hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06811.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NXF2 | Nuclear RNA export factor 2 (Cancer/testis antigen 39) (CT39) (TAP-like protein 2) (TAPL-2) | 5 | UniProt NCBI |
| NUP42 | Nucleoporin NUP42 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1) (Nucleoporin-42) (Nucleoporin-like protein 2) | 5 | UniProt NCBI |
| GLE1 | mRNA export factor GLE1 (hGLE1) (GLE1 RNA export mediator) (GLE1-like protein) (Nucleoporin GLE1) | 5 | UniProt NCBI |
| RAE1 | mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41) | 5 | UniProt NCBI |
| NXT1 | NTF2-related export protein 1 (Protein p15) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-159236 | 8.80508022231e-08 | 1.0 | NXT1 GLE1 NUP42 RAE1 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| KEGG:03013 | 9.59218740742e-08 | 1.0 | NXT1 GLE1 NUP42 RAE1 | Nucleocytoplasmic transport |
| REAC:R-HSA-72202 | 1.44287424832e-07 | 1.0 | NXT1 GLE1 NUP42 RAE1 | Transport of Mature Transcript to Cytoplasm |
| CORUM:1348 | 1.53774525569e-05 | 0.5 | GLE1 NUP42 | GLE1-NUPL2-NUP155 complex |
| REAC:R-HSA-72203 | 2.20624569728e-05 | 1.0 | NXT1 GLE1 NUP42 RAE1 | Processing of Capped Intron-Containing Pre-mRNA |
| WP:WP3998 | 3.1983058296e-05 | 0.75 | GLE1 NUP42 RAE1 | Prader Willi and Angelman syndrome |
| GO:0005643 | 4.8352616995e-05 | 1.0 | NXT1 GLE1 NUP42 RAE1 | nuclear pore |
| GO:0051168 | 0.000427172539681 | 1.0 | NXT1 GLE1 NUP42 RAE1 | nuclear export |
| REAC:R-HSA-8953854 | 0.000868181971164 | 1.0 | NXT1 GLE1 NUP42 RAE1 | Metabolism of RNA |
| KEGG:05014 | 0.00189623846113 | 0.75 | NXT1 GLE1 RAE1 | Amyotrophic lateral sclerosis |
| GO:0051169 | 0.00366770658506 | 1.0 | NXT1 GLE1 NUP42 RAE1 | nuclear transport |
| GO:0006913 | 0.00366770658506 | 1.0 | NXT1 GLE1 NUP42 RAE1 | nucleocytoplasmic transport |
| REAC:R-HSA-170822 | 0.00386628370571 | 0.5 | RAE1 NUP42 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-5619107 | 0.00386628370571 | 0.5 | RAE1 NUP42 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168271 | 0.00415229579539 | 0.5 | RAE1 NUP42 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-168333 | 0.00415229579539 | 0.5 | RAE1 NUP42 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168274 | 0.00415229579539 | 0.5 | RAE1 NUP42 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-159227 | 0.00475483947495 | 0.5 | RAE1 NUP42 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180910 | 0.00475483947495 | 0.5 | RAE1 NUP42 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-180746 | 0.00475483947495 | 0.5 | RAE1 NUP42 | Nuclear import of Rev protein |
| REAC:R-HSA-4085377 | 0.00507136546841 | 0.5 | RAE1 NUP42 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-159230 | 0.00507136546841 | 0.5 | RAE1 NUP42 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-165054 | 0.00507136546841 | 0.5 | RAE1 NUP42 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-3301854 | 0.00539805716719 | 0.5 | RAE1 NUP42 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-176033 | 0.00573491177379 | 0.5 | RAE1 NUP42 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-177243 | 0.00573491177379 | 0.5 | RAE1 NUP42 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-3232142 | 0.006081926491 | 0.5 | RAE1 NUP42 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 0.0068064250699 | 0.5 | RAE1 NUP42 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 0.00718390333861 | 0.5 | RAE1 NUP42 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 0.007571530532 | 0.5 | RAE1 NUP42 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 0.0079693038543 | 0.5 | RAE1 NUP42 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4615885 | 0.008795277704 | 0.5 | RAE1 NUP42 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 0.00922347264132 | 0.5 | RAE1 NUP42 | SUMOylation of RNA binding proteins |
| KEGG:03015 | 0.0101879335017 | 0.5 | GLE1 NXT1 | mRNA surveillance pathway |
| REAC:R-HSA-2980766 | 0.0110375739361 | 0.5 | RAE1 NUP42 | Nuclear Envelope Breakdown |
| REAC:R-HSA-191859 | 0.0130136556072 | 0.5 | RAE1 NUP42 | snRNP Assembly |
| REAC:R-HSA-194441 | 0.0130136556072 | 0.5 | RAE1 NUP42 | Metabolism of non-coding RNA |
| REAC:R-HSA-6784531 | 0.0151515389193 | 0.5 | RAE1 NUP42 | tRNA processing in the nucleus |
| GO:0005635 | 0.0163581002539 | 1.0 | NXT1 GLE1 NUP42 RAE1 | nuclear envelope |
| GO:0006406 | 0.0175369202004 | 0.75 | NXT1 GLE1 RAE1 | mRNA export from nucleus |
| REAC:R-HSA-3371453 | 0.0212029570934 | 0.5 | RAE1 NUP42 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-70171 | 0.0212029570934 | 0.5 | RAE1 NUP42 | Glycolysis |
| REAC:R-HSA-1169408 | 0.0218635493976 | 0.5 | RAE1 NUP42 | ISG15 antiviral mechanism |
| REAC:R-HSA-4551638 | 0.0218635493976 | 0.5 | RAE1 NUP42 | SUMOylation of chromatin organization proteins |
| GO:0051028 | 0.0228491864842 | 0.75 | NXT1 GLE1 RAE1 | mRNA transport |
| REAC:R-HSA-5619102 | 0.0246065982605 | 0.5 | RAE1 NUP42 | SLC transporter disorders |
| REAC:R-HSA-3108214 | 0.0253175164514 | 0.5 | RAE1 NUP42 | SUMOylation of DNA damage response and repair proteins |
| KEGG:05164 | 0.0254912281659 | 0.5 | RAE1 NXT1 | Influenza A |
| REAC:R-HSA-1169410 | 0.0260384914588 | 0.5 | RAE1 NUP42 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-70326 | 0.0313666733646 | 0.5 | RAE1 NUP42 | Glucose metabolism |
| REAC:R-HSA-3371556 | 0.0363250695065 | 0.5 | RAE1 NUP42 | Cellular response to heat stress |
| GO:0006405 | 0.0378152735667 | 0.75 | NXT1 GLE1 RAE1 | RNA export from nucleus |
| REAC:R-HSA-5578749 | 0.041644107744 | 0.5 | RAE1 NUP42 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-9610379 | 0.0492961191682 | 0.5 | RAE1 NUP42 | HCMV Late Events |
| REAC:R-HSA-72306 | 0.0492961191682 | 0.5 | RAE1 NUP42 | tRNA processing |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NUP42 | NXT1 | 0.998 | 0.16 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NUP42 | GLE1 | 0.998 | 0.36 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RAE1 | GLE1 | 0.998 | 0.212 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NUP42 | RAE1 | 0.994 | 0.522 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NXT1 | RAE1 | 0.994 | 0.242 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NXT1 | GLE1 | 0.99 | 0.204 | hein_WMM youn () bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NXT1 | NXF2 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| NXF2 | GLE1 | 0.964 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| NUP42 | NXF2 | 0.957 | bioplex3_HEK293 bioplex () bioplex_WMM | |
| RAE1 | NXF2 | 0.937 | bioplex3_HEK293 bioplex () bioplex_WMM |
Related Complexes