hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_06974.1

Complex Portal: CPX-25016

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
COL21A1	Collagen alpha-1(XXI) chain	5	UniProt NCBI
PLOD3	Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)]	5	UniProt NCBI
COLGALT2	Procollagen galactosyltransferase 2 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 2) (ColGalT 2) (Glycosyltransferase 25 family member 2) (Hydroxylysine galactosyltransferase 2)	5	UniProt NCBI
COL9A2	Collagen alpha-2(IX) chain	5	UniProt NCBI
COL4A2	Collagen alpha-2(IV) chain [Cleaved into: Canstatin]	5	UniProt NCBI
RITA1	RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein)	5	UniProt NCBI
COLEC10	Collectin-10 (Collectin liver protein 1) (CL-L1) (Collectin-34) (CL-34)	5	UniProt NCBI
COL9A3	Collagen alpha-3(IX) chain	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-1650814	8.92163224206e-12	0.75	COLGALT2 COL9A2 PLOD3 COL4A2 COL9A3 COL21A1	Collagen biosynthesis and modifying enzymes
REAC:R-HSA-1474290	6.83069269837e-11	0.75	COLGALT2 COL9A2 PLOD3 COL4A2 COL9A3 COL21A1	Collagen formation
REAC:R-HSA-1474244	7.83665840219e-08	0.75	COLGALT2 COL9A2 PLOD3 COL4A2 COL9A3 COL21A1	Extracellular matrix organization
REAC:R-HSA-8948216	2.13574543247e-07	0.5	COL4A2 COL9A3 COL21A1 COL9A2	Collagen chain trimerization
KEGG:04974	1.5542243847e-06	0.5	COL4A2 COL9A3 COL21A1 COL9A2	Protein digestion and absorption
GO:0030020	4.35075554541e-05	0.5	COL4A2 COL9A3 COL21A1 COL9A2	extracellular matrix structural constituent conferring tensile strength
REAC:R-HSA-419037	6.65860913492e-05	0.375	COL4A2 COL9A2 COL9A3	NCAM1 interactions
HPA:0200273	8.97673402795e-05	0.25	COL9A2 COL9A3	eye; hyaloid membrane[High]
HPA:0200272	0.000179485535893	0.25	COL9A2 COL9A3	eye; hyaloid membrane[>=Medium]
HPA:0200271	0.000179485535893	0.25	COL9A2 COL9A3	eye; hyaloid membrane[>=Low]
HPA:0070113	0.000179485535893	0.25	COL9A2 COL9A3	cartilage; chondrocytes[High]
KEGG:04512	0.000251141708404	0.375	COL4A2 COL9A2 COL9A3	ECM-receptor interaction
REAC:R-HSA-375165	0.000260330782854	0.375	COL4A2 COL9A2 COL9A3	NCAM signaling for neurite out-growth
WP:WP4789	0.000358447219737	0.25	COL9A2 COL9A3	MED and pseudoachondroplasia genes
REAC:R-HSA-2022090	0.000367233569698	0.375	COL4A2 COL9A2 COL9A3	Assembly of collagen fibrils and other multimeric structures
REAC:R-HSA-186797	0.000391615111842	0.375	COL4A2 COL9A2 COL9A3	Signaling by PDGF
REAC:R-HSA-1442490	0.000417047988419	0.375	COL4A2 COL9A2 COL9A3	Collagen degradation
GO:0030198	0.000579646574543	0.625	COLGALT2 COL9A3 PLOD3 COL4A2 COL9A2	extracellular matrix organization
GO:0043062	0.000579646574543	0.625	COLGALT2 COL9A3 PLOD3 COL4A2 COL9A2	extracellular structure organization
GO:0045229	0.000614345450659	0.625	COLGALT2 COL9A3 PLOD3 COL4A2 COL9A2	external encapsulating structure organization
HPA:0070112	0.000627683621469	0.25	COL9A2 COL9A3	cartilage; chondrocytes[>=Medium]
HPA:0070111	0.000627683621469	0.25	COL9A2 COL9A3	cartilage; chondrocytes[>=Low]
HPA:0070000	0.000627683621469	0.25	COL9A2 COL9A3	cartilage
HP:0012770	0.000677898190386	0.25	COL9A2 COL9A3	Reduced arm span
HP:0006190	0.000677898190386	0.25	COL9A2 COL9A3	Radially deviated wrists
HP:0003841	0.000677898190386	0.25	COL9A2 COL9A3	Fragmented epiphyses of the upper limbs
HP:0009189	0.000677898190386	0.25	COL9A2 COL9A3	Fragmentation of the metacarpal epiphyses
HP:0003946	0.000677898190386	0.25	COL9A2 COL9A3	Abnormality of the epiphyses of the elbow
REAC:R-HSA-3000178	0.000696845667831	0.375	COL4A2 COL9A2 COL9A3	ECM proteoglycans
REAC:R-HSA-216083	0.00089567252269	0.375	COL4A2 COL9A2 COL9A3	Integrin cell surface interactions
HP:0006055	0.00135542525381	0.25	COL9A2 COL9A3	Ulnar deviated club hands
HP:0100168	0.00225842370351	0.25	COL9A2 COL9A3	Fragmented epiphyses
HP:0003999	0.00225842370351	0.25	COL9A2 COL9A3	Abnormality of radial epiphyses
HP:0010631	0.00338670821406	0.25	COL9A2 COL9A3	Abnormality of the epiphyses of the feet
HP:0009811	0.00355204850651	0.5	COLEC10 COL9A3 PLOD3 COL9A2	Abnormality of the elbow
GO:0005788	0.00355755965791	0.625	COLGALT2 COL9A3 COL21A1 COL4A2 COL9A2	endoplasmic reticulum lumen
REAC:R-HSA-1474228	0.00418264558662	0.375	COL4A2 COL9A2 COL9A3	Degradation of the extracellular matrix
KEGG:04510	0.00432603102979	0.375	COL4A2 COL9A2 COL9A3	Focal adhesion
HP:0006500	0.00615179618571	0.375	COL9A3 PLOD3 COL9A2	Abnormal lower limb epiphysis morphology
HPA:0200000	0.00625282014335	0.25	COL9A2 COL9A3	eye
HP:0003365	0.0063183945919	0.25	COL9A2 COL9A3	Arthralgia of the hip
HP:0012769	0.0063183945919	0.25	COL9A2 COL9A3	Abnormal arm span
HP:0009486	0.00812142628406	0.25	COL9A2 COL9A3	Radial deviation of the hand
GO:0005581	0.00948397324055	0.375	COL4A2 COL9A2 COL9A3	collagen trimer
KEGG:00514	0.0100194502952	0.25	COLGALT2 PLOD3	Other types of O-glycan biosynthesis
GO:0005201	0.0119973146137	0.5	COL4A2 COL9A3 COL21A1 COL9A2	extracellular matrix structural constituent
HP:0012368	0.0125453921352	0.375	COL9A3 PLOD3 COL9A2	Flat face
HP:0000926	0.0174360327694	0.375	COL9A3 PLOD3 COL9A2	Platyspondyly
HP:0010665	0.0175771621337	0.25	COL9A2 COL9A3	Bilateral coxa valga
HP:0030973	0.0175771621337	0.25	COL9A2 COL9A3	Postexertional symptom exacerbation
HP:0030839	0.0175771621337	0.25	COL9A2 COL9A3	Knee pain
HP:0006505	0.0184420315351	0.375	COL9A3 PLOD3 COL9A2	Abnormal limb epiphysis morphology
KEGG:04151	0.0191136955138	0.375	COL4A2 COL9A2 COL9A3	PI3K-Akt signaling pathway
KEGG:05165	0.0207258251199	0.375	COL4A2 COL9A2 COL9A3	Human papillomavirus infection
KEGG:00310	0.0211290680368	0.25	COLGALT2 PLOD3	Lysine degradation
HP:0100694	0.0270195830756	0.25	COL9A2 COL9A3	Tibial torsion
WP:WP4172	0.0300698308207	0.375	COL4A2 COL9A2 COL9A3	PI3K Akt signaling pathway
HP:0005913	0.0306138099712	0.25	COL9A2 COL9A3	Abnormal metacarpal epiphysis morphology
HP:0010585	0.0344311064357	0.25	COL9A2 COL9A3	Small epiphyses
HP:0007773	0.0344311064357	0.25	COL9A2 COL9A3	Vitreoretinopathy
HP:0003502	0.0344311064357	0.25	COL9A2 COL9A3	Mild short stature
HP:0002996	0.0359718252675	0.375	COLEC10 PLOD3 COL9A3	Limited elbow movement
HP:0010582	0.0384712883781	0.25	COL9A2 COL9A3	Irregular epiphyses
GO:0005594	0.0393180950424	0.25	COL9A2 COL9A3	collagen type IX trimer
GO:0050211	0.0393180950424	0.25	COLGALT2 PLOD3	procollagen galactosyltransferase activity

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
COLGALT2	PLOD3	0.998	0.088	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
COLGALT2	COL9A3	0.988		bioplex3_WMM bioplex3_HCT116 WMM_only
COLGALT2	COL9A2	0.984		bioplex3_WMM bioplex3_HCT116 WMM_only
COL9A2	PLOD3	0.982		bioplex3_WMM bioplex3_HCT116 WMM_only
COL4A2	COLGALT2	0.979	0.114	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
COL9A3	PLOD3	0.978		bioplex3_WMM bioplex3_HCT116 WMM_only
PLOD3	RITA1	0.972		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
PLOD3	COLEC10	0.961		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
COL21A1	PLOD3	0.957		bioplex3_HEK293 bioplex3_WMM WMM_only
COL4A2	PLOD3	0.955	0.174	bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only
COLGALT2	COL21A1	0.925		bioplex3_HEK293 bioplex3_WMM WMM_only
COL4A2	COL21A1	0.896		bioplex3_HEK293 bioplex3_WMM WMM_only
COL9A2	COL9A3	0.616		bioplex3_WMM WMM_only
COLGALT2	RITA1	0.448		bioplex3_HEK293 bioplex3_WMM WMM_only
COL4A2	RITA1	0.403		bioplex3_HEK293 bioplex3_WMM WMM_only
COLGALT2	COLEC10	0.342		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
COL4A2	COL9A3	0.072		bioplex3_WMM WMM_only
COL4A2	COL9A2	0.046		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
COL21A1	huMAP3_02991.1 huMAP3_03726.1 huMAP3_05718.1 huMAP3_06974.1 huMAP3_07512.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_13038.1
PLOD3	huMAP3_02991.1 huMAP3_03159.1 huMAP3_03726.1 huMAP3_05718.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_07512.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1
COLGALT2	huMAP3_00858.1 huMAP3_05924.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_15305.1
COL9A2	huMAP3_00858.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05718.1 huMAP3_05924.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_15305.1
COL4A2	huMAP3_00257.1 huMAP3_00858.1 huMAP3_02991.1 huMAP3_04937.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10144.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_12884.1 huMAP3_13038.1
RITA1	huMAP3_02991.1 huMAP3_03159.1 huMAP3_05718.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07512.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10699.1 huMAP3_10984.1
COLEC10	huMAP3_06974.1
COL9A3	huMAP3_00858.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05924.1 huMAP3_06555.1 huMAP3_06974.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10003.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_15305.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_06974.1

Complex Portal: CPX-25016