hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06955.1

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
ITGB1	Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29)	5	UniProt NCBI
LGALS1	Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)	5	UniProt NCBI
PTPRJ	Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)	5	UniProt NCBI
ITGA1	Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a)	5	UniProt NCBI
ITGA5	Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain]	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0098636	8.67338862712e-06	0.8	LGALS1 ITGA5 ITGB1 ITGA1	protein complex involved in cell adhesion
CORUM:2434	1.36501667663e-05	0.4	ITGB1 ITGA1	ITGA1-ITGB1-COL6A3 complex
CORUM:3112	1.36501667663e-05	0.4	ITGA5 ITGB1	ITGA5-ITGB1-SPP1 complex
CORUM:2385	1.36501667663e-05	0.4	ITGA5 ITGB1	ITGA5-ITGB4 complex
CORUM:2435	1.36501667663e-05	0.4	ITGB1 ITGA1	ITGA1-ITGB1-PTPN2 complex
WP:WP2118	3.90305291366e-05	0.6	ITGA5 ITGB1 ITGA1	Arrhythmogenic right ventricular cardiomyopathy
CORUM:2850	4.09448956317e-05	0.4	ITGA5 ITGB1	ITGA5-ITGB1-FN-1-NOV complex
CORUM:2853	4.09448956317e-05	0.4	ITGA5 ITGB1	ITGA5-ITGB1-CAL4A3 complex
CORUM:2384	4.09448956317e-05	0.4	ITGA5 ITGB1	ITGA5-ITGB1-ADAM15 complex
KEGG:04512	4.44119474406e-05	0.6	ITGA5 ITGB1 ITGA1	ECM-receptor interaction
KEGG:05412	4.64569454207e-05	0.6	ITGA5 ITGB1 ITGA1	Arrhythmogenic right ventricular cardiomyopathy
KEGG:05410	6.51136022216e-05	0.6	ITGA5 ITGB1 ITGA1	Hypertrophic cardiomyopathy
KEGG:05414	6.51136022216e-05	0.6	ITGA5 ITGB1 ITGA1	Dilated cardiomyopathy
CORUM:2383	8.18785830799e-05	0.4	ITGA5 ITGB1	ITGA5-ITGB1-FN1-TGM2 complex
WP:WP185	0.000114104439854	0.6	ITGA5 ITGB1 ITGA1	Integrin mediated cell adhesion
REAC:R-HSA-216083	0.000123167229073	0.6	ITGA5 ITGB1 ITGA1	Integrin cell surface interactions
REAC:R-HSA-1566977	0.000151950811602	0.4	ITGA5 ITGB1	Fibronectin matrix formation
WP:WP4541	0.000170890043196	0.6	ITGA5 ITGB1 ITGA1	Hippo Merlin signaling dysregulation
WP:WP4217	0.000302523176006	0.6	ITGA5 ITGB1 ITGA1	Ebola virus infection in host
REAC:R-HSA-447041	0.000319009353903	0.4	ITGB1 ITGA1	CHL1 interactions
REAC:R-HSA-373760	0.00053040697399	0.6	ITGA5 ITGB1 ITGA1	L1CAM interactions
REAC:R-HSA-75892	0.000683310775372	0.4	ITGB1 ITGA1	Platelet Adhesion to exposed collagen
KEGG:04510	0.0007776530092	0.6	ITGA5 ITGB1 ITGA1	Focal adhesion
GO:0008305	0.000783132248318	0.6	ITGA5 ITGB1 ITGA1	integrin complex
WP:WP306	0.00100625954708	0.6	ITGA5 ITGB1 ITGA1	Focal adhesion
KEGG:04810	0.00111331850639	0.6	ITGA5 ITGB1 ITGA1	Regulation of actin cytoskeleton
REAC:R-HSA-416700	0.0018206657072	0.4	ITGB1 ITGA1	Other semaphorin interactions
WP:WP2643	0.00205749802636	0.4	ITGB1 ITGA1	Nanoparticle mediated activation of receptor signaling
REAC:R-HSA-445144	0.00206313859056	0.4	ITGA5 ITGB1	Signal transduction by L1
WP:WP313	0.00254884296025	0.4	ITGB1 ITGA1	Hepatocyte growth factor receptor signaling
GO:0007160	0.00294018150071	0.8	PTPRJ ITGA5 ITGB1 ITGA1	cell-matrix adhesion
KEGG:04151	0.00349664244214	0.6	ITGA5 ITGB1 ITGA1	PI3K-Akt signaling pathway
KEGG:05165	0.00379627929445	0.6	ITGA5 ITGB1 ITGA1	Human papillomavirus infection
WP:WP4172	0.00385309020299	0.6	ITGA5 ITGB1 ITGA1	PI3K Akt signaling pathway
WP:WP5300	0.00456408083355	0.4	ITGA5 ITGB1	TROP2 regulatory signaling
GO:0034674	0.00468200720083	0.4	ITGA5 ITGB1	integrin alpha5-beta1 complex
GO:0034665	0.00468200720083	0.4	ITGB1 ITGA1	integrin alpha1-beta1 complex
REAC:R-HSA-3000157	0.00531742996423	0.4	ITGB1 ITGA1	Laminin interactions
REAC:R-HSA-1474244	0.00594422623006	0.6	ITGA5 ITGB1 ITGA1	Extracellular matrix organization
KEGG:05133	0.00771708586936	0.4	ITGA5 ITGB1	Pertussis
KEGG:04640	0.00771708586936	0.4	ITGA5 ITGA1	Hematopoietic cell lineage
REAC:R-HSA-1566948	0.00953234360475	0.4	ITGA5 ITGB1	Elastic fibre formation
REAC:R-HSA-9634597	0.00953234360475	0.4	ITGA5 ITGB1	GPER1 signaling
KEGG:05100	0.0128243509281	0.4	ITGA5 ITGB1	Bacterial invasion of epithelial cells
GO:0098639	0.0140440992017	0.4	ITGB1 ITGA1	collagen binding involved in cell-matrix adhesion
GO:0031589	0.0150176339859	0.8	PTPRJ ITGA5 ITGB1 ITGA1	cell-substrate adhesion
GO:0033627	0.0224016609185	0.6	ITGA5 ITGB1 ITGA1	cell adhesion mediated by integrin
REAC:R-HSA-373755	0.0258071378099	0.4	ITGB1 ITGA1	Semaphorin interactions
WP:WP5322	0.0281562480757	0.4	ITGA5 ITGB1	CKAP4 signaling pathway map
KEGG:05135	0.0293384756517	0.4	ITGA5 ITGB1	Yersinia infection
KEGG:03271	0.0332104316595	0.2	ITGB1	Virion - Rotavirus
REAC:R-HSA-6806834	0.035336387757	0.4	PTPRJ ITGB1	Signaling by MET
KEGG:04145	0.038606937256	0.4	ITGA5 ITGB1	Phagosome
GO:0007155	0.0481255792399	1.0	LGALS1 ITGA1 ITGB1 ITGA5 PTPRJ	cell adhesion
CORUM:3058	0.0498708842806	0.2	ITGB1	ITGA11-ITGB1 complex
CORUM:2413	0.0498708842806	0.2	ITGB1	ITGA6-ITGB1 complex
CORUM:2432	0.0498708842806	0.2	ITGB1	ITGA2-ITGB1 complex
CORUM:3035	0.0498708842806	0.2	ITGB1	LAT2-ITGB1 complex
CORUM:2882	0.0498708842806	0.2	ITGA5	ITGA5-ITGB3-COL6A3 complex
CORUM:2418	0.0498708842806	0.2	ITGB1	ITGA4-ITGB1 complex
CORUM:2421	0.0498708842806	0.2	ITGB1	ITGA4-ITGB1-VCAM1 complex
CORUM:2426	0.0498708842806	0.2	ITGB1	ITGA4-ITGB1-THBS1 complex
CORUM:3057	0.0498708842806	0.2	ITGB1	ITGA10-ITGB1 complex
CORUM:2431	0.0498708842806	0.2	ITGB1	ITGA2-ITGB1-COL6A3 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
ITGB1	ITGA5	1.0	0.328	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction
ITGB1	ITGA1	0.996	0.334	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
ITGB1	LGALS1	0.982	0.318	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
LGALS1	ITGA1	0.981	0.18	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ITGA1	PTPRJ	0.969	0.046	bioplex_WMM bioplex3_WMM WMM_only
ITGA1	ITGA5	0.966	0.144	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
LGALS1	PTPRJ	0.959	0.162	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ITGB1	PTPRJ	0.959	0.286	bioplex_WMM bioplex3_WMM WMM_only
LGALS1	ITGA5	0.955	0.17	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ITGA5	PTPRJ	0.883	0.148	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
ITGB1	huMAP3_00444.1 huMAP3_05336.1 huMAP3_05466.1 huMAP3_06221.1 huMAP3_06815.1 huMAP3_06955.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10980.1
LGALS1	huMAP3_00618.1 huMAP3_02873.1 huMAP3_03489.1 huMAP3_04614.1 huMAP3_05351.1 huMAP3_05590.1 huMAP3_06892.1 huMAP3_06908.1 huMAP3_06955.1 huMAP3_07927.1 huMAP3_09169.1 huMAP3_10859.1 huMAP3_10920.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_14792.1
PTPRJ	huMAP3_02703.1 huMAP3_02887.1 huMAP3_04041.1 huMAP3_04390.1 huMAP3_05555.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_05876.1 huMAP3_06048.1 huMAP3_06955.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10744.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_12283.1
ITGA1	huMAP3_01687.1 huMAP3_01717.1 huMAP3_02607.1 huMAP3_03194.1 huMAP3_04614.1 huMAP3_05584.1 huMAP3_05590.1 huMAP3_05876.1 huMAP3_06308.1 huMAP3_06892.1 huMAP3_06955.1 huMAP3_08103.1 huMAP3_08689.1 huMAP3_09105.1 huMAP3_09336.1 huMAP3_10503.1 huMAP3_10848.1 huMAP3_10920.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_11697.1 huMAP3_14792.1 huMAP3_15075.1
ITGA5	huMAP3_02246.1 huMAP3_04658.1 huMAP3_05466.1 huMAP3_06955.1 huMAP3_10503.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_11887.1 huMAP3_14792.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06955.1