hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06971.1

Complex Portal: CPX-12224

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
PLEKHA7	Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)	5	UniProt NCBI
TIAM1	Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)	5	UniProt NCBI
YWHAQ	14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)	5	UniProt NCBI
DENND4A	C-myc promoter-binding protein (DENN domain-containing protein 4A)	5	UniProt NCBI
SAMD4A	Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A)	5	UniProt NCBI
TFEB	Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35)	5	UniProt NCBI
CDC25B	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)	5	UniProt NCBI
SPATA13	Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2)	5	UniProt NCBI
MARK1	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)	5	UniProt NCBI
SAMD4B	Protein Smaug homolog 2 (Smaug 2) (hSmaug2) (Sterile alpha motif domain-containing protein 4B) (SAM domain-containing protein 4B)	5	UniProt NCBI
SYDE2	Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2)	4	UniProt NCBI
MARK3	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (C-TAK1) (cTAK1) (Cdc25C-associated protein kinase 1) (ELKL motif kinase 2) (EMK-2) (Protein kinase STK10) (Ser/Thr protein kinase PAR-1) (Par-1a) (Serine/threonine-protein kinase p78)	5	UniProt NCBI
LNP1	Leukemia NUP98 fusion partner 1	2	UniProt NCBI
PTPN3	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1)	5	UniProt NCBI
KIAA0930	Uncharacterized protein KIAA0930	3	UniProt NCBI
YWHAB	14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]	5	UniProt NCBI
PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]	5	UniProt NCBI
SFN	14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)	5	UniProt NCBI
SPIRE1	Protein spire homolog 1 (Spir-1)	5	UniProt NCBI
FAM53B	Protein FAM53B (Protein simplet)	5	UniProt NCBI
YWHAE	14-3-3 protein epsilon (14-3-3E)	5	UniProt NCBI
YWHAH	14-3-3 protein eta (Protein AS1)	5	UniProt NCBI
YWHAZ	14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)	5	UniProt NCBI
HDAC5	Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)	5	UniProt NCBI
CRTC1	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1)	5	UniProt NCBI
FOXO1	Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma)	5	UniProt NCBI
AGAP1	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP-1) (Centaurin-gamma-2) (Cnt-g2) (GTP-binding and GTPase-activating protein 1) (GGAP1)	5	UniProt NCBI
YWHAG	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9755779	4.35681189038e-15	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	SARS-CoV-2 targets host intracellular signalling and regulatory pathways
REAC:R-HSA-75035	9.42957914659e-15	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
REAC:R-HSA-9735871	3.52846906472e-14	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	SARS-CoV-1 targets host intracellular signalling and regulatory pathways
REAC:R-HSA-111447	3.52846906472e-14	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Activation of BAD and translocation to mitochondria
REAC:R-HSA-9614399	3.90317892992e-12	0.24	YWHAZ YWHAB SFN YWHAG FOXO1 YWHAQ	Regulation of localization of FOXO transcription factors
CORUM:5199	4.08365818032e-12	0.24	YWHAZ YWHAB YWHAG YWHAE YWHAH YWHAQ	Kinase maturation complex 1
REAC:R-HSA-114452	1.09835007528e-11	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Activation of BH3-only proteins
WP:WP5376	6.05096026228e-11	0.24	YWHAZ YWHAB YWHAG YWHAE YWHAH YWHAQ	17p13 3 YWHAE copy number variation
REAC:R-HSA-109606	7.04838478879e-10	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Intrinsic Pathway for Apoptosis
REAC:R-HSA-1445148	5.5805984296e-09	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Translocation of SLC2A4 (GLUT4) to the plasma membrane
REAC:R-HSA-5628897	1.48324675607e-08	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	TP53 Regulates Metabolic Genes
REAC:R-HSA-5625740	1.77539040411e-08	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	RHO GTPases activate PKNs
REAC:R-HSA-69473	2.96417664587e-08	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	G2/M DNA damage checkpoint
REAC:R-HSA-9692914	4.77459665817e-08	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	SARS-CoV-1-host interactions
WP:WP536	6.66954074414e-08	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Calcium regulation in cardiac cells
WP:WP179	8.54697531329e-08	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Cell cycle
REAC:R-HSA-9614085	2.00444466639e-07	0.24	YWHAZ YWHAB SFN YWHAG FOXO1 YWHAQ	FOXO-mediated transcription
WP:WP289	2.01268208068e-07	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Myometrial relaxation and contraction pathways
KEGG:04110	2.90412620248e-07	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Cell cycle
REAC:R-HSA-9678108	5.69373689497e-07	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	SARS-CoV-1 Infection
KEGG:04114	1.15072515135e-06	0.24	YWHAZ YWHAB YWHAG YWHAE YWHAH YWHAQ	Oocyte meiosis
KEGG:05203	1.23573274062e-06	0.28	YWHAZ HDAC5 YWHAB YWHAG YWHAE YWHAH YWHAQ	Viral carcinogenesis
REAC:R-HSA-69481	2.09185484629e-06	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	G2/M Checkpoints
REAC:R-HSA-109581	2.82287681448e-06	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Apoptosis
KEGG:05160	4.59833944013e-06	0.24	YWHAZ YWHAB YWHAG YWHAE YWHAH YWHAQ	Hepatitis C
WP:WP706	5.35929814759e-06	0.24	YWHAZ YWHAB YWHAG YWHAE YWHAH YWHAQ	Sudden infant death syndrome SIDS susceptibility pathways
REAC:R-HSA-9705683	6.6872696909e-06	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	SARS-CoV-2-host interactions
REAC:R-HSA-5357801	8.30726026761e-06	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Programmed Cell Death
KEGG:04390	8.77078161175e-06	0.24	YWHAZ YWHAB YWHAG YWHAE YWHAH YWHAQ	Hippo signaling pathway
REAC:R-HSA-194315	1.21769516175e-05	0.4	SYDE2 SFN YWHAH YWHAB SPATA13 YWHAG YWHAE YWHAZ TIAM1 YWHAQ	Signaling by Rho GTPases
REAC:R-HSA-9716542	1.49897040957e-05	0.4	SYDE2 SFN YWHAH YWHAB SPATA13 YWHAG YWHAE YWHAZ TIAM1 YWHAQ	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
GO:0050815	6.94186470066e-05	0.16	YWHAG YWHAZ YWHAB YWHAE	phosphoserine residue binding
REAC:R-HSA-9694516	8.59959726514e-05	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	SARS-CoV-2 Infection
REAC:R-HSA-69620	9.96449018744e-05	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Cell Cycle Checkpoints
REAC:R-HSA-195258	0.000148632003743	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	RHO GTPase Effectors
REAC:R-HSA-3700989	0.000362599770027	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Transcriptional Regulation by TP53
KEGG:04151	0.000445710166875	0.24	YWHAZ YWHAB YWHAG YWHAE YWHAH YWHAQ	PI3K-Akt signaling pathway
REAC:R-HSA-9679506	0.000737926169023	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	SARS-CoV Infections
REAC:R-HSA-199991	0.00103369751625	0.32	YWHAQ DENND4A YWHAB SFN YWHAG YWHAE YWHAH YWHAZ	Membrane Trafficking
REAC:R-HSA-5653656	0.00154717193757	0.32	YWHAQ DENND4A YWHAB SFN YWHAG YWHAE YWHAH YWHAZ	Vesicle-mediated transport
REAC:R-HSA-162582	0.00219458554591	0.52	SYDE2 FOXO1 YWHAB YWHAH HDAC5 MARK3 SPATA13 YWHAG YWHAE YWHAZ TIAM1 SFN YWHAQ	Signal Transduction
REAC:R-HSA-212436	0.00941513428685	0.36	YWHAZ FOXO1 HDAC5 YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Generic Transcription Pathway
CORUM:5613	0.011455512399	0.08	YWHAB YWHAE	Emerin complex 25
CORUM:5615	0.0185780312927	0.08	YWHAQ YWHAE	Emerin complex 52
REAC:R-HSA-73857	0.022429676417	0.36	YWHAZ FOXO1 HDAC5 YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	RNA Polymerase II Transcription
GO:0005829	0.0245809787895	0.8	CRTC1 YWHAG YWHAQ SAMD4B MARK3 YWHAB YWHAH HDAC5 SPATA13 DENND4A FOXO1 YWHAE SAMD4A SYDE2 PFKFB2 SPIRE1 YWHAZ TIAM1 SFN PLEKHA7	cytosol
REAC:R-HSA-1640170	0.0250351586423	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Cell Cycle
REAC:R-HSA-1643685	0.0288232584901	0.4	YWHAQ YWHAG MARK3 HDAC5 YWHAB SFN FOXO1 YWHAE YWHAH YWHAZ	Disease
GO:0045309	0.0392749504272	0.16	YWHAG YWHAZ YWHAB YWHAE	protein phosphorylated amino acid binding
REAC:R-HSA-9824446	0.0421743002828	0.28	YWHAZ YWHAB YWHAH YWHAG YWHAE SFN YWHAQ	Viral Infection Pathways
WP:WP5401	0.0455309701527	0.08	YWHAG SFN	7q11 23 distal copy number variation
HPA:0460671	0.0490307494704	0.68	YWHAG YWHAQ SAMD4B MARK3 YWHAB FAM53B HDAC5 SPATA13 DENND4A FOXO1 SAMD4A CRTC1 YWHAE YWHAZ TIAM1 SFN PLEKHA7	skin 1; melanocytes[>=Low]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
YWHAZ	YWHAB	1.0	0.915
YWHAG	YWHAH	1.0	0.802
YWHAG	YWHAB	1.0	0.913
YWHAZ	YWHAH	1.0	0.724
YWHAH	YWHAB	1.0	0.77
YWHAG	YWHAE	1.0	0.782
YWHAH	YWHAE	1.0	0.534
YWHAZ	YWHAE	1.0	0.696
YWHAB	YWHAE	1.0	0.704
YWHAZ	YWHAG	1.0	0.864
YWHAQ	YWHAB	0.999	0.572	structurally_consistent (dimer)
YWHAH	SAMD4A	0.999	0.412630536131
YWHAZ	YWHAQ	0.999	0.662	structurally_consistent (dimer)
YWHAG	FAM53B	0.999
YWHAG	YWHAQ	0.999	0.77	structurally_consistent (dimer)
YWHAQ	YWHAH	0.999	0.526	structurally_consistent (dimer)
YWHAH	FAM53B	0.999
YWHAG	SAMD4A	0.999	0.708
YWHAQ	YWHAE	0.999	0.944	structurally_consistent (dimer)
SAMD4A	YWHAE	0.998	0.487119479865
FAM53B	YWHAB	0.998
YWHAG	SFN	0.998	0.644	structurally_consistent (dimer)
YWHAZ	TFEB	0.997	0.622
SAMD4A	YWHAB	0.997	0.301325581395
SAMD4B	YWHAG	0.997	0.3265
YWHAQ	SFN	0.997	0.51	structurally_consistent (dimer)
TFEB	YWHAE	0.996	0.426583333333
YWHAH	MARK3	0.996	0.172
SAMD4B	YWHAE	0.996	0.224
SAMD4B	YWHAB	0.996	0.202722222222
YWHAG	MARK3	0.995	0.202
YWHAQ	FAM53B	0.995
YWHAZ	SFN	0.995	0.732	structurally_consistent (dimer)
YWHAH	TFEB	0.995	0.340814070352
YWHAG	TFEB	0.995	0.578608695652
FAM53B	YWHAE	0.994
SFN	YWHAB	0.994	0.716	structurally_consistent (dimer)
YWHAG	MARK1	0.993	0.39
YWHAQ	TFEB	0.992	0.451702702703
TFEB	YWHAB	0.992	0.3775
MARK1	YWHAH	0.992	0.3034875
SFN	YWHAH	0.991	0.536	structurally_consistent (dimer)
PLEKHA7	YWHAG	0.991	0.5056
YWHAG	PFKFB2	0.991	0.31	mutually_exclusive (P27348)
MARK3	YWHAB	0.991	0.173041666667
PFKFB2	YWHAQ	0.991	0.374	structurally_consistent (dimer)
CRTC1	YWHAG	0.99	0.37136
CDC25B	YWHAH	0.99	0.33
SFN	TFEB	0.99	0.337262626263
YWHAG	CDC25B	0.99	0.346
PFKFB2	YWHAB	0.99	0.314	mutually_exclusive (P27348)
SFN	FAM53B	0.989
SPATA13	YWHAB	0.987	0.237693851718
YWHAG	TIAM1	0.986	0.534
YWHAQ	SAMD4A	0.986	0.533789595376
LNP1	YWHAE	0.986
YWHAZ	LNP1	0.985
PFKFB2	YWHAH	0.985	0.332	mutually_exclusive (P27348)
SFN	YWHAE	0.984	0.643333333333	structurally_consistent (dimer)
YWHAH	LNP1	0.984
YWHAG	DENND4A	0.984	0.488	mutually_exclusive (P27348)
YWHAG	SPIRE1	0.983	0.3
CDC25B	YWHAB	0.983	0.38
YWHAZ	PFKFB2	0.983	0.498996309963	mutually_exclusive (P27348)
YWHAG	LNP1	0.982
YWHAZ	CDC25B	0.982	0.57
YWHAQ	LNP1	0.981
YWHAG	FOXO1	0.981	0.445171521036	mutually_exclusive (P27348)
YWHAH	KIAA0930	0.981	0.246666666667
LNP1	YWHAB	0.98
YWHAG	PTPN3	0.979	0.4224
MARK1	YWHAQ	0.979	0.322	structurally_consistent (dimer)
YWHAQ	CDC25B	0.978	0.39	structurally_consistent (dimer)
SAMD4B	SAMD4A	0.978	0.068
YWHAZ	SPIRE1	0.977	0.294
YWHAQ	SPIRE1	0.977	0.276
YWHAQ	SPATA13	0.976	0.304
YWHAG	KIAA0930	0.976	0.325649224535
HDAC5	YWHAB	0.976	0.4	mutually_exclusive (P31947)
PTPN3	YWHAB	0.975	0.36
YWHAQ	PTPN3	0.975	0.580166666667
YWHAH	SPIRE1	0.975	0.222660377358
YWHAG	SPATA13	0.975	0.382862588235
YWHAH	DENND4A	0.975	0.28	mutually_exclusive (P27348)
SFN	KIAA0930	0.974	0.222	structurally_consistent (dimer)
YWHAZ	SAMD4A	0.974	0.521171428571
SYDE2	YWHAB	0.974
SPIRE1	YWHAB	0.973	0.204
YWHAH	FOXO1	0.973	0.432967741935	mutually_exclusive (P27348)
YWHAQ	MARK3	0.973	0.16
FOXO1	YWHAB	0.972	0.465147618658	mutually_exclusive (P27348)
YWHAH	TIAM1	0.971	0.236
CRTC1	YWHAH	0.971	0.153561845286	mutually_exclusive (P27348)
YWHAH	SPATA13	0.971	0.252554778555
YWHAQ	FOXO1	0.97	0.508	structurally_consistent (dimer)
YWHAH	PTPN3	0.969	0.319
KIAA0930	YWHAB	0.969	0.24373134257
YWHAZ	KIAA0930	0.968	0.330909090909
CRTC1	YWHAB	0.967	0.15486779661
MARK1	YWHAB	0.966	0.268711538462
YWHAZ	FAM53B	0.966
YWHAZ	SPATA13	0.966	0.439017094017
SYDE2	YWHAH	0.965
YWHAG	HDAC5	0.964	0.405777777778
SFN	LNP1	0.964
YWHAZ	SAMD4B	0.964	0.196
SAMD4B	YWHAH	0.963	0.136
YWHAH	HDAC5	0.961	0.290709677419
TIAM1	YWHAB	0.958	0.300446428571
PLEKHA7	YWHAB	0.957	0.263648247322
DENND4A	YWHAB	0.957	0.314	mutually_exclusive (P27348)
PLEKHA7	YWHAH	0.957	0.194
YWHAQ	TIAM1	0.956	0.386
YWHAQ	DENND4A	0.952	0.338	structurally_consistent (dimer)
YWHAQ	KIAA0930	0.952	0.292436781609	structurally_consistent (dimer)
AGAP1	YWHAB	0.95
YWHAZ	MARK3	0.948	0.288909090909
YWHAZ	FOXO1	0.948	0.638	mutually_exclusive (P27348)
SPATA13	YWHAE	0.946	0.392366471735
CDC25B	YWHAE	0.944	0.503
YWHAG	AGAP1	0.939
YWHAZ	DENND4A	0.936	0.320166666667	mutually_exclusive (P27348)
AGAP1	YWHAH	0.931
CRTC1	YWHAQ	0.93	0.208	structurally_consistent (dimer)
SYDE2	YWHAQ	0.924
SYDE2	YWHAG	0.918
YWHAQ	HDAC5	0.903	0.4575
YWHAZ	MARK1	0.888	0.318266666667
YWHAZ	CRTC1	0.876	0.251575264844	mutually_exclusive (P27348)
KIAA0930	YWHAE	0.865	0.344027324121
SAMD4B	YWHAQ	0.853	0.346
SFN	SPATA13	0.843	0.214875
SFN	SAMD4A	0.835	0.356
YWHAZ	HDAC5	0.831	0.513774193548
YWHAZ	PTPN3	0.802	0.506
YWHAZ	SYDE2	0.782
YWHAZ	PLEKHA7	0.777	0.351173076923
YWHAQ	AGAP1	0.752
SAMD4A	MARK3	0.723	0.09
PLEKHA7	YWHAQ	0.723	0.417142857143
AGAP1	DENND4A	0.706
AGAP1	KIAA0930	0.687
MARK1	MARK3	0.683	0.152
MARK1	AGAP1	0.648
PLEKHA7	SPIRE1	0.605	0.092
CDC25B	FAM53B	0.605
PFKFB2	SPIRE1	0.605	0.042
CDC25B	TFEB	0.605	0.112
MARK1	TFEB	0.605	0.112
PLEKHA7	PFKFB2	0.605	0.044
SFN	CDC25B	0.577	0.242
TFEB	FOXO1	0.576	0.15
SAMD4B	FOXO1	0.549	0.108
CDC25B	SPIRE1	0.54	0.132
PFKFB2	DENND4A	0.539	0.028	mutually_exclusive (P27348)
KIAA0930	SPIRE1	0.539	0.05
CDC25B	KIAA0930	0.539	0.128	mutually_exclusive (P27348)
PFKFB2	CDC25B	0.539	0.054	mutually_exclusive (P27348)
PLEKHA7	DENND4A	0.539	0.084
PLEKHA7	CDC25B	0.539	0.126
CDC25B	DENND4A	0.539	0.108
PLEKHA7	KIAA0930	0.539	0.058
PFKFB2	KIAA0930	0.539	0.092	mutually_exclusive (P27348)
KIAA0930	FAM53B	0.539
TFEB	KIAA0930	0.539	0.09
MARK1	FAM53B	0.539
PLEKHA7	TFEB	0.534	0.092
TFEB	TIAM1	0.534	0.076
TIAM1	SPIRE1	0.534	0.202
PFKFB2	TIAM1	0.534	0.124
PFKFB2	FAM53B	0.534
TIAM1	KIAA0930	0.534	0.04
SPIRE1	FAM53B	0.534
CRTC1	KIAA0930	0.534	0.066	mutually_exclusive (P27348)
PLEKHA7	CRTC1	0.534	0.088
CDC25B	TIAM1	0.534	0.162
CRTC1	TIAM1	0.534	0.156
TFEB	FAM53B	0.534
TIAM1	DENND4A	0.534	0.155
CDC25B	HDAC5	0.534	0.088
TIAM1	FAM53B	0.534
CRTC1	SPIRE1	0.534	0.108
PLEKHA7	HDAC5	0.534	0.086
TIAM1	HDAC5	0.534	0.102
PFKFB2	TFEB	0.534	0.108
CRTC1	CDC25B	0.534	0.122	mutually_exclusive (P27348)
TFEB	SPIRE1	0.534	0.106
CRTC1	PFKFB2	0.534	0.04	mutually_exclusive (P27348)
PLEKHA7	FAM53B	0.534
DENND4A	FAM53B	0.516
CRTC1	FAM53B	0.511
CRTC1	TFEB	0.5	0.116
MARK1	SAMD4A	0.496	0.088
TIAM1	FOXO1	0.496	0.16
TFEB	DENND4A	0.495	0.126
MARK1	SPIRE1	0.494	0.12
MARK1	CDC25B	0.494	0.08
MARK1	KIAA0930	0.494	0.054
MARK1	PFKFB2	0.494	0.09	mutually_exclusive (P27348)
PLEKHA7	MARK1	0.494	0.082
YWHAZ	TIAM1	0.493	0.42677992278
TFEB	HDAC5	0.491	0.114
PFKFB2	AGAP1	0.491
AGAP1	SAMD4A	0.491
CRTC1	AGAP1	0.491
AGAP1	FAM53B	0.491
AGAP1	SPIRE1	0.491
AGAP1	TIAM1	0.491
CDC25B	AGAP1	0.491
AGAP1	TFEB	0.491
PFKFB2	HDAC5	0.489	0.062
MARK1	TIAM1	0.489	0.124
SPIRE1	HDAC5	0.489	0.17
SPIRE1	FOXO1	0.489	0.158
KIAA0930	FOXO1	0.489	0.102	mutually_exclusive (P27348)
CDC25B	FOXO1	0.489	0.162	mutually_exclusive (P27348)
PLEKHA7	FOXO1	0.489	0.112
PFKFB2	FOXO1	0.489	0.102	mutually_exclusive (P27348)
DENND4A	KIAA0930	0.48	0.142
DENND4A	SPIRE1	0.48	0.132
SAMD4B	CDC25B	0.48	0.106
PLEKHA7	SAMD4A	0.48	0.082
SAMD4B	TIAM1	0.48	0.132
SAMD4B	SPIRE1	0.48	0.07
TFEB	SAMD4A	0.48	0.102
CDC25B	SAMD4A	0.48	0.08
PFKFB2	SAMD4A	0.48	0.07
TIAM1	SAMD4A	0.48	0.12
SAMD4A	KIAA0930	0.48	0.048
SAMD4A	FAM53B	0.48
SAMD4B	KIAA0930	0.48	0.052
SAMD4A	SPIRE1	0.48	0.148
CRTC1	SAMD4B	0.48	0.03
SAMD4B	FAM53B	0.48
SAMD4A	FOXO1	0.48	0.154
CRTC1	SAMD4A	0.48	0.082
SAMD4B	PFKFB2	0.48	0.04
SAMD4A	HDAC5	0.48	0.138
SAMD4B	TFEB	0.48	0.096
KIAA0930	HDAC5	0.477	0.132	mutually_exclusive (P31947)
FAM53B	FOXO1	0.472
CRTC1	DENND4A	0.467	0.056	mutually_exclusive (P27348)
MARK1	HDAC5	0.466	0.142
FAM53B	HDAC5	0.466
CRTC1	MARK1	0.466	0.098	mutually_exclusive (P27348)
MARK1	FOXO1	0.466	0.138	mutually_exclusive (P27348)
DENND4A	SAMD4A	0.461	0.144
HDAC5	FOXO1	0.46	0.15
CRTC1	FOXO1	0.459	0.092	mutually_exclusive (P27348)
PLEKHA7	PTPN3	0.456	0.138
DENND4A	FOXO1	0.454	0.076	mutually_exclusive (P27348)
CRTC1	HDAC5	0.454	0.112
PLEKHA7	AGAP1	0.448
PTPN3	YWHAE	0.448	0.454925925926
SYDE2	SFN	0.447
CRTC1	SFN	0.447	0.171767901235	mutually_exclusive (P27348)
PFKFB2	SFN	0.447	0.432461538462	mutually_exclusive (P27348)
SFN	TIAM1	0.447	0.368548387097
SYDE2	YWHAE	0.447
SFN	FOXO1	0.447	0.546	mutually_exclusive (P27348)
SFN	HDAC5	0.447	0.274417508418	structurally_consistent (dimer)
SFN	PTPN3	0.447	0.32
TIAM1	MARK3	0.436	0.13
CDC25B	MARK3	0.436	0.082
SPIRE1	MARK3	0.436	0.136
PFKFB2	MARK3	0.436	0.048
KIAA0930	MARK3	0.436	0.082
AGAP1	FOXO1	0.436
DENND4A	MARK3	0.424	0.044
SAMD4B	MARK1	0.416	0.078
FAM53B	MARK3	0.413
MARK1	DENND4A	0.4	0.072	mutually_exclusive (P27348)
SYDE2	MARK1	0.385
SYDE2	CDC25B	0.385
CDC25B	PTPN3	0.385	0.092
MARK1	PTPN3	0.385	0.122
PFKFB2	YWHAE	0.37	0.49695890411	mutually_exclusive (P27348)
SPIRE1	YWHAE	0.37	0.368
SAMD4B	HDAC5	0.359	0.21
SFN	MARK3	0.351	0.112	structurally_consistent (dimer)
MARK1	YWHAE	0.334	0.469033138402
SYDE2	FOXO1	0.324
PTPN3	FOXO1	0.324	0.162
TIAM1	PTPN3	0.319	0.144
SYDE2	PTPN3	0.319
SYDE2	SPIRE1	0.319
SYDE2	PLEKHA7	0.319
SYDE2	HDAC5	0.319
PTPN3	HDAC5	0.319	0.154
SYDE2	TIAM1	0.319
SYDE2	PFKFB2	0.319
SYDE2	CRTC1	0.319
CRTC1	PTPN3	0.319	0.18
PFKFB2	PTPN3	0.319	0.084
PTPN3	SPIRE1	0.319	0.13
PTPN3	FAM53B	0.319
SYDE2	FAM53B	0.319
SYDE2	TFEB	0.319
TFEB	PTPN3	0.319	0.086
SYDE2	KIAA0930	0.29
PTPN3	KIAA0930	0.29	0.148
SYDE2	DENND4A	0.29
DENND4A	PTPN3	0.29	0.102
CRTC1	YWHAE	0.28	0.355333333333
DENND4A	HDAC5	0.278	0.086
CRTC1	MARK3	0.27	0.092
FOXO1	MARK3	0.27	0.088
HDAC5	MARK3	0.27	0.146	mutually_exclusive (P31947)
AGAP1	HDAC5	0.262
SAMD4B	AGAP1	0.262
AGAP1	PTPN3	0.256
SAMD4B	DENND4A	0.254	0.04
TFEB	MARK3	0.254	0.112
HDAC5	YWHAE	0.249	0.52880733195	mutually_exclusive (P31947)
SAMD4B	MARK3	0.249	0.062
SYDE2	AGAP1	0.246
MARK1	SFN	0.246	0.36
SFN	SPIRE1	0.239	0.224564102564
PLEKHA7	SFN	0.239	0.3584
PTPN3	MARK3	0.238	0.222
SYDE2	MARK3	0.238
SYDE2	SAMD4B	0.238
SYDE2	SAMD4A	0.238
SAMD4A	PTPN3	0.238	0.124
SAMD4B	PTPN3	0.232	0.114
PLEKHA7	TIAM1	0.23	0.14
PLEKHA7	MARK3	0.221	0.05
SAMD4B	SFN	0.208	0.09
SFN	DENND4A	0.189	0.203047619048	mutually_exclusive (P27348)
AGAP1	MARK3	0.184
FOXO1	YWHAE	0.18	0.476746666667	mutually_exclusive (P27348)
TIAM1	YWHAE	0.146	0.445033138402
PLEKHA7	SAMD4B	0.144	0.072
DENND4A	YWHAE	0.116	0.12	mutually_exclusive (P27348)
SFN	AGAP1	0.082
YWHAZ	AGAP1	0.077
PLEKHA7	YWHAE	0.075	0.188
AGAP1	YWHAE	0.069
MARK3	YWHAE	0.051	0.27

Related Complexes

Genename	Complexes
PLEKHA7	huMAP3_01010.1 huMAP3_06971.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
TIAM1	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07424.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
YWHAQ	huMAP3_01787.1 huMAP3_06971.1 huMAP3_07424.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
DENND4A	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07424.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_14817.1
SAMD4A	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_14098.1
TFEB	huMAP3_04102.1 huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_08832.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13402.1 huMAP3_13503.1
CDC25B	huMAP3_03088.1 huMAP3_04537.1 huMAP3_06971.1 huMAP3_07002.1 huMAP3_07596.1 huMAP3_07691.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10829.1 huMAP3_12772.1 huMAP3_12897.1
SPATA13	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
MARK1	huMAP3_01298.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_09812.1 huMAP3_10561.1 huMAP3_10808.1 huMAP3_12897.1
SAMD4B	huMAP3_01010.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_14098.1
SYDE2	huMAP3_00566.1 huMAP3_04537.1 huMAP3_06797.1 huMAP3_06971.1 huMAP3_08480.1 huMAP3_08492.1 huMAP3_09272.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10974.1 huMAP3_12897.1 huMAP3_14687.1
MARK3	huMAP3_06971.1 huMAP3_07596.1 huMAP3_09266.1 huMAP3_09812.1 huMAP3_10544.1 huMAP3_10561.1 huMAP3_10808.1 huMAP3_12897.1
LNP1	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13672.1
PTPN3	huMAP3_04537.1 huMAP3_06025.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_11201.1 huMAP3_12897.1
KIAA0930	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_11622.1 huMAP3_12897.1
YWHAB	huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
PFKFB2	huMAP3_01672.1 huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
SFN	huMAP3_01787.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
SPIRE1	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13929.1 huMAP3_15248.1
FAM53B	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
YWHAE	huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13503.1
YWHAH	huMAP3_04051.1 huMAP3_04537.1 huMAP3_06971.1 huMAP3_07306.1 huMAP3_07596.1 huMAP3_08480.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
YWHAZ	huMAP3_00362.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_08480.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
HDAC5	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
CRTC1	huMAP3_01010.1 huMAP3_04051.1 huMAP3_06971.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13650.1
FOXO1	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07424.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
AGAP1	huMAP3_03441.1 huMAP3_06971.1 huMAP3_07158.1 huMAP3_08290.1 huMAP3_15308.1
YWHAG	huMAP3_01010.1 huMAP3_03955.1 huMAP3_06135.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06971.1

Complex Portal: CPX-12224