hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_07032.1

Complex Portal: CPX-11054

Confidence: Very High

Genename	Protein Name	Uniprot Annotation Score	Links
CCDC93	Coiled-coil domain-containing protein 93	5	UniProt NCBI
VPS29	Vacuolar protein sorting-associated protein 29 (hVPS29) (PEP11 homolog) (Vesicle protein sorting 29)	5	UniProt NCBI
COMMD7	COMM domain-containing protein 7	5	UniProt NCBI
COMMD5	COMM domain-containing protein 5 (Hypertension-related calcium-regulated gene protein) (HCaRG)	4	UniProt NCBI
ATAD3C	ATPase family AAA domain-containing protein 3C	2	UniProt NCBI
COMMD6	COMM domain-containing protein 6	5	UniProt NCBI
COMMD4	COMM domain-containing protein 4	5	UniProt NCBI
COMMD1	COMM domain-containing protein 1 (Protein Murr1)	5	UniProt NCBI
COMMD2	COMM domain-containing protein 2	4	UniProt NCBI
RANBP1	Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)	5	UniProt NCBI
VPS35L	VPS35 endosomal protein-sorting factor-like (Esophageal cancer-associated protein)	5	UniProt NCBI
CCDC22	Coiled-coil domain-containing protein 22	5	UniProt NCBI
COMMD9	COMM domain-containing protein 9	5	UniProt NCBI
DENND10	DENN domain-containing protein 10 (Protein FAM45A)	5	UniProt NCBI
COMMD8	COMM domain-containing protein 8	4	UniProt NCBI
VPS26C	Vacuolar protein sorting-associated protein 26C (Down syndrome critical region protein 3) (Down syndrome critical region protein A)	5	UniProt NCBI
COMMD3	COMM domain-containing protein 3 (Protein Bup) (Protein PIL)	5	UniProt NCBI
COMMD10	COMM domain-containing protein 10	5	UniProt NCBI
TGIF1	Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1)	5	UniProt NCBI
TFDP1	Transcription factor Dp-1 (DRTF1-polypeptide 1) (DRTF1) (E2F dimerization partner 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6645	1.27607836257e-38	0.65	CCDC93 COMMD3 COMMD1 COMMD10 COMMD5 COMMD9 CCDC22 COMMD6 COMMD4 VPS35L COMMD8 COMMD7 COMMD2	CCC complex
CORUM:6639	1.338689627e-36	0.65	CCDC93 COMMD3 COMMD1 COMMD10 COMMD5 COMMD9 CCDC22 COMMD6 COMMD4 VPS35L COMMD8 COMMD7 COMMD2	CCC-Wash (WASH1, FAM21C) complex
REAC:R-HSA-8951664	4.16391833754e-13	0.55	COMMD2 COMMD3 COMMD1 COMMD10 COMMD5 COMMD9 CCDC22 COMMD6 COMMD4 COMMD8 COMMD7	Neddylation
CORUM:7131	9.30545235324e-11	0.2	VPS35L CCDC93 CCDC22 COMMD1	COMMD1-CCDC22-CCDC93-C16orf62 complex
CORUM:7134	7.99830998738e-08	0.15	VPS35L CCDC93 COMMD1	COMMD1-CCDC93-C16orf62 complex
CORUM:7132	7.99830998738e-08	0.15	CCDC93 CCDC22 VPS35L	CCDC22-CCDC93-C16orf62 complex
CORUM:7133	7.99830998738e-08	0.15	CCDC93 COMMD1 COMMD6	CCDC93-COMMD1-COMMD6 complex
CORUM:7135	7.9843579229e-07	0.15	CCDC93 CCDC22 VPS35L	CCDC22-CCDC93-C16orf62-FAM21-WASH1 complex
REAC:R-HSA-597592	3.73682913445e-05	0.55	COMMD2 COMMD3 COMMD1 COMMD10 COMMD5 COMMD9 CCDC22 COMMD6 COMMD4 COMMD8 COMMD7	Post-translational protein modification
CORUM:6644	0.000194638873543	0.1	COMMD1 CCDC22	CCDC22-COMMD1-CUL2 complex
CORUM:6658	0.000194638873543	0.1	COMMD8 CCDC22	CCDC22-COMMD8-CUL1 complex
CORUM:6659	0.000194638873543	0.1	COMMD8 CCDC22	Ubiquitin E3 ligase (CCDC22, COMMD8, CUL3)
GO:0098876	0.000736718300971	0.3	CCDC93 COMMD1 VPS35L VPS26C VPS29 CCDC22	vesicle-mediated transport to the plasma membrane
REAC:R-HSA-392499	0.00102522659062	0.55	COMMD2 COMMD3 COMMD1 COMMD10 COMMD5 COMMD9 CCDC22 COMMD6 COMMD4 COMMD8 COMMD7	Metabolism of proteins
GO:0032456	0.00226919430688	0.25	VPS35L CCDC93 VPS26C CCDC22 VPS29	endocytic recycling
GO:0016197	0.032439693653	0.3	CCDC93 VPS35L VPS26C VPS29 DENND10 CCDC22	endosomal transport
GO:0006893	0.0385877019956	0.2	VPS35L CCDC93 CCDC22 COMMD1	Golgi to plasma membrane transport
GO:0032088	0.0415776953599	0.2	CCDC22 COMMD6 COMMD7 COMMD1	negative regulation of NF-kappaB transcription factor activity
CORUM:680	0.0499436884912	0.05	RANBP1	RANBMP-CD39 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CCDC93	COMMD5	1.0	0.65	structurally_consistent (Q9H0A8)
VPS26C	CCDC22	1.0	0.296
CCDC22	COMMD5	1.0	0.514
CCDC93	VPS26C	1.0	0.196	structurally_consistent (Q7Z3J2)
CCDC93	COMMD2	1.0	0.348	structurally_consistent (Q9H0A8)
CCDC93	CCDC22	1.0	0.732
COMMD5	VPS35L	1.0	0.288
CCDC22	COMMD6	1.0	0.358
COMMD4	CCDC22	1.0	0.166
CCDC22	COMMD1	1.0	0.476
VPS26C	VPS35L	1.0	0.886	structurally_consistent (dimer)
COMMD10	CCDC22	1.0	0.804
DENND10	CCDC22	1.0	0.138
VPS26C	COMMD5	1.0	0.324
CCDC93	COMMD1	1.0	0.34
CCDC22	VPS35L	1.0	0.43	structurally_consistent (dimer)
VPS29	VPS35L	1.0	0.186	structurally_consistent (O14972) structurally_consistent (dimer)
CCDC93	COMMD10	1.0	0.792
COMMD2	COMMD5	1.0	0.184
DENND10	VPS26C	1.0	0.072
COMMD2	COMMD1	1.0	0.206
COMMD4	VPS26C	1.0	0.036
COMMD2	COMMD3	1.0	0.888
CCDC22	COMMD3	1.0	0.372
COMMD2	VPS26C	1.0	0.08
CCDC93	COMMD6	1.0	0.428
COMMD6	COMMD3	1.0	0.656
COMMD7	CCDC22	1.0	0.514
CCDC93	VPS35L	1.0	0.442	structurally_consistent (dimer)
COMMD4	COMMD5	1.0	0.156	structurally_consistent (dimer)
COMMD1	VPS35L	1.0	0.138
COMMD10	VPS35L	1.0	0.356
COMMD2	CCDC22	1.0	0.31
VPS29	COMMD3	1.0	0.188	structurally_consistent (Q7Z3J2)
COMMD2	VPS35L	1.0	0.11
CCDC93	DENND10	1.0	0.446
CCDC93	COMMD7	1.0	0.376
VPS29	COMMD5	1.0	0.184
CCDC93	COMMD3	1.0	0.478
VPS29	COMMD1	1.0	0.32	structurally_consistent (dimer)
DENND10	COMMD5	1.0	0.19
COMMD9	CCDC22	1.0	0.508
VPS29	COMMD6	1.0	0.238
COMMD2	COMMD8	1.0	0.456
COMMD4	VPS35L	1.0	0.074
COMMD4	COMMD1	1.0	0.522
VPS29	COMMD10	1.0	0.188
