hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_06998.1
Complex Portal: CPX-12041
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS33B | Vacuolar protein sorting-associated protein 33B (hVPS33B) | 5 | UniProt NCBI |
| MATN4 | Matrilin-4 | 5 | UniProt NCBI |
| VIPAS39 | Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6390 | 3.41752350426e-06 | 0.666666666667 | VPS33B VIPAS39 | Endosomal targeting complex (VIPAS39-VPS33B) |
| HP:0200084 | 7.59175135241e-05 | 0.666666666667 | VPS33B VIPAS39 | Giant cell hepatitis |
| HP:0009806 | 0.000189776464884 | 0.666666666667 | VPS33B VIPAS39 | Nephrogenic diabetes insipidus |
| HP:0001884 | 0.000569225481094 | 0.666666666667 | VPS33B VIPAS39 | Talipes calcaneovalgus |
| HP:0002611 | 0.00151751896202 | 0.666666666667 | VPS33B VIPAS39 | Cholestatic liver disease |
| HP:0001667 | 0.00379223870168 | 0.666666666667 | VPS33B VIPAS39 | Right ventricular hypertrophy |
| HP:0002908 | 0.00379223870168 | 0.666666666667 | VPS33B VIPAS39 | Conjugated hyperbilirubinemia |
| HP:0001947 | 0.00841415615575 | 0.666666666667 | VPS33B VIPAS39 | Renal tubular acidosis |
| HP:0000873 | 0.0180650213362 | 0.666666666667 | VPS33B VIPAS39 | Diabetes insipidus |
| HP:0001707 | 0.0201452261528 | 0.666666666667 | VPS33B VIPAS39 | Abnormal right ventricle morphology |
| HP:0012115 | 0.0287391839378 | 0.666666666667 | VPS33B VIPAS39 | Hepatitis |
| HP:0000121 | 0.0349981079563 | 0.666666666667 | VPS33B VIPAS39 | Nephrocalcinosis |
| GO:0017185 | 0.0393180950424 | 0.666666666667 | VPS33B VIPAS39 | peptidyl-lysine hydroxylation |
| HP:0000112 | 0.0418708017344 | 0.666666666667 | VPS33B VIPAS39 | Nephropathy |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| VIPAS39 | MATN4 | 0.985 |
mutually_exclusive (Q9H267)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| VPS33B | MATN4 | 0.981 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| VPS33B | VIPAS39 | 0.957 | 0.774 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes