hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06867.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAOB | Amine oxidase [flavin-containing] B (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) | 5 | UniProt NCBI |
| MAOA | Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-141333 | 1.70876175213e-06 | 1.0 | MAOB MAOA | Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB |
| REAC:R-HSA-140179 | 1.70876175213e-06 | 1.0 | MAOB MAOA | Amine Oxidase reactions |
| KEGG:00360 | 1.26804361689e-05 | 1.0 | MAOB MAOA | Phenylalanine metabolism |
| KEGG:00340 | 1.70698179197e-05 | 1.0 | MAOB MAOA | Histidine metabolism |
| WP:WP4156 | 2.34100360042e-05 | 1.0 | MAOB MAOA | Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine |
| WP:WP2436 | 2.8092043205e-05 | 1.0 | MAOB MAOA | Dopamine metabolism |
| KEGG:00350 | 5.70619627602e-05 | 1.0 | MAOB MAOA | Tyrosine metabolism |
| KEGG:00380 | 8.58367986819e-05 | 1.0 | MAOB MAOA | Tryptophan metabolism |
| KEGG:00260 | 8.58367986819e-05 | 1.0 | MAOB MAOA | Glycine, serine and threonine metabolism |
| KEGG:05030 | 0.000133307149468 | 1.0 | MAOB MAOA | Cocaine addiction |
| KEGG:00330 | 0.000146800434109 | 1.0 | MAOB MAOA | Arginine and proline metabolism |
| KEGG:00982 | 0.000232637232791 | 1.0 | MAOB MAOA | Drug metabolism - cytochrome P450 |
| KEGG:05031 | 0.00025946123238 | 1.0 | MAOB MAOA | Amphetamine addiction |
| WP:WP4879 | 0.000460113616736 | 1.0 | MAOB MAOA | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| GO:0097621 | 0.000468200720083 | 1.0 | MAOB MAOA | monoamine oxidase activity |
| KEGG:04726 | 0.000566717954934 | 1.0 | MAOB MAOA | Serotonergic synapse |
| KEGG:04728 | 0.00095688522167 | 1.0 | MAOB MAOA | Dopaminergic synapse |
| KEGG:05034 | 0.00179249345126 | 1.0 | MAOB MAOA | Alcoholism |
| GO:0042420 | 0.0028092043205 | 1.0 | MAOB MAOA | dopamine catabolic process |
| GO:0019614 | 0.0028092043205 | 1.0 | MAOB MAOA | catechol-containing compound catabolic process |
| GO:0042424 | 0.0028092043205 | 1.0 | MAOB MAOA | catecholamine catabolic process |
| KEGG:05012 | 0.00458495309323 | 1.0 | MAOB MAOA | Parkinson disease |
| GO:0019336 | 0.00468200720083 | 1.0 | MAOB MAOA | phenol-containing compound catabolic process |
| REAC:R-HSA-211945 | 0.00499983688673 | 1.0 | MAOB MAOA | Phase I - Functionalization of compounds |
| HPA:0481353 | 0.00552452777682 | 1.0 | MAOB MAOA | small intestine; paneth cells[High] |
| HPA:0151353 | 0.00619613703596 | 1.0 | MAOB MAOA | duodenum; paneth cells[High] |
| HPA:0030893 | 0.00654638487541 | 1.0 | MAOB MAOA | appendix; goblet cells[High] |
| GO:0008131 | 0.00702301080125 | 1.0 | MAOB MAOA | primary amine oxidase activity |
| HPA:0031303 | 0.00804366429902 | 1.0 | MAOB MAOA | appendix; enterocytes[High] |
| HPA:0150893 | 0.00905769799226 | 1.0 | MAOB MAOA | duodenum; goblet cells[High] |
| HPA:0400893 | 0.00948016188107 | 1.0 | MAOB MAOA | rectum; goblet cells[High] |
| HPA:0480893 | 0.00948016188107 | 1.0 | MAOB MAOA | small intestine; goblet cells[High] |
| HPA:0131303 | 0.010805326387 | 1.0 | MAOB MAOA | colon; enterocytes[High] |
| HPA:0481352 | 0.0112663055022 | 1.0 | MAOB MAOA | small intestine; paneth cells[>=Medium] |
| HPA:0401303 | 0.0116183587428 | 1.0 | MAOB MAOA | rectum; enterocytes[High] |
| HPA:0031293 | 0.0116183587428 | 1.0 | MAOB MAOA | appendix; endocrine cells[High] |
| HPA:0151303 | 0.0124608793188 | 1.0 | MAOB MAOA | duodenum; enterocytes[High] |
| HPA:0481303 | 0.0130807337426 | 1.0 | MAOB MAOA | small intestine; enterocytes[High] |
| GO:0042402 | 0.0131096201623 | 1.0 | MAOB MAOA | cellular biogenic amine catabolic process |
| HPA:0151352 | 0.0138444184647 | 1.0 | MAOB MAOA | duodenum; paneth cells[>=Medium] |
| HPA:0131293 | 0.014103794442 | 1.0 | MAOB MAOA | colon; endocrine cells[High] |
| WP:WP5420 | 0.0144418640295 | 1.0 | MAOB MAOA | ADHD and autism ASD linked metabolic pathways and SNP |
| HPA:0481351 | 0.0148963655838 | 1.0 | MAOB MAOA | small intestine; paneth cells[>=Low] |
| HPA:0151351 | 0.0165465023119 | 1.0 | MAOB MAOA | duodenum; paneth cells[>=Low] |
| GO:0009310 | 0.016855225923 | 1.0 | MAOB MAOA | amine catabolic process |
| HPA:0481293 | 0.0178409749969 | 1.0 | MAOB MAOA | small intestine; endocrine cells[High] |
| HPA:0271111 | 0.0185811895029 | 1.0 | MAOB MAOA | kidney; bowman's capsule[>=Low] |
| HPA:0271143 | 0.019796826334 | 1.0 | MAOB MAOA | kidney; proximal tubules (cell body)[High] |
| HPA:0151293 | 0.0201067535459 | 1.0 | MAOB MAOA | duodenum; endocrine cells[High] |
| HPA:0030892 | 0.0201067535459 | 1.0 | MAOB MAOA | appendix; goblet cells[>=Medium] |
| REAC:R-HSA-211859 | 0.0225607814134 | 1.0 | MAOB MAOA | Biological oxidations |
| HPA:0150892 | 0.0243548626501 | 1.0 | MAOB MAOA | duodenum; goblet cells[>=Medium] |
| HPA:0480892 | 0.0245263757673 | 1.0 | MAOB MAOA | small intestine; goblet cells[>=Medium] |
| HPA:0400892 | 0.0245263757673 | 1.0 | MAOB MAOA | rectum; goblet cells[>=Medium] |
| REAC:R-HSA-5579012 | 0.0249718442457 | 0.5 | MAOA | Defective MAOA causes BRUNS |
| HPA:0031292 | 0.0293847104887 | 1.0 | MAOB MAOA | appendix; endocrine cells[>=Medium] |
| HPA:0031302 | 0.0295730740175 | 1.0 | MAOB MAOA | appendix; enterocytes[>=Medium] |
| HPA:0030891 | 0.0305239186675 | 1.0 | MAOB MAOA | appendix; goblet cells[>=Low] |
| GO:0016641 | 0.0309012475255 | 1.0 | MAOB MAOA | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor |
| HPA:0131302 | 0.0328673294696 | 1.0 | MAOB MAOA | colon; enterocytes[>=Medium] |
| HPA:0401302 | 0.0336677240168 | 1.0 | MAOB MAOA | rectum; enterocytes[>=Medium] |
| HPA:0150891 | 0.0342743388315 | 1.0 | MAOB MAOA | duodenum; goblet cells[>=Low] |
| HPA:0400891 | 0.0348863698499 | 1.0 | MAOB MAOA | rectum; goblet cells[>=Low] |
| HPA:0480891 | 0.0350915837902 | 1.0 | MAOB MAOA | small intestine; goblet cells[>=Low] |
| HPA:0131292 | 0.035503817072 | 1.0 | MAOB MAOA | colon; endocrine cells[>=Medium] |
| HPA:0031291 | 0.0367549601274 | 1.0 | MAOB MAOA | appendix; endocrine cells[>=Low] |
| HPA:0151302 | 0.0401972584807 | 1.0 | MAOB MAOA | duodenum; enterocytes[>=Medium] |
| HPA:0481302 | 0.0408598407336 | 1.0 | MAOB MAOA | small intestine; enterocytes[>=Medium] |
| HPA:0131291 | 0.0419761804968 | 1.0 | MAOB MAOA | colon; endocrine cells[>=Low] |
| HPA:0100203 | 0.0426532059597 | 1.0 | MAOB MAOA | cerebral cortex; endothelial cells[High] |
| HPA:0151292 | 0.0440235054965 | 1.0 | MAOB MAOA | duodenum; endocrine cells[>=Medium] |
| HPA:0481292 | 0.044253995054 | 1.0 | MAOB MAOA | small intestine; endocrine cells[>=Medium] |
| HPA:0031301 | 0.0485057149607 | 1.0 | MAOB MAOA | appendix; enterocytes[>=Low] |
| GO:0016638 | 0.0491610756088 | 1.0 | MAOB MAOA | oxidoreductase activity, acting on the CH-NH2 group of donors |
| WP:WP1455 | 0.049750157242 | 0.5 | MAOA | Serotonin transporter activity |
| WP:WP4220 | 0.049750157242 | 0.5 | MAOA | Neurotransmitter disorders |
| REAC:R-HSA-379398 | 0.0499419797295 | 0.5 | MAOA | Enzymatic degradation of Dopamine by monoamine oxidase |
| REAC:R-HSA-380612 | 0.0499419797295 | 0.5 | MAOA | Metabolism of serotonin |
| REAC:R-HSA-380615 | 0.0499419797295 | 0.5 | MAOA | Serotonin clearance from the synaptic cleft |
| REAC:R-HSA-379401 | 0.0499419797295 | 0.5 | MAOA | Dopamine clearance from the synaptic cleft |
| REAC:R-HSA-379397 | 0.0499419797295 | 0.5 | MAOA | Enzymatic degradation of dopamine by COMT |
| HPA:0481291 | 0.0499662845592 | 1.0 | MAOB MAOA | small intestine; endocrine cells[>=Low] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAOA | MAOB | 0.975 | 0.212666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| MAOB | huMAP3_06867.1 huMAP3_10839.1 |
| MAOA | huMAP3_01228.1 huMAP3_05905.1 huMAP3_06867.1 huMAP3_10132.1 |