hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06906.1
Complex Portal: CPX-18045
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIGR | Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component] | 5 | UniProt NCBI |
| MUC5AC | Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) | 5 | UniProt NCBI |
| PABIR3 | PABIR family member 1 | 4 | UniProt NCBI |
| JCHAIN | Immunoglobulin J chain (Joining chain of multimeric IgA and IgM) | 5 | UniProt NCBI |
| BPIFA1 | BPI fold-containing family A member 1 (Lung-specific protein X) (Nasopharyngeal carcinoma-related protein) (Palate lung and nasal epithelium clone protein) (Secretory protein in upper respiratory tracts) (Short PLUNC1) (SPLUNC1) (Tracheal epithelium-enriched protein) (Von Ebner protein Hl) | 5 | UniProt NCBI |
| MUC5B | Mucin-5B (MUC-5B) (Cervical mucin) (High molecular weight salivary mucin MG1) (Mucin-5 subtype B, tracheobronchial) (Sublingual gland mucin) | 5 | UniProt NCBI |
| BPIFB1 | BPI fold-containing family B member 1 (Long palate, lung and nasal epithelium carcinoma-associated protein 1) (von Ebner minor salivary gland protein) (VEMSGP) | 5 | UniProt NCBI |
| DMBT1 | Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) | 5 | UniProt NCBI |
| ZG16B | Pancreatic adenocarcinoma up-regulated factor (Zymogen granule protein 16 homolog B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04970 | 0.000333802550546 | 0.333333333333 | MUC5B MUC5AC DMBT1 | Salivary secretion |
| REAC:R-HSA-5083636 | 0.00358554253109 | 0.222222222222 | MUC5B MUC5AC | Defective GALNT12 causes CRCS1 |
| REAC:R-HSA-5083625 | 0.00358554253109 | 0.222222222222 | MUC5B MUC5AC | Defective GALNT3 causes HFTC |
| REAC:R-HSA-5083632 | 0.00438093013445 | 0.222222222222 | MUC5B MUC5AC | Defective C1GALT1C1 causes TNPS |
| REAC:R-HSA-5621480 | 0.00954313848115 | 0.222222222222 | MUC5B MUC5AC | Dectin-2 family |
| REAC:R-HSA-977068 | 0.00954313848115 | 0.222222222222 | MUC5B MUC5AC | Termination of O-glycan biosynthesis |
| GO:0071745 | 0.016855225923 | 0.222222222222 | PIGR JCHAIN | IgA immunoglobulin complex |
| GO:0071746 | 0.016855225923 | 0.222222222222 | PIGR JCHAIN | IgA immunoglobulin complex, circulating |
| GO:0071749 | 0.016855225923 | 0.222222222222 | PIGR JCHAIN | polymeric IgA immunoglobulin complex |
| GO:0071751 | 0.016855225923 | 0.222222222222 | PIGR JCHAIN | secretory IgA immunoglobulin complex |
| REAC:R-HSA-168249 | 0.0199047475117 | 0.555555555556 | BPIFB1 PIGR MUC5B MUC5AC BPIFA1 | Innate Immune System |
| HPA:0151303 | 0.0270559927528 | 0.333333333333 | PIGR DMBT1 JCHAIN | duodenum; enterocytes[High] |
| HPA:0481303 | 0.0290597844822 | 0.333333333333 | PIGR DMBT1 JCHAIN | small intestine; enterocytes[High] |
| KEGG:04657 | 0.0486860700236 | 0.222222222222 | MUC5B MUC5AC | IL-17 signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PIGR | BPIFA1 | 0.994 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM treiber_WMM WMM_only | ||
| PIGR | ZG16B | 0.993 |
structurally_consistent (Q6B0K9)
|
bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM treiber_WMM WMM_only | |
| DMBT1 | PABIR3 | 0.992 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PIGR | JCHAIN | 0.992 | 0.17 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM treiber_WMM WMM_only |
| BPIFA1 | MUC5B | 0.985 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | ||
| BPIFA1 | ZG16B | 0.981 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM treiber_WMM WMM_only | ||
| BPIFA1 | PABIR3 | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PIGR | MUC5B | 0.98 | 0.1166 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| PIGR | DMBT1 | 0.979 | 0.182 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM treiber_WMM | |
| BPIFA1 | MUC5AC | 0.978 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PIGR | BPIFB1 | 0.977 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM | ||
| DMBT1 | JCHAIN | 0.976 | 0.368 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM treiber_WMM | |
| PIGR | MUC5AC | 0.976 | 0.1706 | bioplex_WMM bioplex3_WMM WMM_only | |
| BPIFA1 | BPIFB1 | 0.975 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM | ||
| BPIFA1 | DMBT1 | 0.975 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | ||
| JCHAIN | PABIR3 | 0.974 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MUC5B | BPIFB1 | 0.973 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | ||
| MUC5B | DMBT1 | 0.971 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| ZG16B | JCHAIN | 0.97 |
structurally_consistent (Q6B0K9)
|
bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM treiber_WMM WMM_only | |
| BPIFA1 | JCHAIN | 0.968 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM treiber_WMM WMM_only | ||
| DMBT1 | MUC5AC | 0.968 | 0.236 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| JCHAIN | BPIFB1 | 0.96 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM | ||
| MUC5B | MUC5AC | 0.956 | 0.264 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZG16B | BPIFB1 | 0.95 |
structurally_consistent (Q6B0K9)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ZG16B | MUC5AC | 0.947 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MUC5AC | JCHAIN | 0.946 | 0.168 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| MUC5B | ZG16B | 0.942 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | ||
| DMBT1 | BPIFB1 | 0.929 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| DMBT1 | ZG16B | 0.928 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM treiber_WMM | ||
| MUC5B | JCHAIN | 0.911 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | |
| MUC5AC | BPIFB1 | 0.891 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MUC5B | PABIR3 | 0.059 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PIGR | PABIR3 | 0.021 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ZG16B | PABIR3 | 0.017 | bioplex3_WMM bioplex3_HCT116 WMM_only |
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