hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06847.1
Complex Portal: CPX-19635
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
| GRM3 | Metabotropic glutamate receptor 3 (mGluR3) | 5 | UniProt NCBI |
| PNISR | Arginine/serine-rich protein PNISR (PNN-interacting serine/arginine-rich protein) (SR-related protein) (SR-rich protein) (Serine/arginine-rich-splicing regulatory protein 130) (SRrp130) (Splicing factor, arginine/serine-rich 130) (Splicing factor, arginine/serine-rich 18) | 5 | UniProt NCBI |
| AHCYL1 | S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | 5 | UniProt NCBI |
| NOS1AP | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein) | 5 | UniProt NCBI |
| PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | 5 | UniProt NCBI |
| C1orf226 | Uncharacterized protein C1orf226 | 2 | UniProt NCBI |
| TCOF1 | Treacle protein (Treacher Collins syndrome protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4971 | 0.000167122221162 | 0.333333333333 | PLCD3 PIP4K2A PIP4K2B | Phosphoinositides metabolism |
| WP:WP5411 | 0.000167122221162 | 0.333333333333 | PLCD3 PIP4K2A PIP4K2B | Phosphatidyl inositol phosphate pathway |
| KEGG:00562 | 0.000349846288075 | 0.333333333333 | PLCD3 PIP4K2A PIP4K2B | Inositol phosphate metabolism |
| REAC:R-HSA-8847453 | 0.000478989444628 | 0.222222222222 | PIP4K2A PIP4K2B | Synthesis of PIPs in the nucleus |
| KEGG:04070 | 0.000786208588489 | 0.333333333333 | PLCD3 PIP4K2A PIP4K2B | Phosphatidylinositol signaling system |
| REAC:R-HSA-6811555 | 0.00286935042585 | 0.222222222222 | PIP4K2A PIP4K2B | PI5P Regulates TP53 Acetylation |
| REAC:R-HSA-6804758 | 0.0344394959621 | 0.222222222222 | PIP4K2A PIP4K2B | Regulation of TP53 Activity through Acetylation |
| CORUM:6371 | 0.0499842271994 | 0.111111111111 | GRM3 | mGluR3-mGluR8 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PIP4K2A | PIP4K2B | 1.0 | 0.318 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| PIP4K2A | PLCD3 | 0.999 | 0.068 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PIP4K2A | NOS1AP | 0.997 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PIP4K2A | PNISR | 0.99 | 0.024 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| PIP4K2A | TCOF1 | 0.984 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| PIP4K2A | GRM3 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PIP4K2A | AHCYL1 | 0.974 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| NOS1AP | C1orf226 | 0.973 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PIP4K2B | NOS1AP | 0.971 | 0.042 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PIP4K2A | C1orf226 | 0.952 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AHCYL1 | PLCD3 | 0.951 | 0.082 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PIP4K2B | PLCD3 | 0.95 | 0.068 |
structurally_consistent (O43865)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PLCD3 | NOS1AP | 0.948 | 0.18 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| PLCD3 | TCOF1 | 0.908 | 0.028 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| PLCD3 | PNISR | 0.902 | 0.066 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| PIP4K2B | AHCYL1 | 0.552 | 0.042 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PNISR | GRM3 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TCOF1 | PNISR | 0.4 | 0.204 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM | |
| PIP4K2B | GRM3 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GRM3 | C1orf226 | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TCOF1 | NOS1AP | 0.304 | 0.084 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PIP4K2B | TCOF1 | 0.26 | 0.044 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| TCOF1 | GRM3 | 0.225 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PLCD3 | C1orf226 | 0.211 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only | |
| AHCYL1 | NOS1AP | 0.191 | 0.16 | bioplex_WMM bioplex3_WMM WMM_only | |
| PNISR | C1orf226 | 0.189 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| AHCYL1 | GRM3 | 0.18 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PNISR | NOS1AP | 0.167 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only | |
| PLCD3 | GRM3 | 0.142 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PIP4K2B | C1orf226 | 0.131 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| GRM3 | NOS1AP | 0.123 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TCOF1 | C1orf226 | 0.117 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only | |
| AHCYL1 | PNISR | 0.088 | 0.032 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| PIP4K2B | PNISR | 0.082 | 0.022 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| AHCYL1 | C1orf226 | 0.06 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only | |
| AHCYL1 | TCOF1 | 0.059 | 0.09 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
Related Complexes