.99	0.114
SPECC1L	MYL6B	0.989	0.094
DOCK7	COBL	0.988
SPECC1L	CGN	0.988	0.042
NEXN	PLEKHG3	0.987
MYO5B	COBL	0.987	0.076
SPECC1L	TPM4	0.985	0.056
ARHGAP11A	MYL6B	0.985	0.164188194662
SPECC1L	PLEKHG3	0.984	0.104
PLEKHG3	MYO5B	0.984	0.112
SPECC1	CGN	0.983	0.094
KCTD10	MYL6B	0.983	0.048
NEXN	TPM2	0.983
NEXN	ARHGAP11A	0.983
LMO7	MYO5B	0.982	0.146
PLEKHG3	CGN	0.982	0.116
SPECC1L	PPP1R12A	0.982	0.182
SPECC1	PLEKHG3	0.982	0.134
DOCK7	MYL6B	0.982
MPRIP	ARHGAP11A	0.981
PLEKHG3	ARHGAP11A	0.981	0.192
PPP1R9A	MYO5B	0.981	0.176
TPM2	ARHGAP11A	0.979	0.112
MPRIP	PPP1R12A	0.978
MPRIP	PLEKHG3	0.977
KCTD10	DOCK7	0.977
MYL6B	MYO5B	0.976	0.102
PLEKHG3	MYL6B	0.975	0.166
SPECC1L	PPP1R9A	0.974	0.064
LMO7	ARHGAP11A	0.973	0.154
KCTD10	LRCH3	0.973	0.046
KCTD10	MYO5B	0.969	0.09
TPM4	ARHGAP11A	0.969	0.12
SPECC1L	LRCH3	0.968	0.04
CGN	MYO5B	0.966	0.118
PLEKHG3	PPP1R12A	0.965	0.176
PPP1R9A	PPP1R12A	0.965	0.088
SPECC1	DOCK7	0.964
KCTD10	ARHGAP11A	0.962	0.112
DOCK7	MYO5B	0.961
NEXN	LRCH3	0.961
PLEKHG3	LMO7	0.96	0.14
MYO5B	LRCH3	0.959	0.046
PLEKHG3	TPM4	0.956	0.1
SPECC1	TPM4	0.955	0.06
SPECC1L	DOCK7	0.954
MPRIP	TPM4	0.953
CGN	DOCK7	0.95
MYL6B	LRCH3	0.948	0.016
CGN	PPP1R12A	0.945	0.102
SPECC1L	ARHGAP11A	0.944	0.082
LMO7	MYL6B	0.943	0.174
SPECC1	LMO7	0.942	0.096
TPM4	MYO5B	0.94	0.132
KCTD10	TPM2	0.929	0.054
KCTD10	PPP1R12A	0.927	0.206
SPECC1L	TPM2	0.925	0.058
SPECC1	PPP1R12A	0.92	0.16
MPRIP	COBL	0.918
KCTD10	PLEKHG3	0.908	0.086
LMO7	TPM4	0.905	0.188
CGN	TPM4	0.9	0.054
NEXN	MYL6B	0.897
COBL	LRCH3	0.89	0.052
NEXN	CGN	0.884
SPECC1	MYL6B	0.87	0.114
PPP1R12A	COBL	0.851	0.072
NEXN	DOCK7	0.843
PPP1R9A	ARHGAP11A	0.841	0.096
KCTD10	NEXN	0.827
TPM2	MYL6B	0.82	0.14
KCTD10	SPECC1L	0.816	0.088
PLEKHG3	LRCH3	0.814	0.07
MPRIP	SPECC1	0.796
DOCK7	TPM2	0.796
LMO7	COBL	0.796	0.132
CGN	TPM2	0.785	0.058
PPP1R9A	COBL	0.781	0.104
PPP1R9A	SPECC1	0.781	0.09
SPECC1	TPM2	0.778	0.04
NEXN	COBL	0.773
SPECC1L	COBL	0.773	0.078
ARHGAP11A	COBL	0.773	0.112
ARHGAP11A	MYO5B	0.773	0.08
NEXN	SPECC1	0.773
KCTD10	COBL	0.773	0.108
TPM2	COBL	0.773	0.144
NEXN	PPP1R12A	0.773
KCTD10	SPECC1	0.773	0.042
ARHGAP11A	PPP1R12A	0.773	0.122
SPECC1	MYO5B	0.773	0.092
SPECC1	COBL	0.773	0.082
CGN	ARHGAP11A	0.773	0.094
NEXN	MYO5B	0.773
CGN	COBL	0.773	0.084
PLEKHG3	COBL	0.773	0.132
SPECC1	ARHGAP11A	0.773	0.048
MYL6B	COBL	0.773	0.144
DOCK7	TPM4	0.773
DOCK7	PPP1R12A	0.766
DOCK7	ARHGAP11A	0.764
KCTD10	CGN	0.764	0.11
LMO7	LRCH3	0.734	0.032
TPM4	MYL6B	0.731	0.3
CGN	LRCH3	0.729	0.03
PLEKHG3	TPM2	0.707	0.096
MPRIP	CGN	0.691
TPM2	MYO5B	0.691	0.056
PPP1R9A	CGN	0.628	0.08
TPM2	PPP1R12A	0.581	0.146
TPM4	LRCH3	0.557	0.026
TPM4	PPP1R12A	0.552	0.118
CGN	MYL6B	0.548	0.158
MPRIP	LRCH3	0.453
KCTD10	TPM4	0.411	0.06
ARHGAP11A	LRCH3	0.383	0.054
DOCK7	LMO7	0.372
TPM4	COBL	0.357	0.112
LMO7	PPP1R12A	0.307	0.192
SPECC1	LRCH3	0.288	0.04
PPP1R9A	DOCK7	0.285
MPRIP	LMO7	0.276
PPP1R9A	MYL6B	0.256	0.086
MPRIP	MYL6B	0.221
LMO7	TPM2	0.203	0.146
PPP1R9A	LRCH3	0.186	0.05
MPRIP	DOCK7	0.171
PPP1R9A	TPM4	0.169	0.08
TPM2	LRCH3	0.149	0.048
PPP1R9A	LMO7	0.125	0.112
MPRIP	TPM2	0.122
MPRIP	KCTD10	0.06
KCTD10	PPP1R9A	0.047	0.1
KCTD10	LMO7	0.011	0.07

Related Complexes

Genename	Complexes
ARHGAP11A	huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1
PPP1R12A	huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1 huMAP3_12994.1
MYL6B	huMAP3_06763.1 huMAP3_08205.1 huMAP3_09348.1
SPECC1L	huMAP3_03989.1 huMAP3_05613.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1
CGN	huMAP3_05977.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1 huMAP3_13918.1
SPECC1	huMAP3_05613.1 huMAP3_06763.1 huMAP3_08371.1
PLEKHG3	huMAP3_05613.1 huMAP3_06763.1 huMAP3_09542.1
MYO5B	huMAP3_06763.1 huMAP3_08951.1 huMAP3_09348.1
MPRIP	huMAP3_01198.1 huMAP3_05613.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1
COBL	huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1
KCTD10	huMAP3_03319.1 huMAP3_06763.1 huMAP3_08951.1 huMAP3_09348.1 huMAP3_14151.1
LRCH3	huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1 huMAP3_13571.1
TPM4	huMAP3_06153.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1
DOCK7	huMAP3_05977.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1 huMAP3_13571.1
TPM2	huMAP3_06153.1 huMAP3_06763.1 huMAP3_09121.1 huMAP3_13838.1
LMO7	huMAP3_05977.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1
NEXN	huMAP3_05153.1 huMAP3_06763.1 huMAP3_07928.1 huMAP3_09542.1 huMAP3_13792.1
PPP1R9A	huMAP3_03989.1 huMAP3_06763.1 huMAP3_08205.1 huMAP3_09542.1 huMAP3_14504.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06763.1

Complex Portal: CPX-19885