hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07033.1
Complex Portal: CPX-20402
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMPDL3B | Acid sphingomyelinase-like phosphodiesterase 3b (ASM-like phosphodiesterase 3b) (EC 3.1.4.-) | 5 | UniProt NCBI |
| RGS12 | Regulator of G-protein signaling 12 (RGS12) | 5 | UniProt NCBI |
| GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | 5 | UniProt NCBI |
| GNB4 | Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4) | 5 | UniProt NCBI |
| GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) | 5 | UniProt NCBI |
| GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3) | 5 | UniProt NCBI |
| GNG4 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 | 5 | UniProt NCBI |
| GNAO1 | Guanine nucleotide-binding protein G(o) subunit alpha | 5 | UniProt NCBI |
| GNG12 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04727 | 5.56872114791e-14 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | GABAergic synapse |
| REAC:R-HSA-392170 | 5.69200514162e-14 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | ADP signalling through P2Y purinoceptor 12 |
| KEGG:05032 | 6.20700841013e-14 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | Morphine addiction |
| KEGG:04713 | 1.04258756973e-13 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | Circadian entrainment |
| GO:0005834 | 1.29500980951e-13 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | heterotrimeric G-protein complex |
| KEGG:04724 | 2.22286105039e-13 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | Glutamatergic synapse |
| KEGG:04726 | 2.89441754152e-13 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | Serotonergic synapse |
| KEGG:04725 | 4.40046497153e-13 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | Cholinergic synapse |
| GO:1905360 | 5.30629130082e-13 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | GTPase complex |
| REAC:R-HSA-392518 | 8.70438574994e-13 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Signal amplification |
| REAC:R-HSA-991365 | 1.62276991723e-12 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Activation of GABAB receptors |
| REAC:R-HSA-977444 | 1.62276991723e-12 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | GABA B receptor activation |
| KEGG:04926 | 1.77668896369e-12 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | Relaxin signaling pathway |
| KEGG:04728 | 1.89838978679e-12 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | Dopaminergic synapse |
| REAC:R-HSA-9660821 | 2.37735886493e-12 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | ADORA2B mediated anti-inflammatory cytokines production |
| REAC:R-HSA-418597 | 2.37735886493e-12 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | G alpha (z) signalling events |
| REAC:R-HSA-9634597 | 2.85232767191e-12 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | GPER1 signaling |
| KEGG:04723 | 3.56464259802e-12 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | Retrograde endocannabinoid signaling |
| WP:WP536 | 4.16406883951e-12 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | Calcium regulation in cardiac cells |
| REAC:R-HSA-977443 | 6.57866360223e-12 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | GABA receptor activation |
| KEGG:05034 | 1.77776398507e-11 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | Alcoholism |
| REAC:R-HSA-8964315 | 2.34279723366e-11 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | G beta:gamma signalling through BTK |
| REAC:R-HSA-392851 | 2.34279723366e-11 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Prostacyclin signalling through prostacyclin receptor |
| GO:0031234 | 2.44789974494e-11 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | extrinsic component of cytoplasmic side of plasma membrane |
| REAC:R-HSA-500657 | 3.3182050777e-11 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Presynaptic function of Kainate receptors |
| REAC:R-HSA-418217 | 3.3182050777e-11 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | G beta:gamma signalling through PLC beta |
| REAC:R-HSA-4086398 | 3.35180405683e-11 | 0.666666666667 | GNB1 GNG11 GNG12 GNAO1 GNB4 GNG4 | Ca2+ pathway |
| REAC:R-HSA-8964616 | 4.59338890316e-11 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | G beta:gamma signalling through CDC42 |
| REAC:R-HSA-9009391 | 8.96106278e-11 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Extra-nuclear estrogen signaling |
| REAC:R-HSA-9662851 | 8.96106278e-11 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Anti-inflammatory response favouring Leishmania parasite infection |
| REAC:R-HSA-9664433 | 8.96106278e-11 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Leishmania parasite growth and survival |
| KEGG:05163 | 1.07768734892e-10 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | Human cytomegalovirus infection |
| REAC:R-HSA-392451 | 1.09018278882e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | G beta:gamma signalling through PI3Kgamma |
| KEGG:05170 | 1.11811003535e-10 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-400042 | 1.41050263113e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Adrenaline,noradrenaline inhibits insulin secretion |
| REAC:R-HSA-202040 | 1.41050263113e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | G-protein activation |
| REAC:R-HSA-451326 | 1.41050263113e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Activation of kainate receptors upon glutamate binding |
| REAC:R-HSA-418592 | 1.41050263113e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | ADP signalling through P2Y purinoceptor 1 |
| REAC:R-HSA-428930 | 1.41050263113e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Thromboxane signalling through TP receptor |
| WP:WP35 | 1.43754339828e-10 | 0.666666666667 | GNB1 GNG11 GNG12 GNAO1 GNAI3 GNG4 | G protein signaling pathways |
| REAC:R-HSA-1296041 | 1.80189734833e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Activation of G protein gated Potassium channels |
| REAC:R-HSA-420092 | 1.80189734833e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Glucagon-type ligand receptors |
| REAC:R-HSA-997272 | 1.80189734833e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| REAC:R-HSA-1296059 | 1.80189734833e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | G protein gated Potassium channels |
| REAC:R-HSA-111885 | 3.7335250344e-10 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Opioid Signalling |
| REAC:R-HSA-418594 | 4.03307066621e-10 | 0.777777777778 | RGS12 GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | G alpha (i) signalling events |
| REAC:R-HSA-456926 | 4.31912768671e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Thrombin signalling through proteinase activated receptors (PARs) |
| REAC:R-HSA-163359 | 4.31912768671e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Glucagon signaling in metabolic regulation |
| REAC:R-HSA-397795 | 4.31912768671e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | G-protein beta:gamma signalling |
| REAC:R-HSA-1296065 | 4.31912768671e-10 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Inwardly rectifying K+ channels |
| GO:0019897 | 5.53137912074e-10 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | extrinsic component of plasma membrane |
| KEGG:04371 | 6.98088752233e-10 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Apelin signaling pathway |
| REAC:R-HSA-418555 | 1.0339342523e-09 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | G alpha (s) signalling events |
| REAC:R-HSA-432040 | 1.48631561726e-09 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-6814122 | 1.73363866033e-09 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| REAC:R-HSA-381676 | 1.73363866033e-09 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-445717 | 2.01279774624e-09 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Aquaporin-mediated transport |
| WP:WP3929 | 2.1347204781e-09 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Chemokine signaling pathway |
| KEGG:04062 | 2.75481259175e-09 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Chemokine signaling pathway |
| REAC:R-HSA-9658195 | 1.13062702108e-08 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Leishmania infection |
| REAC:R-HSA-3858494 | 1.13062702108e-08 | 0.666666666667 | GNB1 GNG11 GNG12 GNAO1 GNB4 GNG4 | Beta-catenin independent WNT signaling |
| REAC:R-HSA-9824443 | 1.13062702108e-08 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Parasitic Infection Pathways |
| GO:0019898 | 1.18614999938e-08 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | extrinsic component of membrane |
| GO:0009898 | 1.18614999938e-08 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | cytoplasmic side of plasma membrane |
| REAC:R-HSA-112314 | 2.81303360613e-08 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-416482 | 3.43444959498e-08 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | G alpha (12/13) signalling events |
| REAC:R-HSA-422356 | 4.3808822216e-08 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Regulation of insulin secretion |
| REAC:R-HSA-1296071 | 4.738886091e-08 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Potassium Channels |
| REAC:R-HSA-388396 | 4.86132060027e-08 | 0.777777777778 | RGS12 GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | GPCR downstream signalling |
| GO:0098562 | 5.08812294015e-08 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | cytoplasmic side of membrane |
| REAC:R-HSA-373080 | 5.5249571459e-08 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Class B/2 (Secretin family receptors) |
| REAC:R-HSA-8939211 | 7.31693799847e-08 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | ESR-mediated signaling |
| REAC:R-HSA-418346 | 7.40895733361e-08 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Platelet homeostasis |
| REAC:R-HSA-372790 | 1.20969723027e-07 | 0.777777777778 | RGS12 GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Signaling by GPCR |
| REAC:R-HSA-112315 | 1.28252913838e-07 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Transmission across Chemical Synapses |
| REAC:R-HSA-390466 | 1.73177789986e-07 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Chaperonin-mediated protein folding |
| REAC:R-HSA-76002 | 1.91811224112e-07 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Platelet activation, signaling and aggregation |
| GO:0007186 | 2.14302260503e-07 | 0.888888888889 | RGS12 GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | G protein-coupled receptor signaling pathway |
| REAC:R-HSA-163685 | 2.45186016854e-07 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Integration of energy metabolism |
| REAC:R-HSA-391251 | 2.59217745739e-07 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Protein folding |
| REAC:R-HSA-9006931 | 4.18484631995e-07 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Signaling by Nuclear Receptors |
| WP:WP289 | 5.98623825582e-07 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Myometrial relaxation and contraction pathways |
| WP:WP4223 | 1.07022725358e-06 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Ras signaling |
| KEGG:05167 | 1.16061325618e-06 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-195721 | 1.26665254988e-06 | 0.666666666667 | GNB1 GNG11 GNG12 GNAO1 GNB4 GNG4 | Signaling by WNT |
| REAC:R-HSA-112316 | 1.29244834232e-06 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Neuronal System |
| REAC:R-HSA-416476 | 1.55471969867e-06 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | G alpha (q) signalling events |
| KEGG:04014 | 1.83196641183e-06 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Ras signaling pathway |
| KEGG:05200 | 3.06894136919e-06 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Pathways in cancer |
| WP:WP3932 | 1.46983632398e-05 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Focal adhesion PI3K Akt mTOR signaling pathway |
| KEGG:04151 | 1.65562011587e-05 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | PI3K-Akt signaling pathway |
| GO:0098552 | 2.010836375e-05 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | side of membrane |
| GO:0098797 | 2.11775833461e-05 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | plasma membrane protein complex |
| WP:WP4172 | 2.2858668546e-05 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | PI3K Akt signaling pathway |
| REAC:R-HSA-500792 | 2.56519594799e-05 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | GPCR ligand binding |
| CORUM:7160 | 2.73623797451e-05 | 0.222222222222 | GNB1 GNG4 | GNAS-L-GNB1-GNG4 complex |
| CORUM:7202 | 2.73623797451e-05 | 0.222222222222 | GNG11 GNB4 | GNAS-L-GNB4-GNG11 complex |
| CORUM:7163 | 2.73623797451e-05 | 0.222222222222 | GNB4 GNG4 | GNAS-L-GNB4-GNG4 complex |
| CORUM:7207 | 2.73623797451e-05 | 0.222222222222 | GNB4 GNG12 | GNAS-L-GNB4-GNG12 complex |
| CORUM:7204 | 2.73623797451e-05 | 0.222222222222 | GNB1 GNG12 | GNAS-L-GNB1-GNG12 complex |
| CORUM:7195 | 2.73623797451e-05 | 0.222222222222 | GNG11 GNB1 | GNAS-L-GNB1-GNG11 complex |
| REAC:R-HSA-109582 | 3.79190436273e-05 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Hemostasis |
| CORUM:7031 | 8.20609246787e-05 | 0.222222222222 | GNB1 GNG4 | GNAI1-GNB1-GNG4 complex |
| CORUM:7034 | 8.20609246787e-05 | 0.222222222222 | GNB4 GNG4 | GNAI1-GNB4-GNG4 complex |
| CORUM:7081 | 8.20609246787e-05 | 0.222222222222 | GNG11 GNB1 | GNAI1-GNB1-GNG11 complex |
| CORUM:7084 | 8.20609246787e-05 | 0.222222222222 | GNG11 GNB4 | GNAI1-GNB4-GNG11 complex |
| CORUM:7089 | 8.20609246787e-05 | 0.222222222222 | GNB4 GNG12 | GNAI1-GNB4-GNG12 complex |
| REAC:R-HSA-162582 | 0.000250148479521 | 0.888888888889 | RGS12 GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | Signal Transduction |
| WP:WP2032 | 0.000380392295535 | 0.333333333333 | GNAI3 GNB1 GNAO1 | Thyroid stimulating hormone TSH signaling pathway |
| REAC:R-HSA-5663205 | 0.000716014897471 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Infectious disease |
| REAC:R-HSA-382551 | 0.00167406377481 | 0.555555555556 | GNG4 GNG11 GNG12 GNB4 GNB1 | Transport of small molecules |
