hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_06976.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UGT1A8 | UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H) | 5 | UniProt NCBI |
| UGT1A7 | UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00053 | 3.75535994234e-05 | 1.0 | UGT1A8 UGT1A7 | Ascorbate and aldarate metabolism |
| KEGG:00040 | 4.8770908342e-05 | 1.0 | UGT1A8 UGT1A7 | Pentose and glucuronate interconversions |
| WP:WP698 | 6.51224637934e-05 | 1.0 | UGT1A8 UGT1A7 | Glucuronidation |
| KEGG:00860 | 8.58367986819e-05 | 1.0 | UGT1A8 UGT1A7 | Porphyrin metabolism |
| KEGG:00140 | 0.000126804361689 | 1.0 | UGT1A8 UGT1A7 | Steroid hormone biosynthesis |
| REAC:R-HSA-156588 | 0.000205051410255 | 1.0 | UGT1A8 UGT1A7 | Glucuronidation |
| KEGG:00830 | 0.000207276360454 | 1.0 | UGT1A8 UGT1A7 | Retinol metabolism |
| KEGG:05204 | 0.000224021038984 | 1.0 | UGT1A8 UGT1A7 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 0.000232637232791 | 1.0 | UGT1A8 UGT1A7 | Drug metabolism - cytochrome P450 |
| KEGG:04976 | 0.000268727704965 | 1.0 | UGT1A8 UGT1A7 | Bile secretion |
| KEGG:00980 | 0.000278156747244 | 1.0 | UGT1A8 UGT1A7 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:00983 | 0.000359441594481 | 1.0 | UGT1A8 UGT1A7 | Drug metabolism - other enzymes |
| REAC:R-HSA-9749641 | 0.000743311362176 | 1.0 | UGT1A8 UGT1A7 | Aspirin ADME |
| KEGG:01240 | 0.00144865854745 | 1.0 | UGT1A8 UGT1A7 | Biosynthesis of cofactors |
| KEGG:05207 | 0.00214640767613 | 1.0 | UGT1A8 UGT1A7 | Chemical carcinogenesis - receptor activation |
| WP:WP5224 | 0.00232397811969 | 1.0 | UGT1A8 UGT1A7 | 2q37 copy number variation syndrome |
| GO:0051552 | 0.0028092043205 | 1.0 | UGT1A8 UGT1A7 | flavone metabolic process |
| GO:0052696 | 0.0028092043205 | 1.0 | UGT1A8 UGT1A7 | flavonoid glucuronidation |
| GO:0009698 | 0.00468200720083 | 1.0 | UGT1A8 UGT1A7 | phenylpropanoid metabolic process |
| GO:0009804 | 0.00468200720083 | 1.0 | UGT1A8 UGT1A7 | coumarin metabolic process |
| REAC:R-HSA-156580 | 0.00539968713673 | 1.0 | UGT1A8 UGT1A7 | Phase II - Conjugation of compounds |
| REAC:R-HSA-9748784 | 0.0055363880769 | 1.0 | UGT1A8 UGT1A7 | Drug ADME |
| GO:0052697 | 0.00702301080125 | 1.0 | UGT1A8 UGT1A7 | xenobiotic glucuronidation |
| GO:0009812 | 0.00983221512175 | 1.0 | UGT1A8 UGT1A7 | flavonoid metabolic process |
| REAC:R-HSA-211859 | 0.0225607814134 | 1.0 | UGT1A8 UGT1A7 | Biological oxidations |
| GO:0001972 | 0.0365196561665 | 1.0 | UGT1A8 UGT1A7 | retinoic acid binding |
| GO:0052695 | 0.0426062655276 | 1.0 | UGT1A8 UGT1A7 | cellular glucuronidation |
| GO:0006063 | 0.0491610756088 | 1.0 | UGT1A8 UGT1A7 | uronic acid metabolic process |
| GO:0019585 | 0.0491610756088 | 1.0 | UGT1A8 UGT1A7 | glucuronate metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UGT1A8 | UGT1A7 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes