hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07062.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PHF20 | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) | 5 | UniProt NCBI |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 (MLL1/MLL complex subunit KANSL1) (MSL1 homolog 1) (hMSL1v1) (NSL complex protein NSL1) (Non-specific lethal 1 homolog) | 5 | UniProt NCBI |
| DUS2 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2) | 5 | UniProt NCBI |
| KAT8 | Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7221 | 5.8916765743e-08 | 0.75 | PHF20 KANSL1 KAT8 | NSL complex |
| CORUM:5386 | 1.82202245565e-06 | 0.75 | PHF20 KANSL1 KAT8 | MLL1-WDR5 complex |
| REAC:R-HSA-9772755 | 1.38374083551e-05 | 0.75 | PHF20 KANSL1 KAT8 | Formation of WDR5-containing histone-modifying complexes |
| CORUM:610 | 3.07520988333e-05 | 0.5 | KANSL1 KAT8 | MSL complex |
| GO:0044545 | 6.34131776058e-05 | 0.75 | PHF20 KANSL1 KAT8 | NSL complex |
| REAC:R-HSA-3214847 | 0.000487256563506 | 0.75 | PHF20 KANSL1 KAT8 | HATs acetylate histones |
| REAC:R-HSA-212165 | 0.00113904971457 | 0.75 | PHF20 KANSL1 KAT8 | Epigenetic regulation of gene expression |
| GO:0071339 | 0.00172575455775 | 0.75 | PHF20 KANSL1 KAT8 | MLL1 complex |
| GO:0044665 | 0.00190418300832 | 0.75 | PHF20 KANSL1 KAT8 | MLL1/2 complex |
| REAC:R-HSA-3247509 | 0.00356469194611 | 0.75 | PHF20 KANSL1 KAT8 | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 0.00356469194611 | 0.75 | PHF20 KANSL1 KAT8 | Chromatin organization |
| GO:1902562 | 0.00440499676786 | 0.75 | PHF20 KANSL1 KAT8 | H4 histone acetyltransferase complex |
| GO:0035097 | 0.0159688263229 | 0.75 | PHF20 KANSL1 KAT8 | histone methyltransferase complex |
| GO:0000123 | 0.0420072408269 | 0.75 | PHF20 KANSL1 KAT8 | histone acetyltransferase complex |
| GO:0034708 | 0.0464975978221 | 0.75 | PHF20 KANSL1 KAT8 | methyltransferase complex |
| CORUM:724 | 0.049938562206 | 0.25 | KAT8 | MAF2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PHF20 | KANSL1 | 0.999 | 0.41 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| KANSL1 | DUS2 | 0.995 | 0.046 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| KANSL1 | KAT8 | 0.994 | 0.192 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| PHF20 | KAT8 | 0.99 | 0.266 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PHF20 | DUS2 | 0.572 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes