hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06884.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NCOR1 | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | 5 | UniProt NCBI |
| TBL1Y | F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked) | 5 | UniProt NCBI |
| GPS2 | G protein pathway suppressor 2 (GPS-2) | 5 | UniProt NCBI |
| TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:741 | 7.01534115619e-09 | 0.75 | TBL1XR1 NCOR1 GPS2 | NCOR-HDAC3 complex |
| CORUM:15 | 1.40299620761e-08 | 0.75 | TBL1XR1 NCOR1 GPS2 | NCOR complex |
| REAC:R-HSA-9022537 | 2.80599241523e-08 | 0.75 | TBL1XR1 NCOR1 GPS2 | Loss of MECP2 binding ability to the NCoR/SMRT complex |
| CORUM:2183 | 8.41624867868e-08 | 0.75 | TBL1XR1 NCOR1 GPS2 | Kaiso-NCOR complex |
| REAC:R-HSA-9005895 | 1.68324973574e-07 | 0.75 | TBL1XR1 NCOR1 GPS2 | Pervasive developmental disorders |
| REAC:R-HSA-9005891 | 1.68324973574e-07 | 0.75 | TBL1XR1 NCOR1 GPS2 | Loss of function of MECP2 in Rett syndrome |
| REAC:R-HSA-9697154 | 1.68324973574e-07 | 0.75 | TBL1XR1 NCOR1 GPS2 | Disorders of Nervous System Development |
| REAC:R-HSA-9675151 | 1.68324973574e-07 | 0.75 | TBL1XR1 NCOR1 GPS2 | Disorders of Developmental Biology |
| WP:WP4312 | 4.00454251624e-06 | 0.75 | TBL1XR1 NCOR1 GPS2 | Rett syndrome causing genes |
| REAC:R-HSA-9022692 | 5.12049513312e-06 | 0.75 | TBL1XR1 NCOR1 GPS2 | Regulation of MECP2 expression and activity |
| REAC:R-HSA-9029569 | 6.29837429836e-06 | 0.75 | TBL1XR1 NCOR1 GPS2 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
| REAC:R-HSA-9024446 | 1.28002609524e-05 | 0.75 | TBL1XR1 NCOR1 GPS2 | NR1H2 and NR1H3-mediated signaling |
| REAC:R-HSA-8986944 | 3.27872895639e-05 | 0.75 | TBL1XR1 NCOR1 GPS2 | Transcriptional Regulation by MECP2 |
| CORUM:58 | 5.12488211613e-05 | 0.5 | TBL1XR1 GPS2 | SMRT complex |
| REAC:R-HSA-3214815 | 0.000114832276301 | 0.75 | TBL1XR1 NCOR1 GPS2 | HDACs deacetylate histones |
| REAC:R-HSA-1989781 | 0.000219007946647 | 0.75 | TBL1XR1 NCOR1 GPS2 | PPARA activates gene expression |
| REAC:R-HSA-400206 | 0.000225769742075 | 0.75 | TBL1XR1 NCOR1 GPS2 | Regulation of lipid metabolism by PPARalpha |
| REAC:R-HSA-9609690 | 0.000391711563853 | 0.75 | TBL1XR1 NCOR1 GPS2 | HCMV Early Events |
| REAC:R-HSA-9609646 | 0.000650875640662 | 0.75 | TBL1XR1 NCOR1 GPS2 | HCMV Infection |
| GO:0003714 | 0.000674576947494 | 1.0 | TBL1XR1 GPS2 NCOR1 TBL1Y | transcription corepressor activity |
| CORUM:5614 | 0.000875235624471 | 0.5 | TBL1XR1 TBL1Y | Emerin complex 32 |
| REAC:R-HSA-350054 | 0.00236402400204 | 0.5 | TBL1XR1 NCOR1 | Notch-HLH transcription pathway |
| REAC:R-HSA-9006931 | 0.00343792850162 | 0.75 | TBL1XR1 NCOR1 GPS2 | Signaling by Nuclear Receptors |
| REAC:R-HSA-4839726 | 0.00356469194611 | 0.75 | TBL1XR1 NCOR1 GPS2 | Chromatin organization |
| REAC:R-HSA-3247509 | 0.00356469194611 | 0.75 | TBL1XR1 NCOR1 GPS2 | Chromatin modifying enzymes |
| REAC:R-HSA-2122947 | 0.0079693038543 | 0.5 | TBL1XR1 NCOR1 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-9707616 | 0.008795277704 | 0.5 | TBL1XR1 NCOR1 | Heme signaling |
| REAC:R-HSA-2644603 | 0.0110375739361 | 0.5 | TBL1XR1 NCOR1 | Signaling by NOTCH1 in Cancer |
| REAC:R-HSA-2644602 | 0.0110375739361 | 0.5 | TBL1XR1 NCOR1 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644606 | 0.0110375739361 | 0.5 | TBL1XR1 NCOR1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894862 | 0.0110375739361 | 0.5 | TBL1XR1 NCOR1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2894858 | 0.0110375739361 | 0.5 | TBL1XR1 NCOR1 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-2151201 | 0.0115164156767 | 0.5 | TBL1XR1 NCOR1 | Transcriptional activation of mitochondrial biogenesis |
| GO:0017053 | 0.0118300289699 | 0.75 | TBL1XR1 NCOR1 GPS2 | transcription repressor complex |
| GO:0000118 | 0.0159688263229 | 0.75 | TBL1XR1 NCOR1 TBL1Y | histone deacetylase complex |
| REAC:R-HSA-1980143 | 0.0174510452107 | 0.5 | TBL1XR1 NCOR1 | Signaling by NOTCH1 |
| REAC:R-HSA-9707564 | 0.0174510452107 | 0.5 | TBL1XR1 NCOR1 | Cytoprotection by HMOX1 |
| REAC:R-HSA-400253 | 0.0186613511621 | 0.5 | TBL1XR1 NCOR1 | Circadian Clock |
| KEGG:04310 | 0.0276522587106 | 0.5 | TBL1XR1 TBL1Y | Wnt signaling pathway |
| REAC:R-HSA-381340 | 0.0282617295192 | 0.5 | TBL1XR1 NCOR1 | Transcriptional regulation of white adipocyte differentiation |
| GO:0003712 | 0.0326761482103 | 1.0 | TBL1XR1 GPS2 NCOR1 TBL1Y | transcription coregulator activity |
| REAC:R-HSA-1592230 | 0.0371865475195 | 0.5 | TBL1XR1 NCOR1 | Mitochondrial biogenesis |
| CORUM:425 | 0.049938562206 | 0.25 | GPS2 | MSH4-MSH5-GPS2 complex |
| CORUM:3204 | 0.049938562206 | 0.25 | NCOR1 | SMAD2-SKI-NCOR complex |
| CORUM:3205 | 0.049938562206 | 0.25 | NCOR1 | SMAD3-SKI-NCOR complex |
| CORUM:3206 | 0.049938562206 | 0.25 | NCOR1 | SMAD4-SKI-NCOR complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NCOR1 | GPS2 | 1.0 | 0.152 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| TBL1XR1 | GPS2 | 1.0 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| GPS2 | TBL1Y | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NCOR1 | TBL1Y | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TBL1XR1 | TBL1Y | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NCOR1 | TBL1XR1 | 0.969 | 0.148 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes