hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06989.1
Complex Portal: CPX-13574
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| INTS5 | Integrator complex subunit 5 (Int5) | 5 | UniProt NCBI |
| INTS11 | Integrator complex subunit 11 (Int11) (EC 3.1.27.-) (Cleavage and polyadenylation-specific factor 3-like protein) (CPSF3-like protein) (Protein related to CPSF subunits of 68 kDa) (RC-68) | 5 | UniProt NCBI |
| INTS6 | Integrator complex subunit 6 (Int6) (DBI-1) (Protein DDX26) (Protein deleted in cancer 1) (DICE1) | 5 | UniProt NCBI |
| INTS7 | Integrator complex subunit 7 (Int7) | 5 | UniProt NCBI |
| INTS4 | Integrator complex subunit 4 (Int4) | 5 | UniProt NCBI |
| FOXC1 | Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) | 5 | UniProt NCBI |
| INTS1 | Integrator complex subunit 1 (Int1) | 5 | UniProt NCBI |
| INTS12 | Integrator complex subunit 12 (Int12) (PHD finger protein 22) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1153 | 2.04803534183e-20 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | Integrator complex |
| CORUM:1155 | 4.43714403265e-20 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | Integrator-RNAPII complex |
| GO:0032039 | 7.13736251907e-16 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | integrator complex |
| GO:0016180 | 9.31369988243e-15 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | snRNA processing |
| REAC:R-HSA-6807505 | 8.85107357602e-14 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | RNA polymerase II transcribes snRNA genes |
| CORUM:1154 | 7.27891517895e-13 | 0.625 | INTS5 INTS7 INTS6 INTS4 INTS11 | DSS1 complex |
| GO:0016073 | 1.89128383461e-12 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | snRNA metabolic process |
| GO:0034243 | 3.72896859502e-11 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | regulation of transcription elongation by RNA polymerase II |
| GO:0032784 | 1.55809258516e-10 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | regulation of DNA-templated transcription elongation |
| GO:0006368 | 2.09860712973e-10 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | transcription elongation by RNA polymerase II |
| GO:0006354 | 6.56629513842e-10 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | DNA-templated transcription elongation |
| GO:0034472 | 1.02328314981e-08 | 0.625 | INTS1 INTS5 INTS12 INTS6 INTS7 | snRNA 3'-end processing |
| GO:0034470 | 1.70237288123e-06 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | ncRNA processing |
| GO:0031123 | 1.53576106888e-05 | 0.625 | INTS1 INTS5 INTS12 INTS6 INTS7 | RNA 3'-end processing |
| GO:0034660 | 2.48097305115e-05 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | ncRNA metabolic process |
| REAC:R-HSA-73857 | 2.80793096136e-05 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | RNA Polymerase II Transcription |
| REAC:R-HSA-74160 | 6.70866002994e-05 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | Gene expression (Transcription) |
| GO:0006396 | 0.000407850440383 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | RNA processing |
| GO:0006366 | 0.00276616156096 | 1.0 | INTS5 FOXC1 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | transcription by RNA polymerase II |
| GO:0140513 | 0.00521846176444 | 0.875 | INTS5 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | nuclear protein-containing complex |
| GO:0006355 | 0.019276917338 | 1.0 | INTS5 FOXC1 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | regulation of DNA-templated transcription |
| GO:2001141 | 0.0202331041081 | 1.0 | INTS5 FOXC1 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | regulation of RNA biosynthetic process |
| GO:0006351 | 0.0281694782025 | 1.0 | INTS5 FOXC1 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | DNA-templated transcription |
| GO:0032774 | 0.0306853042962 | 1.0 | INTS5 FOXC1 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | RNA biosynthetic process |
| GO:0051252 | 0.0471731106254 | 1.0 | INTS5 FOXC1 INTS11 INTS4 INTS1 INTS12 INTS6 INTS7 | regulation of RNA metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| INTS1 | INTS12 | 1.0 | 0.49 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo fraction | |
| INTS12 | INTS4 | 1.0 | 0.614 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| INTS5 | INTS4 | 0.998 | 0.906 |
structurally_consistent (Q9NVH2)
|
hein_WMM bioplex_WMM bioplex3_WMM Malo fraction |
| INTS11 | INTS4 | 0.998 | 0.494 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () Malo fraction |
| INTS5 | INTS12 | 0.997 | 0.478 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| INTS7 | INTS5 | 0.996 | 0.912 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM Malo fraction |
| INTS6 | INTS4 | 0.993 | 0.886 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| INTS7 | INTS4 | 0.992 | 0.764 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| INTS6 | INTS11 | 0.99 | 0.56 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| FOXC1 | INTS1 | 0.985 | 0.088 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| INTS1 | INTS4 | 0.981 | 0.774 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| INTS5 | INTS6 | 0.968 | 0.874 | hein_WMM bioplex3_WMM WMM_only | |
| FOXC1 | INTS6 | 0.965 | 0.1 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| FOXC1 | INTS12 | 0.962 | 0.148 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| INTS5 | INTS11 | 0.961 | 0.734 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| INTS7 | INTS11 | 0.958 | 0.208 |
structurally_consistent (Q96HW7)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM Malo fraction |
| INTS6 | INTS1 | 0.955 | 0.728 |
structurally_consistent (Q9H0H0)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| INTS6 | INTS12 | 0.954 | 0.48 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| INTS7 | INTS1 | 0.949 | 0.456 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM Malo fraction | |
| INTS7 | INTS12 | 0.944 | 0.326 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| INTS5 | INTS1 | 0.932 | 0.694 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| INTS12 | INTS11 | 0.86 | 0.432 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| FOXC1 | INTS4 | 0.737 | 0.086 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| INTS1 | INTS11 | 0.709 | 0.476 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| FOXC1 | INTS5 | 0.552 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| FOXC1 | INTS11 | 0.282 | 0.046 | hein_WMM bioplex3_WMM WMM_only | |
| FOXC1 | INTS7 | 0.142 | 0.062 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| INTS7 | INTS6 | 0.066 | 0.45 |
structurally_consistent (Q9H0H0)
|
hein_WMM WMM_only |
Related Complexes