hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06909.1
Complex Portal: CPX-11349
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GYG2 | Glycogenin-2 (GN-2) (GN2) (EC 2.4.1.186) | 5 | UniProt NCBI |
| PPP1R3F | Protein phosphatase 1 regulatory subunit 3F (R3F) | 5 | UniProt NCBI |
| PPP1R3C | Protein phosphatase 1 regulatory subunit 3C (Protein phosphatase 1 regulatory subunit 5) (PP1 subunit R5) (Protein targeting to glycogen) (PTG) | 5 | UniProt NCBI |
| STBD1 | Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1) | 5 | UniProt NCBI |
| GYS2 | Glycogen [starch] synthase, liver (EC 2.4.1.11) (Glycogen synthase 2) | 5 | UniProt NCBI |
| PYGB | Glycogen phosphorylase, brain form (EC 2.4.1.1) | 5 | UniProt NCBI |
| PYGL | Glycogen phosphorylase, liver form (EC 2.4.1.1) | 5 | UniProt NCBI |
| AGL | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | 5 | UniProt NCBI |
| PPP1R3D | Protein phosphatase 1 regulatory subunit 3D (Protein phosphatase 1 regulatory subunit 6) (PP1 subunit R6) (Protein phosphatase 1-binding subunit R6) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0044042 | 2.09163844533e-16 | 1.0 | PPP1R3C PYGL GYG2 STBD1 GYS2 AGL PPP1R3F PPP1R3D | glucan metabolic process |
| GO:0005977 | 2.09163844533e-16 | 1.0 | PPP1R3C PYGL GYG2 STBD1 GYS2 AGL PPP1R3F PPP1R3D | glycogen metabolic process |
| GO:0006112 | 7.30231684163e-16 | 1.0 | PPP1R3C PYGL GYG2 STBD1 GYS2 AGL PPP1R3F PPP1R3D | energy reserve metabolic process |
| GO:0005976 | 2.85753823697e-15 | 1.0 | PPP1R3C PYGL GYG2 STBD1 GYS2 AGL PPP1R3F PPP1R3D | polysaccharide metabolic process |
| REAC:R-HSA-8982491 | 9.09057856855e-11 | 0.625 | GYG2 AGL PYGL GYS2 PPP1R3C | Glycogen metabolism |
| GO:0015980 | 1.29627908319e-10 | 1.0 | PPP1R3C PYGL GYG2 STBD1 GYS2 AGL PPP1R3F PPP1R3D | energy derivation by oxidation of organic compounds |
| GO:0005975 | 1.92342887521e-09 | 1.0 | PPP1R3C PYGL GYG2 STBD1 GYS2 AGL PPP1R3F PPP1R3D | carbohydrate metabolic process |
| GO:0006091 | 3.59469732014e-09 | 1.0 | PPP1R3C PYGL GYG2 STBD1 GYS2 AGL PPP1R3F PPP1R3D | generation of precursor metabolites and energy |
| KEGG:00500 | 2.29632234234e-08 | 0.5 | GYG2 AGL PYGL GYS2 | Starch and sucrose metabolism |
| GO:2001069 | 2.76161616937e-08 | 0.5 | PPP1R3F PPP1R3D STBD1 PPP1R3C | glycogen binding |
| GO:0005978 | 1.01074594165e-07 | 0.625 | GYG2 PPP1R3D GYS2 PPP1R3C PPP1R3F | glycogen biosynthetic process |
| GO:0009250 | 1.01074594165e-07 | 0.625 | GYG2 PPP1R3D GYS2 PPP1R3C PPP1R3F | glucan biosynthetic process |
| KEGG:04910 | 1.19422170614e-07 | 0.625 | PPP1R3F PPP1R3D PYGL GYS2 PPP1R3C | Insulin signaling pathway |
| WP:WP500 | 2.20384027668e-07 | 0.5 | GYG2 AGL PYGL GYS2 | Glycogen synthesis and degradation |
| GO:0030247 | 6.06890408176e-07 | 0.5 | PPP1R3F PPP1R3D STBD1 PPP1R3C | polysaccharide binding |
| GO:0000271 | 7.6793688751e-07 | 0.625 | GYG2 PPP1R3D GYS2 PPP1R3C PPP1R3F | polysaccharide biosynthetic process |
| WP:WP5173 | 2.80202851888e-06 | 0.375 | GYG2 PYGL GYS2 | Disorders of galactose metabolism |
| KEGG:04931 | 6.45298240943e-06 | 0.5 | PPP1R3C PPP1R3D PYGL GYS2 | Insulin resistance |
| REAC:R-HSA-70221 | 6.53409203551e-06 | 0.375 | GYG2 PYGL AGL | Glycogen breakdown (glycogenolysis) |
| REAC:R-HSA-3322077 | 8.313982098e-06 | 0.375 | GYG2 GYS2 PPP1R3C | Glycogen synthesis |
| REAC:R-HSA-3229121 | 8.313982098e-06 | 0.375 | GYG2 GYS2 PPP1R3C | Glycogen storage diseases |
| GO:0030246 | 1.53576106888e-05 | 0.625 | PPP1R3F PPP1R3D PYGL STBD1 PPP1R3C | carbohydrate binding |
| REAC:R-HSA-71387 | 1.81028586836e-05 | 0.625 | GYG2 AGL PYGL GYS2 PPP1R3C | Metabolism of carbohydrates |
| REAC:R-HSA-3858516 | 5.57856177121e-05 | 0.25 | GYG2 GYS2 | Glycogen storage disease type 0 (liver GYS2) |
| REAC:R-HSA-5663084 | 9.23525641109e-05 | 0.375 | GYG2 GYS2 PPP1R3C | Diseases of carbohydrate metabolism |
| WP:WP4861 | 9.61282732853e-05 | 0.375 | PPP1R3F PPP1R3D PPP1R3C | Endoplasmic reticulum stress response in coronavirus infection |
| GO:0016051 | 0.000130618732098 | 0.625 | GYG2 PPP1R3D GYS2 PPP1R3C PPP1R3F | carbohydrate biosynthetic process |
| REAC:R-HSA-3878781 | 0.000167311042734 | 0.25 | GYG2 GYS2 | Glycogen storage disease type IV (GBE1) |
| GO:0009251 | 0.00045145282213 | 0.375 | STBD1 PYGL AGL | glucan catabolic process |
| GO:0005980 | 0.00045145282213 | 0.375 | STBD1 PYGL AGL | glycogen catabolic process |
| GO:0000272 | 0.00045145282213 | 0.375 | STBD1 PYGL AGL | polysaccharide catabolic process |
| GO:0008157 | 0.00244160521127 | 0.375 | PPP1R3F PPP1R3D PPP1R3C | protein phosphatase 1 binding |
| GO:0000164 | 0.00300428100757 | 0.375 | PPP1R3F PPP1R3D PPP1R3C | protein phosphatase type 1 complex |
| GO:0010962 | 0.00824905178996 | 0.375 | PPP1R3F PPP1R3D PPP1R3C | regulation of glucan biosynthetic process |
| GO:0005979 | 0.00824905178996 | 0.375 | PPP1R3F PPP1R3D PPP1R3C | regulation of glycogen biosynthetic process |
| GO:0032885 | 0.0139126682532 | 0.375 | PPP1R3F PPP1R3D PPP1R3C | regulation of polysaccharide biosynthetic process |
| GO:0070873 | 0.0139126682532 | 0.375 | PPP1R3F PPP1R3D PPP1R3C | regulation of glycogen metabolic process |
| WP:WP410 | 0.0194081878965 | 0.25 | PPP1R3C STBD1 | Exercise induced circadian regulation |
| GO:0032881 | 0.0217028525661 | 0.375 | PPP1R3F PPP1R3D PPP1R3C | regulation of polysaccharide metabolic process |
| REAC:R-HSA-5668914 | 0.0234275992564 | 0.375 | GYG2 GYS2 PPP1R3C | Diseases of metabolism |
| HP:0003077 | 0.0306789550085 | 0.375 | GYS2 PYGL AGL | Hyperlipidemia |
| GO:0016758 | 0.0433830596151 | 0.5 | GYG2 AGL PYGL GYS2 | hexosyltransferase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| STBD1 | AGL | 1.0 | 0.216 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STBD1 | PYGB | 0.999 | 0.185 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PYGB | PYGL | 0.998 | 0.366 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only | |
| GYG2 | STBD1 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GYG2 | AGL | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| STBD1 | GYS2 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PPP1R3C | STBD1 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| STBD1 | PPP1R3D | 0.992 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PPP1R3F | STBD1 | 0.99 | 0.104 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| STBD1 | PYGL | 0.988 | 0.228 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GYG2 | GYS2 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| GYG2 | PPP1R3F | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PPP1R3C | PPP1R3D | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PPP1R3C | AGL | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GYS2 | PYGB | 0.957 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GYG2 | PYGB | 0.948 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| PPP1R3F | PPP1R3D | 0.925 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only | |
| PYGB | PPP1R3D | 0.909 | 0.082 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PYGB | AGL | 0.898 | 0.206 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| GYS2 | AGL | 0.893 | bioplex_WMM bioplex3_WMM WMM_only | ||
| AGL | PPP1R3D | 0.871 | 0.078 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| GYS2 | PPP1R3D | 0.866 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PPP1R3F | PYGB | 0.865 | 0.07 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PPP1R3F | AGL | 0.812 | 0.05 | bioplex3_WMM WMM_only | |
| PPP1R3F | GYS2 | 0.745 | bioplex3_WMM WMM_only | ||
| PPP1R3F | PYGL | 0.569 | 0.03 | bioplex3_WMM WMM_only | |
| PYGL | PPP1R3D | 0.515 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| PPP1R3C | GYS2 | 0.268 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GYG2 | PPP1R3D | 0.263 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GYS2 | PYGL | 0.215 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PYGL | AGL | 0.172 | 0.054 | bioplex_WMM bioplex3_WMM fraction | |
| GYG2 | PYGL | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PPP1R3C | PYGL | 0.005 | bioplex3_HEK293 bioplex () |
Related Complexes