hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06996.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IFI44 | Interferon-induced protein 44 (p44) (Microtubule-associated protein 44) | 3 | UniProt NCBI |
| IFI44L | Interferon-induced protein 44-like | 4 | UniProt NCBI |
| TRIM21 | E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21) | 5 | UniProt NCBI |
| IFNA14 | Interferon alpha-14 (IFN-alpha-14) (Interferon alpha-H) (LeIF H) (Interferon lambda-2-H) | 5 | UniProt NCBI |
| IFNA21 | Interferon alpha-21 (IFN-alpha-21) (Interferon alpha-F) (LeIF F) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0009615 | 0.000122361174566 | 1.0 | IFI44 TRIM21 IFNA21 IFNA14 IFI44L | response to virus |
| WP:WP4912 | 0.00254884296025 | 0.4 | IFNA21 IFNA14 | SARS coronavirus and innate immunity |
| REAC:R-HSA-913531 | 0.00269181495124 | 0.6 | TRIM21 IFNA14 IFNA21 | Interferon Signaling |
| WP:WP4558 | 0.00348396083589 | 0.4 | IFNA21 IFNA14 | Overview of interferons mediated signaling pathway |
| KEGG:05320 | 0.00352719256651 | 0.4 | IFNA21 IFNA14 | Autoimmune thyroid disease |
| REAC:R-HSA-912694 | 0.00383489202506 | 0.4 | IFNA21 IFNA14 | Regulation of IFNA/IFNB signaling |
| TF:M08395 | 0.00435861461376 | 1.0 | IFI44 TRIM21 IFNA21 IFNA14 IFI44L | Factor: PBX4:HOXA10; motif: NCATAAATCA |
| REAC:R-HSA-933541 | 0.0061489605225 | 0.4 | IFNA21 IFNA14 | TRAF6 mediated IRF7 activation |
| KEGG:04622 | 0.00937366158534 | 0.4 | IFNA21 IFNA14 | RIG-I-like receptor signaling pathway |
| KEGG:04623 | 0.0108758996329 | 0.4 | IFNA21 IFNA14 | Cytosolic DNA-sensing pathway |
| WP:WP4655 | 0.0121292354685 | 0.4 | IFNA21 IFNA14 | Cytosolic DNA sensing pathway |
| KEGG:04620 | 0.0168082536599 | 0.4 | IFNA21 IFNA14 | Toll-like receptor signaling pathway |
| WP:WP75 | 0.0197951791935 | 0.4 | IFNA21 IFNA14 | Toll like receptor signaling pathway |
| WP:WP5095 | 0.020275205407 | 0.4 | IFNA21 IFNA14 | Overview of proinflammatory and profibrotic mediators |
| KEGG:04650 | 0.0263659307172 | 0.4 | IFNA21 IFNA14 | Natural killer cell mediated cytotoxicity |
| REAC:R-HSA-909733 | 0.0275944536635 | 0.4 | IFNA21 IFNA14 | Interferon alpha/beta signaling |
| GO:0043207 | 0.0315682132639 | 1.0 | IFI44 TRIM21 IFNA21 IFNA14 IFI44L | response to external biotic stimulus |
| GO:0051707 | 0.0315682132639 | 1.0 | IFI44 TRIM21 IFNA21 IFNA14 IFI44L | response to other organism |
| KEGG:04936 | 0.0340898047114 | 0.4 | IFNA21 IFNA14 | Alcoholic liver disease |
| KEGG:05162 | 0.0340898047114 | 0.4 | IFNA21 IFNA14 | Measles |
| GO:0009607 | 0.0371851125029 | 1.0 | IFI44 TRIM21 IFNA21 IFNA14 IFI44L | response to biotic stimulus |
| KEGG:05160 | 0.0380272112444 | 0.4 | IFNA21 IFNA14 | Hepatitis C |
| KEGG:04630 | 0.0380272112444 | 0.4 | IFNA21 IFNA14 | JAK-STAT signaling pathway |
| KEGG:04217 | 0.0415700968186 | 0.4 | IFNA21 IFNA14 | Necroptosis |
| REAC:R-HSA-168928 | 0.0417637628913 | 0.4 | IFNA21 IFNA14 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| WP:WP4630 | 0.0434056741534 | 0.4 | IFNA21 IFNA14 | Measles virus infection |
| KEGG:05164 | 0.0458988724567 | 0.4 | IFNA21 IFNA14 | Influenza A |
| KEGG:05152 | 0.0471742362289 | 0.4 | IFNA21 IFNA14 | Tuberculosis |
| KEGG:04621 | 0.0471742362289 | 0.4 | IFNA21 IFNA14 | NOD-like receptor signaling pathway |
| KEGG:05161 | 0.0484667159694 | 0.4 | IFNA21 IFNA14 | Hepatitis B |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IFI44 | IFNA21 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IFI44L | IFNA21 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IFNA21 | IFNA14 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TRIM21 | IFNA14 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IFNA21 | TRIM21 | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IFI44 | IFI44L | 0.572 | 0.378 | bioplex_WMM bioplex3_WMM WMM_only |
| IFI44 | IFNA14 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| IFI44L | IFNA14 | 0.49 | bioplex_WMM bioplex3_WMM WMM_only | |
| IFI44L | TRIM21 | 0.245 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only |
| IFI44 | TRIM21 | 0.184 | 0.028 | bioplex_WMM bioplex3_WMM WMM_only |
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