hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06799.1
Complex Portal: CPX-25710
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GPALPP1 | GPALPP motifs-containing protein 1 (Lipopolysaccharide-specific response protein 7) | 3 | UniProt NCBI |
| SNIP1 | Smad nuclear-interacting protein 1 (FHA domain-containing protein SNIP1) | 5 | UniProt NCBI |
| CCDC9 | Coiled-coil domain-containing protein 9 | 4 | UniProt NCBI |
| NKTR | NK-tumor recognition protein (NK-TR protein) (Natural-killer cells cyclophilin-related protein) (Peptidyl-prolyl cis-trans isomerase NKTR) (PPIase) (EC 5.2.1.8) (Rotamase) | 5 | UniProt NCBI |
| MAGOHB | Protein mago nashi homolog 2 | 5 | UniProt NCBI |
| EIF4A3 | Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed] | 5 | UniProt NCBI |
| PNN | Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein) | 5 | UniProt NCBI |
| NKAPD1 | Uncharacterized protein NKAPD1 (NKAP domain containing protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035145 | 8.89269760433e-06 | 0.5 | PNN EIF4A3 CCDC9 MAGOHB | exon-exon junction complex |
| REAC:R-HSA-72163 | 0.000495335177477 | 0.5 | PNN EIF4A3 SNIP1 MAGOHB | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.000567724058779 | 0.5 | PNN EIF4A3 SNIP1 MAGOHB | mRNA Splicing |
| KEGG:03015 | 0.000632962160982 | 0.375 | EIF4A3 MAGOHB PNN | mRNA surveillance pathway |
| KEGG:03013 | 0.000866047705047 | 0.375 | EIF4A3 MAGOHB PNN | Nucleocytoplasmic transport |
| REAC:R-HSA-72203 | 0.00169661698674 | 0.5 | PNN EIF4A3 SNIP1 MAGOHB | Processing of Capped Intron-Containing Pre-mRNA |
| HPA:0010000 | 0.0368302147851 | 0.875 | NKTR PNN SNIP1 EIF4A3 GPALPP1 CCDC9 NKAPD1 | adipose tissue |
| HPA:0010011 | 0.0368302147851 | 0.875 | NKTR PNN SNIP1 EIF4A3 GPALPP1 CCDC9 NKAPD1 | adipose tissue; adipocytes[>=Low] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CCDC9 | EIF4A3 | 1.0 | 0.1 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () |
| PNN | CCDC9 | 0.999 | 0.158 |
mutually_exclusive (P38919)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () |
| EIF4A3 | SNIP1 | 0.998 | 0.506 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PNN | EIF4A3 | 0.996 | 0.896 |
mutually_exclusive (O00422)
structurally_consistent (dimer) |
hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM |
| NKTR | CCDC9 | 0.996 | 0.062 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| EIF4A3 | NKAPD1 | 0.994 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CCDC9 | MAGOHB | 0.99 | 0.058 |
mutually_exclusive (P38919)
|
hein_WMM bioplex3_WMM hein () |
| PNN | SNIP1 | 0.989 | 0.442 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NKTR | PNN | 0.989 | 0.29 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CCDC9 | SNIP1 | 0.987 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NKTR | NKAPD1 | 0.986 | 0.17 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NKTR | EIF4A3 | 0.985 | 0.292 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| CCDC9 | NKAPD1 | 0.981 | 0.078 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GPALPP1 | CCDC9 | 0.974 | 0.136 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PNN | MAGOHB | 0.97 | 0.766 | hein_WMM bioplex3_WMM WMM_only | |
| PNN | NKAPD1 | 0.968 | 0.098 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PNN | GPALPP1 | 0.937 | 0.328 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| GPALPP1 | SNIP1 | 0.896 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NKTR | SNIP1 | 0.889 | 0.217 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MAGOHB | EIF4A3 | 0.869 | 0.84 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_WMM gupta_WMM WMM_only |
| GPALPP1 | NKAPD1 | 0.742 | 0.16 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NKTR | GPALPP1 | 0.668 | 0.126 | bioplex_WMM bioplex3_WMM WMM_only | |
| GPALPP1 | EIF4A3 | 0.357 | 0.136 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| NKAPD1 | SNIP1 | 0.302 | 0.14 | bioplex3_WMM WMM_only | |
| NKTR | MAGOHB | 0.232 | 0.15 | hein_WMM WMM_only |
Related Complexes