hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07065.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BOD1L1 | Biorientation of chromosomes in cell division protein 1-like 1 | 5 | UniProt NCBI |
| SETD1A | Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1) | 5 | UniProt NCBI |
| SETD1B | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | 5 | UniProt NCBI |
| KMT2A | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | 5 | UniProt NCBI |
| CXXC1 | CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1) | 5 | UniProt NCBI |
| HCFC2 | Host cell factor 2 (HCF-2) (C2 factor) | 5 | UniProt NCBI |
| KDM6A | Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A) | 5 | UniProt NCBI |
| HCFC1 | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | 5 | UniProt NCBI |
| DPY30 | Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L) | 5 | UniProt NCBI |
| ASH2L | Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein) | 5 | UniProt NCBI |
| RBBP5 | Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) | 5 | UniProt NCBI |
| KMT2C | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | 5 | UniProt NCBI |
| BOD1 | Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9772755 | 1.48291076855e-32 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | Formation of WDR5-containing histone-modifying complexes |
| GO:0035097 | 2.9626181575e-27 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | histone methyltransferase complex |
| CORUM:6470 | 1.05592035459e-25 | 0.692307692308 | DPY30 BOD1 BOD1L1 CXXC1 RBBP5 ASH2L HCFC2 HCFC1 SETD1B | Set1B complex |
| GO:0048188 | 1.17100295982e-25 | 0.769230769231 | SETD1A BOD1 BOD1L1 HCFC1 RBBP5 DPY30 ASH2L HCFC2 CXXC1 SETD1B | Set1C/COMPASS complex |
| GO:0034708 | 4.32384751388e-25 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | methyltransferase complex |
| REAC:R-HSA-212165 | 1.32523138708e-23 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | Epigenetic regulation of gene expression |
| CORUM:6469 | 4.09518090355e-19 | 0.538461538462 | DPY30 CXXC1 RBBP5 ASH2L HCFC2 HCFC1 SETD1A | Set1A complex |
| CORUM:6462 | 7.28175775162e-13 | 0.384615384615 | KMT2A ASH2L RBBP5 HCFC1 DPY30 | MLL1 complex |
| GO:1990234 | 1.23181151841e-12 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | transferase complex |
| CORUM:6461 | 1.63764777805e-12 | 0.384615384615 | KMT2C KDM6A RBBP5 DPY30 ASH2L | MLL3 complex |
| CORUM:6460 | 3.27380073825e-12 | 0.384615384615 | HCFC2 ASH2L RBBP5 HCFC1 DPY30 | MLL2 complex |
| CORUM:5195 | 3.27380073825e-12 | 0.384615384615 | KMT2C KDM6A RBBP5 DPY30 ASH2L | PTIP-HMT complex |
| REAC:R-HSA-74160 | 5.47608497612e-12 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | Gene expression (Transcription) |
| REAC:R-HSA-3214841 | 1.57573543774e-11 | 0.538461538462 | DPY30 SETD1B RBBP5 KMT2C KMT2A ASH2L SETD1A | PKMTs methylate histone lysines |
| REAC:R-HSA-3247509 | 1.99948930673e-11 | 0.692307692308 | DPY30 SETD1B RBBP5 KDM6A KMT2C KMT2A ASH2L HCFC1 SETD1A | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 1.99948930673e-11 | 0.692307692308 | DPY30 SETD1B RBBP5 KDM6A KMT2C KMT2A ASH2L HCFC1 SETD1A | Chromatin organization |
| REAC:R-HSA-8936459 | 5.14113312938e-11 | 0.538461538462 | DPY30 SETD1B RBBP5 KMT2C KMT2A ASH2L SETD1A | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| CORUM:6851 | 1.05641911521e-10 | 0.307692307692 | KMT2A RBBP5 DPY30 ASH2L | MWRAD complex (MLL1, WDR5, RBBP5, ASH2L, DPY30) |
| GO:0140513 | 1.25019016013e-10 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | nuclear protein-containing complex |
| CORUM:2731 | 3.16769554386e-10 | 0.307692307692 | ASH2L RBBP5 SETD1A CXXC1 | Set1A complex |
| CORUM:2730 | 3.16769554386e-10 | 0.307692307692 | ASH2L RBBP5 SETD1B CXXC1 | Set1B complex |
| CORUM:1256 | 7.3876470612e-10 | 0.307692307692 | KMT2A RBBP5 HCFC1 ASH2L | MLL-HCF complex |
| CORUM:6467 | 2.65693210741e-09 | 0.307692307692 | KDM6A RBBP5 DPY30 ASH2L | MLL4 complex |
| WP:WP5351 | 3.1803967742e-09 | 0.384615384615 | KMT2C KDM6A RBBP5 DPY30 ASH2L | Kleefstra syndrome |
| GO:0071339 | 4.62437882766e-09 | 0.461538461538 | DPY30 RBBP5 KMT2A HCFC2 ASH2L HCFC1 | MLL1 complex |
| GO:0044666 | 5.3393134954e-09 | 0.384615384615 | KMT2C KDM6A RBBP5 DPY30 ASH2L | MLL3/4 complex |
| GO:0044665 | 5.68920262044e-09 | 0.461538461538 | DPY30 RBBP5 KMT2A HCFC2 ASH2L HCFC1 | MLL1/2 complex |
| GO:1902494 | 8.51681575761e-09 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | catalytic complex |
| CORUM:3075 | 1.04225209759e-08 | 0.307692307692 | KDM6A RBBP5 KMT2C ASH2L | UTX-MLL2/3 complex |
| REAC:R-HSA-8878171 | 5.15638686028e-08 | 0.538461538462 | DPY30 SETD1B RBBP5 KMT2C KMT2A ASH2L SETD1A | Transcriptional regulation by RUNX1 |
| CORUM:6457 | 1.23488636402e-07 | 0.230769230769 | KMT2A RBBP5 ASH2L | MLL1 core complex |
| CORUM:6849 | 1.23488636402e-07 | 0.230769230769 | ASH2L DPY30 RBBP5 | WRAD complex (WDR5, RBBP5, ASH2L, DPY30) |
| CORUM:5386 | 3.12615342348e-07 | 0.307692307692 | KMT2A RBBP5 HCFC1 ASH2L | MLL1-WDR5 complex |
| CORUM:1400 | 1.07886252823e-06 | 0.230769230769 | ASH2L KMT2C RBBP5 | ASCOM complex |
| CORUM:1254 | 1.07886252823e-06 | 0.230769230769 | ASH2L DPY30 RBBP5 | Menin-associated histone methyltransferase complex |
| CORUM:1401 | 3.69326381329e-06 | 0.230769230769 | KMT2A SETD1A RBBP5 | MOF complex |
| REAC:R-HSA-5619507 | 6.12774587464e-06 | 0.384615384615 | KMT2C KDM6A RBBP5 DPY30 ASH2L | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 6.12774587464e-06 | 0.384615384615 | KMT2C KDM6A RBBP5 DPY30 ASH2L | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| GO:0042800 | 6.18707875607e-06 | 0.307692307692 | KMT2C KMT2A SETD1A SETD1B | histone H3K4 methyltransferase activity |
| KEGG:00310 | 8.89263718528e-06 | 0.307692307692 | KMT2C KMT2A SETD1A SETD1B | Lysine degradation |
| CORUM:2721 | 1.71822102318e-05 | 0.230769230769 | ASH2L SETD1A HCFC1 | HCF-1 complex |
| WP:WP2369 | 2.38293101107e-05 | 0.307692307692 | KMT2C KMT2A SETD1A SETD1B | Histone modifications |
| GO:0006325 | 4.65968938697e-05 | 0.615384615385 | DPY30 RBBP5 KDM6A KMT2A ASH2L HCFC2 HCFC1 SETD1A | chromatin organization |
| CORUM:6850 | 0.00012303818858 | 0.153846153846 | ASH2L RBBP5 | WRA complex (WDR5, RBBP5, ASH2L) |
| CORUM:7367 | 0.00012303818858 | 0.153846153846 | ASH2L RBBP5 | ASH2L-KDM6B-KDM6B-WDR5 complex |
| GO:0071824 | 0.000148816711032 | 0.615384615385 | DPY30 RBBP5 KDM6A KMT2A ASH2L HCFC2 HCFC1 SETD1A | protein-DNA complex organization |
| CORUM:1399 | 0.000245952888523 | 0.153846153846 | ASH2L RBBP5 | WDR5-ASH2L-RBBP5-MLL2 complex |
| CORUM:6845 | 0.000245952888523 | 0.153846153846 | ASH2L RBBP5 | NIF1-ASH2L-RBBP5-WDR5 complex |
| CORUM:6340 | 0.00040971577212 | 0.153846153846 | ASH2L RBBP5 | PITX2-MLL4-ASH2L-RBBP5-PTIP complex |
| GO:0005654 | 0.000642773776147 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | nucleoplasm |
| GO:0045815 | 0.000667257175244 | 0.307692307692 | KMT2A RBBP5 DPY30 ASH2L | transcription initiation-coupled chromatin remodeling |
| GO:0141137 | 0.000758918101843 | 0.307692307692 | KMT2A RBBP5 DPY30 ASH2L | positive regulation of gene expression, epigenetic |
| GO:0006338 | 0.00077163134189 | 0.538461538462 | DPY30 RBBP5 KDM6A KMT2A HCFC2 ASH2L HCFC1 | chromatin remodeling |
| GO:0140938 | 0.000970130895603 | 0.307692307692 | KMT2C KMT2A SETD1A SETD1B | histone H3 methyltransferase activity |
| GO:0031981 | 0.00148875347378 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | nuclear lumen |
| REAC:R-HSA-212436 | 0.00263447397095 | 0.538461538462 | DPY30 SETD1B RBBP5 KMT2C KMT2A ASH2L SETD1A | Generic Transcription Pathway |
| GO:0042054 | 0.00300713646241 | 0.307692307692 | KMT2C KMT2A SETD1A SETD1B | histone methyltransferase activity |
| GO:0016279 | 0.00328524790479 | 0.307692307692 | KMT2C KMT2A SETD1A SETD1B | protein-lysine N-methyltransferase activity |
| GO:0016278 | 0.00358213796116 | 0.307692307692 | KMT2C KMT2A SETD1A SETD1B | lysine N-methyltransferase activity |
| REAC:R-HSA-73857 | 0.00544250481316 | 0.538461538462 | DPY30 SETD1B RBBP5 KMT2C KMT2A ASH2L SETD1A | RNA Polymerase II Transcription |
| KEGG:04934 | 0.00938681844439 | 0.230769230769 | KMT2A RBBP5 ASH2L | Cushing syndrome |
| GO:0140993 | 0.00971552919451 | 0.384615384615 | KMT2C KMT2A KDM6A SETD1A SETD1B | histone modifying activity |
| HP:0007655 | 0.0113895015741 | 0.153846153846 | KMT2A KDM6A | Eversion of lateral third of lower eyelids |
| REAC:R-HSA-1266738 | 0.0128571598228 | 0.461538461538 | KMT2C RBBP5 KDM6A KMT2A ASH2L DPY30 | Developmental Biology |
| CORUM:1257 | 0.0153095106232 | 0.153846153846 | KMT2A RBBP5 | ALL-1 supercomplex |
| GO:0008170 | 0.0220795117761 | 0.307692307692 | KMT2C KMT2A SETD1A SETD1B | N-methyltransferase activity |
| GO:0043233 | 0.0244298182677 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | organelle lumen |
| GO:0031974 | 0.0244298182677 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | membrane-enclosed lumen |
| GO:0070013 | 0.0244298182677 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | intracellular organelle lumen |
| GO:0008276 | 0.0258736341179 | 0.307692307692 | KMT2C KMT2A SETD1A SETD1B | protein methyltransferase activity |
| GO:0032991 | 0.0292789767838 | 1.0 | SETD1A RBBP5 BOD1L1 ASH2L HCFC1 KMT2C KMT2A DPY30 KDM6A BOD1 HCFC2 CXXC1 SETD1B | protein-containing complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| RBBP5 | ASH2L | 1.0 | 0.438 |
| CXXC1 | RBBP5 | 1.0 | 0.27 |
| RBBP5 | SETD1A | 1.0 | 0.208 |
| SETD1B | RBBP5 | 1.0 | 0.106 |
| CXXC1 | SETD1A | 1.0 | 0.46 |
| KMT2A | HCFC2 | 1.0 | 0.144 |
| CXXC1 | ASH2L | 1.0 | 0.474 |
| CXXC1 | SETD1B | 1.0 | 0.236 |
| HCFC2 | ASH2L | 0.999 | 0.276 |
| CXXC1 | BOD1L1 | 0.999 | 0.256 |
| HCFC2 | HCFC1 | 0.999 | 0.196 |
| HCFC2 | SETD1A | 0.999 | 0.462 |
| SETD1B | ASH2L | 0.999 | 0.22 |
| BOD1L1 | SETD1A | 0.999 | 0.392 |
| BOD1L1 | HCFC2 | 0.999 | 0.188 |
| CXXC1 | HCFC2 | 0.999 | 0.306 |
| SETD1A | ASH2L | 0.999 | 0.566 |
| CXXC1 | BOD1 | 0.999 | 0.128 |
| KMT2A | RBBP5 | 0.999 | 0.156 |
| BOD1L1 | RBBP5 | 0.999 | 0.324 |
| BOD1 | ASH2L | 0.999 | 0.182 |
| CXXC1 | HCFC1 | 0.999 | 0.274 |
| RBBP5 | BOD1 | 0.998 | 0.134 |
| DPY30 | RBBP5 | 0.998 | 0.466 |
| BOD1L1 | ASH2L | 0.998 | 0.386 |
| KMT2A | ASH2L | 0.997 | 0.196 |
| CXXC1 | DPY30 | 0.997 | 0.234 |
| DPY30 | ASH2L | 0.997 | 0.414 |
| SETD1B | BOD1 | 0.996 | 0.166 |
| HCFC2 | RBBP5 | 0.996 | 0.348 |
| HCFC1 | SETD1A | 0.994 | 0.448 |
| BOD1L1 | HCFC1 | 0.993 | 0.138 |
| KDM6A | RBBP5 | 0.993 | 0.316 |
| HCFC1 | ASH2L | 0.992 | 0.168 |
| HCFC1 | RBBP5 | 0.989 | 0.068 |
| BOD1L1 | KDM6A | 0.98 | 0.15 |
| SETD1B | KDM6A | 0.976 | 0.28 |
| KMT2A | KDM6A | 0.976 | 0.284 |
| KDM6A | ASH2L | 0.973 | 0.204 |
| RBBP5 | KMT2C | 0.972 | 0.094 |
| CXXC1 | KMT2A | 0.962 | 0.196 |
| SETD1B | SETD1A | 0.96 | 0.304 |
| KMT2C | ASH2L | 0.955 | 0.082 |
| BOD1L1 | BOD1 | 0.955 | 0.132 |
| BOD1L1 | KMT2A | 0.947 | 0.18 |
| SETD1B | KMT2A | 0.946 | 0.222 |
| HCFC2 | DPY30 | 0.945 | 0.34 |
| BOD1L1 | SETD1B | 0.945 | 0.196 |
| CXXC1 | KDM6A | 0.943 | 0.208 |
| KMT2A | SETD1A | 0.941 | 0.204 |
| BOD1 | SETD1A | 0.94 | 0.062 |
| SETD1B | HCFC1 | 0.94 | 0.14 |
| KDM6A | SETD1A | 0.93 | 0.228 |
| KDM6A | HCFC1 | 0.853 | 0.12 |
| SETD1B | HCFC2 | 0.842 | 0.154 |
| KMT2A | HCFC1 | 0.825 | 0.09 |
| KDM6A | DPY30 | 0.824 | 0.212 |
| KDM6A | BOD1 | 0.798 | 0.152 |
| HCFC2 | KDM6A | 0.769 | 0.22 |
| HCFC1 | BOD1 | 0.705 | 0.226 |
| DPY30 | BOD1 | 0.673 | 0.104 |
| DPY30 | SETD1A | 0.606 | 0.154 |
| BOD1L1 | DPY30 | 0.499 | 0.362 |
| SETD1B | DPY30 | 0.452 | 0.212 |
| KMT2A | BOD1 | 0.373 | 0.15 |
| KMT2A | DPY30 | 0.362 | 0.078 |
| HCFC2 | BOD1 | 0.276 | 0.236 |
| KDM6A | KMT2C | 0.266 | 0.166 |
| HCFC1 | DPY30 | 0.193 | 0.164 |
| KMT2C | SETD1A | 0.095 | 0.144 |
| CXXC1 | KMT2C | 0.095 | 0.144 |
| HCFC2 | KMT2C | 0.082 | 0.112 |
| SETD1B | KMT2C | 0.079 | 0.104 |
| BOD1L1 | KMT2C | 0.079 | 0.096 |
| KMT2C | BOD1 | 0.079 | 0.096 |
| DPY30 | KMT2C | 0.078 | 0.1 |
| KMT2A | KMT2C | 0.071 | 0.07 |
| HCFC1 | KMT2C | 0.024 | 0.19 |
Related Complexes