hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06804.1
Confidence: Very High  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
KMT2C | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | 5 | UniProt   NCBI |
ASH2L | Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  CORUM:1400 | 3.58839967947e-05 | 1.0 | ASH2L KMT2C | ASCOM complex |
  CORUM:6461 | 6.15154230766e-05 | 1.0 | ASH2L KMT2C | MLL3 complex |
  CORUM:5195 | 7.68942788458e-05 | 1.0 | ASH2L KMT2C | PTIP-HMT complex |
  CORUM:3075 | 0.000112778275641 | 1.0 | ASH2L KMT2C | UTX-MLL2/3 complex |
  WP:WP5351 | 0.000172808629413 | 1.0 | ASH2L KMT2C | Kleefstra syndrome |
  REAC:R-HSA-9772755 | 0.00133283416666 | 1.0 | ASH2L KMT2C | Formation of WDR5-containing histone-modifying complexes |
  REAC:R-HSA-3214841 | 0.00389255927135 | 1.0 | ASH2L KMT2C | PKMTs methylate histone lysines |
  REAC:R-HSA-8936459 | 0.00539968713673 | 1.0 | ASH2L KMT2C | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
  REAC:R-HSA-5619507 | 0.0095092591506 | 1.0 | ASH2L KMT2C | Activation of HOX genes during differentiation |
  REAC:R-HSA-5617472 | 0.0095092591506 | 1.0 | ASH2L KMT2C | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
  REAC:R-HSA-212165 | 0.0248368520672 | 1.0 | ASH2L KMT2C | Epigenetic regulation of gene expression |
  GO:0044666 | 0.0257510396046 | 1.0 | ASH2L KMT2C | MLL3/4 complex |
  REAC:R-HSA-8878171 | 0.0378576166184 | 1.0 | ASH2L KMT2C | Transcriptional regulation by RUNX1 |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
---|---|---|---|---|
 KMT2C |  ASH2L | 0.955 | 0.082           | bioplex3_HEK293     bioplex3_WMM     WMM_only     |
Related Complexes