hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06830.1

Complex Portal: CPX-13824

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
RTRAF	RNA transcription, translation and transport factor protein (CLE7 homolog) (CLE) (hCLE)	5	UniProt NCBI
HNRNPU	Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (GRIP120) (Nuclear p120 ribonucleoprotein) (Scaffold-attachment factor A) (SAF-A) (p120) (pp120)	5	UniProt NCBI
LSG1	Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.1.-)	5	UniProt NCBI
SERBP1	SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein)	5	UniProt NCBI
USP10	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)	5	UniProt NCBI
AVEN	Cell death regulator Aven	4	UniProt NCBI
RFC1	Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)	5	UniProt NCBI
RIOK2	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2)	5	UniProt NCBI
FOCAD	Focadhesin	5	UniProt NCBI
DDX1	ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB)	5	UniProt NCBI
DDX55	ATP-dependent RNA helicase DDX55 (EC 3.6.4.13) (DEAD box protein 55)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6301	0.000341558207359	0.181818181818	RTRAF DDX1	tRNA Splicing Ligase Complex
HPA:0050012	0.00190680270363	0.636363636364	LSG1 AVEN DDX55 HNRNPU RFC1 DDX1 RTRAF	breast; adipocytes[>=Medium]
HPA:0170251	0.00548295118537	0.818181818182	LSG1 USP10 AVEN DDX55 DDX1 RTRAF SERBP1 HNRNPU RFC1	endometrium 2; cells in endometrial stroma[>=Low]
CORUM:1332	0.00644975181622	0.181818181818	HNRNPU DDX1	Large Drosha complex
HPA:0530722	0.00894528004033	0.727272727273	LSG1 USP10 AVEN DDX1 RTRAF SERBP1 HNRNPU DDX55	spleen; cells in white pulp[>=Medium]
HPA:0050011	0.0112414440665	0.727272727273	LSG1 USP10 AVEN DDX55 DDX1 RFC1 HNRNPU RTRAF	breast; adipocytes[>=Low]
HPA:0310442	0.0143969223789	0.818181818182	LSG1 USP10 AVEN DDX55 DDX1 RTRAF SERBP1 HNRNPU RFC1	lymph node; non-germinal center cells[>=Medium]
HPA:0010000	0.0144996706465	0.818181818182	LSG1 USP10 AVEN DDX55 DDX1 RTRAF SERBP1 HNRNPU RFC1	adipose tissue
HPA:0010011	0.0144996706465	0.818181818182	LSG1 USP10 AVEN DDX55 DDX1 RTRAF SERBP1 HNRNPU RFC1	adipose tissue; adipocytes[>=Low]
HPA:0340461	0.0161949270037	0.818181818182	LSG1 USP10 AVEN DDX55 DDX1 RTRAF SERBP1 HNRNPU RFC1	ovary; ovarian stroma cells[>=Low]
HPA:0250121	0.0192582851085	0.818181818182	LSG1 USP10 AVEN DDX55 DDX1 RTRAF SERBP1 HNRNPU RFC1	hippocampus; glial cells[>=Low]
HPA:0080132	0.0194349484877	0.818181818182	LSG1 USP10 AVEN DDX55 DDX1 RTRAF SERBP1 HNRNPU RFC1	caudate; neuronal cells[>=Medium]
HPA:0090162	0.0198827923769	0.818181818182	LSG1 USP10 AVEN DDX55 DDX1 RTRAF SERBP1 HNRNPU RFC1	cerebellum; Purkinje cells[>=Medium]
HPA:0040083	0.0218900261845	0.545454545455	USP10 AVEN DDX1 RFC1 SERBP1 HNRNPU	bone marrow; hematopoietic cells[High]
HPA:0040082	0.0230703619751	0.818181818182	LSG1 USP10 AVEN DDX55 DDX1 RTRAF SERBP1 HNRNPU RFC1	bone marrow; hematopoietic cells[>=Medium]
HPA:0590052	0.025188281828	0.909090909091	LSG1 USP10 AVEN DDX55 DDX1 FOCAD RTRAF SERBP1 HNRNPU RFC1	thyroid gland; glandular cells[>=Medium]
HPA:0010012	0.0258073078917	0.636363636364	LSG1 AVEN HNRNPU RTRAF SERBP1 DDX1 DDX55	adipose tissue; adipocytes[>=Medium]
HPA:0530721	0.0316046563383	0.818181818182	LSG1 USP10 AVEN DDX55 DDX1 RTRAF SERBP1 HNRNPU RFC1	spleen; cells in white pulp[>=Low]
HPA:0330222	0.0322877616595	0.818181818182	LSG1 USP10 AVEN DDX55 DDX1 RTRAF SERBP1 HNRNPU RFC1	oral mucosa; squamous epithelial cells[>=Medium]
HPA:0090163	0.033221942682	0.545454545455	LSG1 USP10 AVEN HNRNPU RTRAF DDX1	cerebellum; Purkinje cells[High]
HPA:0310432	0.0389360298684	0.727272727273	LSG1 USP10 AVEN DDX1 RTRAF SERBP1 HNRNPU RFC1	lymph node; germinal center cells[>=Medium]
HPA:0080121	0.0441864154783	0.818181818182	LSG1 USP10 AVEN DDX55 DDX1 RTRAF SERBP1 HNRNPU RFC1	caudate; glial cells[>=Low]
HPA:0130052	0.0447510573968	0.909090909091	LSG1 USP10 AVEN DDX55 DDX1 FOCAD RTRAF SERBP1 HNRNPU RFC1	colon; glandular cells[>=Medium]
HPA:0610832	0.0453915720676	0.909090909091	LSG1 USP10 AVEN DDX55 DDX1 FOCAD RTRAF SERBP1 HNRNPU RFC1	urinary bladder; urothelial cells[>=Medium]
HPA:0020052	0.0456338520433	0.909090909091	LSG1 USP10 AVEN DDX55 DDX1 FOCAD RTRAF SERBP1 HNRNPU RFC1	adrenal gland; glandular cells[>=Medium]
HPA:0130053	0.0470044934853	0.636363636364	USP10 AVEN DDX1 FOCAD RTRAF SERBP1 HNRNPU	colon; glandular cells[High]
HPA:0540053	0.0485274562693	0.636363636364	LSG1 USP10 HNRNPU RTRAF SERBP1 DDX1 DDX55	stomach 1; glandular cells[High]
HPA:0480052	0.048803489142	0.909090909091	LSG1 USP10 AVEN DDX55 DDX1 FOCAD RTRAF SERBP1 HNRNPU RFC1	small intestine; glandular cells[>=Medium]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
RTRAF	DDX1	1.0	0.97	mutually_exclusive (Q9Y3I0)
FOCAD	DDX55	0.997	0.03
FOCAD	SERBP1	0.997	0.19
RTRAF	RFC1	0.997	0.036
RTRAF	FOCAD	0.996	0.074
FOCAD	RFC1	0.996	0.024
AVEN	HNRNPU	0.996	0.102
AVEN	USP10	0.995	0.114
USP10	DDX55	0.995	0.176
FOCAD	AVEN	0.995	0.372
AVEN	SERBP1	0.995	0.112
RTRAF	DDX55	0.994	0.034
FOCAD	HNRNPU	0.994	0.09
AVEN	RIOK2	0.991	0.078
RTRAF	SERBP1	0.991	0.174
USP10	SERBP1	0.991	0.548
FOCAD	DDX1	0.991	0.058
RFC1	SERBP1	0.99	0.224
AVEN	RFC1	0.99	0.038
SERBP1	DDX55	0.99	0.31
LSG1	DDX55	0.99	0.07
FOCAD	USP10	0.989	0.034
RFC1	DDX55	0.988	0.142
DDX1	DDX55	0.985	0.054
AVEN	DDX1	0.985	0.138
AVEN	DDX55	0.984	0.05
LSG1	HNRNPU	0.978	0.122
RIOK2	HNRNPU	0.975	0.285333333333
DDX1	RFC1	0.975	0.078
RFC1	LSG1	0.974	0.08
RTRAF	HNRNPU	0.973	0.172
RFC1	RIOK2	0.97	0.248
RFC1	HNRNPU	0.969	0.186
RIOK2	SERBP1	0.968	0.472
AVEN	LSG1	0.964	0.048
FOCAD	RIOK2	0.964	0.106
RTRAF	LSG1	0.963	0.042
RFC1	USP10	0.958	0.17
USP10	LSG1	0.955	0.096
RTRAF	AVEN	0.951	0.094
DDX1	SERBP1	0.945	0.262
RTRAF	USP10	0.936	0.248
FOCAD	LSG1	0.932	0.03
LSG1	SERBP1	0.923	0.322
SERBP1	HNRNPU	0.904	0.57
RTRAF	RIOK2	0.868	0.108
DDX1	HNRNPU	0.848	0.548
DDX1	LSG1	0.778	0.1
DDX55	HNRNPU	0.755	0.257
RIOK2	USP10	0.693	0.278
USP10	HNRNPU	0.598	0.408
DDX1	USP10	0.538	0.306
RIOK2	DDX55	0.48	0.076
RIOK2	LSG1	0.428	0.196
DDX1	RIOK2	0.069	0.342

Related Complexes

Genename	Complexes
RTRAF	huMAP3_00117.1 huMAP3_02515.1 huMAP3_06830.1 huMAP3_06888.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_07781.1 huMAP3_07963.1 huMAP3_08241.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1 huMAP3_14669.1
HNRNPU	huMAP3_06830.1
LSG1	huMAP3_03324.1 huMAP3_04327.1 huMAP3_05711.1 huMAP3_06830.1 huMAP3_06888.1 huMAP3_08526.1 huMAP3_09754.1 huMAP3_09891.1 huMAP3_10631.1 huMAP3_10976.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
SERBP1	huMAP3_05785.1 huMAP3_06830.1 huMAP3_07574.1 huMAP3_08003.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
USP10	huMAP3_02784.1 huMAP3_04273.1 huMAP3_06830.1 huMAP3_06888.1 huMAP3_08526.1 huMAP3_09829.1 huMAP3_09891.1 huMAP3_10364.1 huMAP3_10631.1 huMAP3_10976.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
AVEN	huMAP3_00371.1 huMAP3_01744.1 huMAP3_05711.1 huMAP3_06830.1 huMAP3_06888.1 huMAP3_07538.1 huMAP3_07909.1 huMAP3_08526.1 huMAP3_09754.1 huMAP3_09891.1 huMAP3_10631.1 huMAP3_10976.1 huMAP3_11111.1 huMAP3_14559.1
RFC1	huMAP3_01449.1 huMAP3_06830.1
RIOK2	huMAP3_01847.1 huMAP3_06830.1 huMAP3_08417.1 huMAP3_10014.1 huMAP3_15290.1
FOCAD	huMAP3_00319.1 huMAP3_05398.1 huMAP3_05711.1 huMAP3_06830.1 huMAP3_07574.1 huMAP3_07909.1 huMAP3_09754.1 huMAP3_09891.1 huMAP3_10631.1 huMAP3_11111.1
DDX1	huMAP3_00810.1 huMAP3_00865.1 huMAP3_02778.1 huMAP3_06830.1 huMAP3_06848.1 huMAP3_06888.1 huMAP3_07391.1 huMAP3_07781.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
DDX55	huMAP3_05962.1 huMAP3_06830.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06830.1

Complex Portal: CPX-13824