hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06798.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LDHB | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | 5 | UniProt NCBI |
| ACADM | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (MCAD) (EC 1.3.8.7) (Medium chain acyl-CoA dehydrogenase) (MCADH) | 5 | UniProt NCBI |
| LDHA | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5314 | 2.34100360042e-05 | 1.0 | LDHB LDHA | Lactate shuttle in glial cells |
| WP:WP4236 | 3.31996874241e-05 | 1.0 | LDHB LDHA | Krebs cycle disorders |
| KEGG:00640 | 7.55949079301e-05 | 1.0 | LDHB LDHA | Propanoate metabolism |
| KEGG:00620 | 0.000146800434109 | 1.0 | LDHB LDHA | Pyruvate metabolism |
| KEGG:00270 | 0.00016825963378 | 1.0 | LDHB LDHA | Cysteine and methionine metabolism |
| KEGG:00010 | 0.000307419292249 | 1.0 | LDHB LDHA | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 0.000359441594481 | 1.0 | LDHB LDHA | Central carbon metabolism in cancer |
| WP:WP534 | 0.00036647347272 | 1.0 | LDHB LDHA | Glycolysis and gluconeogenesis |
| KEGG:04922 | 0.000680516741066 | 1.0 | LDHB LDHA | Glucagon signaling pathway |
| REAC:R-HSA-70268 | 0.000743311362176 | 1.0 | LDHB LDHA | Pyruvate metabolism |
| KEGG:04066 | 0.00078862558789 | 1.0 | LDHB LDHA | HIF-1 signaling pathway |
| WP:WP4018 | 0.00118114272566 | 1.0 | LDHB LDHA | Clear cell renal cell carcinoma pathways |
| WP:WP5355 | 0.00155570330173 | 1.0 | LDHB LDHA | Metabolic Epileptic Disorders |
| REAC:R-HSA-71406 | 0.00226581808332 | 1.0 | LDHB LDHA | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0004459 | 0.00468200720083 | 1.0 | LDHB LDHA | L-lactate dehydrogenase activity |
| GO:0004457 | 0.00468200720083 | 1.0 | LDHB LDHA | lactate dehydrogenase activity |
| GO:0006089 | 0.016855225923 | 1.0 | LDHB LDHA | lactate metabolic process |
| REAC:R-HSA-1428517 | 0.0242575818332 | 1.0 | LDHB LDHA | The citric acid (TCA) cycle and respiratory electron transport |
| WP:WP5166 | 0.0373151717536 | 0.5 | LDHA | Glyoxylate metabolism |
| WP:WP2456 | 0.049750157242 | 0.5 | LDHA | HIF1A and PPARG regulation of glycolysis |
| WP:WP5211 | 0.049750157242 | 0.5 | LDHA | Glucose metabolism in triple negative breast cancer cells |
| HP:0031236 | 0.0499436884913 | 0.5 | LDHA | Predominantly dermal neutrophilic infiltrate |
| HP:0007432 | 0.0499436884913 | 0.5 | LDHA | Intermittent generalized erythematous papular rash |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LDHB | LDHA | 0.997 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM | |
| ACADM | LDHA | 0.988 | hein_WMM bioplex_WMM Guru bioplex3_WMM fraction boldt_WMM treiber_WMM | |
| LDHB | ACADM | 0.757 | 0.112 | hein_WMM bioplex_WMM Guru bioplex3_WMM fraction boldt_WMM treiber_WMM |
Related Complexes