hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06892.1

Complex Portal: CPX-10817

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
HEG1	Protein HEG homolog 1	5	UniProt NCBI
LGALS1	Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)	5	UniProt NCBI
ITGA3	Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]	5	UniProt NCBI
NECTIN1	Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111)	5	UniProt NCBI
CSPG4	Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan)	5	UniProt NCBI
ITGA1	Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a)	5	UniProt NCBI
PODXL	Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)	5	UniProt NCBI
ITGA2	Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b)	5	UniProt NCBI
SDK1	Protein sidekick-1	5	UniProt NCBI
MRC2	C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protein) (CD antigen CD280)	5	UniProt NCBI
ENPP4	Bis(5'-adenosyl)-triphosphatase ENPP4 (EC 3.6.1.29) (AP3A hydrolase) (AP3Aase) (Ectonucleotide pyrophosphatase/phosphodiesterase family member 4) (E-NPP 4) (NPP-4)	5	UniProt NCBI
LGALS8	Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)	5	UniProt NCBI
KIAA0319L	Dyslexia-associated protein KIAA0319-like protein (Adeno-associated virus receptor) (AAVR)	5	UniProt NCBI
FLT4	Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)	5	UniProt NCBI
PTPRG	Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6951	0.000245952888523	0.153846153846	ITGA3 CSPG4	NG2-galectin-3-alpha3beta1-integrin complex
WP:WP4541	0.00874887147704	0.230769230769	ITGA1 ITGA3 FLT4	Hippo Merlin signaling dysregulation
GO:0070161	0.0153609640443	0.538461538462	HEG1 ITGA3 ITGA1 CSPG4 MRC2 NECTIN1 PODXL	anchoring junction
KEGG:04510	0.0244409768372	0.230769230769	ITGA1 ITGA3 FLT4	Focal adhesion
WP:WP5087	0.0287514677441	0.307692307692	ITGA1 ITGA3 FLT4 PODXL	Pleural mesothelioma

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
HEG1	LGALS8	0.999	0.048
LGALS8	PODXL	0.999	0.038
LGALS8	PTPRG	0.997	0.048
LGALS8	CSPG4	0.996	0.038
LGALS8	KIAA0319L	0.996	0.044
ITGA1	LGALS8	0.994	0.058
LGALS8	MRC2	0.993	0.048	structurally_consistent (dimer)
NECTIN1	LGALS8	0.991	0.054
ITGA3	LGALS8	0.989	0.044
KIAA0319L	PODXL	0.986	0.07
ENPP4	LGALS8	0.983	0.046
LGALS1	ITGA1	0.981	0.18
LGALS8	FLT4	0.978	0.048
ITGA2	CSPG4	0.977	0.134
ENPP4	MRC2	0.976	0.108
HEG1	PODXL	0.975	0.038
ITGA3	ITGA2	0.967	0.55
HEG1	CSPG4	0.967	0.068
HEG1	ITGA1	0.967	0.074
PTPRG	PODXL	0.966	0.106
PODXL	CSPG4	0.965	0.016
KIAA0319L	CSPG4	0.961	0.066
ITGA3	CSPG4	0.959	0.098
LGALS8	SDK1	0.959
ITGA2	LGALS8	0.956	0.032
NECTIN1	ITGA1	0.955	0.056
HEG1	NECTIN1	0.954	0.052
HEG1	MRC2	0.954	0.124
LGALS1	NECTIN1	0.953	0.126
ITGA1	MRC2	0.946	0.074
LGALS1	PODXL	0.945	0.036
ITGA1	KIAA0319L	0.944	0.05
HEG1	KIAA0319L	0.933	0.066
NECTIN1	PTPRG	0.932	0.088
LGALS1	PTPRG	0.931	0.156
PTPRG	KIAA0319L	0.929	0.096
LGALS1	SDK1	0.929
HEG1	ITGA2	0.927	0.086
ITGA1	ITGA2	0.923	0.196
MRC2	CSPG4	0.919	0.074
ITGA3	ITGA1	0.917	0.226	mutually_exclusive (P05556)
ITGA1	PTPRG	0.899	0.156
ITGA2	KIAA0319L	0.896	0.05
HEG1	PTPRG	0.895	0.108
LGALS1	HEG1	0.878	0.116
NECTIN1	PODXL	0.871	0.05
LGALS1	KIAA0319L	0.863	0.056
ITGA1	CSPG4	0.859	0.192
ITGA1	PODXL	0.858	0.052
PTPRG	CSPG4	0.839	0.102
NECTIN1	KIAA0319L	0.838	0.036
LGALS1	MRC2	0.835	0.128
ITGA1	SDK1	0.832
SDK1	CSPG4	0.826
HEG1	ITGA3	0.82	0.106
ITGA2	MRC2	0.805	0.078
LGALS1	FLT4	0.801	0.112
ENPP4	ITGA1	0.791	0.078	mutually_exclusive (P17931)
ITGA3	PTPRG	0.783	0.144
ENPP4	KIAA0319L	0.767	0.09
ENPP4	CSPG4	0.766	0.088
ITGA3	MRC2	0.764	0.116
NECTIN1	MRC2	0.742	0.0265
LGALS1	CSPG4	0.725	0.078
PTPRG	MRC2	0.724	0.054
ITGA2	PTPRG	0.698	0.108
ITGA3	KIAA0319L	0.69	0.038
KIAA0319L	MRC2	0.688	0.062
ITGA3	PODXL	0.674	0.176
PODXL	SDK1	0.632
HEG1	SDK1	0.619
SDK1	MRC2	0.602
KIAA0319L	SDK1	0.592
ITGA2	SDK1	0.583
SDK1	FLT4	0.566
LGALS1	LGALS8	0.527	0.038
KIAA0319L	FLT4	0.506	0.054
ITGA2	PODXL	0.479	0.064
ENPP4	SDK1	0.466
ITGA3	NECTIN1	0.457	0.062
NECTIN1	CSPG4	0.452	0.148
HEG1	FLT4	0.447	0.1
ENPP4	PTPRG	0.444	0.048
ENPP4	HEG1	0.42	0.072
NECTIN1	ITGA2	0.412	0.112
NECTIN1	SDK1	0.401
PODXL	MRC2	0.396	0.054
ITGA1	FLT4	0.366	0.128583333333
FLT4	CSPG4	0.362	0.076
ENPP4	PODXL	0.346	0.066
ENPP4	ITGA3	0.344	0.072
PODXL	FLT4	0.344	0.126
ENPP4	ITGA2	0.291	0.11
ITGA3	SDK1	0.261
NECTIN1	FLT4	0.255	0.108
ENPP4	FLT4	0.202	0.088
PTPRG	SDK1	0.198
LGALS1	ITGA2	0.19	0.18
FLT4	MRC2	0.187	0.114
LGALS1	ITGA3	0.181	0.19
ITGA2	FLT4	0.171	0.098
ENPP4	NECTIN1	0.17	0.04
ITGA3	FLT4	0.161	0.076
PTPRG	FLT4	0.101	0.146
LGALS1	ENPP4	0.008	0.142

Related Complexes

Genename	Complexes
HEG1	huMAP3_01687.1 huMAP3_01717.1 huMAP3_02607.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_05876.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10744.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_11697.1 huMAP3_14792.1 huMAP3_15183.1
LGALS1	huMAP3_00618.1 huMAP3_02873.1 huMAP3_03489.1 huMAP3_04614.1 huMAP3_05351.1 huMAP3_05590.1 huMAP3_06892.1 huMAP3_06908.1 huMAP3_06955.1 huMAP3_07927.1 huMAP3_09169.1 huMAP3_10859.1 huMAP3_10920.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_14792.1
ITGA3	huMAP3_01687.1 huMAP3_02607.1 huMAP3_02968.1 huMAP3_05532.1 huMAP3_06815.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_08957.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10980.1
NECTIN1	huMAP3_01687.1 huMAP3_01717.1 huMAP3_02607.1 huMAP3_03194.1 huMAP3_04614.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_06236.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10848.1 huMAP3_10920.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_11697.1 huMAP3_14792.1 huMAP3_15075.1
CSPG4	huMAP3_05584.1 huMAP3_05590.1 huMAP3_06048.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10744.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
ITGA1	huMAP3_01687.1 huMAP3_01717.1 huMAP3_02607.1 huMAP3_03194.1 huMAP3_04614.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_05876.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_06955.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10848.1 huMAP3_10920.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_11697.1 huMAP3_14792.1 huMAP3_15075.1
PODXL	huMAP3_02042.1 huMAP3_03524.1 huMAP3_05584.1 huMAP3_05632.1 huMAP3_06892.1 huMAP3_08443.1 huMAP3_08912.1 huMAP3_10503.1 huMAP3_10724.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_15183.1
ITGA2	huMAP3_01687.1 huMAP3_02607.1 huMAP3_02968.1 huMAP3_05532.1 huMAP3_06815.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_08957.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10980.1
SDK1	huMAP3_02607.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_11349.1 huMAP3_14792.1
MRC2	huMAP3_02703.1 huMAP3_02887.1 huMAP3_04041.1 huMAP3_04390.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_06048.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10744.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
ENPP4	huMAP3_01162.1 huMAP3_01717.1 huMAP3_02703.1 huMAP3_02887.1 huMAP3_04041.1 huMAP3_04384.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10744.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
LGALS8	huMAP3_01687.1 huMAP3_01717.1 huMAP3_02607.1 huMAP3_05584.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
KIAA0319L	huMAP3_01717.1 huMAP3_02887.1 huMAP3_03801.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_09837.1 huMAP3_10503.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
FLT4	huMAP3_02607.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_11605.1 huMAP3_13582.1
PTPRG	huMAP3_01687.1 huMAP3_01717.1 huMAP3_02042.1 huMAP3_02607.1 huMAP3_05632.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_08103.1 huMAP3_08443.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10724.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_12658.1 huMAP3_14792.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06892.1

Complex Portal: CPX-10817