| GO:0031681 | 0.00546674693619 | 0.333333333333 | GNG11 GNG4 GNG12 | G-protein beta-subunit binding |
| GO:0098796 | 0.00630695715281 | 0.777777777778 | GNB1 GNG11 GNAO1 GNG12 GNAI3 GNB4 GNG4 | membrane protein complex |
| GO:0003924 | 0.00712903067205 | 0.555555555556 | RGS12 GNAI3 GNAO1 GNB1 GNG11 | GTPase activity |
| WP:WP4900 | 0.00842967875969 | 0.222222222222 | GNAI3 GNAO1 | Purinergic signaling |
| WP:WP722 | 0.00991991165725 | 0.222222222222 | GNAI3 GNAO1 | Serotonin HTR1 group and FOS pathway |
| GO:0007212 | 0.0106791414882 | 0.333333333333 | GNAI3 GNB1 GNAO1 | dopamine receptor signaling pathway |
| REAC:R-HSA-1643685 | 0.0165408171212 | 0.666666666667 | GNB1 GNG11 GNG12 GNAI3 GNB4 GNG4 | Disease |
| KEGG:04730 | 0.0189437044705 | 0.222222222222 | GNAI3 GNAO1 | Long-term depression |
| GO:1903351 | 0.029267276266 | 0.333333333333 | GNAI3 GNB1 GNAO1 | cellular response to dopamine |
| GO:1903350 | 0.029267276266 | 0.333333333333 | GNAI3 GNB1 GNAO1 | response to dopamine |
| GO:0071870 | 0.0325091721374 | 0.333333333333 | GNAI3 GNB1 GNAO1 | cellular response to catecholamine stimulus |
| GO:0071869 | 0.0325091721374 | 0.333333333333 | GNAI3 GNB1 GNAO1 | response to catecholamine |
| GO:0071868 | 0.0325091721374 | 0.333333333333 | GNAI3 GNB1 GNAO1 | cellular response to monoamine stimulus |
| GO:0071867 | 0.0325091721374 | 0.333333333333 | GNAI3 GNB1 GNAO1 | response to monoamine |
| CORUM:7162 | 0.0499842271994 | 0.111111111111 | GNG4 | GNAS-L-GNB3-GNG4 complex |
| CORUM:7206 | 0.0499842271994 | 0.111111111111 | GNG12 | GNAS-L-GNB3-GNG12 complex |
| CORUM:7209 | 0.0499842271994 | 0.111111111111 | GNB1 | GNAS-L-GNB1-GNG13 complex |
| CORUM:7212 | 0.0499842271994 | 0.111111111111 | GNB4 | GNAS-L-GNB4-GNG13 complex |
| CORUM:7201 | 0.0499842271994 | 0.111111111111 | GNG11 | GNAS-L-GNB3-GNG11 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GNAI3 | GNAO1 | 0.999 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RGS12 | GNAI3 | 0.998 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GNAI3 | GNG12 | 0.997 | 0.086 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| GNAI3 | GNB1 | 0.997 | 0.23 |
structurally_consistent (P16520)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| GNAI3 | GNG4 | 0.996 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GNAI3 | GNB4 | 0.995 | 0.488 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| GNG4 | GNB1 | 0.994 | 0.154 |
structurally_consistent (P16520)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GNG12 | GNB1 | 0.994 | 0.162 |
structurally_consistent (P16520)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| GNB4 | GNG12 | 0.989 | 0.228 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| GNG11 | GNAI3 | 0.987 | 0.156 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GNB4 | GNB1 | 0.98 | 0.788 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| GNAO1 | GNG4 | 0.979 | 0.288 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNB4 | GNG4 | 0.964 | 0.294 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SMPDL3B | GNAI3 | 0.964 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNAO1 | GNB1 | 0.962 | 0.126 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| GNG4 | GNG12 | 0.951 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only | |
| RGS12 | GNG4 | 0.899 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only | |
| RGS12 | GNAO1 | 0.809 | 0.152 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNG11 | GNB1 | 0.704 | 0.306 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SMPDL3B | GNAO1 | 0.681 | 0.092 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| SMPDL3B | GNG12 | 0.563 | 0.116 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNG11 | GNAO1 | 0.445 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNAO1 | GNB4 | 0.431 | 0.176 |
mutually_exclusive (O60262)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| RGS12 | GNB1 | 0.431 | 0.27 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNG11 | GNG4 | 0.4 | 0.148 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNG11 | GNB4 | 0.388 | 0.294 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RGS12 | GNG11 | 0.367 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only | |
| RGS12 | GNB4 | 0.337 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNAO1 | GNG12 | 0.286 | 0.088 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| RGS12 | GNG12 | 0.283 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| GNG11 | GNG12 | 0.143 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMPDL3B | GNB4 | 0.118 | 0.168 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMPDL3B | GNG4 | 0.046 | 0.094 | bioplex3_WMM WMM_only | |
| SMPDL3B | GNB1 | 0.033 | 0.1 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes