List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_06808.1

Confidence: Very High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
DCAF1	DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein)	5	UniProt   NCBI
DCAF8L2	DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C)	2	UniProt   NCBI
CRBN	Protein cereblon	5	UniProt   NCBI
RBX1	E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]	5	UniProt   NCBI
CUL4A	Cullin-4A (CUL-4A)	5	UniProt   NCBI
CUL4B	Cullin-4B (CUL-4B)	5	UniProt   NCBI
DTL	Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)	5	UniProt   NCBI
DDB1	DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)	5	UniProt   NCBI
BRWD3	Bromodomain and WD repeat-containing protein 3	5	UniProt   NCBI
DDA1	DET1- and DDB1-associated protein 1 (Placenta cross-immune reaction antigen 1) (PCIA-1)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0080008	5.61926895674e-19	0.9	CUL4A CUL4B DDA1 DCAF1 CRBN RBX1 DTL DCAF8L2 DDB1	Cul4-RING E3 ubiquitin ligase complex
GO:0031461	1.47714963752e-12	0.9	CUL4A CUL4B DDA1 DCAF1 CRBN RBX1 DTL DCAF8L2 DDB1	cullin-RING ubiquitin ligase complex
GO:0031464	2.32763219017e-12	0.6	CUL4A DDB1 CRBN RBX1 DTL CUL4B	Cul4A-RING E3 ubiquitin ligase complex
CORUM:6875	8.06664600281e-12	0.4	DDB1 CRBN RBX1 CUL4A	CRBN-DDB1-CUL4A-RBX1 E3 ubiquitin ligase
CORUM:1162	4.03199797571e-11	0.4	DDB1 CUL4A RBX1 CUL4B	Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1)
GO:0000151	1.40985089719e-10	0.9	CUL4A CUL4B DDA1 DCAF1 CRBN RBX1 DTL DCAF8L2 DDB1	ubiquitin ligase complex
REAC:R-HSA-110314	1.5510254452e-09	0.5	DDB1 CUL4A RBX1 DTL CUL4B	Recognition of DNA damage by PCNA-containing replication complex
REAC:R-HSA-73893	1.66143924879e-08	0.5	DDB1 CUL4A RBX1 DTL CUL4B	DNA Damage Bypass
CORUM:391	1.68385473419e-08	0.3	CUL4A RBX1 DDB1	Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)
CORUM:2722	1.68385473419e-08	0.3	CUL4A RBX1 DDB1	Ubiquitin E3 ligase (DDB1, CUL4A, RBX1)
CORUM:6486	1.68385473419e-08	0.3	CUL4A DDB1 DTL	CUL4A-DDB1-DTL complex
GO:0031465	2.76191861336e-08	0.4	DDB1 DTL RBX1 CUL4B	Cul4B-RING E3 ubiquitin ligase complex
CORUM:2172	6.73299894294e-08	0.3	CUL4A RBX1 DDB1	Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1)
CORUM:6482	1.68264493604e-07	0.3	DTL CUL4B DDB1	CUL4B-DDB1-DTL-CSN complex
CORUM:1214	1.68264493604e-07	0.3	CUL4A RBX1 DDB1	Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1)
CORUM:1211	3.36408067008e-07	0.3	DDB1 RBX1 CUL4B	Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1)
REAC:R-HSA-8951664	6.00228081961e-07	0.6	CUL4A DDB1 DDA1 RBX1 DTL CUL4B	Neddylation
WP:WP4753	1.32525793849e-06	0.4	DDB1 CUL4A RBX1 CUL4B	Nucleotide excision repair
GO:1990234	1.54664239811e-06	0.9	CUL4A CUL4B DDA1 DCAF1 CRBN RBX1 DTL DCAF8L2 DDB1	transferase complex
REAC:R-HSA-5696394	1.94851007479e-06	0.4	DDB1 CUL4A RBX1 CUL4B	DNA Damage Recognition in GG-NER
KEGG:03420	2.31932768775e-06	0.4	DDB1 CUL4A RBX1 CUL4B	Nucleotide excision repair
GO:0140535	2.59440577325e-06	0.9	CUL4A CUL4B DDA1 DCAF1 CRBN RBX1 DTL DCAF8L2 DDB1	intracellular protein-containing complex
REAC:R-HSA-5696400	2.67060771041e-06	0.4	DDB1 CUL4A RBX1 CUL4B	Dual Incision in GG-NER
REAC:R-HSA-5696395	2.95075305606e-06	0.4	DDB1 CUL4A RBX1 CUL4B	Formation of Incision Complex in GG-NER
CORUM:726	3.69251717673e-06	0.3	CUL4A RBX1 DDB1	DDB2 complex
CORUM:728	3.69251717673e-06	0.3	CUL4A RBX1 DDB1	CSA-POLIIa complex
CORUM:727	3.69251717673e-06	0.3	CUL4A RBX1 DDB1	CSA complex
KEGG:05170	4.58598435337e-06	0.5	DDB1 CUL4A DCAF1 CUL4B RBX1	Human immunodeficiency virus 1 infection
REAC:R-HSA-6781823	7.11352916135e-06	0.4	DDB1 CUL4A RBX1 CUL4B	Formation of TC-NER Pre-Incision Complex
WP:WP5114	1.15733662318e-05	0.4	DDB1 CUL4A RBX1 CUL4B	Nucleotide excision repair in xeroderma pigmentosum
GO:0045732	1.47064684114e-05	0.6	CUL4A DDB1 DCAF1 DDA1 RBX1 DTL	positive regulation of protein catabolic process
REAC:R-HSA-6782210	1.55950062043e-05	0.4	DDB1 CUL4A RBX1 CUL4B	Gap-filling DNA repair synthesis and ligation in TC-NER
REAC:R-HSA-6782135	1.66291944782e-05	0.4	DDB1 CUL4A RBX1 CUL4B	Dual incision in TC-NER
WP:WP4541	3.50558212031e-05	0.4	DDB1 CUL4A DCAF1 RBX1	Hippo Merlin signaling dysregulation
REAC:R-HSA-6781827	3.52668021108e-05	0.4	DDB1 CUL4A RBX1 CUL4B	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
REAC:R-HSA-5696399	4.77943696984e-05	0.4	DDB1 CUL4A RBX1 CUL4B	Global Genome Nucleotide Excision Repair (GG-NER)
GO:0043687	5.08048355225e-05	0.8	CUL4A CUL4B DDA1 DCAF1 CRBN RBX1 DTL DDB1	post-translational protein modification
WP:WP4946	6.75663156792e-05	0.4	DDB1 CUL4A RBX1 CUL4B	DNA repair pathways full network
KEGG:04120	7.05246698215e-05	0.4	DDB1 CUL4A RBX1 CUL4B	Ubiquitin mediated proteolysis
GO:0010498	9.01632007068e-05	0.7	CUL4A DDB1 DDA1 CRBN RBX1 DTL CUL4B	proteasomal protein catabolic process
CORUM:224	9.22394575203e-05	0.2	RBX1 CUL4B	CAND1-CUL4B-RBX1 complex
CORUM:6488	9.22394575203e-05	0.2	CUL4A DDB1	CUL4A-DDB1-EED complex
CORUM:6489	9.22394575203e-05	0.2	CUL4A DDB1	CUL4A-DDB1-WDR5 complex
CORUM:6490	9.22394575203e-05	0.2	CUL4B DDB1	CUL4B-DDB1-WDR26 complex
CORUM:6553	9.22394575203e-05	0.2	CUL4B DDB1	CUL4B-DDB1-TLE3 complex
CORUM:6491	9.22394575203e-05	0.2	CUL4A DDB1	CUL4A-DDB1-RBBP5 complex
CORUM:223	9.22394575203e-05	0.2	CUL4A RBX1	CAND1-CUL4A-RBX1 complex
CORUM:6487	9.22394575203e-05	0.2	CUL4B DDB1	CUL4B-DDB1-TLE2 complex
CORUM:6493	9.22394575203e-05	0.2	CUL4A DDB1	CUL4A-DDB1-WDR57 complex
CORUM:6494	9.22394575203e-05	0.2	CUL4A DDB1	CUL4A-DDB1-WDR61 complex
CORUM:6495	9.22394575203e-05	0.2	CUL4B DDB1	CUL4B-DDB1-GRWD1 complex
CORUM:6550	9.22394575203e-05	0.2	CUL4A DDB1	CUL4B-DDB1-TLE1 complex
CORUM:6492	9.22394575203e-05	0.2	CUL4A DDB1	CUL4A-DDB1-WDR5B complex
GO:0030163	0.000111433438132	0.8	CUL4A CUL4B DDA1 DCAF1 CRBN RBX1 DTL DDB1	protein catabolic process
REAC:R-HSA-5696398	0.000138239115309	0.4	DDB1 CUL4A RBX1 CUL4B	Nucleotide Excision Repair
CORUM:6291	0.000184411585051	0.2	CUL4A DDB1	Ubiquitin E3 ligase (DDIT4, DDB1, BTRC, CUL4A)
CORUM:6290	0.000184411585051	0.2	DCAF1 DDB1	Ubiquitin E3 ligase (DDB1, DYRK2, EDD, VPRBP)
REAC:R-HSA-73894	0.000217508574823	0.5	DDB1 CUL4A RBX1 DTL CUL4B	DNA Repair
GO:0016567	0.000364333435574	0.7	CUL4A DDB1 DDA1 CRBN RBX1 DTL CUL4B	protein ubiquitination
GO:0009411	0.000401127164141	0.5	DDB1 CUL4A RBX1 DTL CUL4B	response to UV
GO:0042176	0.000423454860605	0.6	CUL4A DDB1 DCAF1 DDA1 RBX1 DTL	regulation of protein catabolic process
GO:1902494	0.000662262703055	0.9	CUL4A CUL4B DDA1 DCAF1 CRBN RBX1 DTL DCAF8L2 DDB1	catalytic complex
GO:0032446	0.00088947026641	0.7	CUL4A DDB1 DDA1 CRBN RBX1 DTL CUL4B	protein modification by small protein conjugation
GO:0051603	0.00107119804474	0.7	CUL4A DDB1 DDA1 CRBN RBX1 DTL CUL4B	proteolysis involved in protein catabolic process
GO:0043161	0.00130077111047	0.6	CUL4A DDB1 DDA1 CRBN RBX1 DTL	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0009057	0.00135639782295	0.8	CUL4A CUL4B DDA1 DCAF1 CRBN RBX1 DTL DDB1	macromolecule catabolic process
GO:1901565	0.0014401908811	0.8	CUL4A CUL4B DDA1 DCAF1 CRBN RBX1 DTL DDB1	organonitrogen compound catabolic process
GO:0070647	0.00176090365143	0.7	CUL4A DDB1 DDA1 CRBN RBX1 DTL CUL4B	protein modification by small protein conjugation or removal
GO:0009416	0.0036852365438	0.5	DDB1 CUL4A RBX1 DTL CUL4B	response to light stimulus
GO:0009896	0.00532495701577	0.6	CUL4A DDB1 DCAF1 DDA1 RBX1 DTL	positive regulation of catabolic process
GO:0034644	0.0065610560312	0.4	DDB1 CUL4A RBX1 CUL4B	cellular response to UV
GO:0006511	0.0130588724203	0.6	CUL4A DDB1 DDA1 CRBN RBX1 DTL	ubiquitin-dependent protein catabolic process
REAC:R-HSA-597592	0.0133621598082	0.6	CUL4A DDB1 DDA1 RBX1 DTL CUL4B	Post-translational protein modification
GO:0071482	0.0137249930817	0.4	DDB1 CUL4A RBX1 CUL4B	cellular response to light stimulus
GO:0019941	0.0143680008842	0.6	CUL4A DDB1 DDA1 CRBN RBX1 DTL	modification-dependent protein catabolic process
GO:0043632	0.0163434963921	0.6	CUL4A DDB1 DDA1 CRBN RBX1 DTL	modification-dependent macromolecule catabolic process
CORUM:929	0.0170546710554	0.2	CUL4A DDB1	CEN complex
GO:0009314	0.0189637966682	0.5	DDB1 CUL4A RBX1 DTL CUL4B	response to radiation
GO:1901575	0.0227580155965	0.8	CUL4A CUL4B DDA1 DCAF1 CRBN RBX1 DTL DDB1	organic substance catabolic process
GO:0006508	0.0495346868368	0.7	CUL4A DDB1 DDA1 CRBN RBX1 DTL CUL4B	proteolysis



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
CUL4A	CUL4B	0.999	0.374	hein_WMM     bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     boldt     youn_WMM     gupta_WMM     boldt_WMM     WMM_only
DTL	CUL4B	0.999	0.11	hein_WMM     bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     hein ()     bioplex3_HCT116
DDB1	DDA1	0.999	0.2	hein_WMM     bioplex_WMM     Guru     bioplex3_WMM     boldt     hein ()     fraction     boldt_WMM
DDA1	DCAF1	0.999	0.188	hein_WMM     bioplex_WMM     Guru     bioplex3_WMM     boldt     hein ()     Malo     fraction     boldt_WMM
CUL4A	DDA1	0.999	0.12	hein_WMM     bioplex_WMM     bioplex3_WMM     hein ()
DTL	CUL4A	0.999	0.242	hein_WMM     bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     hein ()     bioplex3_HCT116
DTL	DDB1	0.999	0.226	hein_WMM     bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     hein ()     bioplex3_HCT116
CUL4A	RBX1	0.998	0.878	hein_WMM     bioplex3_HEK293     bioplex3_WMM     hein ()
CUL4B	DDB1	0.998	0.272	hein_WMM     bioplex3_HEK293     bioplex_WMM     Guru     bioplex3_WMM     boldt     youn_WMM     hein ()     bioplex3_HCT116     gupta_WMM     fraction     boldt_WMM
CRBN	CUL4B	0.997	0.136	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
DTL	DDA1	0.997	0.14	hein_WMM     bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     hein ()
CUL4B	DCAF1	0.997	0.048	hein_WMM     bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     hein ()     bioplex3_HCT116
CUL4A	BRWD3	0.996		hein_WMM     bioplex_WMM     bioplex3_WMM     hein ()
CUL4B	RBX1	0.996	0.138	hein_WMM     bioplex3_HEK293     bioplex3_WMM     hein ()
CUL4A	DDB1	0.995	0.628	hein_WMM     bioplex_WMM     Guru     bioplex3_WMM     boldt     youn_WMM     hein ()     gupta_WMM     fraction     boldt_WMM
CUL4B	DDA1	0.994	0.092	hein_WMM     bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     hein ()
DDB1	BRWD3	0.991		hein_WMM     bioplex_WMM     bioplex3_WMM     hein ()
BRWD3	DDA1	0.989		hein_WMM     bioplex_WMM     bioplex3_WMM     WMM_only
DDB1	DCAF1	0.987	0.164	hein_WMM     bioplex_WMM     Guru     bioplex3_WMM     boldt     hein ()     gupta_WMM     fraction     boldt_WMM
CRBN	CUL4A	0.985	0.228	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
DTL	RBX1	0.983	0.19	hein_WMM     bioplex3_WMM     hein ()
CRBN	DDB1	0.983	0.307	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
DTL	DCAF1	0.983	0.114	hein_WMM     bioplex_WMM     bioplex3_WMM     WMM_only
BRWD3	DCAF1	0.982		hein_WMM     bioplex_WMM     bioplex3_WMM     WMM_only
DDB1	RBX1	0.969	0.638	hein_WMM     bioplex3_HEK293     bioplex3_WMM     boldt     hein ()     boldt_WMM
CUL4B	BRWD3	0.955		hein_WMM     bioplex_WMM     bioplex3_WMM     hein ()
BRWD3	RBX1	0.941		hein_WMM     hein ()
CUL4A	DCAF1	0.939	0.126	hein_WMM     bioplex_WMM     bioplex3_WMM     hein ()     gupta_WMM
RBX1	DDA1	0.785	0.306	hein_WMM     WMM_only
RBX1	DCAF1	0.781	0.114	hein_WMM     WMM_only
CRBN	RBX1	0.75	0.3	bioplex3_HEK293     bioplex3_WMM     WMM_only
CRBN	DCAF1	0.588	0.114	bioplex_WMM     bioplex3_WMM     WMM_only
DTL	CRBN	0.18	0.094	bioplex_WMM     bioplex3_WMM     WMM_only
DTL	BRWD3	0.149		hein_WMM     WMM_only
CRBN	DDA1	0.058	0.034	bioplex_WMM     bioplex3_WMM     WMM_only





Related Complexes

Genename	Complexes
DCAF1	huMAP3_05150.1 huMAP3_06808.1 huMAP3_07675.1 huMAP3_09779.1
DCAF8L2	huMAP3_00263.1 huMAP3_00860.1 huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_11100.1 huMAP3_11271.1 huMAP3_12806.1 huMAP3_13329.1 huMAP3_14528.1
CRBN	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
RBX1	huMAP3_02231.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
CUL4A	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
CUL4B	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
DTL	huMAP3_01951.1 huMAP3_06559.1 huMAP3_06808.1 huMAP3_07938.1 huMAP3_09191.1 huMAP3_09779.1 huMAP3_10656.1 huMAP3_14528.1 huMAP3_14584.1
DDB1	huMAP3_02229.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_11271.1 huMAP3_14528.1
BRWD3	huMAP3_02229.1 huMAP3_02953.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1
DDA1	huMAP3_02953.1 huMAP3_05150.1 huMAP3_06808.1 huMAP3_08251.1 huMAP3_09283.1 huMAP3_09779.1 huMAP3_10612.1 huMAP3_14528.1