hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07022.1
Complex Portal: CPX-12786
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NDST3 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 (Glucosaminyl N-deacetylase/N-sulfotransferase 3) (NDST-3) (hNDST-3) (N-heparan sulfate sulfotransferase 3) (N-HSST 3) [Includes: Heparan sulfate N-deacetylase NDST3 (EC 3.-.-.-); [heparan sulfate]-glucosamine N-sulfotransferase NDST3 (EC 2.8.2.8)] | 5 | UniProt NCBI |
| NDST2 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 2) (NDST-2) (N-heparan sulfate sulfotransferase 2) (N-HSST 2) [Includes: Heparan sulfate N-deacetylase 2 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 2 (EC 2.8.2.-)] | 5 | UniProt NCBI |
| DIPK2B | Divergent protein kinase domain 2B (Deleted in autism-related protein 1) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00534 | 0.0001601688991 | 0.666666666667 | NDST3 NDST2 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
| WP:WP5395 | 0.00079501095268 | 0.666666666667 | NDST3 NDST2 | Glycosaminoglycan synthesis in fibroblasts |
| REAC:R-HSA-2022928 | 0.00257431960226 | 0.666666666667 | NDST3 NDST2 | HS-GAG biosynthesis |
| REAC:R-HSA-1638091 | 0.00833431912959 | 0.666666666667 | NDST3 NDST2 | Heparan sulfate/heparin (HS-GAG) metabolism |
| GO:0015016 | 0.00842684400117 | 0.666666666667 | NDST3 NDST2 | [heparan sulfate]-glucosamine N-sulfotransferase activity |
| WP:WP702 | 0.0101834993772 | 0.666666666667 | NDST3 NDST2 | Metapathway biotransformation Phase I and II |
| GO:0015014 | 0.0393180950424 | 0.666666666667 | NDST3 NDST2 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process |
| REAC:R-HSA-1630316 | 0.0406752460979 | 0.666666666667 | NDST3 NDST2 | Glycosaminoglycan metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NDST3 | NDST2 | 0.995 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NDST2 | DIPK2B | 0.959 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| NDST3 | DIPK2B | 0.415 | bioplex3_WMM WMM_only |
Related Complexes