hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06911.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SYNJ1 | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1) | 5 | UniProt NCBI |
| AP1S1 | AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin) | 5 | UniProt NCBI |
| AP1B1 | AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7476 | 2.05032700758e-05 | 0.666666666667 | AP1B1 AP1S1 | AP1B1-AP1G2-AP1M-1AP1S1 complex |
| CORUM:36 | 9.56644648234e-05 | 0.666666666667 | AP1B1 AP1S1 | AP1 adaptor complex |
| CORUM:144 | 0.000122991556209 | 0.666666666667 | AP1B1 AP1S1 | Gamma-BAR-AP1 complex |
| REAC:R-HSA-164940 | 0.000306718584473 | 0.666666666667 | AP1B1 AP1S1 | Nef mediated downregulation of MHC class I complex cell surface expression |
| HP:0011967 | 0.000354217072454 | 0.666666666667 | AP1B1 AP1S1 | Decreased circulating copper concentration |
| HP:0010837 | 0.000455401167586 | 0.666666666667 | AP1B1 AP1S1 | Decreased circulating ceruloplasmin concentration |
| HP:0033144 | 0.000695688281083 | 0.666666666667 | AP1B1 AP1S1 | Abnormal circulating ceruloplasmin concentration |
| GO:0030118 | 0.000878441055398 | 1.0 | AP1B1 SYNJ1 AP1S1 | clathrin coat |
| HP:0010836 | 0.00115089028102 | 0.666666666667 | AP1B1 AP1S1 | Abnormal circulating copper concentration |
| REAC:R-HSA-164938 | 0.00143063482691 | 0.666666666667 | AP1B1 AP1S1 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| HP:0001406 | 0.00193466002352 | 0.666666666667 | AP1B1 AP1S1 | Intrahepatic cholestasis |
| HP:0031865 | 0.00216216836724 | 0.666666666667 | AP1B1 AP1S1 | Abnormal liver physiology |
| REAC:R-HSA-164952 | 0.00239054881557 | 0.666666666667 | AP1B1 AP1S1 | The role of Nef in HIV-1 replication and disease pathogenesis |
| REAC:R-HSA-432720 | 0.00359505378021 | 0.666666666667 | AP1B1 AP1S1 | Lysosome Vesicle Biogenesis |
| KEGG:04142 | 0.00569595332742 | 0.666666666667 | AP1B1 AP1S1 | Lysosome |
| GO:0110010 | 0.00842684400117 | 0.666666666667 | AP1B1 AP1S1 | basolateral protein secretion |
| HP:0011030 | 0.00888120343534 | 0.666666666667 | AP1B1 AP1S1 | Abnormal blood transition element cation concentration |
| REAC:R-HSA-432722 | 0.00973406489476 | 0.666666666667 | AP1B1 AP1S1 | Golgi Associated Vesicle Biogenesis |
| GO:0048475 | 0.0101882437539 | 1.0 | AP1B1 SYNJ1 AP1S1 | coated membrane |
| GO:0030117 | 0.0101882437539 | 1.0 | AP1B1 SYNJ1 AP1S1 | membrane coat |
| KEGG:05170 | 0.0140204887763 | 0.666666666667 | AP1B1 AP1S1 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-199991 | 0.0145539954891 | 1.0 | AP1B1 SYNJ1 AP1S1 | Membrane Trafficking |
| REAC:R-HSA-199992 | 0.0164154902665 | 0.666666666667 | AP1B1 AP1S1 | trans-Golgi Network Vesicle Budding |
| REAC:R-HSA-5653656 | 0.017135828319 | 1.0 | AP1B1 SYNJ1 AP1S1 | Vesicle-mediated transport |
| HP:0010876 | 0.0228523059604 | 1.0 | AP1B1 SYNJ1 AP1S1 | Abnormal circulating protein concentration |
| REAC:R-HSA-2132295 | 0.0460272953732 | 0.666666666667 | AP1B1 AP1S1 | MHC class II antigen presentation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| AP1S1 | SYNJ1 | 0.987 | 0.072 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| AP1S1 | AP1B1 | 0.985 | 0.112 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM fraction |
| AP1B1 | SYNJ1 | 0.961 | 0.194 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
Related Complexes