hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06888.1

Complex Portal: CPX-22441

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
TMA16	Translation machinery-associated protein 16	5	UniProt NCBI
RTRAF	RNA transcription, translation and transport factor protein (CLE7 homolog) (CLE) (hCLE)	5	UniProt NCBI
G3BP2	Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)	5	UniProt NCBI
YTHDF3	YTH domain-containing family protein 3 (DF3)	5	UniProt NCBI
LSG1	Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.1.-)	5	UniProt NCBI
UBAP2L	Ubiquitin-associated protein 2-like (Protein NICE-4) (RNA polymerase II degradation factor UBAP2L)	5	UniProt NCBI
USP10	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)	5	UniProt NCBI
CAPRIN1	Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105)	5	UniProt NCBI
AVEN	Cell death regulator Aven	4	UniProt NCBI
FAM98A	Protein FAM98A	5	UniProt NCBI
RTCB	RNA-splicing ligase RtcB homolog (EC 6.5.1.8) (3'-phosphate/5'-hydroxy nucleic acid ligase)	5	UniProt NCBI
EIF5B	Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2)	5	UniProt NCBI
CCDC124	Coiled-coil domain-containing protein 124	5	UniProt NCBI
DDX1	ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0062028	1.31622611039e-07	0.285714285714	USP10 CAPRIN1 G3BP2 UBAP2L	regulation of stress granule assembly
CORUM:6301	3.64803730192e-07	0.214285714286	RTRAF DDX1 RTCB	tRNA Splicing Ligase Complex
GO:0034063	1.17307883431e-06	0.357142857143	USP10 CAPRIN1 G3BP2 UBAP2L YTHDF3	stress granule assembly
GO:0072669	1.8396911621e-06	0.285714285714	RTRAF DDX1 FAM98A RTCB	tRNA-splicing ligase complex
GO:0006388	8.65858915641e-06	0.285714285714	RTRAF DDX1 FAM98A RTCB	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0000394	1.29807707416e-05	0.285714285714	RTRAF DDX1 FAM98A RTCB	RNA splicing, via endonucleolytic cleavage and ligation
GO:0003723	8.32620458838e-05	0.785714285714	RTCB CCDC124 UBAP2L USP10 CAPRIN1 G3BP2 RTRAF FAM98A DDX1 EIF5B YTHDF3	RNA binding
GO:0062029	0.000139871762976	0.214285714286	CAPRIN1 G3BP2 UBAP2L	positive regulation of stress granule assembly
HPA:0170251	0.00141086551865	0.785714285714	RTCB UBAP2L USP10 CAPRIN1 G3BP2 RTRAF AVEN LSG1 DDX1 EIF5B CCDC124	endometrium 2; cells in endometrial stroma[>=Low]
HPA:0340462	0.0014409910491	0.642857142857	RTCB USP10 CAPRIN1 G3BP2 RTRAF AVEN DDX1 EIF5B CCDC124	ovary; ovarian stroma cells[>=Medium]
HPA:0090163	0.00184527557565	0.571428571429	USP10 CAPRIN1 RTRAF AVEN LSG1 DDX1 EIF5B CCDC124	cerebellum; Purkinje cells[High]
REAC:R-HSA-6784531	0.00500745031661	0.214285714286	RTRAF DDX1 RTCB	tRNA processing in the nucleus
HPA:0340461	0.0051937673087	0.785714285714	RTCB UBAP2L USP10 CAPRIN1 G3BP2 RTRAF AVEN LSG1 DDX1 EIF5B CCDC124	ovary; ovarian stroma cells[>=Low]
HPA:0250121	0.00639532962642	0.785714285714	RTCB UBAP2L USP10 CAPRIN1 G3BP2 RTRAF AVEN LSG1 DDX1 EIF5B CCDC124	hippocampus; glial cells[>=Low]
HPA:0080132	0.00646584865083	0.785714285714	RTCB UBAP2L USP10 CAPRIN1 G3BP2 RTRAF AVEN LSG1 DDX1 EIF5B CCDC124	caudate; neuronal cells[>=Medium]
HPA:0170053	0.00862979559571	0.5	USP10 CAPRIN1 G3BP2 RTRAF CCDC124 DDX1 EIF5B	endometrium 2; glandular cells[High]
GO:0140694	0.0112914709834	0.428571428571	UBAP2L USP10 CAPRIN1 G3BP2 EIF5B YTHDF3	non-membrane-bounded organelle assembly
HPA:0330222	0.0118893880335	0.785714285714	RTCB UBAP2L USP10 CAPRIN1 G3BP2 RTRAF AVEN LSG1 DDX1 EIF5B CCDC124	oral mucosa; squamous epithelial cells[>=Medium]
HPA:0530722	0.013540335197	0.642857142857	RTCB USP10 CAPRIN1 RTRAF AVEN LSG1 DDX1 EIF5B CCDC124	spleen; cells in white pulp[>=Medium]
HPA:0050012	0.0160367037299	0.5	LSG1 CAPRIN1 RTRAF CCDC124 DDX1 EIF5B AVEN	breast; adipocytes[>=Medium]
HPA:0080121	0.0173152346733	0.785714285714	RTCB UBAP2L USP10 CAPRIN1 G3BP2 RTRAF AVEN LSG1 DDX1 EIF5B CCDC124	caudate; glial cells[>=Low]
HPA:0050011	0.0173512306702	0.642857142857	USP10 CAPRIN1 G3BP2 RTRAF AVEN LSG1 DDX1 EIF5B CCDC124	breast; adipocytes[>=Low]
HPA:0351182	0.0190633112218	0.714285714286	RTCB UBAP2L USP10 CAPRIN1 G3BP2 RTRAF AVEN DDX1 EIF5B CCDC124	pancreas; pancreatic endocrine cells[>=Medium]
HPA:0630222	0.0240530935622	0.714285714286	RTCB UBAP2L LSG1 CAPRIN1 G3BP2 AVEN USP10 DDX1 EIF5B CCDC124	cervix; squamous epithelial cells[>=Medium]
REAC:R-HSA-72306	0.0292019596348	0.214285714286	RTRAF DDX1 RTCB	tRNA processing
HPA:0390052	0.0319025975604	0.785714285714	RTCB UBAP2L USP10 CAPRIN1 G3BP2 RTRAF AVEN LSG1 DDX1 EIF5B CCDC124	prostate; glandular cells[>=Medium]
GO:0010494	0.0342451924324	0.285714285714	DDX1 CAPRIN1 G3BP2 YTHDF3	cytoplasmic stress granule
HPA:0270352	0.0355122292246	0.642857142857	UBAP2L USP10 CAPRIN1 G3BP2 RTRAF CCDC124 LSG1 DDX1 EIF5B	kidney; cells in glomeruli[>=Medium]
HPA:0100121	0.0357401639938	0.785714285714	RTCB UBAP2L USP10 CAPRIN1 G3BP2 RTRAF AVEN LSG1 DDX1 EIF5B CCDC124	cerebral cortex; glial cells[>=Low]
HPA:0490692	0.0379471654324	0.642857142857	RTCB USP10 CAPRIN1 G3BP2 RTRAF AVEN LSG1 DDX1 CCDC124	smooth muscle; smooth muscle cells[>=Medium]
HPA:0310442	0.0400655367892	0.714285714286	UBAP2L USP10 CAPRIN1 G3BP2 RTRAF AVEN LSG1 DDX1 EIF5B CCDC124	lymph node; non-germinal center cells[>=Medium]
HPA:0630053	0.0419816401046	0.428571428571	USP10 CAPRIN1 RTRAF CCDC124 DDX1 EIF5B	cervix; glandular cells[High]
HPA:0291161	0.0422118441506	0.714285714286	RTCB UBAP2L USP10 CAPRIN1 G3BP2 RTRAF CCDC124 LSG1 DDX1 EIF5B	liver; cholangiocytes[>=Low]
HPA:0550053	0.0496231540166	0.571428571429	USP10 CAPRIN1 G3BP2 RTRAF CCDC124 LSG1 DDX1 EIF5B	stomach 2; glandular cells[High]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
DDX1	RTCB	1.0	0.978	structurally_consistent (dimer)
RTRAF	DDX1	1.0	0.97	mutually_exclusive (Q9Y3I0)
G3BP2	USP10	1.0	0.144
CAPRIN1	G3BP2	1.0	0.212
FAM98A	DDX1	0.999	0.222
RTRAF	FAM98A	0.999	0.178	structurally_consistent (dimer)
FAM98A	RTCB	0.998	0.25
RTRAF	RTCB	0.996	0.92	structurally_consistent (dimer)
AVEN	USP10	0.995	0.114
AVEN	EIF5B	0.993	0.116
YTHDF3	UBAP2L	0.991	0.508
G3BP2	TMA16	0.99	0.146
CAPRIN1	USP10	0.989	0.48
AVEN	DDX1	0.985	0.138
FAM98A	AVEN	0.984	0.072
EIF5B	LSG1	0.983	0.142
FAM98A	YTHDF3	0.981	0.392
EIF5B	CCDC124	0.98	0.282
AVEN	RTCB	0.978	0.106
RTRAF	YTHDF3	0.978	0.116
AVEN	G3BP2	0.978	0.132
AVEN	YTHDF3	0.973	0.06
G3BP2	LSG1	0.97	0.2
AVEN	CAPRIN1	0.97	0.118
AVEN	CCDC124	0.97	0.098
TMA16	LSG1	0.965	0.104
AVEN	LSG1	0.964	0.048
RTRAF	LSG1	0.963	0.042
RTRAF	CAPRIN1	0.961	0.15
USP10	TMA16	0.959	0.098
RTRAF	UBAP2L	0.955	0.138
USP10	LSG1	0.955	0.096
RTRAF	AVEN	0.951	0.094
RTCB	TMA16	0.949	0.084
USP10	UBAP2L	0.942	0.642
RTRAF	USP10	0.936	0.248
CCDC124	RTCB	0.932	0.144
CCDC124	USP10	0.916	0.248
RTCB	UBAP2L	0.91	0.08
EIF5B	RTCB	0.909	0.23
YTHDF3	USP10	0.902	0.366
YTHDF3	CCDC124	0.89	0.162
AVEN	TMA16	0.889	0.042
EIF5B	USP10	0.886	0.536
YTHDF3	G3BP2	0.876	0.162
YTHDF3	EIF5B	0.873	0.226
CAPRIN1	UBAP2L	0.869	0.598
RTRAF	CCDC124	0.866	0.094
RTCB	LSG1	0.862	0.062
YTHDF3	DDX1	0.858	0.182
YTHDF3	RTCB	0.852	0.18
CAPRIN1	RTCB	0.818	0.154
YTHDF3	TMA16	0.814	0.114
AVEN	UBAP2L	0.805	0.098
DDX1	LSG1	0.778	0.1
EIF5B	DDX1	0.758	0.306
RTCB	USP10	0.74	0.13
FAM98A	UBAP2L	0.729	0.24
YTHDF3	LSG1	0.722	0.136
FAM98A	USP10	0.717	0.394
DDX1	TMA16	0.71	0.078
RTRAF	TMA16	0.708	0.07
RTRAF	G3BP2	0.691	0.154
CCDC124	LSG1	0.678	0.132
EIF5B	UBAP2L	0.663	0.368
RTCB	G3BP2	0.617	0.128
DDX1	USP10	0.538	0.306
RTRAF	EIF5B	0.521	0.15
FAM98A	EIF5B	0.505	0.268
DDX1	G3BP2	0.418	0.271428571429
CCDC124	CAPRIN1	0.412	0.366
CCDC124	UBAP2L	0.365	0.436
FAM98A	CAPRIN1	0.356	0.312
FAM98A	G3BP2	0.339	0.166
FAM98A	TMA16	0.289	0.092
CCDC124	G3BP2	0.271	0.17
G3BP2	UBAP2L	0.249	0.26
DDX1	CAPRIN1	0.199	0.252
YTHDF3	CAPRIN1	0.163	0.346
FAM98A	LSG1	0.162	0.08
DDX1	UBAP2L	0.158	0.162
CCDC124	DDX1	0.154	0.094
CCDC124	TMA16	0.121	0.138
EIF5B	TMA16	0.095	0.198
EIF5B	G3BP2	0.08	0.263
UBAP2L	TMA16	0.06	0.094
CAPRIN1	LSG1	0.059	0.126
EIF5B	CAPRIN1	0.04	0.43
CAPRIN1	TMA16	0.039	0.09
FAM98A	CCDC124	0.031	0.194
UBAP2L	LSG1	0.027	0.07

Related Complexes

Genename	Complexes
TMA16	huMAP3_03324.1 huMAP3_04273.1 huMAP3_06888.1 huMAP3_08526.1 huMAP3_09829.1 huMAP3_09891.1 huMAP3_10631.1 huMAP3_10976.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
RTRAF	huMAP3_00117.1 huMAP3_02515.1 huMAP3_06830.1 huMAP3_06888.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_07781.1 huMAP3_07963.1 huMAP3_08241.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1 huMAP3_14669.1
G3BP2	huMAP3_02784.1 huMAP3_04273.1 huMAP3_05303.1 huMAP3_06888.1 huMAP3_08431.1 huMAP3_08543.1 huMAP3_09891.1 huMAP3_10207.1 huMAP3_10631.1 huMAP3_10976.1 huMAP3_11111.1 huMAP3_11427.1 huMAP3_12093.1 huMAP3_14270.1 huMAP3_14559.1
YTHDF3	huMAP3_00405.1 huMAP3_00843.1 huMAP3_02678.1 huMAP3_04763.1 huMAP3_05880.1 huMAP3_06888.1 huMAP3_07391.1 huMAP3_07881.1 huMAP3_10307.1 huMAP3_10523.1 huMAP3_10590.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
LSG1	huMAP3_03324.1 huMAP3_04327.1 huMAP3_05711.1 huMAP3_06830.1 huMAP3_06888.1 huMAP3_08526.1 huMAP3_09754.1 huMAP3_09891.1 huMAP3_10631.1 huMAP3_10976.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
UBAP2L	huMAP3_02979.1 huMAP3_05880.1 huMAP3_06888.1 huMAP3_09898.1 huMAP3_10307.1 huMAP3_10523.1 huMAP3_10590.1 huMAP3_10631.1 huMAP3_10943.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
USP10	huMAP3_02784.1 huMAP3_04273.1 huMAP3_06830.1 huMAP3_06888.1 huMAP3_08526.1 huMAP3_09829.1 huMAP3_09891.1 huMAP3_10364.1 huMAP3_10631.1 huMAP3_10976.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
CAPRIN1	huMAP3_01928.1 huMAP3_02784.1 huMAP3_04258.1 huMAP3_04327.1 huMAP3_05303.1 huMAP3_05711.1 huMAP3_06888.1 huMAP3_07425.1 huMAP3_07909.1 huMAP3_07963.1 huMAP3_08326.1 huMAP3_08526.1 huMAP3_09383.1 huMAP3_09754.1 huMAP3_09891.1 huMAP3_10207.1 huMAP3_10307.1 huMAP3_10364.1 huMAP3_10631.1 huMAP3_10976.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
AVEN	huMAP3_00371.1 huMAP3_01744.1 huMAP3_05711.1 huMAP3_06830.1 huMAP3_06888.1 huMAP3_07538.1 huMAP3_07909.1 huMAP3_08526.1 huMAP3_09754.1 huMAP3_09891.1 huMAP3_10631.1 huMAP3_10976.1 huMAP3_11111.1 huMAP3_14559.1
FAM98A	huMAP3_00232.1 huMAP3_02515.1 huMAP3_06888.1 huMAP3_07425.1 huMAP3_08003.1 huMAP3_09988.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
RTCB	huMAP3_02515.1 huMAP3_04351.1 huMAP3_06888.1 huMAP3_07391.1 huMAP3_07425.1 huMAP3_07781.1 huMAP3_07963.1 huMAP3_08241.1 huMAP3_09423.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
EIF5B	huMAP3_00588.1 huMAP3_03309.1 huMAP3_03324.1 huMAP3_06888.1 huMAP3_09891.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_10841.1 huMAP3_10943.1 huMAP3_10976.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
CCDC124	huMAP3_00588.1 huMAP3_01744.1 huMAP3_02373.1 huMAP3_05711.1 huMAP3_06888.1 huMAP3_07523.1 huMAP3_07909.1 huMAP3_08025.1 huMAP3_08220.1 huMAP3_08526.1 huMAP3_09594.1 huMAP3_09754.1 huMAP3_09891.1 huMAP3_10359.1 huMAP3_10631.1 huMAP3_10719.1 huMAP3_11021.1 huMAP3_11099.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1
DDX1	huMAP3_00810.1 huMAP3_00865.1 huMAP3_02778.1 huMAP3_06830.1 huMAP3_06848.1 huMAP3_06888.1 huMAP3_07391.1 huMAP3_07781.1 huMAP3_09836.1 huMAP3_10307.1 huMAP3_10631.1 huMAP3_11111.1 huMAP3_14270.1 huMAP3_14559.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06888.1

Complex Portal: CPX-22441