hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06787.1

Complex Portal: CPX-24939

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
CLTA	Clathrin light chain A (Lca)	5	UniProt NCBI
PIK3C2A	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha)	5	UniProt NCBI
CLINT1	Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR)	5	UniProt NCBI
DENND1A	DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A)	5	UniProt NCBI
PICALM	Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)	5	UniProt NCBI
STAMBPL1	AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1)	5	UniProt NCBI
BMP2K	BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1)	5	UniProt NCBI
HIP1	Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I)	5	UniProt NCBI
TNRC6A	Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa)	5	UniProt NCBI
DAB2	Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)	5	UniProt NCBI
GAK	Cyclin-G-associated kinase (EC 2.7.11.1)	5	UniProt NCBI
STAMBP	STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase)	5	UniProt NCBI
GTSE1	G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog)	5	UniProt NCBI
NUMB	Protein numb homolog (h-Numb) (Protein S171)	5	UniProt NCBI
ZNF106	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474)	5	UniProt NCBI
WNK1	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)	5	UniProt NCBI
PAAT	ATPase PAAT (EC 3.6.1.-) (Protein associated with ABC transporters) (PAAT)	5	UniProt NCBI
CLTCL1	Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0030276	1.48653646937e-09	0.388888888889	CLTA CLTCL1 HIP1 CLINT1 GAK PIK3C2A PICALM	clathrin binding
GO:0030136	1.53287181528e-09	0.5	CLTA DAB2 NUMB HIP1 CLINT1 PIK3C2A DENND1A CLTCL1 PICALM	clathrin-coated vesicle
REAC:R-HSA-8856828	4.20066517246e-08	0.388888888889	CLTA DAB2 CLTCL1 HIP1 GAK PIK3C2A PICALM	Clathrin-mediated endocytosis
GO:0030135	8.23232578951e-08	0.5	CLTA DAB2 NUMB HIP1 CLINT1 PIK3C2A DENND1A CLTCL1 PICALM	coated vesicle
GO:0048268	9.87040132025e-08	0.277777777778	HIP1 CLTA GAK PICALM PIK3C2A	clathrin coat assembly
GO:0006897	1.38711054816e-06	0.555555555556	CLTA DAB2 CLTCL1 PIK3C2A CLINT1 BMP2K HIP1 DENND1A PICALM GAK	endocytosis
REAC:R-HSA-199991	2.24926182738e-06	0.5	CLTA DAB2 CLTCL1 HIP1 CLINT1 GAK PIK3C2A DENND1A PICALM	Membrane Trafficking
REAC:R-HSA-5653656	3.61355454281e-06	0.5	CLTA DAB2 CLTCL1 HIP1 CLINT1 GAK PIK3C2A DENND1A PICALM	Vesicle-mediated transport
REAC:R-HSA-199992	5.49221508142e-06	0.277777777778	CLTA PICALM CLINT1 GAK PIK3C2A	trans-Golgi Network Vesicle Budding
GO:0098657	1.95436112745e-05	0.555555555556	CLTA DAB2 CLTCL1 PIK3C2A CLINT1 BMP2K HIP1 DENND1A PICALM GAK	import into cell
GO:0072583	5.62913092884e-05	0.277777777778	CLTA GAK DAB2 PICALM BMP2K	clathrin-dependent endocytosis
GO:0006898	7.92228884787e-05	0.388888888889	CLTA DAB2 CLTCL1 HIP1 GAK PICALM BMP2K	receptor-mediated endocytosis
REAC:R-HSA-196025	7.93957060989e-05	0.166666666667	CLTA DAB2 CLTCL1	Formation of annular gap junctions
REAC:R-HSA-190873	0.000105779435363	0.166666666667	CLTA DAB2 CLTCL1	Gap junction degradation
REAC:R-HSA-432722	0.000151265785011	0.222222222222	PIK3C2A GAK CLINT1 PICALM	Golgi Associated Vesicle Biogenesis
GO:1903077	0.000475649605248	0.222222222222	NUMB WNK1 PICALM DAB2	negative regulation of protein localization to plasma membrane
GO:1904376	0.000702659935418	0.222222222222	NUMB WNK1 PICALM DAB2	negative regulation of protein localization to cell periphery
GO:1905476	0.00118358163092	0.222222222222	NUMB WNK1 PICALM DAB2	negative regulation of protein localization to membrane
REAC:R-HSA-8856825	0.00141446842493	0.222222222222	CLTA CLTCL1 PICALM DAB2	Cargo recognition for clathrin-mediated endocytosis
REAC:R-HSA-190828	0.00430373127092	0.166666666667	CLTA DAB2 CLTCL1	Gap junction trafficking
REAC:R-HSA-157858	0.00464909988722	0.166666666667	CLTA DAB2 CLTCL1	Gap junction trafficking and regulation
GO:0030118	0.00644711978039	0.222222222222	CLTA CLTCL1 CLINT1 PICALM	clathrin coat
GO:0016192	0.00689288704259	0.555555555556	CLTA DAB2 CLTCL1 PIK3C2A CLINT1 BMP2K HIP1 DENND1A PICALM GAK	vesicle-mediated transport
KEGG:04144	0.00919513218523	0.222222222222	CLTA CLTCL1 DAB2 STAMBP	Endocytosis
GO:0031410	0.0288822156412	0.611111111111	CLTA DAB2 NUMB PIK3C2A CLINT1 STAMBP STAMBPL1 HIP1 DENND1A CLTCL1 PICALM	cytoplasmic vesicle
GO:0097708	0.0294210200031	0.611111111111	CLTA DAB2 NUMB PIK3C2A CLINT1 STAMBP STAMBPL1 HIP1 DENND1A CLTCL1 PICALM	intracellular vesicle

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PIK3C2A	STAMBPL1	0.999	0.0870769230769
STAMBPL1	CLINT1	0.999	0.134
STAMBP	CLINT1	0.999	0.162	structurally_consistent (dimer)
PICALM	CLINT1	0.999	0.292
PIK3C2A	CLINT1	0.998	0.068
PICALM	CLTA	0.998
STAMBPL1	GAK	0.998	0.056
PICALM	BMP2K	0.998	0.118
GTSE1	STAMBPL1	0.997	0.24
PIK3C2A	BMP2K	0.997	0.156
CLINT1	GAK	0.996	0.098	mutually_exclusive (O95630)
BMP2K	DAB2	0.996	0.036
GTSE1	CLINT1	0.996	0.104
PICALM	DAB2	0.995	0.158
BMP2K	CLTA	0.995
CLTCL1	STAMBPL1	0.994	0.141	structurally_consistent (dimer)
ZNF106	STAMBPL1	0.994	0.106
PIK3C2A	CLTCL1	0.994	0.136
CLINT1	CLTA	0.994
PICALM	STAMBPL1	0.994	0.056	structurally_consistent (dimer)
PICALM	CLTCL1	0.994	0.378	structurally_consistent (Q96FJ0)
NUMB	GAK	0.993	0.082
CLTCL1	STAMBP	0.993	0.126
CLTA	GAK	0.993
PICALM	PIK3C2A	0.993	0.132
STAMBPL1	CLTA	0.992
BMP2K	STAMBPL1	0.992	0.126
BMP2K	CLINT1	0.991	0.072
DENND1A	HIP1	0.991	0.104
PAAT	STAMBP	0.99	0.094
CLTCL1	NUMB	0.99	0.158
WNK1	NUMB	0.99	0.068
PIK3C2A	CLTA	0.99
CLTCL1	CLINT1	0.989	0.088
ZNF106	CLTA	0.989
WNK1	STAMBPL1	0.989	0.04
GTSE1	DENND1A	0.989	0.102
STAMBPL1	NUMB	0.988	0.101333333333
PICALM	TNRC6A	0.988	0.142
BMP2K	WNK1	0.988	0.17
TNRC6A	CLTA	0.988
GTSE1	HIP1	0.988	0.098
GTSE1	ZNF106	0.987	0.12
ZNF106	CLTCL1	0.987	0.092
CLTCL1	CLTA	0.987
DENND1A	NUMB	0.986	0.156
BMP2K	HIP1	0.986	0.066
BMP2K	STAMBP	0.984	0.058
GTSE1	PICALM	0.984	0.166
STAMBPL1	STAMBP	0.984	0.03
PIK3C2A	ZNF106	0.983	0.128
DENND1A	STAMBPL1	0.982	0.118
BMP2K	ZNF106	0.982	0.052
DENND1A	CLTA	0.982
PIK3C2A	DENND1A	0.981	0.12
ZNF106	GAK	0.981	0.096
ZNF106	WNK1	0.981	0.05
WNK1	GAK	0.98	0.114
PIK3C2A	GAK	0.979	0.14
DENND1A	CLTCL1	0.977	0.126
DAB2	NUMB	0.977	0.09
GTSE1	STAMBP	0.977	0.108
DENND1A	BMP2K	0.976	0.12
WNK1	STAMBP	0.976	0.084
PICALM	DENND1A	0.976	0.136
PAAT	STAMBPL1	0.976	0.084	structurally_consistent (dimer)
DAB2	HIP1	0.975	0.062
TNRC6A	STAMBPL1	0.973	0.12
PIK3C2A	DAB2	0.973	0.136
GTSE1	WNK1	0.973	0.122
STAMBP	CLTA	0.972
PIK3C2A	STAMBP	0.97	0.064
BMP2K	NUMB	0.97	0.136
HIP1	CLTA	0.97
DENND1A	GAK	0.97	0.14
HIP1	STAMBPL1	0.968	0.062
ZNF106	NUMB	0.967	0.052
PIK3C2A	NUMB	0.966	0.09
CLTCL1	GAK	0.965	0.184
GTSE1	BMP2K	0.963	0.126
WNK1	HIP1	0.963	0.022
HIP1	STAMBP	0.962	0.048
DAB2	CLINT1	0.962	0.062
PICALM	ZNF106	0.96	0.066
GTSE1	CLTCL1	0.959	0.144
PAAT	HIP1	0.959	0.06
GTSE1	PIK3C2A	0.958	0.138
BMP2K	GAK	0.957	0.106
HIP1	GAK	0.955	0.058
TNRC6A	BMP2K	0.954	0.102
DAB2	CLTA	0.953
CLTCL1	HIP1	0.953	0.18
BMP2K	CLTCL1	0.952	0.088
WNK1	CLTA	0.947
PAAT	CLTCL1	0.946	0.098
HIP1	NUMB	0.945	0.058
PIK3C2A	HIP1	0.944	0.084
DENND1A	DAB2	0.943	0.05
DENND1A	CLINT1	0.943	0.094
TNRC6A	PIK3C2A	0.94	0.198
STAMBP	GAK	0.938	0.104	structurally_consistent (dimer)
DAB2	GAK	0.937	0.068
GTSE1	DAB2	0.935	0.092
PICALM	NUMB	0.933	0.092
TNRC6A	DAB2	0.928	0.094
PAAT	PIK3C2A	0.928	0.126
PICALM	HIP1	0.925	0.044
PICALM	GAK	0.919	0.076
TNRC6A	CLINT1	0.916	0.138
PAAT	CLINT1	0.907	0.078
STAMBP	NUMB	0.907	0.02
PIK3C2A	WNK1	0.906	0.07
DENND1A	WNK1	0.88	0.09
GTSE1	CLTA	0.873
PAAT	PICALM	0.869	0.118	mutually_exclusive (Q96FJ0)
GTSE1	NUMB	0.862	0.125333333333
ZNF106	CLINT1	0.86	0.04
CLINT1	NUMB	0.857	0.138
PAAT	BMP2K	0.855	0.118
PAAT	NUMB	0.854	0.094
TNRC6A	DENND1A	0.842	0.126
HIP1	CLINT1	0.839	0.136
PICALM	WNK1	0.836	0.07
TNRC6A	STAMBP	0.832	0.134
WNK1	CLTCL1	0.831	0.214
PAAT	GAK	0.829	0.152
GTSE1	TNRC6A	0.823	0.15
DAB2	CLTCL1	0.815	0.164347826087
DENND1A	STAMBP	0.808	0.07
DAB2	WNK1	0.781	0.024
DAB2	ZNF106	0.781	0.114
TNRC6A	NUMB	0.777	0.104
NUMB	CLTA	0.771
DAB2	STAMBPL1	0.764	0.054
TNRC6A	CLTCL1	0.748	0.174
PICALM	STAMBP	0.738	0.044
PAAT	DENND1A	0.729	0.134
WNK1	CLINT1	0.709	0.114
GTSE1	GAK	0.701	0.186
PAAT	CLTA	0.643
TNRC6A	WNK1	0.62	0.148
TNRC6A	HIP1	0.608	0.062
PAAT	DAB2	0.601	0.078
PAAT	GTSE1	0.578	0.15
TNRC6A	GAK	0.485	0.136
ZNF106	HIP1	0.288	0.09
ZNF106	STAMBP	0.203	0.04
PAAT	WNK1	0.157	0.078
DENND1A	ZNF106	0.149	0.062
PAAT	TNRC6A	0.131	0.094
DAB2	STAMBP	0.115	0.052
TNRC6A	ZNF106	0.073	0.136
PAAT	ZNF106	0.023	0.098

Related Complexes

Genename	Complexes
CLTA	huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1
PIK3C2A	huMAP3_03408.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_12918.1
CLINT1	huMAP3_05120.1 huMAP3_05849.1 huMAP3_06787.1 huMAP3_08320.1 huMAP3_08744.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12394.1 huMAP3_12918.1
DENND1A	huMAP3_03408.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_12918.1
PICALM	huMAP3_01840.1 huMAP3_03408.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10673.1 huMAP3_10762.1 huMAP3_12394.1
STAMBPL1	huMAP3_04518.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_12918.1
BMP2K	huMAP3_03408.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_12918.1
HIP1	huMAP3_03848.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_12918.1
TNRC6A	huMAP3_02184.1 huMAP3_02426.1 huMAP3_04863.1 huMAP3_06787.1 huMAP3_08646.1 huMAP3_09137.1 huMAP3_09157.1 huMAP3_10669.1 huMAP3_10762.1 huMAP3_11061.1 huMAP3_11083.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13205.1
DAB2	huMAP3_03408.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1
GAK	huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_12918.1
STAMBP	huMAP3_04518.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13374.1
GTSE1	huMAP3_01751.1 huMAP3_03408.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1
NUMB	huMAP3_06740.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_14578.1
ZNF106	huMAP3_03408.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_12918.1
WNK1	huMAP3_03408.1 huMAP3_04809.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_09965.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_12918.1
PAAT	huMAP3_00821.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_11906.1 huMAP3_12394.1 huMAP3_12918.1
CLTCL1	huMAP3_03408.1 huMAP3_06787.1 huMAP3_08744.1 huMAP3_10762.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13956.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06787.1

Complex Portal: CPX-24939