hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07026.1
Complex Portal: CPX-20609
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| INA | Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5) | 5 | UniProt NCBI |
| NEFL | Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein) | 5 | UniProt NCBI |
| KRT7 | Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7) | 5 | UniProt NCBI |
| VIM | Vimentin | 5 | UniProt NCBI |
| IDE | Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin) | 5 | UniProt NCBI |
| NES | Nestin | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045104 | 2.34020517034e-08 | 1.0 | VIM KRT7 NES INA NEFL | intermediate filament cytoskeleton organization |
| GO:0045103 | 2.58397654225e-08 | 1.0 | VIM KRT7 NES INA NEFL | intermediate filament-based process |
| GO:0005882 | 6.32904857747e-08 | 1.0 | VIM KRT7 NES INA NEFL | intermediate filament |
| GO:0045111 | 4.67969746305e-07 | 1.0 | VIM KRT7 NES INA NEFL | intermediate filament cytoskeleton |
| GO:0045109 | 9.69325556185e-06 | 0.8 | VIM KRT7 INA NEFL | intermediate filament organization |
| GO:0099513 | 0.000946108360196 | 1.0 | VIM KRT7 NES INA NEFL | polymeric cytoskeletal fiber |
| GO:0099512 | 0.00395121770293 | 1.0 | VIM KRT7 NES INA NEFL | supramolecular fiber |
| GO:0099081 | 0.00420676058059 | 1.0 | VIM KRT7 NES INA NEFL | supramolecular polymer |
| GO:0099184 | 0.0140440992017 | 0.4 | INA NEFL | structural constituent of postsynaptic intermediate filament cytoskeleton |
| GO:0099160 | 0.0140440992017 | 0.4 | INA NEFL | postsynaptic intermediate filament cytoskeleton |
| WP:WP5417 | 0.0212523049113 | 0.4 | NEFL NES | Cell lineage map for neuronal differentiation |
| GO:0099080 | 0.0373995595185 | 1.0 | VIM KRT7 NES INA NEFL | supramolecular complex |
| GO:0099571 | 0.0468008499735 | 0.4 | INA NEFL | postsynaptic cytoskeleton |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NES | VIM | 0.994 | 0.532833333333 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () treiber_WMM | |
| IDE | NES | 0.992 | 0.138 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () | |
| INA | VIM | 0.991 | 0.325107990434 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM | |
| NEFL | NES | 0.99 | 0.144 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| IDE | VIM | 0.987 | 0.194610526316 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| INA | NES | 0.984 | 0.114 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| KRT7 | VIM | 0.964 | 0.402608695652 | hein_WMM bioplex3_HEK293 boldt_WMM WMM_only | |
| NEFL | VIM | 0.956 | 0.286 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| INA | NEFL | 0.861 | 0.158 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| IDE | NEFL | 0.859 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| IDE | INA | 0.808 | 0.05 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| INA | KRT7 | 0.38 | 0.136 | bioplex3_HEK293 WMM_only | |
| IDE | KRT7 | 0.232 | 0.058 | hein_WMM WMM_only boldt_WMM | |
| KRT7 | NES | 0.154 | 0.434 | hein_WMM hein () | |
| NEFL | KRT7 | 0.112 | 0.2 | bioplex3_HEK293 youn_WMM gupta_WMM WMM_only |
Related Complexes