VPS26C	COMMD6	1.0	0.244
VPS29	COMMD8	1.0	0.122	structurally_consistent (O14972)
COMMD8	COMMD5	1.0	0.106
COMMD8	CCDC22	1.0	0.122
COMMD5	COMMD6	1.0	0.266
COMMD7	COMMD5	1.0	0.642
DENND10	COMMD1	1.0	0.15
VPS29	COMMD2	1.0	0.206
VPS26C	COMMD1	1.0	0.092	structurally_consistent (Q9UBQ0)
VPS35L	COMMD3	1.0	0.142	structurally_consistent (dimer)
COMMD8	COMMD1	1.0	0.55
COMMD2	COMMD4	1.0	0.45	structurally_consistent (dimer)
COMMD6	VPS35L	1.0	0.172
VPS29	COMMD4	1.0	0.088
CCDC93	COMMD9	1.0	0.414
COMMD7	COMMD2	1.0	0.206
COMMD4	COMMD3	1.0	0.608
VPS26C	COMMD3	1.0	0.048
DENND10	COMMD6	1.0	0.504
COMMD4	COMMD8	0.999	0.394	structurally_consistent (dimer)
COMMD10	COMMD8	0.999	0.338
COMMD10	VPS26C	0.999	0.43
VPS29	CCDC22	0.999	0.354	structurally_consistent (Q7Z3J2)
COMMD2	DENND10	0.999	0.188
DENND10	VPS35L	0.999	0.204
CCDC93	COMMD4	0.999	0.256	structurally_consistent (dimer)
COMMD7	VPS35L	0.999	0.398
COMMD8	VPS35L	0.999	0.078	mutually_exclusive (O14972)
COMMD6	TFDP1	0.999	0.058
COMMD4	DENND10	0.999	0.14
COMMD2	COMMD6	0.999	0.506
COMMD10	DENND10	0.999	0.104
DENND10	COMMD3	0.999	0.122
COMMD9	COMMD6	0.999	0.438
COMMD7	COMMD1	0.999	0.32
COMMD5	COMMD1	0.999	0.206
COMMD4	COMMD6	0.999	0.746
COMMD8	COMMD3	0.999	0.492
DENND10	COMMD8	0.999	0.382
COMMD6	COMMD1	0.999	0.812
CCDC93	COMMD8	0.999	0.116	structurally_consistent (Q9H0A8)
VPS29	VPS26C	0.999	0.146	structurally_consistent (Q7Z3J2) structurally_consistent (dimer)
COMMD10	COMMD1	0.999	0.504
COMMD10	COMMD6	0.999	0.354
COMMD10	COMMD4	0.999	0.65
TFDP1	COMMD1	0.999	0.072
COMMD9	COMMD5	0.999	0.308
COMMD5	COMMD3	0.999	0.26
COMMD8	COMMD6	0.999	0.562
COMMD9	COMMD8	0.999	0.59
COMMD10	COMMD3	0.999	0.848
COMMD10	COMMD5	0.999	0.754
VPS29	COMMD9	0.999	0.328	structurally_consistent (O14972)
COMMD9	COMMD1	0.999	0.548
VPS29	DENND10	0.999	0.244
COMMD2	COMMD10	0.999	0.658
COMMD1	COMMD3	0.999	0.42
COMMD9	COMMD10	0.999	0.93
COMMD8	TFDP1	0.999	0.114
COMMD9	COMMD3	0.999	0.676
COMMD9	VPS35L	0.999	0.214
VPS29	CCDC93	0.999	0.274
COMMD9	VPS26C	0.999	0.266	structurally_consistent (dimer)
COMMD9	COMMD7	0.999	0.724
COMMD7	VPS26C	0.999	0.24
COMMD7	COMMD10	0.999	0.444
VPS29	COMMD7	0.999	0.328
COMMD7	COMMD3	0.998	0.202
COMMD7	COMMD6	0.998	0.56
VPS26C	COMMD8	0.998	0.032	structurally_consistent (dimer)
COMMD9	DENND10	0.998	0.092
COMMD7	COMMD4	0.998	0.408
COMMD9	COMMD2	0.998	0.398
COMMD7	DENND10	0.998	0.208
COMMD7	COMMD8	0.998	0.414
COMMD9	COMMD4	0.998	0.486
COMMD4	TFDP1	0.997	0.086
COMMD5	TFDP1	0.994	0.05
TGIF1	COMMD8	0.991	0.084
COMMD2	TGIF1	0.99	0.09
COMMD4	TGIF1	0.988	0.062
RANBP1	COMMD5	0.986	0.08
COMMD10	TFDP1	0.984	0.09
VPS26C	TFDP1	0.984	0.032
TFDP1	VPS35L	0.984	0.022
DENND10	TFDP1	0.984	0.076
COMMD7	TFDP1	0.984	0.102
ATAD3C	COMMD1	0.978
RANBP1	COMMD1	0.974	0.068
TGIF1	COMMD3	0.974	0.092
CCDC93	TFDP1	0.972	0.054
COMMD9	TFDP1	0.97	0.098
RANBP1	VPS35L	0.965	0.04
ATAD3C	COMMD3	0.959
VPS29	TFDP1	0.954	0.088
COMMD8	RANBP1	0.952	0.078
COMMD2	TFDP1	0.926	0.09
COMMD2	RANBP1	0.926	0.098
CCDC22	TFDP1	0.918	0.082
RANBP1	COMMD6	0.91	0.076
COMMD9	RANBP1	0.908	0.094
TFDP1	COMMD3	0.901	0.088
COMMD10	RANBP1	0.891	0.032
VPS26C	RANBP1	0.889	0.026
DENND10	RANBP1	0.875	0.072
COMMD2	ATAD3C	0.869
COMMD10	ATAD3C	0.856
ATAD3C	COMMD6	0.824
VPS29	RANBP1	0.712	0.07
RANBP1	COMMD3	0.665	0.062
TGIF1	CCDC22	0.634	0.05
COMMD10	TGIF1	0.634	0.112
TGIF1	COMMD1	0.634	0.138
DENND10	TGIF1	0.634	0.088
COMMD7	TGIF1	0.634	0.204
TGIF1	COMMD6	0.634	0.074
COMMD9	TGIF1	0.634	0.136
CCDC93	TGIF1	0.634	0.138
VPS29	TGIF1	0.634	0.06
TGIF1	VPS35L	0.634	0.098
TGIF1	COMMD5	0.634	0.06
TGIF1	VPS26C	0.634	0.034
COMMD8	ATAD3C	0.605
COMMD4	RANBP1	0.556	0.028
VPS26C	ATAD3C	0.476
CCDC93	RANBP1	0.436	0.046
ATAD3C	COMMD5	0.41
CCDC22	RANBP1	0.225	0.028
ATAD3C	VPS35L	0.209
TGIF1	TFDP1	0.188	0.088
COMMD7	ATAD3C	0.186
DENND10	ATAD3C	0.186
COMMD4	ATAD3C	0.136
CCDC93	ATAD3C	0.128
CCDC22	ATAD3C	0.113
COMMD9	ATAD3C	0.105
VPS29	ATAD3C	0.082
ATAD3C	TFDP1	0.056
TGIF1	ATAD3C	0.021
COMMD7	RANBP1	0.009	0.058
RANBP1	TFDP1	0.003	0.102
RANBP1	ATAD3C	0.001

Related Complexes

Genename	Complexes
CCDC93	huMAP3_01290.1 huMAP3_07032.1 huMAP3_14444.1
VPS29	huMAP3_01277.1 huMAP3_01290.1 huMAP3_07032.1 huMAP3_13244.1 huMAP3_14444.1
COMMD7	huMAP3_01290.1 huMAP3_07032.1 huMAP3_14444.1
COMMD5	huMAP3_03516.1 huMAP3_07032.1 huMAP3_14444.1
ATAD3C	huMAP3_02696.1 huMAP3_03516.1 huMAP3_03751.1 huMAP3_07032.1 huMAP3_14444.1
COMMD6	huMAP3_03516.1 huMAP3_07032.1 huMAP3_14444.1
COMMD4	huMAP3_01290.1 huMAP3_07032.1 huMAP3_14444.1
COMMD1	huMAP3_03516.1 huMAP3_07032.1 huMAP3_14444.1
COMMD2	huMAP3_01290.1 huMAP3_07032.1 huMAP3_14444.1
RANBP1	huMAP3_01999.1 huMAP3_03516.1 huMAP3_07032.1 huMAP3_07331.1 huMAP3_08226.1 huMAP3_08641.1 huMAP3_09825.1 huMAP3_10000.1 huMAP3_12581.1
VPS35L	huMAP3_03516.1 huMAP3_07032.1 huMAP3_14444.1
CCDC22	huMAP3_01290.1 huMAP3_07032.1 huMAP3_14444.1
COMMD9	huMAP3_01290.1 huMAP3_07032.1 huMAP3_14444.1
DENND10	huMAP3_01290.1 huMAP3_07032.1 huMAP3_11422.1 huMAP3_14444.1
COMMD8	huMAP3_01290.1 huMAP3_07032.1 huMAP3_14444.1
VPS26C	huMAP3_01290.1 huMAP3_07032.1 huMAP3_14444.1
COMMD3	huMAP3_07032.1 huMAP3_14444.1
COMMD10	huMAP3_01290.1 huMAP3_07032.1 huMAP3_14444.1
TGIF1	huMAP3_01290.1 huMAP3_07032.1 huMAP3_14444.1
TFDP1	huMAP3_03516.1 huMAP3_07032.1 huMAP3_14051.1 huMAP3_14444.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_07032.1

Complex Portal: CPX-11054