hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06890.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CAP2 | Adenylyl cyclase-associated protein 2 (CAP 2) | 5 | UniProt NCBI |
| ACTA2 | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | 5 | UniProt NCBI |
| CAP1 | Adenylyl cyclase-associated protein 1 (CAP 1) | 5 | UniProt NCBI |
| UBC | Polyubiquitin-C [Cleaved into: Ubiquitin] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428890 | 0.000286914834749 | 0.5 | CAP1 CAP2 | Role of ABL in ROBO-SLIT signaling |
| HPA:0640693 | 0.00100425205668 | 0.5 | CAP2 ACTA2 | endometrium; smooth muscle cells[High] |
| REAC:R-HSA-376176 | 0.00211233137107 | 0.75 | CAP1 CAP2 UBC | Signaling by ROBO receptors |
| HPA:0640692 | 0.00305176668958 | 0.5 | CAP2 ACTA2 | endometrium; smooth muscle cells[>=Medium] |
| HPA:0641521 | 0.0053119718598 | 0.5 | CAP2 ACTA2 | endometrium; nonciliated luminal epithelial cells[>=Low] |
| HPA:0640691 | 0.00552828160678 | 0.5 | CAP2 ACTA2 | endometrium; smooth muscle cells[>=Low] |
| HPA:0641502 | 0.00574888724989 | 0.5 | CAP2 ACTA2 | endometrium; ciliated epithelial cells[>=Medium] |
| HPA:0641501 | 0.00845873934088 | 0.5 | CAP2 ACTA2 | endometrium; ciliated epithelial cells[>=Low] |
| HPA:0640000 | 0.0184778630307 | 0.5 | CAP2 ACTA2 | endometrium |
| REAC:R-HSA-422475 | 0.0253860120448 | 0.75 | CAP1 CAP2 UBC | Axon guidance |
| REAC:R-HSA-9013694 | 0.0267695204965 | 0.5 | ACTA2 UBC | Signaling by NOTCH4 |
| REAC:R-HSA-9675108 | 0.0283171453534 | 0.75 | CAP1 CAP2 UBC | Nervous system development |
| GO:0008179 | 0.042122686785 | 0.5 | CAP1 CAP2 | adenylate cyclase binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CAP2 | CAP1 | 1.0 | 0.416 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| ACTA2 | CAP2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| ACTA2 | CAP1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| CAP2 | UBC | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CAP1 | UBC | 0.591 | bioplex3_WMM WMM_only boldt_WMM | |
| ACTA2 | UBC | 0.099 | bioplex3_WMM boldt boldt_WMM WMM_only |
Related Complexes