hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07002.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EGFLAM | Pikachurin (Agrin-like protein) (EGF-like, fibronectin type-III and laminin G-like domain-containing protein) | 5 | UniProt NCBI |
| BTRC | F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) | 5 | UniProt NCBI |
| CDC25B | M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B) | 5 | UniProt NCBI |
| ZNF704 | Zinc finger protein 704 | 3 | UniProt NCBI |
| FBXW11 | F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS) | 5 | UniProt NCBI |
| CDC25A | M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A) | 5 | UniProt NCBI |
| USP37 | Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.4.19.12) (Deubiquitinating enzyme 37) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) | 5 | UniProt NCBI |
| HIVEP2 | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | 5 | UniProt NCBI |
| UBE2R2 | Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2) | 5 | UniProt NCBI |
| CDC34 | Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1) | 5 | UniProt NCBI |
| TRPV6 | Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2) | 5 | UniProt NCBI |
| BHLHE40 | Class E basic helix-loop-helix protein 40 (bHLHe40) (Class B basic helix-loop-helix protein 2) (bHLHb2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated by retinoic acid gene 13 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04710 | 4.67042578594e-05 | 0.3 | BTRC FBXW11 BHLHE40 | Circadian rhythm |
| KEGG:04120 | 7.05246698215e-05 | 0.4 | CDC34 BTRC FBXW11 UBE2R2 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-2871837 | 0.00366640411985 | 0.3 | BTRC FBXW11 CDC34 | FCERI mediated NF-kB activation |
| REAC:R-HSA-202424 | 0.00613516450091 | 0.3 | BTRC FBXW11 CDC34 | Downstream TCR signaling |
| REAC:R-HSA-983168 | 0.00628073795298 | 0.4 | CDC34 BTRC FBXW11 UBE2R2 | Antigen processing: Ubiquitination & Proteasome degradation |
| REAC:R-HSA-5607764 | 0.00634443554182 | 0.3 | BTRC FBXW11 CDC34 | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-5684264 | 0.00922174626729 | 0.2 | BTRC FBXW11 | MAP3K8 (TPL2)-dependent MAPK1/3 activation |
| REAC:R-HSA-202403 | 0.01035862204 | 0.3 | BTRC FBXW11 CDC34 | TCR signaling |
| REAC:R-HSA-2454202 | 0.0118886569504 | 0.3 | BTRC FBXW11 CDC34 | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-983169 | 0.0139889418844 | 0.4 | CDC34 BTRC FBXW11 UBE2R2 | Class I MHC mediated antigen processing & presentation |
| WP:WP3594 | 0.0141100878239 | 0.3 | BTRC FBXW11 BHLHE40 | Circadian rhythm genes |
| REAC:R-HSA-5621481 | 0.0150034597897 | 0.3 | BTRC FBXW11 CDC34 | C-type lectin receptors (CLRs) |
| KEGG:04340 | 0.0206782019073 | 0.2 | BTRC FBXW11 | Hedgehog signaling pathway |
| REAC:R-HSA-8866652 | 0.04382523057 | 0.2 | UBE2R2 CDC34 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| BTRC | FBXW11 | 1.0 | 0.305047619048 |
| UBE2R2 | CDC34 | 0.999 | 0.186 |
| CDC25A | FBXW11 | 0.999 | |
| ZNF704 | FBXW11 | 0.998 | |
| BTRC | ZNF704 | 0.997 | |
| USP37 | FBXW11 | 0.997 | 0.144 |
| CDC25B | FBXW11 | 0.997 | 0.116 |
| HIVEP2 | FBXW11 | 0.997 | 0.166 |
| BTRC | CDC34 | 0.995 | 0.122 |
| BTRC | BHLHE40 | 0.994 | |
| BTRC | CDC25A | 0.993 | |
| BTRC | HIVEP2 | 0.992 | 0.074 |
| USP37 | BTRC | 0.992 | 0.25 |
| BTRC | CDC25B | 0.991 | 0.22 |
| CDC34 | FBXW11 | 0.99 | 0.026 |
| BTRC | TRPV6 | 0.977 | |
| BTRC | UBE2R2 | 0.971 | 0.152 |
| BTRC | EGFLAM | 0.963 | |
| BHLHE40 | FBXW11 | 0.952 | |
| HIVEP2 | CDC25B | 0.863 | 0.086 |
| USP37 | BHLHE40 | 0.814 | |
| UBE2R2 | FBXW11 | 0.809 | 0.054 |
| HIVEP2 | BHLHE40 | 0.806 | |
| USP37 | CDC34 | 0.782 | 0.092 |
| HIVEP2 | CDC34 | 0.768 | 0.036 |
| BHLHE40 | CDC25B | 0.768 | |
| BHLHE40 | CDC34 | 0.768 | |
| USP37 | HIVEP2 | 0.685 | 0.108 |
| USP37 | CDC25B | 0.675 | 0.136 |
| CDC25B | CDC34 | 0.658 | 0.046 |
| EGFLAM | TRPV6 | 0.572 | |
| USP37 | TRPV6 | 0.572 | |
| TRPV6 | BHLHE40 | 0.557 | |
| TRPV6 | CDC25A | 0.502 | |
| TRPV6 | CDC34 | 0.502 | |
| EGFLAM | FBXW11 | 0.485 | |
| CDC25B | CDC25A | 0.475 | |
| HIVEP2 | TRPV6 | 0.35 | |
| TRPV6 | CDC25B | 0.35 | |
| USP37 | CDC25A | 0.333 | |
| USP37 | EGFLAM | 0.333 | |
| HIVEP2 | CDC25A | 0.304 | |
| EGFLAM | BHLHE40 | 0.303 | |
| TRPV6 | FBXW11 | 0.187 | |
| EGFLAM | CDC25A | 0.172 | |
| BHLHE40 | CDC25A | 0.172 | |
| HIVEP2 | EGFLAM | 0.164 | |
| EGFLAM | CDC25B | 0.164 | |
| CDC25A | CDC34 | 0.164 | |
| EGFLAM | CDC34 | 0.164 | |
| EGFLAM | UBE2R2 | 0.11 | |
| CDC25A | UBE2R2 | 0.11 | |
| BHLHE40 | UBE2R2 | 0.11 | |
| CDC25B | UBE2R2 | 0.11 | 0.064 |
| HIVEP2 | UBE2R2 | 0.11 | 0.014 |
| TRPV6 | UBE2R2 | 0.11 | |
| USP37 | UBE2R2 | 0.11 | 0.052 |
Related Complexes