hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06903.1
Complex Portal: CPX-13079
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRRG1 | Transmembrane gamma-carboxyglutamic acid protein 1 (Proline-rich gamma-carboxyglutamic acid protein 1) (Proline-rich Gla protein 1) | 4 | UniProt NCBI |
| ARRDC1 | Arrestin domain-containing protein 1 (Alpha-arrestin 1) | 5 | UniProt NCBI |
| HECW1 | E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1) | 5 | UniProt NCBI |
| HECW2 | E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2) | 5 | UniProt NCBI |
| TMEM171 | Transmembrane protein 171 | 3 | UniProt NCBI |
| ILDR1 | Immunoglobulin-like domain-containing receptor 1 (Angulin-2) | 5 | UniProt NCBI |
| NEDD4L | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | 5 | UniProt NCBI |
| FAIM2 | Protein lifeguard 2 (Fas apoptotic inhibitory molecule 2) (Neural membrane protein 35) (Transmembrane BAX inhibitor motif-containing protein 2) | 5 | UniProt NCBI |
| NEDD4 | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | 5 | UniProt NCBI |
| LDLRAD4 | Low-density lipoprotein receptor class A domain-containing protein 4 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0048814 | 0.000196881712788 | 0.4 | HECW1 NEDD4 NEDD4L HECW2 | regulation of dendrite morphogenesis |
| WP:WP4904 | 0.000869375693182 | 0.2 | NEDD4 LDLRAD4 | LDLRAD4 and what we know about it |
| GO:0050773 | 0.00105973484827 | 0.4 | HECW1 NEDD4 NEDD4L HECW2 | regulation of dendrite development |
| GO:0048813 | 0.00769229904439 | 0.4 | HECW1 NEDD4 NEDD4L HECW2 | dendrite morphogenesis |
| GO:0016358 | 0.0498283342602 | 0.4 | HECW1 NEDD4 NEDD4L HECW2 | dendrite development |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NEDD4 | ILDR1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| LDLRAD4 | HECW2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NEDD4L | ILDR1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NEDD4 | TMEM171 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| HECW1 | TMEM171 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| HECW1 | LDLRAD4 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ILDR1 | HECW2 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| HECW1 | ILDR1 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NEDD4L | TMEM171 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| HECW2 | TMEM171 | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NEDD4 | PRRG1 | 0.992 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NEDD4 | LDLRAD4 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| HECW1 | PRRG1 | 0.99 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NEDD4 | NEDD4L | 0.99 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| PRRG1 | HECW2 | 0.99 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NEDD4L | PRRG1 | 0.987 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NEDD4 | HECW2 | 0.985 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NEDD4 | ARRDC1 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| NEDD4 | FAIM2 | 0.98 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NEDD4L | LDLRAD4 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ARRDC1 | NEDD4L | 0.967 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NEDD4L | HECW2 | 0.966 | 0.192 | bioplex_WMM bioplex3_WMM WMM_only | |
| HECW1 | HECW2 | 0.964 | 0.202 | bioplex_WMM bioplex3_WMM WMM_only | |
| HECW1 | NEDD4L | 0.956 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only | |
| NEDD4 | HECW1 | 0.953 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ARRDC1 | HECW2 | 0.291 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ARRDC1 | PRRG1 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FAIM2 | NEDD4L | 0.022 | bioplex3_HCT116 WMM_only |
Related Complexes