hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06940.1

Complex Portal: CPX-17484

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
ARVCF	Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome)	5	UniProt NCBI
CTNNA2	Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein)	5	UniProt NCBI
ZFP82	Zinc finger protein 82 homolog (Zfp-82) (Zinc finger protein 545)	3	UniProt NCBI
CDH1	Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]	5	UniProt NCBI
CTNNBIP1	Beta-catenin-interacting protein 1 (Inhibitor of beta-catenin and Tcf-4)	5	UniProt NCBI
CDH10	Cadherin-10 (T2-cadherin)	5	UniProt NCBI
CTNNA1	Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)	5	UniProt NCBI
CDH2	Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)	5	UniProt NCBI
APC	Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)	5	UniProt NCBI
CTNND1	Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))	5	UniProt NCBI
CTNNB1	Catenin beta-1 (Beta-catenin)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0016342	1.69151611321e-08	0.625	CTNNA2 CTNND1 CDH10 CTNNB1 CTNNA1	catenin complex
REAC:R-HSA-418990	1.59637187216e-07	0.5	CTNND1 CDH10 CTNNB1 CTNNA1	Adherens junctions interactions
GO:0005912	6.6792565317e-07	0.75	CTNNA1 CDH10 CTNNB1 CTNNA2 CTNND1 ARVCF	adherens junction
REAC:R-HSA-421270	1.15734333971e-06	0.5	CTNND1 CDH10 CTNNB1 CTNNA1	Cell-cell junction organization
KEGG:04670	3.80354806386e-06	0.5	CTNNA2 CTNNA1 CTNNB1 CTNND1	Leukocyte transendothelial migration
KEGG:04520	3.80354806386e-06	0.5	CTNNA2 CTNNA1 CTNNB1 CTNND1	Adherens junction
REAC:R-HSA-446728	7.94405385637e-06	0.5	CTNND1 CDH10 CTNNB1 CTNNA1	Cell junction organization
CORUM:6206	2.39226645298e-05	0.25	CTNNBIP1 CTNNB1	ICAT-AR-beta-catenin complex
CORUM:4096	2.39226645298e-05	0.25	CTNNA1 CTNNB1	CTNNA1-CTNNB1 complex
GO:0019897	2.44300642267e-05	0.625	CTNNA2 CTNND1 CDH10 CTNNB1 CTNNA1	extrinsic component of plasma membrane
REAC:R-HSA-1500931	3.39080087254e-05	0.5	CTNND1 CDH10 CTNNB1 CTNNA1	Cell-Cell communication
GO:0007043	4.34062803888e-05	0.625	CTNND1 CTNNA1 ARVCF CTNNB1 CDH10	cell-cell junction assembly
REAC:R-HSA-5218920	4.61108204583e-05	0.375	CTNND1 CTNNA1 CTNNB1	VEGFR2 mediated vascular permeability
REAC:R-HSA-525793	4.61108204583e-05	0.375	CTNNA2 CTNNA1 CTNNB1	Myogenesis
GO:0005911	0.000104266399628	0.75	CTNNA1 CDH10 CTNNB1 CTNNA2 CTNND1 ARVCF	cell-cell junction
KEGG:05213	0.000116307002573	0.375	CTNNA2 CTNNA1 CTNNB1	Endometrial cancer
GO:0045296	0.000124258387278	0.75	CTNNA1 CDH10 CTNNB1 CTNNA2 CTNND1 ARVCF	cadherin binding
CORUM:6337	0.000143457417375	0.25	CTNND1 CTNNB1	Amot-cadherin-11-beta-catenin-p120 complex
GO:0045216	0.000164659045641	0.625	CTNND1 CTNNA1 ARVCF CTNNB1 CDH10	cell-cell junction organization
GO:0019898	0.000212950278859	0.625	CTNNA2 CTNND1 CDH10 CTNNB1 CTNNA1	extrinsic component of membrane
KEGG:05412	0.000262665274355	0.375	CTNNA2 CTNNA1 CTNNB1	Arrhythmogenic right ventricular cardiomyopathy
WP:WP4155	0.000283445979884	0.375	CTNNA2 CTNNA1 CTNNB1	Endometrial cancer
WP:WP2118	0.000314757575276	0.375	CTNNA2 CTNNA1 CTNNB1	Arrhythmogenic right ventricular cardiomyopathy
KEGG:05100	0.000367694824708	0.375	CTNNA2 CTNNA1 CTNNB1	Bacterial invasion of epithelial cells
GO:0034330	0.000704588688695	0.75	CTNNA1 CDH10 CTNNB1 CTNNA2 CTNND1 ARVCF	cell junction organization
GO:0050839	0.00121717517376	0.75	CTNNA1 CDH10 CTNNB1 CTNNA2 CTNND1 ARVCF	cell adhesion molecule binding
WP:WP4541	0.00137027616359	0.375	CDH10 CTNNB1 CTNNA1	Hippo Merlin signaling dysregulation
KEGG:05226	0.00188812744317	0.375	CTNNA2 CTNNA1 CTNNB1	Gastric cancer
REAC:R-HSA-8876493	0.00200443712543	0.25	CTNND1 CTNNB1	InlA-mediated entry of Listeria monocytogenes into host cells
REAC:R-HSA-4420097	0.00237597190289	0.375	CTNND1 CTNNA1 CTNNB1	VEGFA-VEGFR2 Pathway
WP:WP5087	0.00243275441359	0.5	CTNNA2 CDH10 CTNNB1 CTNNA1	Pleural mesothelioma
KEGG:04390	0.00260993521755	0.375	CTNNA2 CTNNA1 CTNNB1	Hippo signaling pathway
REAC:R-HSA-194138	0.00309630954826	0.375	CTNND1 CTNNA1 CTNNB1	Signaling by VEGF
