hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06980.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRIM1 | DNA primase small subunit (EC 2.7.7.102) (DNA primase 49 kDa subunit) (p49) | 5 | UniProt NCBI |
| BTF3 | Transcription factor BTF3 (Nascent polypeptide-associated complex subunit beta) (NAC-beta) (RNA polymerase B transcription factor 3) | 5 | UniProt NCBI |
| POLA1 | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | 5 | UniProt NCBI |
| NLGN4Y | Neuroligin-4, Y-linked (Neuroligin Y) | 5 | UniProt NCBI |
| BTF3L4 | Transcription factor BTF3 homolog 4 (Basic transcription factor 3-like 4) | 3 | UniProt NCBI |
| C15orf39 | Uncharacterized protein C15orf39 | 3 | UniProt NCBI |
| PRIM2 | DNA primase large subunit (DNA primase 58 kDa subunit) (p58) | 5 | UniProt NCBI |
| POLA2 | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1100 | 3.36110250117e-12 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA polymerase alpha-primase complex |
| CORUM:1107 | 4.23035314849e-10 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA synthesome core complex |
| REAC:R-HSA-68952 | 5.4816582917e-10 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA replication initiation |
| CORUM:1098 | 7.0490440398e-10 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA synthesome complex (13 subunits) |
| CORUM:1108 | 2.39845456287e-09 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA synthesome complex (15 subunits) |
| CORUM:1111 | 3.35710066077e-09 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 3.35710066077e-09 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-113501 | 5.59299191682e-09 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-174430 | 5.59299191682e-09 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Telomere C-strand synthesis initiation |
| REAC:R-HSA-69109 | 7.82847303023e-09 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Leading Strand Synthesis |
| REAC:R-HSA-69091 | 7.82847303023e-09 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Polymerase switching |
| REAC:R-HSA-69166 | 7.82847303023e-09 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Removal of the Flap Intermediate |
| GO:0006269 | 9.20740386965e-09 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA replication, synthesis of RNA primer |
| GO:0005658 | 9.20740386965e-09 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | alpha DNA polymerase:primase complex |
| REAC:R-HSA-69183 | 1.0672851369e-08 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Processive synthesis on the lagging strand |
| REAC:R-HSA-69186 | 3.78412664014e-08 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Lagging Strand Synthesis |
| REAC:R-HSA-113510 | 5.71078496603e-08 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | E2F mediated regulation of DNA replication |
| KEGG:03030 | 1.06671103772e-07 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA replication |
| REAC:R-HSA-174411 | 1.16611614338e-07 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Polymerase switching on the C-strand of the telomere |
| REAC:R-HSA-69190 | 2.80123063934e-07 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA strand elongation |
| REAC:R-HSA-68962 | 3.18690821415e-07 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Activation of the pre-replicative complex |
| REAC:R-HSA-174417 | 3.61103717138e-07 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Telomere C-strand (Lagging Strand) Synthesis |
| WP:WP466 | 3.73087109052e-07 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA replication |
| REAC:R-HSA-180786 | 1.93858490754e-06 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Extension of Telomeres |
| REAC:R-HSA-9710421 | 4.03938085227e-06 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Defective pyroptosis |
| GO:0042575 | 8.89269760433e-06 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA polymerase complex |
| GO:0043601 | 1.34203446702e-05 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | nuclear replisome |
| GO:0030894 | 1.94862705925e-05 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | replisome |
| REAC:R-HSA-9645723 | 2.05516498559e-05 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Diseases of programmed cell death |
| REAC:R-HSA-157579 | 3.00928438357e-05 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Telomere Maintenance |
| REAC:R-HSA-69239 | 6.06857205648e-05 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Synthesis of DNA |
| GO:0006270 | 6.58289200244e-05 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA replication initiation |
| REAC:R-HSA-73886 | 7.88413959175e-05 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Chromosome Maintenance |
| REAC:R-HSA-69206 | 8.65980296911e-05 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | G1/S Transition |
| REAC:R-HSA-69002 | 0.000141818979527 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA Replication Pre-Initiation |
| REAC:R-HSA-453279 | 0.000141818979527 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Mitotic G1 phase and G1/S transition |
| GO:0043596 | 0.000150338896321 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | nuclear replication fork |
| REAC:R-HSA-69242 | 0.000194205912298 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | S Phase |
| REAC:R-HSA-69306 | 0.00027852607085 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA Replication |
| WP:WP45 | 0.000402879316066 | 0.375 | PRIM2 PRIM1 POLA2 | G1 to S cell cycle control |
| CORUM:1003 | 0.000668735194034 | 0.25 | POLA1 POLA2 | RC complex (Replication competent complex) |
| GO:0005657 | 0.00123045452734 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | replication fork |
| GO:0055029 | 0.00504805624577 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 0.00527377501199 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA-directed RNA polymerase complex |
| GO:0030880 | 0.00599633581038 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | RNA polymerase complex |
| REAC:R-HSA-69278 | 0.0220129016806 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Cell Cycle, Mitotic |
| GO:0006261 | 0.0281979257523 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | DNA-templated DNA replication |
| REAC:R-HSA-1640170 | 0.0491409220523 | 0.5 | POLA1 PRIM1 POLA2 PRIM2 | Cell Cycle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PRIM1 | POLA2 | 0.999 | 0.81 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM fraction |
| PRIM1 | PRIM2 | 0.999 | 0.922 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| PRIM1 | NLGN4Y | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NLGN4Y | PRIM2 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRIM1 | BTF3L4 | 0.995 | 0.034 | bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| PRIM1 | POLA1 | 0.994 | 0.818 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM fraction |
| PRIM1 | BTF3 | 0.988 | 0.204 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| PRIM2 | BTF3L4 | 0.982 | 0.022 | bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| POLA1 | POLA2 | 0.979 | 0.84 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| C15orf39 | POLA2 | 0.971 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PRIM1 | C15orf39 | 0.969 | 0.078 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| POLA1 | PRIM2 | 0.969 | 0.838 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| PRIM2 | BTF3 | 0.966 | 0.246 | bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| PRIM2 | POLA2 | 0.966 | 0.872 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| BTF3 | BTF3L4 | 0.957 | 0.162 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| POLA1 | C15orf39 | 0.928 | 0.09 | hein_WMM bioplex3_WMM WMM_only |
| C15orf39 | PRIM2 | 0.925 | 0.104 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| POLA1 | BTF3 | 0.913 | 0.16 | bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| POLA1 | BTF3L4 | 0.307 | 0.038 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM fraction |
| POLA2 | BTF3 | 0.061 | 0.28 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| POLA2 | BTF3L4 | 0.047 | 0.042 | bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| C15orf39 | BTF3 | 0.006 | 0.03 | bioplex3_WMM WMM_only |
Related Complexes