hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06953.1
Complex Portal: CPX-19529
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CDH8 | Cadherin-8 | 5 | UniProt NCBI |
| CDH24 | Cadherin-24 | 5 | UniProt NCBI |
| CDH12 | Cadherin-12 (Brain cadherin) (BR-cadherin) (Neural type cadherin 2) (N-cadherin 2) | 5 | UniProt NCBI |
| CDH11 | Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-418990 | 1.96624496318e-09 | 1.0 | CDH8 CDH11 CDH24 CDH12 | Adherens junctions interactions |
| REAC:R-HSA-421270 | 1.43082133475e-08 | 1.0 | CDH8 CDH11 CDH24 CDH12 | Cell-cell junction organization |
| WP:WP4540 | 4.1838518539e-08 | 1.0 | CDH8 CDH11 CDH24 CDH12 | Hippo signaling regulation pathways |
| WP:WP4541 | 7.94631888247e-08 | 1.0 | CDH8 CDH11 CDH24 CDH12 | Hippo Merlin signaling dysregulation |
| REAC:R-HSA-446728 | 9.87962469194e-08 | 1.0 | CDH8 CDH11 CDH24 CDH12 | Cell junction organization |
| GO:0016342 | 2.32998347586e-07 | 1.0 | CDH8 CDH11 CDH24 CDH12 | catenin complex |
| REAC:R-HSA-1500931 | 4.2458167031e-07 | 1.0 | CDH8 CDH11 CDH24 CDH12 | Cell-Cell communication |
| GO:0016339 | 1.07671286089e-06 | 1.0 | CDH8 CDH11 CDH24 CDH12 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO:0044331 | 1.54994552959e-06 | 1.0 | CDH8 CDH11 CDH24 CDH12 | cell-cell adhesion mediated by cadherin |
| GO:0034332 | 1.737817715e-06 | 1.0 | CDH8 CDH11 CDH24 CDH12 | adherens junction organization |
| WP:WP5087 | 1.87804194763e-05 | 1.0 | CDH8 CDH11 CDH24 CDH12 | Pleural mesothelioma |
| GO:0019897 | 7.35215694974e-05 | 1.0 | CDH8 CDH11 CDH24 CDH12 | extrinsic component of plasma membrane |
| GO:0007043 | 0.000116335377665 | 1.0 | CDH8 CDH11 CDH24 CDH12 | cell-cell junction assembly |
| GO:0098742 | 0.000223536588601 | 1.0 | CDH8 CDH11 CDH24 CDH12 | cell-cell adhesion via plasma-membrane adhesion molecules |
| GO:0005912 | 0.000317929863268 | 1.0 | CDH8 CDH11 CDH24 CDH12 | adherens junction |
| GO:0045216 | 0.000337873942943 | 1.0 | CDH8 CDH11 CDH24 CDH12 | cell-cell junction organization |
| GO:0019898 | 0.000415139510394 | 1.0 | CDH8 CDH11 CDH24 CDH12 | extrinsic component of membrane |
| GO:0034329 | 0.00553001869835 | 1.0 | CDH8 CDH11 CDH24 CDH12 | cell junction assembly |
| GO:0005509 | 0.00728390316897 | 1.0 | CDH8 CDH11 CDH24 CDH12 | calcium ion binding |
| GO:0005911 | 0.00918000006897 | 1.0 | CDH8 CDH11 CDH24 CDH12 | cell-cell junction |
| GO:0045296 | 0.0103222422745 | 1.0 | CDH8 CDH11 CDH24 CDH12 | cadherin binding |
| GO:0098797 | 0.0296421612139 | 1.0 | CDH8 CDH11 CDH24 CDH12 | plasma membrane protein complex |
| GO:0034330 | 0.0329918597872 | 1.0 | CDH8 CDH11 CDH24 CDH12 | cell junction organization |
| GO:0050839 | 0.0476113999152 | 1.0 | CDH8 CDH11 CDH24 CDH12 | cell adhesion molecule binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CDH24 | CDH12 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CDH8 | CDH11 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CDH8 | CDH24 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CDH8 | CDH12 | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CDH11 | CDH24 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes