hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06826.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CXCL1 | Growth-regulated alpha protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)] | 5 | UniProt NCBI |
| BIRC3 | Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1) | 5 | UniProt NCBI |
| HTRA2 | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | 5 | UniProt NCBI |
| TANK | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | 5 | UniProt NCBI |
| TRAF2 | TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) | 5 | UniProt NCBI |
| TRAF1 | TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) | 5 | UniProt NCBI |
| IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04621 | 1.0018931476e-07 | 0.714285714286 | BIRC3 IKBKE TRAF2 CXCL1 TANK | NOD-like receptor signaling pathway |
| REAC:R-HSA-5357905 | 4.81392295814e-07 | 0.571428571429 | BIRC3 IKBKE TRAF1 TRAF2 | Regulation of TNFR1 signaling |
| GO:0071345 | 9.40092084372e-07 | 1.0 | BIRC3 TANK HTRA2 CXCL1 IKBKE TRAF2 TRAF1 | cellular response to cytokine stimulus |
| REAC:R-HSA-75893 | 1.03686148446e-06 | 0.571428571429 | BIRC3 IKBKE TRAF1 TRAF2 | TNF signaling |
| KEGG:04064 | 1.50150118715e-06 | 0.571428571429 | BIRC3 TRAF1 CXCL1 TRAF2 | NF-kappa B signaling pathway |
| GO:0034097 | 2.15578894388e-06 | 1.0 | BIRC3 TANK HTRA2 CXCL1 IKBKE TRAF2 TRAF1 | response to cytokine |
| KEGG:04668 | 3.01488595818e-06 | 0.571428571429 | BIRC3 TRAF1 CXCL1 TRAF2 | TNF signaling pathway |
| WP:WP231 | 3.17701648977e-06 | 0.571428571429 | BIRC3 TRAF1 TANK TRAF2 | TNF alpha signaling pathway |
| KEGG:04210 | 7.74732710295e-06 | 0.571428571429 | BIRC3 TRAF2 TRAF1 HTRA2 | Apoptosis |
| REAC:R-HSA-168164 | 9.40454269709e-06 | 0.571428571429 | BIRC3 IKBKE TANK TRAF2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 1.02705207546e-05 | 0.571428571429 | BIRC3 IKBKE TANK TRAF2 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 1.02705207546e-05 | 0.571428571429 | BIRC3 IKBKE TANK TRAF2 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-5357786 | 2.62784267685e-05 | 0.428571428571 | BIRC3 IKBKE TRAF2 | TNFR1-induced proapoptotic signaling |
| REAC:R-HSA-166016 | 3.17773652341e-05 | 0.571428571429 | BIRC3 IKBKE TANK TRAF2 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-73887 | 3.61497405074e-05 | 0.571428571429 | BIRC3 IKBKE TRAF1 TRAF2 | Death Receptor Signaling |
| KEGG:05417 | 3.94968604363e-05 | 0.571428571429 | TRAF2 IKBKE CXCL1 TANK | Lipid and atherosclerosis |
| WP:WP2036 | 4.32211615904e-05 | 0.428571428571 | BIRC3 TRAF1 TRAF2 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| GO:0019221 | 4.35128948917e-05 | 0.857142857143 | BIRC3 TANK CXCL1 TRAF2 IKBKE TRAF1 | cytokine-mediated signaling pathway |
| REAC:R-HSA-933541 | 4.73926619295e-05 | 0.428571428571 | TRAF2 TANK IKBKE | TRAF6 mediated IRF7 activation |
| REAC:R-HSA-168898 | 5.66464039369e-05 | 0.571428571429 | BIRC3 IKBKE TANK TRAF2 | Toll-like Receptor Cascades |
| CORUM:5210 | 6.1565588648e-05 | 0.285714285714 | TRAF2 TANK | TANK-TRAF2-TRAF3 complex |
| REAC:R-HSA-5357956 | 6.42919230078e-05 | 0.428571428571 | BIRC3 TRAF1 TRAF2 | TNFR1-induced NF-kappa-B signaling pathway |
| WP:WP5039 | 0.000133340269976 | 0.428571428571 | TRAF2 CXCL1 TANK | SARS CoV 2 innate immunity evasion and cell specific immune response |
| WP:WP3865 | 0.000149593274002 | 0.428571428571 | TRAF2 TANK IKBKE | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04622 | 0.000151447938236 | 0.428571428571 | TRAF2 TANK IKBKE | RIG-I-like receptor signaling pathway |
| KEGG:04657 | 0.000253000862682 | 0.428571428571 | TRAF2 CXCL1 IKBKE | IL-17 signaling pathway |
| KEGG:05222 | 0.000353303499329 | 0.428571428571 | BIRC3 TRAF1 TRAF2 | Small cell lung cancer |
| WP:WP254 | 0.000373640809752 | 0.428571428571 | BIRC3 TRAF1 TRAF2 | Apoptosis |
| CORUM:5212 | 0.000573957048441 | 0.285714285714 | TRAF2 TANK | Kinase maturation complex 2 |
| GO:0043122 | 0.000643414431898 | 0.714285714286 | BIRC3 IKBKE TRAF1 TANK TRAF2 | regulation of canonical NF-kappaB signal transduction |
| GO:0071310 | 0.000646800778556 | 1.0 | BIRC3 TANK HTRA2 CXCL1 IKBKE TRAF2 TRAF1 | cellular response to organic substance |
