hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06815.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ITGB1 | Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29) | 5 | UniProt NCBI |
| ITGA3 | Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] | 5 | UniProt NCBI |
| ITGA2 | Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) | 5 | UniProt NCBI |
| ITGA8 | Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] | 5 | UniProt NCBI |
| ITGA9 | Integrin alpha-9 (Integrin alpha-RLC) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2118 | 1.08868750006e-08 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:04512 | 1.80072369785e-08 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | ECM-receptor interaction |
| KEGG:05412 | 1.91326892896e-08 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:05414 | 3.01414712223e-08 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | Dilated cardiomyopathy |
| KEGG:05410 | 3.01414712223e-08 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | Hypertrophic cardiomyopathy |
| WP:WP185 | 4.6154770768e-08 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | Integrin mediated cell adhesion |
| REAC:R-HSA-216083 | 5.72026034674e-08 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | Integrin cell surface interactions |
| WP:WP4541 | 7.94631888247e-08 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | Hippo Merlin signaling dysregulation |
| GO:0008305 | 8.0516650888e-08 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | integrin complex |
| KEGG:04510 | 8.46748806039e-07 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | Focal adhesion |
| WP:WP306 | 8.62144238876e-07 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | Focal adhesion |
| KEGG:04810 | 1.37223941713e-06 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | Regulation of actin cytoskeleton |
| GO:0098636 | 1.737817715e-06 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | protein complex involved in cell adhesion |
| WP:WP4823 | 2.08824407225e-06 | 0.75 | ITGB1 ITGA3 ITGA8 | Genes controlling nephrogenesis |
| WP:WP3932 | 3.67968103286e-06 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | Focal adhesion PI3K Akt mTOR signaling pathway |
| CORUM:2401 | 5.12628525639e-06 | 0.5 | ITGB1 ITGA3 | ITGA3-ITGB1-THBS1 complex |
| CORUM:2406 | 5.12628525639e-06 | 0.5 | ITGB1 ITGA3 | ITGA3-ITGB1 complex |
| CORUM:2442 | 5.12628525639e-06 | 0.5 | ITGB1 ITGA9 | ITGA9-ITGB1-VCAM1 complex |
| CORUM:2439 | 5.12628525639e-06 | 0.5 | ITGB1 ITGA8 | ITGA8-ITGB1 complex |
| CORUM:2443 | 5.12628525639e-06 | 0.5 | ITGB1 ITGA9 | ITGA9-ITGB1-TNC complex |
| CORUM:2444 | 5.12628525639e-06 | 0.5 | ITGB1 ITGA9 | ITGB1-ITGA9 complex |
| CORUM:2971 | 5.12628525639e-06 | 0.5 | ITGB1 ITGA9 | ITGA9-ITGB1-VEGFC complex |
| CORUM:3111 | 5.12628525639e-06 | 0.5 | ITGB1 ITGA9 | ITGA9-ITGB1-SPP1 complex |
| CORUM:2447 | 5.12628525639e-06 | 0.5 | ITGB1 ITGA9 | ITGA9-ITGB1-ADAM12 complex |
| CORUM:2989 | 5.12628525639e-06 | 0.5 | ITGB1 ITGA9 | ITGA9-ITGB1-ADAM8 complex |
| CORUM:2972 | 5.12628525639e-06 | 0.5 | ITGB1 ITGA9 | ITGA9-ITGB1-VEGFA complex |
| WP:WP4172 | 5.25751448284e-06 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | PI3K Akt signaling pathway |
| KEGG:04151 | 6.41284406676e-06 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | PI3K-Akt signaling pathway |
| KEGG:05165 | 7.16515850814e-06 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | Human papillomavirus infection |
| GO:0033627 | 7.70499617526e-06 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | cell adhesion mediated by integrin |
| REAC:R-HSA-1474244 | 1.05306246315e-05 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | Extracellular matrix organization |
| CORUM:2399 | 1.53774525569e-05 | 0.5 | ITGB1 ITGA3 | ITGA3-ITGB1-CD63 complex |
| CORUM:2446 | 1.53774525569e-05 | 0.5 | ITGB1 ITGA9 | ITGA9-ITGB1-FIGF complex |
| CORUM:2445 | 1.53774525569e-05 | 0.5 | ITGB1 ITGA9 | ITGA9-ITGB1-ADAM15 complex |
| CORUM:2400 | 1.53774525569e-05 | 0.5 | ITGB1 ITGA3 | ITGA3-ITGB1-CD151 complex |
| CORUM:2440 | 1.53774525569e-05 | 0.5 | ITGB1 ITGA9 | ITGA9-ITGB1-ADAM9 complex |
| CORUM:2398 | 1.53774525569e-05 | 0.5 | ITGB1 ITGA3 | ITGA3-ITGB1-BSG complex |
| CORUM:6951 | 3.07520988333e-05 | 0.5 | ITGB1 ITGA3 | NG2-galectin-3-alpha3beta1-integrin complex |
| GO:0007229 | 3.3758447769e-05 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | integrin-mediated signaling pathway |
| REAC:R-HSA-3000178 | 4.31752882115e-05 | 0.75 | ITGB1 ITGA8 ITGA9 | ECM proteoglycans |
| KEGG:04514 | 6.21896513057e-05 | 0.75 | ITGB1 ITGA8 ITGA9 | Cell adhesion molecules |
| GO:0005178 | 0.000107432498963 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | integrin binding |
| GO:0048333 | 0.000109904886398 | 0.75 | ITGB1 ITGA3 ITGA8 | mesodermal cell differentiation |
| GO:0098802 | 0.000289685648329 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | plasma membrane signaling receptor complex |
| GO:0001707 | 0.000437924933217 | 0.75 | ITGB1 ITGA3 ITGA8 | mesoderm formation |
| GO:0048332 | 0.000510886175237 | 0.75 | ITGB1 ITGA3 ITGA8 | mesoderm morphogenesis |
| GO:0007160 | 0.000592905829921 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | cell-matrix adhesion |
| REAC:R-HSA-445144 | 0.0013924419067 | 0.5 | ITGB1 ITGA9 | Signal transduction by L1 |
| REAC:R-HSA-210991 | 0.00194479046925 | 0.5 | ITGB1 ITGA3 | Basigin interactions |
| WP:WP5348 | 0.00251837499235 | 0.5 | ITGB1 ITGA3 | 11p11 2 copy number variation syndrome |
| WP:WP5053 | 0.0027493593259 | 0.5 | ITGB1 ITGA8 | Development of ureteric collection system |
| GO:0034679 | 0.0028092043205 | 0.5 | ITGB1 ITGA9 | integrin alpha9-beta1 complex |
| GO:0034678 | 0.0028092043205 | 0.5 | ITGB1 ITGA8 | integrin alpha8-beta1 complex |
| GO:0034667 | 0.0028092043205 | 0.5 | ITGB1 ITGA3 | integrin alpha3-beta1 complex |
| REAC:R-HSA-8874081 | 0.00282403231951 | 0.5 | ITGB1 ITGA3 | MET activates PTK2 signaling |
| GO:0031589 | 0.00304132743104 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | cell-substrate adhesion |
| REAC:R-HSA-3000157 | 0.00359044851421 | 0.5 | ITGB1 ITGA3 | Laminin interactions |
| REAC:R-HSA-2129379 | 0.00415229579539 | 0.5 | ITGB1 ITGA8 | Molecules associated with elastic fibres |
| WP:WP2572 | 0.00480287938686 | 0.5 | ITGB1 ITGA3 | Primary focal segmental glomerulosclerosis FSGS |
| GO:0007498 | 0.00508133939815 | 0.75 | ITGB1 ITGA3 ITGA8 | mesoderm development |
| REAC:R-HSA-8875878 | 0.00573491177379 | 0.5 | ITGB1 ITGA3 | MET promotes cell motility |
| REAC:R-HSA-1566948 | 0.00643909852192 | 0.5 | ITGB1 ITGA8 | Elastic fibre formation |
| GO:0043235 | 0.00669062030536 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | receptor complex |
| REAC:R-HSA-2173789 | 0.00837722051003 | 0.5 | ITGB1 ITGA8 | TGF-beta receptor signaling activates SMADs |
| KEGG:05222 | 0.00909742323246 | 0.5 | ITGB1 ITGA3 | Small cell lung cancer |
| WP:WP4658 | 0.00992155513194 | 0.5 | ITGB1 ITGA3 | Small cell lung cancer |
| GO:0001704 | 0.0131184183431 | 0.75 | ITGB1 ITGA3 ITGA8 | formation of primary germ layer |
| GO:0098640 | 0.0168521501606 | 0.5 | ITGB1 ITGA9 | integrin binding involved in cell-matrix adhesion |
| WP:WP4217 | 0.0168573248614 | 0.5 | ITGB1 ITGA3 | Ebola virus infection in host |
| REAC:R-HSA-6806834 | 0.0239057396727 | 0.5 | ITGB1 ITGA3 | Signaling by MET |
| KEGG:03271 | 0.0244342250794 | 0.25 | ITGB1 | Virion - Rotavirus |
| CORUM:3035 | 0.0249718442456 | 0.25 | ITGB1 | LAT2-ITGB1 complex |
| CORUM:2431 | 0.0249718442456 | 0.25 | ITGB1 | ITGA2-ITGB1-COL6A3 complex |
| CORUM:3058 | 0.0249718442456 | 0.25 | ITGB1 | ITGA11-ITGB1 complex |
| CORUM:2413 | 0.0249718442456 | 0.25 | ITGB1 | ITGA6-ITGB1 complex |
| CORUM:2432 | 0.0249718442456 | 0.25 | ITGB1 | ITGA2-ITGB1 complex |
| CORUM:3057 | 0.0249718442456 | 0.25 | ITGB1 | ITGA10-ITGB1 complex |
| CORUM:2426 | 0.0249718442456 | 0.25 | ITGB1 | ITGA4-ITGB1-THBS1 complex |
| CORUM:2418 | 0.0249718442456 | 0.25 | ITGB1 | ITGA4-ITGB1 complex |
| CORUM:2421 | 0.0249718442456 | 0.25 | ITGB1 | ITGA4-ITGB1-VCAM1 complex |
| GO:0098797 | 0.0296421612139 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | plasma membrane protein complex |
| REAC:R-HSA-170834 | 0.0380580405855 | 0.5 | ITGB1 ITGA8 | Signaling by TGF-beta Receptor Complex |
| GO:0098634 | 0.042122686785 | 0.5 | ITGB1 ITGA9 | cell-matrix adhesion mediator activity |
| HPA:0270353 | 0.0432340582692 | 0.75 | ITGB1 ITGA3 ITGA8 | kidney; cells in glomeruli[High] |
| GO:0007369 | 0.0464975978221 | 0.75 | ITGB1 ITGA3 ITGA8 | gastrulation |
| GO:0050839 | 0.0476113999152 | 1.0 | ITGB1 ITGA9 ITGA3 ITGA8 | cell adhesion molecule binding |
| CORUM:3059 | 0.049938562206 | 0.25 | ITGB1 | ITGA11-ITGB1-COL1A1 complex |
| CORUM:3104 | 0.049938562206 | 0.25 | ITGB1 | ITGB1-NRP1 complex |
| CORUM:7012 | 0.049938562206 | 0.25 | ITGB1 | ITGB1-RACK1 complex |
| CORUM:3112 | 0.049938562206 | 0.25 | ITGB1 | ITGA5-ITGB1-SPP1 complex |
| CORUM:2385 | 0.049938562206 | 0.25 | ITGB1 | ITGA5-ITGB4 complex |
| CORUM:2397 | 0.049938562206 | 0.25 | ITGB1 | ITGA7-ITGB1-ITGB1BP3 complex |
| CORUM:2411 | 0.049938562206 | 0.25 | ITGB1 | ITGA6-ITGB1-CD151 complex |
| CORUM:2417 | 0.049938562206 | 0.25 | ITGB1 | ITGA4-ITGB1-EMILIN1 complex |
| CORUM:2419 | 0.049938562206 | 0.25 | ITGB1 | ITGA4-ITGB1-CD81 complex |
| CORUM:2420 | 0.049938562206 | 0.25 | ITGB1 | ITGA4-ITGB1-CD53 complex |
| CORUM:2422 | 0.049938562206 | 0.25 | ITGB1 | ITGA4-ITGB1-JAM2 complex |
| CORUM:2423 | 0.049938562206 | 0.25 | ITGB1 | ITGA4-ITGB1-CD47 complex |
| CORUM:2885 | 0.049938562206 | 0.25 | ITGB1 | ITGAV-ITGB1-SPP1 complex |
| CORUM:2424 | 0.049938562206 | 0.25 | ITGB1 | ITGA4-ITGB1-CD63 complex |
| CORUM:2429 | 0.049938562206 | 0.25 | ITGB1 | ITGA2-ITGB1-CD47 complex |
| CORUM:2430 | 0.049938562206 | 0.25 | ITGB1 | ITGA2-ITGB1-CHAD complex |
| CORUM:2434 | 0.049938562206 | 0.25 | ITGB1 | ITGA1-ITGB1-COL6A3 complex |
| CORUM:2435 | 0.049938562206 | 0.25 | ITGB1 | ITGA1-ITGB1-PTPN2 complex |
| CORUM:2436 | 0.049938562206 | 0.25 | ITGB1 | ITGAV-ITGB1 complex |
| CORUM:2390 | 0.049938562206 | 0.25 | ITGB1 | CD98-LAT2-ITGB1 complex |
| CORUM:2428 | 0.049938562206 | 0.25 | ITGB1 | ITGA4-ITGB1-THBS2 complex |
| CORUM:2437 | 0.049938562206 | 0.25 | ITGB1 | ITGA6-ITGB1-CYR61 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ITGB1 | ITGA2 | 0.993 | 0.352 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| ITGB1 | ITGA8 | 0.989 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM fraction | |
| ITGB1 | ITGA3 | 0.968 | 0.442 | hein_WMM bioplex_WMM bioplex3_WMM hein () treiber_WMM |
| ITGA3 | ITGA2 | 0.967 | 0.55 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ITGB1 | ITGA9 | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ITGA8 | ITGA2 | 0.243 | bioplex_WMM bioplex3_WMM WMM_only | |
| ITGA8 | ITGA3 | 0.078 | bioplex3_WMM WMM_only |
Related Complexes