hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07028.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ALDH7A1 | Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) | 5 | UniProt NCBI |
| FAM81A | Protein FAM81A | 3 | UniProt NCBI |
| PCCB | Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta) | 5 | UniProt NCBI |
| PCCA | Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7057 | 5.12628525639e-06 | 0.5 | PCCB PCCA | Propionyl-CoA carboxylase |
| KEGG:00280 | 5.19957804829e-06 | 0.75 | ALDH7A1 PCCA PCCB | Valine, leucine and isoleucine degradation |
| REAC:R-HSA-71032 | 6.15041976665e-05 | 0.5 | PCCB PCCA | Propionyl-CoA catabolism |
| WP:WP5031 | 9.18788843787e-05 | 0.5 | PCCB PCCA | Biotin metabolism including IMDs |
| HP:0003353 | 0.000100319571443 | 0.5 | PCCB PCCA | Propionyl-CoA carboxylase deficiency |
| REAC:R-HSA-3371599 | 0.000215205765992 | 0.5 | PCCB PCCA | Defective HLCS causes multiple carboxylase deficiency |
| REAC:R-HSA-3323169 | 0.000286914834749 | 0.5 | PCCB PCCA | Defects in biotin (Btn) metabolism |
| HP:0410066 | 0.000501460556964 | 0.5 | PCCB PCCA | Increased level of hippuric acid in urine |
| HP:0011695 | 0.000501460556964 | 0.5 | PCCB PCCA | Cerebellar hemorrhage |
| REAC:R-HSA-196780 | 0.000563428413222 | 0.5 | PCCB PCCA | Biotin transport and metabolism |
| WP:WP4686 | 0.000644879603036 | 0.5 | PCCB PCCA | Leucine isoleucine and valine metabolism |
| KEGG:00630 | 0.000813386863776 | 0.5 | PCCB PCCA | Glyoxylate and dicarboxylate metabolism |
| KEGG:00640 | 0.00116323751441 | 0.5 | PCCB PCCA | Propanoate metabolism |
| HP:0003108 | 0.00150383256857 | 0.5 | PCCB PCCA | Hyperglycinuria |
| HP:0033099 | 0.00150383256857 | 0.5 | PCCB PCCA | Increased serine family amino acid in urine |
| REAC:R-HSA-3296482 | 0.00156635412759 | 0.5 | PCCB PCCA | Defects in vitamin and cofactor metabolism |
| HP:0006846 | 0.00220521848756 | 0.5 | PCCB PCCA | Acute encephalopathy |
| GO:0004658 | 0.0028092043205 | 0.5 | PCCB PCCA | propionyl-CoA carboxylase activity |
| HP:0002154 | 0.00400802433742 | 0.5 | PCCB PCCA | Hyperglycinemia |
| HP:0003128 | 0.00412165152512 | 0.75 | ALDH7A1 PCCA PCCB | Lactic acidosis |
| HP:0010895 | 0.0051092979876 | 0.5 | PCCB PCCA | Abnormal circulating glycine concentration |
| REAC:R-HSA-77289 | 0.00573491177379 | 0.5 | PCCB PCCA | Mitochondrial Fatty Acid Beta-Oxidation |
| HP:0010894 | 0.00701084122037 | 0.5 | PCCB PCCA | Abnormal circulating serine family amino acid concentration |
| HP:0001943 | 0.00814145236404 | 0.75 | ALDH7A1 PCCA PCCB | Hypoglycemia |
| KEGG:01200 | 0.0133093129958 | 0.5 | PCCB PCCA | Carbon metabolism |
| HP:0011015 | 0.0149729444549 | 0.75 | ALDH7A1 PCCA PCCB | Abnormal blood glucose concentration |
| HP:0004354 | 0.0153053110125 | 0.75 | ALDH7A1 PCCA PCCB | Abnormal circulating carboxylic acid concentration |
| HP:0033100 | 0.018706736024 | 0.5 | PCCB PCCA | Increased proteinogenic amino acid level in urine |
| WP:WP5316 | 0.0208408229239 | 0.5 | PCCB PCCA | Primary ovarian insufficiency |
| HPA:0271131 | 0.0221669069693 | 0.75 | ALDH7A1 FAM81A PCCB | kidney; distal tubules[>=Low] |
| HPA:0271141 | 0.024382283244 | 0.75 | ALDH7A1 FAM81A PCCB | kidney; proximal tubules (cell body)[>=Low] |
| HP:0004396 | 0.028689358225 | 0.5 | PCCB PCCA | Poor appetite |
| HP:0001941 | 0.0337929626939 | 0.75 | ALDH7A1 PCCA PCCB | Acidosis |
| WP:WP5219 | 0.0373138951921 | 0.25 | ALDH7A1 | Diet dependent trimethylamine trimethylamine N oxide metabolism |
| HP:0004360 | 0.040406598238 | 0.75 | ALDH7A1 PCCA PCCB | Abnormality of acid-base homeostasis |
| GO:0019626 | 0.042122686785 | 0.5 | PCCB PCCA | short-chain fatty acid catabolic process |
| GO:0016421 | 0.042122686785 | 0.5 | PCCB PCCA | CoA carboxylase activity |
| HPA:0290403 | 0.0452634487734 | 0.75 | ALDH7A1 PCCA PCCB | liver; hepatocytes[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PCCB | PCCA | 1.0 | 0.626 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| ALDH7A1 | PCCB | 0.971 | 0.078 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| FAM81A | PCCB | 0.951 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FAM81A | PCCA | 0.938 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ALDH7A1 | PCCA | 0.717 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes