hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06877.1

Complex Portal: CPX-17535

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
ATP1A1	Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1)	5	UniProt NCBI
SLC25A5	ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed]	5	UniProt NCBI
RPN1	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1)	5	UniProt NCBI
ATP2B1	Plasma membrane calcium-transporting ATPase 1 (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 1) (PMCA1) (Plasma membrane calcium pump isoform 1)	5	UniProt NCBI
SSR4	Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HPA:0400892	6.13844296597e-05	0.8	ATP2B1 ATP1A1 SSR4 RPN1	rectum; goblet cells[>=Medium]
HPA:0401302	0.000115592880458	0.8	ATP2B1 ATP1A1 SSR4 RPN1	rectum; enterocytes[>=Medium]
HPA:0401292	0.00012264832028	0.8	ATP2B1 ATP1A1 SSR4 RPN1	rectum; endocrine cells[>=Medium]
HPA:0400891	0.000124097164236	0.8	ATP2B1 ATP1A1 SSR4 RPN1	rectum; goblet cells[>=Low]
HPA:0480891	0.000125558765349	0.8	ATP2B1 ATP1A1 SSR4 RPN1	small intestine; goblet cells[>=Low]
HPA:0151302	0.000164659975839	0.8	ATP2B1 ATP1A1 SSR4 RPN1	duodenum; enterocytes[>=Medium]
HPA:0401291	0.000179518516146	0.8	ATP2B1 ATP1A1 SSR4 RPN1	rectum; endocrine cells[>=Low]
HPA:0481291	0.000254109911781	0.8	ATP2B1 ATP1A1 SSR4 RPN1	small intestine; endocrine cells[>=Low]
HPA:0151291	0.000269357753223	0.8	ATP2B1 ATP1A1 SSR4 RPN1	duodenum; endocrine cells[>=Low]
KEGG:04022	0.0002928242891	0.6	ATP2B1 ATP1A1 SLC25A5	cGMP-PKG signaling pathway
HPA:0131301	0.00030473053159	0.8	ATP2B1 ATP1A1 SSR4 RPN1	colon; enterocytes[>=Low]
HPA:0401301	0.000322177343193	0.8	ATP2B1 ATP1A1 SSR4 RPN1	rectum; enterocytes[>=Low]
HPA:0151301	0.000375671158326	0.8	ATP2B1 ATP1A1 SSR4 RPN1	duodenum; enterocytes[>=Low]
HPA:0481301	0.000435534570221	0.8	ATP2B1 ATP1A1 SSR4 RPN1	small intestine; enterocytes[>=Low]
HPA:0481353	0.000674946064635	0.6	SSR4 ATP1A1 RPN1	small intestine; paneth cells[High]
HPA:0151353	0.000801529372806	0.6	SSR4 ATP1A1 RPN1	duodenum; paneth cells[High]
HPA:0091072	0.00175600888296	0.6	SSR4 ATP1A1 ATP2B1	cerebellum; white matter cells - cytoplasm/membrane[>=Medium]
HPA:0481352	0.00196040491767	0.6	SSR4 ATP1A1 RPN1	small intestine; paneth cells[>=Medium]
HPA:0151352	0.00266668656129	0.6	SSR4 ATP1A1 RPN1	duodenum; paneth cells[>=Medium]
HPA:0481351	0.00297460874017	0.6	SSR4 ATP1A1 RPN1	small intestine; paneth cells[>=Low]
HPA:0151351	0.0034791930104	0.6	SSR4 ATP1A1 RPN1	duodenum; paneth cells[>=Low]
HPA:0091071	0.00384518126735	0.6	SSR4 ATP1A1 ATP2B1	cerebellum; white matter cells - cytoplasm/membrane[>=Low]
HPA:0461391	0.00442599517947	0.8	ATP2B1 ATP1A1 SSR4 RPN1	skin 1; cells in basal layer[>=Low]
HPA:0091002	0.00481433106028	0.6	SSR4 ATP1A1 ATP2B1	cerebellum; molecular layer cells - cytoplasm/membrane[>=Medium]
KEGG:04978	0.00488363922167	0.4	ATP1A1 ATP2B1	Mineral absorption
KEGG:04961	0.00488363922167	0.4	ATP1A1 ATP2B1	Endocrine and other factor-regulated calcium reabsorption
HPA:0150892	0.00618773296518	0.6	SSR4 ATP1A1 RPN1	duodenum; goblet cells[>=Medium]
HPA:0480892	0.00625267658924	0.6	SSR4 ATP1A1 RPN1	small intestine; goblet cells[>=Medium]
HPA:0091001	0.00658414755959	0.6	SSR4 ATP1A1 ATP2B1	cerebellum; molecular layer cells - cytoplasm/membrane[>=Low]
HPA:0031302	0.00825845805429	0.6	ATP2B1 ATP1A1 RPN1	appendix; enterocytes[>=Medium]
HPA:0030891	0.0086560775544	0.6	ATP2B1 ATP1A1 RPN1	appendix; goblet cells[>=Low]
KEGG:04970	0.00908648748607	0.4	ATP1A1 ATP2B1	Salivary secretion
HPA:0131302	0.00966136583656	0.6	ATP2B1 ATP1A1 RPN1	colon; enterocytes[>=Medium]
HPA:0401332	0.0100127876744	0.6	SSR4 RPN1 ATP2B1	rectum; mucosal lymphoid cells[>=Medium]
HPA:0150891	0.0102818072433	0.6	SSR4 ATP1A1 RPN1	duodenum; goblet cells[>=Low]
REAC:R-HSA-936837	0.0106339701454	0.4	ATP1A1 ATP2B1	Ion transport by P-type ATPases
HPA:0130891	0.0108340378335	0.6	ATP2B1 ATP1A1 RPN1	colon; goblet cells[>=Low]
HPA:0131292	0.0108340378335	0.6	ATP2B1 ATP1A1 RPN1	colon; endocrine cells[>=Medium]
HPA:0461451	0.0109279327193	0.6	SSR4 RPN1 ATP2B1	skin 1; hair follicles[>=Low]
HPA:0031291	0.0114054497431	0.6	ATP2B1 ATP1A1 RPN1	appendix; endocrine cells[>=Low]
KEGG:04972	0.0115077320087	0.4	ATP1A1 ATP2B1	Pancreatic secretion
KEGG:04925	0.012157220678	0.4	ATP1A1 ATP2B1	Aldosterone synthesis and secretion
REAC:R-HSA-5578775	0.0123986787504	0.4	ATP1A1 ATP2B1	Ion homeostasis
HPA:0481302	0.0133449870931	0.6	SSR4 ATP1A1 RPN1	small intestine; enterocytes[>=Medium]
HPA:0131291	0.0138891082735	0.6	ATP2B1 ATP1A1 RPN1	colon; endocrine cells[>=Low]
HPA:0151292	0.0149049151547	0.6	SSR4 ATP1A1 RPN1	duodenum; endocrine cells[>=Medium]
HPA:0481292	0.0150207060255	0.6	SSR4 ATP1A1 RPN1	small intestine; endocrine cells[>=Medium]
HPA:0031301	0.0172071774588	0.6	ATP2B1 ATP1A1 RPN1	appendix; enterocytes[>=Low]
HPA:0131331	0.0191811519078	0.6	SSR4 RPN1 ATP2B1	colon; mucosal lymphoid cells[>=Low]
HPA:0401331	0.0241927281198	0.6	SSR4 RPN1 ATP2B1	rectum; mucosal lymphoid cells[>=Low]
KEGG:04261	0.0314069031448	0.4	ATP1A1 ATP2B1	Adrenergic signaling in cardiomyocytes
HPA:0091063	0.0462886790066	0.4	ATP1A1 ATP2B1	cerebellum; synaptic glomeruli - core[High]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
RPN1	ATP1A1	0.997	0.604	hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
ATP1A1	SLC25A5	0.993	0.524	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM
SLC25A5	SSR4	0.989	0.32	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM treiber_WMM
RPN1	ATP2B1	0.987	0.312	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
ATP1A1	ATP2B1	0.982	0.35	hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction
RPN1	SSR4	0.98	0.776	hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
SLC25A5	ATP2B1	0.969	0.214	hein_WMM bioplex_WMM bioplex3_WMM fraction
ATP1A1	SSR4	0.955	0.312	hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
RPN1	SLC25A5	0.706	0.602	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM
SSR4	ATP2B1	0.27	0.196	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only

Related Complexes

Genename	Complexes
ATP1A1	huMAP3_01366.1 huMAP3_02027.1 huMAP3_06198.1 huMAP3_06877.1 huMAP3_07397.1 huMAP3_10473.1 huMAP3_10607.1
SLC25A5	huMAP3_02620.1 huMAP3_05630.1 huMAP3_06877.1 huMAP3_07568.1 huMAP3_08106.1 huMAP3_09153.1 huMAP3_10473.1 huMAP3_10607.1
RPN1	huMAP3_00921.1 huMAP3_06187.1 huMAP3_06877.1 huMAP3_07211.1 huMAP3_08167.1 huMAP3_09332.1 huMAP3_09592.1 huMAP3_10071.1 huMAP3_10473.1
ATP2B1	huMAP3_06877.1 huMAP3_08416.1 huMAP3_10473.1
SSR4	huMAP3_02620.1 huMAP3_05630.1 huMAP3_06187.1 huMAP3_06601.1 huMAP3_06877.1 huMAP3_07397.1 huMAP3_08106.1 huMAP3_09153.1 huMAP3_10473.1 huMAP3_10607.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06877.1

Complex Portal: CPX-17535