| WP:WP4658 | 0.000679987909493 | 0.428571428571 | BIRC3 TRAF1 TRAF2 | Small cell lung cancer |
| REAC:R-HSA-168928 | 0.000867554862533 | 0.428571428571 | TRAF2 TANK IKBKE | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| GO:0007249 | 0.00107649837207 | 0.714285714286 | BIRC3 IKBKE TRAF1 TANK TRAF2 | canonical NF-kappaB signal transduction |
| WP:WP5182 | 0.00161645869838 | 0.285714285714 | BIRC3 TRAF2 | Pro survival signaling of neuroprotectin D1 |
| CORUM:6344 | 0.00186280835388 | 0.285714285714 | BIRC3 TRAF2 | TNF-R1-associated signaling complex |
| REAC:R-HSA-5676594 | 0.00209171533568 | 0.285714285714 | BIRC3 TRAF2 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| REAC:R-HSA-9013973 | 0.00250948572249 | 0.285714285714 | IKBKE TANK | TICAM1-dependent activation of IRF3/IRF7 |
| KEGG:05167 | 0.0026347269947 | 0.428571428571 | TRAF2 CXCL1 IKBKE | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-168249 | 0.00300736036824 | 0.714285714286 | BIRC3 IKBKE TRAF2 CXCL1 TANK | Innate Immune System |
| REAC:R-HSA-936964 | 0.00345846977329 | 0.285714285714 | IKBKE TANK | Activation of IRF3, IRF7 mediated by TBK1, IKBKE |
| GO:0010033 | 0.00347163817246 | 1.0 | BIRC3 TANK HTRA2 CXCL1 IKBKE TRAF2 TRAF1 | response to organic substance |
| KEGG:04215 | 0.00414129361738 | 0.285714285714 | BIRC3 HTRA2 | Apoptosis - multiple species |
| WP:WP4950 | 0.00575727775656 | 0.285714285714 | TRAF2 TRAF1 | 16p11 2 distal deletion syndrome |
| WP:WP5406 | 0.00669310065721 | 0.285714285714 | TRAF2 TRAF1 | 13q12 12 copy number variation |
| GO:0070887 | 0.00786905702861 | 1.0 | BIRC3 TANK HTRA2 CXCL1 IKBKE TRAF2 TRAF1 | cellular response to chemical stimulus |
| GO:0071356 | 0.00993228783009 | 0.571428571429 | BIRC3 TRAF1 TANK TRAF2 | cellular response to tumor necrosis factor |
| WP:WP3941 | 0.0111348137492 | 0.285714285714 | TRAF2 TRAF1 | Oxidative damage response |
| GO:0007166 | 0.0151539774256 | 1.0 | BIRC3 TANK HTRA2 CXCL1 IKBKE TRAF2 TRAF1 | cell surface receptor signaling pathway |
| GO:0034612 | 0.0154598067374 | 0.571428571429 | BIRC3 TRAF1 TANK TRAF2 | response to tumor necrosis factor |
| REAC:R-HSA-5213460 | 0.0164719839916 | 0.285714285714 | BIRC3 TRAF2 | RIPK1-mediated regulated necrosis |
| REAC:R-HSA-5675482 | 0.0164719839916 | 0.285714285714 | BIRC3 TRAF2 | Regulation of necroptotic cell death |
| WP:WP2018 | 0.0182511871587 | 0.285714285714 | TRAF2 TRAF1 | RANKL RANK signaling pathway |
| GO:0035556 | 0.021775623789 | 1.0 | BIRC3 TANK HTRA2 CXCL1 IKBKE TRAF2 TRAF1 | intracellular signal transduction |
| KEGG:05168 | 0.0266135315089 | 0.428571428571 | BIRC3 IKBKE TRAF2 | Herpes simplex virus 1 infection |
| KEGG:05022 | 0.0378661997772 | 0.428571428571 | HTRA2 TANK TRAF2 | Pathways of neurodegeneration - multiple diseases |
| GO:0042221 | 0.0437548495009 | 1.0 | BIRC3 TANK HTRA2 CXCL1 IKBKE TRAF2 TRAF1 | response to chemical |
| KEGG:05200 | 0.0470519816091 | 0.428571428571 | BIRC3 TRAF1 TRAF2 | Pathways in cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TRAF2 | TRAF1 | 1.0 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TRAF1 | 0.999 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TRAF2 | 0.999 | 0.148952380952 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| HTRA2 | TRAF2 | 0.994 | 0.034 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| CXCL1 | TRAF2 | 0.987 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TANK | IKBKE | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HTRA2 | TRAF1 | 0.98 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TRAF2 | IKBKE | 0.976 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | TRAF2 | 0.969 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | TRAF1 | 0.966 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HTRA2 | TANK | 0.952 | 0.096 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| BIRC3 | IKBKE | 0.892 | bioplex3_WMM WMM_only | |
| TRAF1 | IKBKE | 0.796 | bioplex3_WMM WMM_only | |
| HTRA2 | IKBKE | 0.451 | bioplex3_WMM WMM_only | |
| BIRC3 | TANK | 0.384 | bioplex3_WMM WMM_only | |
| BIRC3 | HTRA2 | 0.306 | bioplex3_WMM WMM_only | |
| CXCL1 | TANK | 0.043 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes