hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06979.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KCNJ5 | G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5) | 5 | UniProt NCBI |
| KCNJ18 | Inward rectifier potassium channel 18 (Inward rectifier K(+) channel Kir2.6) (Potassium channel, inwardly rectifying subfamily J member 18) | 5 | UniProt NCBI |
| WDR45B | WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B) (WIPI49-like protein) | 5 | UniProt NCBI |
| KCNJ3 | G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04921 | 9.10876349728e-05 | 0.75 | KCNJ5 KCNJ3 KCNJ18 | Oxytocin signaling pathway |
| GO:0005242 | 0.000174830724535 | 0.75 | KCNJ5 KCNJ3 KCNJ18 | inward rectifier potassium channel activity |
| HP:0003752 | 0.000334337547576 | 0.5 | KCNJ5 KCNJ18 | Episodic flaccid weakness |
| HP:0001962 | 0.00043431544324 | 0.75 | KCNJ5 KCNJ3 KCNJ18 | Palpitations |
| HP:0008153 | 0.000701980712879 | 0.5 | KCNJ5 KCNJ18 | Periodic hypokalemic paresis |
| HP:0003768 | 0.00120317586686 | 0.5 | KCNJ5 KCNJ18 | Periodic paralysis |
| GO:1990573 | 0.00172575455775 | 0.75 | KCNJ5 KCNJ3 KCNJ18 | potassium ion import across plasma membrane |
| KEGG:04929 | 0.00247340401034 | 0.5 | KCNJ5 KCNJ3 | GnRH secretion |
| REAC:R-HSA-1296059 | 0.00258893271292 | 0.5 | KCNJ5 KCNJ3 | G protein gated Potassium channels |
| REAC:R-HSA-1296041 | 0.00258893271292 | 0.5 | KCNJ5 KCNJ3 | Activation of G protein gated Potassium channels |
| REAC:R-HSA-997272 | 0.00258893271292 | 0.5 | KCNJ5 KCNJ3 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| HP:0010547 | 0.00260592941411 | 0.5 | KCNJ5 KCNJ18 | Muscle flaccidity |
| REAC:R-HSA-1296065 | 0.00359044851421 | 0.5 | KCNJ5 KCNJ3 | Inwardly rectifying K+ channels |
| REAC:R-HSA-991365 | 0.00539805716719 | 0.5 | KCNJ5 KCNJ3 | Activation of GABAB receptors |
| REAC:R-HSA-977444 | 0.00539805716719 | 0.5 | KCNJ5 KCNJ3 | GABA B receptor activation |
| KEGG:05032 | 0.0056793701001 | 0.5 | KCNJ5 KCNJ3 | Morphine addiction |
| KEGG:04713 | 0.00654897197861 | 0.5 | KCNJ5 KCNJ3 | Circadian entrainment |
| GO:0005249 | 0.00751763182363 | 0.75 | KCNJ5 KCNJ3 KCNJ18 | voltage-gated potassium channel activity |
| REAC:R-HSA-977443 | 0.00837722051003 | 0.5 | KCNJ5 KCNJ3 | GABA receptor activation |
| GO:0015467 | 0.00842684400117 | 0.5 | KCNJ5 KCNJ3 | G-protein activated inward rectifier potassium channel activity |
| KEGG:04726 | 0.00867836513934 | 0.5 | KCNJ5 KCNJ3 | Serotonergic synapse |
| KEGG:04725 | 0.00974438450458 | 0.5 | KCNJ18 KCNJ3 | Cholinergic synapse |
| KEGG:04915 | 0.0104133784038 | 0.5 | KCNJ5 KCNJ3 | Estrogen signaling pathway |
| GO:0005267 | 0.0137962469792 | 0.75 | KCNJ5 KCNJ3 KCNJ18 | potassium channel activity |
| KEGG:04728 | 0.014619629343 | 0.5 | KCNJ5 KCNJ3 | Dopaminergic synapse |
| WP:WP536 | 0.015715675352 | 0.5 | KCNJ5 KCNJ3 | Calcium regulation in cardiac cells |
| GO:0086089 | 0.0168521501606 | 0.5 | KCNJ5 KCNJ3 | voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization |
| KEGG:04723 | 0.017422762868 | 0.5 | KCNJ5 KCNJ3 | Retrograde endocannabinoid signaling |
| HP:0001657 | 0.0198386649826 | 0.5 | KCNJ5 KCNJ18 | Prolonged QT interval |
| REAC:R-HSA-1296071 | 0.0218635493976 | 0.5 | KCNJ5 KCNJ3 | Potassium Channels |
| GO:0099587 | 0.0269276802074 | 0.75 | KCNJ5 KCNJ3 KCNJ18 | inorganic ion import across plasma membrane |
| GO:0098659 | 0.0269276802074 | 0.75 | KCNJ5 KCNJ3 KCNJ18 | inorganic cation import across plasma membrane |
| HP:0002795 | 0.0285838989014 | 1.0 | KCNJ5 KCNJ3 WDR45B KCNJ18 | Abnormal respiratory system physiology |
| HP:0031547 | 0.0315158796726 | 0.5 | KCNJ5 KCNJ18 | Abnormal QT interval |
| GO:0022843 | 0.0339114962397 | 0.75 | KCNJ5 KCNJ3 KCNJ18 | voltage-gated monoatomic cation channel activity |
| GO:0015079 | 0.0378152735667 | 0.75 | KCNJ5 KCNJ3 KCNJ18 | potassium ion transmembrane transporter activity |
| GO:0099094 | 0.0378152735667 | 0.75 | KCNJ5 KCNJ3 KCNJ18 | ligand-gated monoatomic cation channel activity |
| GO:0098914 | 0.042122686785 | 0.5 | KCNJ5 KCNJ3 | membrane repolarization during atrial cardiac muscle cell action potential |
| HP:0002900 | 0.0424493051949 | 0.5 | KCNJ5 KCNJ18 | Hypokalemia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KCNJ5 | KCNJ18 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| KCNJ5 | KCNJ3 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KCNJ5 | WDR45B | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| KCNJ18 | KCNJ3 | 0.214 | bioplex3_WMM WMM_only | |
| KCNJ3 | WDR45B | 0.1 | bioplex_WMM bioplex3_WMM WMM_only | |
| KCNJ18 | WDR45B | 0.042 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| KCNJ5 | huMAP3_02913.1 huMAP3_05562.1 huMAP3_06979.1 |
| KCNJ18 | huMAP3_02913.1 huMAP3_05562.1 huMAP3_06979.1 |
| WDR45B | huMAP3_06979.1 huMAP3_09511.1 huMAP3_15073.1 |
| KCNJ3 | huMAP3_02913.1 huMAP3_06979.1 |