List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_06942.1

Confidence: Very High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
AEBP2	Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2)	5	UniProt   NCBI
PHF1	PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1)	5	UniProt   NCBI
EED	Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)	5	UniProt   NCBI
PHF19	PHD finger protein 19 (Polycomb-like protein 3) (hPCL3)	5	UniProt   NCBI
EZH1	Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)	5	UniProt   NCBI
SUZ12	Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog)	5	UniProt   NCBI
JARID2	Protein Jumonji (Jumonji/ARID domain-containing protein 2)	5	UniProt   NCBI
EZH2	Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)	5	UniProt   NCBI
EPOP	Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28)	4	UniProt   NCBI
LCOR	Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2)	5	UniProt   NCBI
MTF2	Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2)	5	UniProt   NCBI
SKIDA1	SKI/DACH domain-containing protein 1 (Protein DLN-1)	3	UniProt   NCBI
MAMDC4	Apical endosomal glycoprotein (MAM domain-containing protein 4)	4	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:03083	3.30661600008e-22	0.846153846154	EPOP SUZ12 MTF2 PHF1 EED EZH2 PHF19 LCOR AEBP2 JARID2 EZH1	Polycomb repressive complex
GO:0035098	1.60482750213e-18	0.615384615385	SUZ12 PHF1 EED EZH2 PHF19 AEBP2 MTF2 EZH1	ESC/E(Z) complex
WP:WP2916	8.10078606207e-17	0.538461538462	SUZ12 MTF2 EED EZH2 AEBP2 JARID2 EZH1	Interactome of polycomb repressive complex 2 PRC2
GO:0035097	1.16143591985e-14	0.692307692308	SUZ12 MTF2 PHF1 EED EZH2 PHF19 AEBP2 JARID2 EZH1	histone methyltransferase complex
REAC:R-HSA-212300	1.97744479615e-14	0.615384615385	SUZ12 PHF1 JARID2 EZH2 PHF19 AEBP2 EED MTF2	PRC2 methylates histones and DNA
GO:0031519	1.4588343597e-13	0.615384615385	SUZ12 PHF1 EED EZH2 PHF19 AEBP2 MTF2 EZH1	PcG protein complex
GO:0034708	3.28327579252e-13	0.692307692308	SUZ12 MTF2 PHF1 EED EZH2 PHF19 AEBP2 JARID2 EZH1	methyltransferase complex
CORUM:7304	2.11387990692e-11	0.307692307692	SUZ12 EED EZH2 PHF19	HIC1-PCL3L-PCR2 complex
REAC:R-HSA-212165	9.96984849921e-11	0.615384615385	SUZ12 PHF1 JARID2 EZH2 PHF19 AEBP2 EED MTF2	Epigenetic regulation of gene expression
CORUM:974	1.05641911521e-10	0.307692307692	EZH2 EED AEBP2 SUZ12	EED-EZH2 complex
CORUM:6910	3.08880131998e-08	0.230769230769	EZH2 EED PHF19	EED-EZH2-PHF19 complex
GO:0001222	5.08630500987e-08	0.461538461538	SUZ12 PHF1 MTF2 EZH2 LCOR EED	transcription corepressor binding
GO:0003682	1.20815037796e-07	0.692307692308	EPOP SUZ12 MTF2 PHF1 JARID2 EZH2 PHF19 EED EZH1	chromatin binding
CORUM:105	3.08563128138e-07	0.230769230769	EZH2 EED SUZ12	Polycomb repressive complex 2 (PRC 2)
GO:0001221	4.98285232463e-06	0.461538461538	SUZ12 PHF1 MTF2 EZH2 LCOR EED	transcription coregulator binding
HP:0001814	5.72127466756e-06	0.230769230769	EZH2 EED SUZ12	Deep-set nails
GO:0042054	1.5590429161e-05	0.384615384615	SUZ12 EED EZH2 JARID2 EZH1	histone methyltransferase activity
WP:WP2369	2.38293101107e-05	0.307692307692	EZH2 EED AEBP2 EZH1	Histone modifications
CORUM:5521	4.10333215354e-05	0.153846153846	EED EZH2	EED-EZH polycomb complex
CORUM:5502	4.10333215354e-05	0.153846153846	EED EZH2	EED-EZH-YY1 polycomb complex
REAC:R-HSA-3214841	8.11209731999e-05	0.307692307692	EZH2 EED AEBP2 SUZ12	PKMTs methylate histone lysines
GO:1990234	9.56291364165e-05	0.692307692308	SUZ12 MTF2 PHF1 EED EZH2 PHF19 AEBP2 JARID2 EZH1	transferase complex
CORUM:7375	0.00012303818858	0.153846153846	SUZ12 EZH2	BRD7-EZH2-SUZ12 complex
CORUM:1177	0.00012303818858	0.153846153846	EED EZH2	Polycomb repressive complex 4
HP:0010300	0.000125416456279	0.230769230769	EZH2 EED SUZ12	Abnormally low-pitched voice
WP:WP5366	0.000139538607333	0.307692307692	SUZ12 EED JARID2 EZH1	NF1 copy number variation syndrome
HP:0001816	0.000207294223637	0.230769230769	EZH2 EED SUZ12	Thin nail
GO:0008276	0.000236619141204	0.384615384615	SUZ12 EED EZH2 JARID2 EZH1	protein methyltransferase activity
WP:WP4204	0.000257181924203	0.230769230769	EZH2 EED SUZ12	Tumor suppressor activity of SMARCB1
HP:0002002	0.000273973726053	0.307692307692	JARID2 EED EZH2 SUZ12	Deep philtrum
WP:WP2853	0.000287677385111	0.307692307692	JARID2 MTF2 AEBP2 EZH2	Endoderm differentiation
WP:WP4553	0.000313870061761	0.230769230769	EZH2 EED SUZ12	FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma
GO:0046976	0.000548960443183	0.230769230769	EZH2 EZH1 JARID2	histone H3K27 methyltransferase activity
REAC:R-HSA-74160	0.000882385919153	0.615384615385	SUZ12 PHF1 JARID2 EZH2 PHF19 AEBP2 EED MTF2	Gene expression (Transcription)
REAC:R-HSA-8953750	0.000884720867689	0.230769230769	EZH2 EED SUZ12	Transcriptional Regulation by E2F6
GO:0140513	0.00213464356125	0.692307692308	SUZ12 MTF2 PHF1 EED EZH2 PHF19 AEBP2 JARID2 EZH1	nuclear protein-containing complex
HP:0001769	0.00229320549081	0.230769230769	EZH2 EED SUZ12	Broad foot
HP:0001176	0.00229320549081	0.230769230769	EZH2 EED SUZ12	Large hands
GO:0044877	0.00316449681366	0.692307692308	EPOP SUZ12 MTF2 PHF1 JARID2 EZH2 PHF19 EED EZH1	protein-containing complex binding
REAC:R-HSA-8943724	0.00427519866048	0.230769230769	EZH2 EED SUZ12	Regulation of PTEN gene transcription
HP:0001548	0.00474535422065	0.230769230769	EZH2 EED SUZ12	Overgrowth
REAC:R-HSA-9710421	0.00524772341864	0.230769230769	EZH2 EED SUZ12	Defective pyroptosis
GO:0008168	0.00599897335678	0.384615384615	SUZ12 EED EZH2 JARID2 EZH1	methyltransferase activity
GO:0016741	0.00805724695291	0.384615384615	SUZ12 EED EZH2 JARID2 EZH1	transferase activity, transferring one-carbon groups
GO:0140993	0.00971552919451	0.384615384615	SUZ12 EED EZH2 JARID2 EZH1	histone modifying activity
GO:0035064	0.0108850206991	0.307692307692	SUZ12 PHF1 MTF2 PHF19	methylated histone binding
GO:0140034	0.0123598285834	0.307692307692	SUZ12 PHF1 MTF2 PHF19	methylation-dependent protein binding
HP:5200005	0.0130762370753	0.230769230769	EZH2 EED SUZ12	Abnormal pitch
HP:0000337	0.0139068977837	0.307692307692	JARID2 EED EZH2 SUZ12	Broad forehead
REAC:R-HSA-3247509	0.014461109312	0.307692307692	EZH2 EED AEBP2 SUZ12	Chromatin modifying enzymes
REAC:R-HSA-4839726	0.014461109312	0.307692307692	EZH2 EED AEBP2 SUZ12	Chromatin organization
HP:0000995	0.0171794098817	0.230769230769	EZH2 EED SUZ12	Melanocytic nevus
REAC:R-HSA-9645723	0.0174426638491	0.230769230769	EZH2 EED SUZ12	Diseases of programmed cell death
HP:0005616	0.0180904348567	0.230769230769	EZH2 EED SUZ12	Accelerated skeletal maturation
HP:5200010	0.0200069455336	0.230769230769	EZH2 EED SUZ12	Abnormal Intonation
WP:WP2857	0.0200903042289	0.230769230769	JARID2 AEBP2 MTF2	Mesodermal commitment pathway
WP:WP4239	0.0225202466365	0.230769230769	EZH2 EED SUZ12	Epithelial to mesenchymal transition in colorectal cancer
HP:0012785	0.0253551276674	0.307692307692	JARID2 EED EZH2 SUZ12	Flexion contracture of finger
HP:0034681	0.0258443744681	0.307692307692	JARID2 EED EZH2 SUZ12	Finger joint contracture
HP:0001800	0.0265485203708	0.230769230769	EZH2 EED SUZ12	Hypoplastic toenails
REAC:R-HSA-5617472	0.0274863098733	0.230769230769	EZH2 EED SUZ12	Activation of anterior HOX genes in hindbrain development during early embryogenesis
REAC:R-HSA-5619507	0.0274863098733	0.230769230769	EZH2 EED SUZ12	Activation of HOX genes during differentiation
GO:0006338	0.0282446740081	0.461538461538	PHF1 PHF19 JARID2 EZH2 MTF2 EZH1	chromatin remodeling
REAC:R-HSA-2559580	0.0282646390335	0.230769230769	EZH2 EED SUZ12	Oxidative Stress Induced Senescence
HP:0002213	0.0302896654553	0.230769230769	EZH2 EED SUZ12	Fine hair
HP:0031434	0.0302896654553	0.230769230769	EZH2 EED SUZ12	Abnormal prosody
GO:0042393	0.0318672973188	0.384615384615	SUZ12 PHF1 EZH1 MTF2 PHF19	histone binding
GO:1902494	0.0352829702563	0.692307692308	SUZ12 MTF2 PHF1 EED EZH2 PHF19 AEBP2 JARID2 EZH1	catalytic complex
REAC:R-HSA-9609690	0.0397255285121	0.230769230769	EZH2 EED SUZ12	HCMV Early Events
HP:0011304	0.04522902013	0.230769230769	EZH2 EED SUZ12	Broad thumb
HP:0009473	0.0462523600836	0.307692307692	JARID2 EED EZH2 SUZ12	Joint contracture of the hand
HP:0001582	0.0487021031066	0.230769230769	EZH2 EED SUZ12	Redundant skin



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
EED	EZH2	1.0	0.15
SUZ12	EZH2	1.0	0.632
EED	SUZ12	1.0	0.482
AEBP2	SUZ12	1.0	0.158
AEBP2	EED	1.0	0.132
PHF1	EED	1.0	0.146
EZH2	EPOP	1.0
PHF1	SUZ12	1.0	0.198
PHF19	EED	0.999	0.146
PHF19	EZH1	0.999	0.126
PHF19	SUZ12	0.999	0.088
AEBP2	EZH2	0.999	0.136
PHF1	EPOP	0.999
PHF1	EZH2	0.999	0.162
PHF19	EZH2	0.999	0.158
SUZ12	EPOP	0.999
AEBP2	JARID2	0.998	0.116
AEBP2	EZH1	0.998	0.14
JARID2	EZH2	0.998	0.066
EED	EPOP	0.998
PHF19	EPOP	0.997
EZH1	SUZ12	0.997	0.218
PHF1	EZH1	0.996	0.096
SUZ12	JARID2	0.993	0.22
AEBP2	EPOP	0.991
EED	MTF2	0.991	0.26
PHF1	AEBP2	0.99	0.076
SUZ12	MTF2	0.989	0.234
SUZ12	SKIDA1	0.988
EED	EZH1	0.988	0.394
JARID2	EPOP	0.986
PHF1	LCOR	0.986
MTF2	SKIDA1	0.984
PHF1	JARID2	0.984	0.076
EZH1	JARID2	0.982	0.08
EZH1	MTF2	0.982	0.282
EZH2	MTF2	0.979	0.112
EZH1	EPOP	0.977
PHF1	MAMDC4	0.976
PHF19	AEBP2	0.976	0.106
PHF19	MTF2	0.975	0.08
EED	JARID2	0.974	0.11
PHF1	PHF19	0.971	0.104
EZH1	EZH2	0.965	0.344
EZH1	SKIDA1	0.962
EED	SKIDA1	0.954
PHF19	JARID2	0.953	0.108
PHF1	MTF2	0.95	0.114
AEBP2	MTF2	0.946	0.226
EPOP	MTF2	0.944
EZH2	SKIDA1	0.937
LCOR	SUZ12	0.915
PHF19	SKIDA1	0.905
JARID2	MTF2	0.879	0.098
LCOR	EPOP	0.658
LCOR	EZH1	0.625
LCOR	EED	0.588
LCOR	EZH2	0.567
LCOR	JARID2	0.164
LCOR	AEBP2	0.143
LCOR	MTF2	0.143
LCOR	PHF19	0.143





Related Complexes

Genename	Complexes
AEBP2	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
PHF1	huMAP3_02446.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
EED	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
PHF19	huMAP3_03842.1 huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
EZH1	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
SUZ12	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
JARID2	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
EZH2	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
EPOP	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
LCOR	huMAP3_02446.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
MTF2	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
SKIDA1	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
MAMDC4	huMAP3_02446.1 huMAP3_06942.1 huMAP3_12479.1 huMAP3_15092.1 huMAP3_15095.1