GO:0098609	0.00374962654073	0.75	CTNNA1 CDH10 CTNNB1 CTNNA2 CTNND1 ARVCF	cell-cell adhesion
GO:0034329	0.00534753059989	0.625	CTNND1 CTNNA1 ARVCF CTNNB1 CDH10	cell junction assembly
GO:0070161	0.00699213554829	0.75	CTNNA1 CDH10 CTNNB1 CTNNA2 CTNND1 ARVCF	anchoring junction
REAC:R-HSA-8876384	0.00949504138694	0.25	CTNND1 CTNNB1	Listeria monocytogenes entry into host cells
WP:WP4534	0.0184665051061	0.25	CTNNA1 CTNNB1	Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms
REAC:R-HSA-5626467	0.0224821270291	0.25	CTNNA1 CTNNB1	RHO GTPases activate IQGAPs
REAC:R-HSA-3769402	0.0348192347107	0.25	CTNNBIP1 CTNNB1	Deactivation of the beta-catenin transactivating complex
GO:0098797	0.0427090045815	0.625	CTNNA2 CTNND1 CDH10 CTNNB1 CTNNA1	plasma membrane protein complex
CORUM:5262	0.0499436884912	0.125	CTNNB1	TCF4-CTNNB1 complex
CORUM:5281	0.0499436884912	0.125	CTNNB1	Cell-cell junction complex (CDH1-CTNNB1)
CORUM:6336	0.0499436884912	0.125	CTNNB1	CTNNB1-DNMT1 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CTNNB1	CTNNA1	1.0	0.718	structurally_consistent (dimer)
CDH1	CTNNB1	0.999	0.386	structurally_consistent (dimer)
CTNNA2	CTNNB1	0.999		structurally_consistent (dimer)
CTNNBIP1	CTNNB1	0.999	0.094	structurally_consistent (dimer)
CTNNA2	CTNNA1	0.999
APC	CTNNB1	0.999	0.258
CDH10	CTNNB1	0.999	0.096
CTNNBIP1	CTNNA1	0.999	0.118
ARVCF	CTNNA1	0.998	0.122
CTNNB1	ARVCF	0.998	0.154
CDH1	CTNND1	0.995	0.172	structurally_consistent (dimer)
CDH1	CDH10	0.994
CDH10	CTNND1	0.994	0.086
CTNNBIP1	APC	0.993	0.218
ARVCF	CTNND1	0.992	0.084
CTNNA1	CTNND1	0.992	0.686
CDH10	ARVCF	0.991	0.066
CTNNA2	CTNNBIP1	0.99		structurally_consistent (P35222)
APC	CTNNA1	0.989	0.23
ZFP82	CTNNB1	0.983		structurally_consistent (dimer)
CDH1	CTNNA1	0.981	0.52	structurally_consistent (P35222)
CDH1	ARVCF	0.98	0.218
CDH2	CTNNB1	0.98	0.366	structurally_consistent (dimer)
CDH10	CTNNA1	0.947	0.094
CDH2	CTNND1	0.927	0.108
ZFP82	CTNNBIP1	0.905
CTNNB1	CTNND1	0.901	0.606
CDH10	APC	0.821	0.116
CTNNA2	ARVCF	0.782
APC	ARVCF	0.661	0.072
CDH1	CTNNBIP1	0.652	0.086	mutually_exclusive (P35222)
CDH2	CTNNA1	0.642	0.192
CDH1	CTNNA2	0.64
CTNNA2	APC	0.594
CDH10	CTNNBIP1	0.502
CDH2	ARVCF	0.357	0.238
CDH1	CDH2	0.331	0.302	mutually_exclusive (P35222)
ZFP82	CTNNA1	0.277
CTNNBIP1	ARVCF	0.237	0.04
CDH10	CDH2	0.215	0.147
CDH1	ZFP82	0.199
CDH1	APC	0.186	0.256
CTNNA2	ZFP82	0.179		structurally_consistent (P35222)
CTNNA2	CDH2	0.131
ZFP82	APC	0.102
CDH2	APC	0.091	0.226
CTNNA2	CTNND1	0.089
ZFP82	ARVCF	0.078
CTNNBIP1	CDH2	0.076	0.126	mutually_exclusive (P35222)
CTNNBIP1	CTNND1	0.068	0.058
ZFP82	CDH2	0.062
APC	CTNND1	0.02	0.084
ZFP82	CTNND1	0.013
CDH10	CTNNA2	0.013

Related Complexes

Genename	Complexes
ARVCF	huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CTNNA2	huMAP3_05114.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_11960.1 huMAP3_12107.1 huMAP3_13361.1
ZFP82	huMAP3_05114.1 huMAP3_06940.1 huMAP3_07339.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_11965.1 huMAP3_12009.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_13514.1 huMAP3_14353.1 huMAP3_14650.1
CDH1	huMAP3_02788.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1
CTNNBIP1	huMAP3_05114.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_11872.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1 huMAP3_15078.1
CDH10	huMAP3_02788.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CTNNA1	huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CDH2	huMAP3_05114.1 huMAP3_06940.1 huMAP3_07339.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12009.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1 huMAP3_15017.1
APC	huMAP3_05114.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CTNND1	huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CTNNB1	huMAP3_05114.1 huMAP3_06940.1 huMAP3_07339.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_11965.1 huMAP3_12009.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_13514.1 huMAP3_14650.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06940.1

Complex Portal: CPX-17484