hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07009.1
Complex Portal: CPX-16987
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EXOC6B | Exocyst complex component 6B (Exocyst complex component Sec15B) (SEC15-like protein 2) | 5 | UniProt NCBI |
| EXOC1 | Exocyst complex component 1 (Exocyst complex component Sec3) | 5 | UniProt NCBI |
| EXOC2 | Exocyst complex component 2 (Exocyst complex component Sec5) | 5 | UniProt NCBI |
| EXOC7 | Exocyst complex component 7 (Exocyst complex component Exo70) | 5 | UniProt NCBI |
| EXOC8 | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | 5 | UniProt NCBI |
| PRR30 | Proline-rich protein 30 | 2 | UniProt NCBI |
| EXOC5 | Exocyst complex component 5 (Exocyst complex component Sec10) (hSec10) | 5 | UniProt NCBI |
| IL1R2 | Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)] | 5 | UniProt NCBI |
| EXOC3 | Exocyst complex component 3 (Exocyst complex component Sec6) | 5 | UniProt NCBI |
| EXOC6 | Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0090522 | 3.92947304954e-22 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | vesicle tethering involved in exocytosis |
| CORUM:6167 | 2.48276456313e-21 | 0.7 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC5 EXOC8 | Exocyst complex |
| CORUM:89 | 2.48276456313e-21 | 0.7 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC5 EXOC8 | Exocyst Sec6/8 complex |
| GO:0000145 | 1.31033635192e-19 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | exocyst |
| REAC:R-HSA-5620916 | 3.26241956972e-17 | 0.7 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC5 EXOC8 | VxPx cargo-targeting to cilium |
| REAC:R-HSA-264876 | 1.19139497426e-16 | 0.7 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC5 EXOC8 | Insulin processing |
| GO:0099022 | 2.54890688034e-16 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | vesicle tethering |
| GO:0006904 | 1.02434361033e-15 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | vesicle docking involved in exocytosis |
| GO:0090148 | 4.15548118225e-15 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | membrane fission |
| GO:0140029 | 4.51791042961e-14 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | exocytic process |
| GO:0048278 | 4.51791042961e-14 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | vesicle docking |
| REAC:R-HSA-5620920 | 5.45947237299e-14 | 0.7 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC5 EXOC8 | Cargo trafficking to the periciliary membrane |
| GO:0006903 | 7.17247402565e-14 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | vesicle targeting |
| GO:0099023 | 1.27761086799e-13 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | vesicle tethering complex |
| GO:0140056 | 3.20427632492e-13 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | organelle localization by membrane tethering |
| REAC:R-HSA-2980736 | 7.91500664218e-13 | 0.7 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC5 EXOC8 | Peptide hormone metabolism |
| GO:0022406 | 9.1112586284e-13 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | membrane docking |
| REAC:R-HSA-1445148 | 1.09591369293e-12 | 0.7 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC5 EXOC8 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| GO:0000281 | 1.25470584294e-12 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | mitotic cytokinesis |
| WP:WP5366 | 4.90945441501e-12 | 0.7 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC5 EXOC8 | NF1 copy number variation syndrome |
| WP:WP4352 | 6.61225858856e-12 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | Ciliary landscape |
| GO:0061640 | 9.46652863509e-12 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | cytoskeleton-dependent cytokinesis |
| GO:0000910 | 3.44909497412e-10 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | cytokinesis |
| GO:0051650 | 5.69004898506e-10 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | establishment of vesicle localization |
| GO:0051648 | 7.57332993085e-10 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | vesicle localization |
| GO:0005938 | 7.57332993085e-10 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | cell cortex |
| REAC:R-HSA-5617833 | 1.51826760337e-09 | 0.7 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC5 EXOC8 | Cilium Assembly |
| GO:0006887 | 6.10776565608e-09 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | exocytosis |
| GO:0051301 | 8.98884795622e-09 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | cell division |
| CORUM:6169 | 1.68385473419e-08 | 0.3 | EXOC7 EXOC6 EXOC5 | Exocyst EXOC5-EXOC6-EXOC7 subcomplex |
| GO:0006893 | 1.98313435235e-08 | 0.6 | EXOC6 EXOC2 EXOC5 EXOC1 EXOC6B EXOC8 | Golgi to plasma membrane transport |
| REAC:R-HSA-1852241 | 2.13812440419e-08 | 0.7 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC5 EXOC8 | Organelle biogenesis and maintenance |
| GO:0051656 | 3.15795996159e-07 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | establishment of organelle localization |
| GO:0006892 | 6.60927727648e-07 | 0.6 | EXOC6 EXOC2 EXOC5 EXOC1 EXOC6B EXOC8 | post-Golgi vesicle-mediated transport |
| GO:0032940 | 2.03460285452e-06 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | secretion by cell |
| GO:0051640 | 2.25542291982e-06 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | organelle localization |
| REAC:R-HSA-199991 | 3.5925595953e-06 | 0.7 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC5 EXOC8 | Membrane Trafficking |
| GO:0046903 | 4.27211934785e-06 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | secretion |
| GO:0098876 | 4.29108809649e-06 | 0.6 | EXOC6 EXOC2 EXOC5 EXOC1 EXOC6B EXOC8 | vesicle-mediated transport to the plasma membrane |
| GO:0140352 | 4.40839899942e-06 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | export from cell |
| REAC:R-HSA-5653656 | 5.23447069721e-06 | 0.7 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC5 EXOC8 | Vesicle-mediated transport |
| GO:0061024 | 9.98728135355e-06 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | membrane organization |
| GO:1903047 | 1.5705820618e-05 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | mitotic cell cycle process |
| CORUM:6168 | 3.07577115383e-05 | 0.2 | EXOC5 EXOC6 | Exocyst EXOC5-EXOC6 subcomplex |
| GO:0000278 | 7.1157960354e-05 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | mitotic cell cycle |
| GO:0048193 | 0.000371213922121 | 0.6 | EXOC6 EXOC2 EXOC5 EXOC1 EXOC6B EXOC8 | Golgi vesicle transport |
| GO:0022402 | 0.000792598743402 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | cell cycle process |
| GO:0016192 | 0.00194426097733 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | vesicle-mediated transport |
| WP:WP2290 | 0.00272734094269 | 0.2 | EXOC2 EXOC8 | RalA downstream regulated genes |
| GO:0007049 | 0.00560105754087 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | cell cycle |
| REAC:R-HSA-392499 | 0.00618775137334 | 0.7 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC5 EXOC8 | Metabolism of proteins |
| GO:0051649 | 0.0122001542269 | 0.8 | EXOC3 EXOC6 EXOC2 EXOC7 EXOC1 EXOC6B EXOC5 EXOC8 | establishment of localization in cell |
| KEGG:05132 | 0.0198241007008 | 0.3 | EXOC2 EXOC5 EXOC7 | Salmonella infection |
| GO:0051668 | 0.0207394393406 | 0.6 | EXOC6 EXOC2 EXOC5 EXOC1 EXOC6B EXOC8 | localization within membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EXOC6B | EXOC8 | 1.0 | 0.46 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM | |
| EXOC7 | EXOC8 | 1.0 | 0.878 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM |
| EXOC8 | EXOC6 | 1.0 | 0.218 |
structurally_consistent (Q9UPT5)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM |
| EXOC7 | EXOC6 | 1.0 | 0.102 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM |
| EXOC1 | EXOC3 | 1.0 | 0.82 |
mutually_exclusive (Q96KP1)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM |
| EXOC5 | EXOC6 | 1.0 | 0.214 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM | |
| EXOC8 | EXOC5 | 1.0 | 0.736 |
structurally_consistent (Q96A65)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM |
| EXOC2 | EXOC3 | 1.0 | 0.956 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| EXOC6B | EXOC5 | 1.0 | 0.268 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt Malo fraction boldt_WMM |
| EXOC1 | EXOC2 | 1.0 | 0.834 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo fraction boldt_WMM |
| EXOC7 | EXOC3 | 1.0 | 0.486 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC3 | EXOC6 | 1.0 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC5 | EXOC3 | 1.0 | 0.608 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC6B | EXOC7 | 1.0 | 0.48 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt Malo fraction boldt_WMM | |
| EXOC1 | EXOC6 | 1.0 | 0.176 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC2 | EXOC8 | 1.0 | 0.512 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC1 | EXOC8 | 1.0 | 0.606 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC6B | EXOC3 | 1.0 | 0.392 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC2 | EXOC6 | 1.0 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| EXOC1 | EXOC7 | 0.999 | 0.57 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| EXOC1 | EXOC5 | 0.999 | 0.782 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| EXOC7 | EXOC5 | 0.999 | 0.802 | bioplex_WMM bioplex3_WMM boldt Malo fraction boldt_WMM | |
| IL1R2 | EXOC6B | 0.999 |
structurally_consistent (O00471)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IL1R2 | EXOC8 | 0.999 |
structurally_consistent (O00471)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| EXOC6B | EXOC2 | 0.999 | 0.362 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| IL1R2 | EXOC6 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| EXOC8 | EXOC3 | 0.999 | 0.786 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| IL1R2 | EXOC7 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| EXOC6B | EXOC6 | 0.998 | 0.016 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| IL1R2 | EXOC1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| IL1R2 | EXOC5 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| EXOC6B | EXOC1 | 0.998 | 0.374 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| EXOC2 | EXOC5 | 0.998 | 0.788 | bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| IL1R2 | EXOC2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| EXOC2 | EXOC7 | 0.996 | 0.4 | bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM | |
| IL1R2 | EXOC3 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| IL1R2 | PRR30 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes