hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06819.1
Complex Portal: CPX-24246
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FBXW4 | F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4) | 4 | UniProt NCBI |
| DCAF5 | DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) | 5 | UniProt NCBI |
| PFDN5 | Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1) | 5 | UniProt NCBI |
| WSB2 | WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein) | 3 | UniProt NCBI |
| VBP1 | Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1) | 5 | UniProt NCBI |
| PFDN2 | Prefoldin subunit 2 | 5 | UniProt NCBI |
| PFDN6 | Prefoldin subunit 6 (Protein Ke2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4918 | 2.50173792132e-11 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | Cellular proteostasis |
| CORUM:33 | 2.88300486966e-11 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | Prefoldin complex |
| CORUM:112 | 2.88300486966e-11 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | Prefoldin complex |
| GO:0016272 | 1.38095933257e-08 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | prefoldin complex |
| REAC:R-HSA-390466 | 2.38218500144e-08 | 0.714285714286 | VBP1 PFDN2 FBXW4 PFDN6 PFDN5 | Chaperonin-mediated protein folding |
| REAC:R-HSA-391251 | 3.5685870487e-08 | 0.714285714286 | VBP1 PFDN2 FBXW4 PFDN6 PFDN5 | Protein folding |
| REAC:R-HSA-389957 | 6.24091028415e-08 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | Prefoldin mediated transfer of substrate to CCT/TriC |
| REAC:R-HSA-389958 | 1.277713074e-07 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| GO:1905907 | 3.03561565333e-07 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | negative regulation of amyloid fibril formation |
| GO:1905906 | 1.25481586619e-06 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | regulation of amyloid fibril formation |
| REAC:R-HSA-392499 | 5.70757035849e-05 | 1.0 | DCAF5 PFDN2 PFDN5 FBXW4 WSB2 VBP1 PFDN6 | Metabolism of proteins |
| GO:1990000 | 6.76004009067e-05 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | amyloid fibril formation |
| GO:0061077 | 0.000476112840015 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | chaperone-mediated protein folding |
| GO:0001540 | 0.000698604747216 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | amyloid-beta binding |
| GO:0051082 | 0.00355458399407 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | unfolded protein binding |
| GO:1902904 | 0.00503558984177 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | negative regulation of supramolecular fiber organization |
| REAC:R-HSA-8951664 | 0.0233324089042 | 0.428571428571 | WSB2 FBXW4 DCAF5 | Neddylation |
| GO:0006457 | 0.0273552115046 | 0.571428571429 | PFDN2 PFDN6 PFDN5 VBP1 | protein folding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PFDN2 | VBP1 | 1.0 | 0.924 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| PFDN6 | PFDN2 | 1.0 | 0.954 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| PFDN5 | PFDN2 | 1.0 | 0.93 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| PFDN5 | VBP1 | 1.0 | 0.866 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| PFDN6 | VBP1 | 1.0 | 0.91 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| PFDN6 | PFDN5 | 0.999 | 0.914 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| FBXW4 | PFDN2 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| WSB2 | PFDN5 | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PFDN6 | DCAF5 | 0.986 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| FBXW4 | VBP1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| WSB2 | PFDN2 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| WSB2 | VBP1 | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| FBXW4 | PFDN5 | 0.957 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| DCAF5 | PFDN2 | 0.955 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| DCAF5 | VBP1 | 0.951 | 0.132 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| DCAF5 | PFDN5 | 0.95 | 0.102 |
mutually_exclusive (O60925)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| PFDN6 | FBXW4 | 0.875 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| PFDN6 | WSB2 | 0.819 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| WSB2 | FBXW4 | 0.046 | bioplex3_WMM WMM_only |
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