hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07025.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TGFB3 | Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)] | 5 | UniProt NCBI |
| TGFB2 | Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)] | 5 | UniProt NCBI |
| LTBP3 | Latent-transforming growth factor beta-binding protein 3 (LTBP-3) | 5 | UniProt NCBI |
| TGFB1 | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2129379 | 0.000693757271364 | 1.0 | LTBP3 TGFB2 | Molecules associated with elastic fibres |
| REAC:R-HSA-1566948 | 0.00107651990384 | 1.0 | LTBP3 TGFB2 | Elastic fibre formation |
| REAC:R-HSA-2173789 | 0.00140118463675 | 1.0 | LTBP3 TGFB2 | TGF-beta receptor signaling activates SMADs |
| REAC:R-HSA-170834 | 0.00639247771471 | 1.0 | LTBP3 TGFB2 | Signaling by TGF-beta Receptor Complex |
| REAC:R-HSA-9006936 | 0.0098732254038 | 1.0 | LTBP3 TGFB2 | Signaling by TGFB family members |
| HP:0001634 | 0.0201155433461 | 1.0 | LTBP3 TGFB2 | Mitral valve prolapse |
| HP:0001633 | 0.0323058496858 | 1.0 | LTBP3 TGFB2 | Abnormal mitral valve morphology |
| GO:2000738 | 0.0365196561665 | 1.0 | LTBP3 TGFB2 | positive regulation of stem cell differentiation |
| HP:0006705 | 0.0418509928331 | 1.0 | LTBP3 TGFB2 | Abnormal atrioventricular valve morphology |
| REAC:R-HSA-1474244 | 0.0442193366216 | 1.0 | LTBP3 TGFB2 | Extracellular matrix organization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TGFB1 | LTBP3 | 0.983 | 0.426 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| TGFB3 | TGFB1 | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TGFB2 | TGFB1 | 0.974 | 0.482551724138 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| TGFB3 | TGFB2 | 0.214 | bioplex3_WMM WMM_only | |
| TGFB2 | LTBP3 | 0.153 | 0.232 | bioplex3_WMM WMM_only |
| TGFB3 | LTBP3 | 0.042 | bioplex3_WMM WMM_only |
Related Complexes