hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06956.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BAP1 | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) | 5 | UniProt NCBI |
| ASXL1 | Polycomb group protein ASXL1 (Additional sex combs-like protein 1) | 5 | UniProt NCBI |
| ASXL2 | Putative Polycomb group protein ASXL2 (Additional sex combs-like protein 2) | 5 | UniProt NCBI |
| KDM1B | Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5689603 | 2.56660509194e-07 | 1.0 | BAP1 ASXL1 KDM1B ASXL2 | UCH proteinases |
| GO:0035517 | 1.53784171933e-06 | 0.75 | BAP1 ASXL1 ASXL2 | PR-DUB complex |
| REAC:R-HSA-5688426 | 1.50136248309e-05 | 1.0 | BAP1 ASXL1 KDM1B ASXL2 | Deubiquitination |
| KEGG:03083 | 2.91718888289e-05 | 0.75 | BAP1 ASXL1 ASXL2 | Polycomb repressive complex |
| WP:WP5351 | 0.00103429913449 | 0.5 | BAP1 ASXL1 | Kleefstra syndrome |
| HP:0003764 | 0.00207834768342 | 0.75 | BAP1 ASXL1 ASXL2 | Nevus |
| GO:0031519 | 0.00440499676786 | 0.75 | BAP1 ASXL1 ASXL2 | PcG protein complex |
| HP:0000520 | 0.00881998427789 | 0.75 | BAP1 ASXL1 ASXL2 | Proptosis |
| REAC:R-HSA-597592 | 0.0091733555377 | 1.0 | BAP1 ASXL1 KDM1B ASXL2 | Post-translational protein modification |
| HP:0006191 | 0.0092117244708 | 0.5 | ASXL1 ASXL2 | Deep palmar crease |
| HP:0000998 | 0.0106782218975 | 0.75 | BAP1 ASXL1 ASXL2 | Hypertrichosis |
| GO:0003682 | 0.0197806640281 | 1.0 | BAP1 ASXL1 KDM1B ASXL2 | chromatin binding |
| REAC:R-HSA-392499 | 0.0339333915692 | 1.0 | BAP1 ASXL1 KDM1B ASXL2 | Metabolism of proteins |
| HP:0001052 | 0.0391604009626 | 0.5 | ASXL1 ASXL2 | Nevus flammeus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ASXL2 | KDM1B | 0.999 | 0.226 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| ASXL2 | BAP1 | 0.998 | 0.292 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| KDM1B | BAP1 | 0.997 | 0.328 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| BAP1 | ASXL1 | 0.995 | 0.15 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 |
| KDM1B | ASXL1 | 0.944 | 0.18 | hein_WMM bioplex3_WMM WMM_only |
| ASXL2 | ASXL1 | 0.933 | 0.204 | bioplex3_WMM WMM_only |
Related Complexes