hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_07069.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NDUFS5 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 (Complex I-15 kDa) (CI-15 kDa) (NADH-ubiquinone oxidoreductase 15 kDa subunit) | 5 | UniProt NCBI |
| NDUFB8 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial (Complex I-ASHI) (CI-ASHI) (NADH-ubiquinone oxidoreductase ASHI subunit) | 5 | UniProt NCBI |
| UQCRQ | Cytochrome b-c1 complex subunit 8 (Complex III subunit 8) (Complex III subunit VIII) (Ubiquinol-cytochrome c reductase complex 9.5 kDa protein) (Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP111 | 1.17898981996e-05 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Electron transport chain OXPHOS system in mitochondria |
| KEGG:00190 | 1.54230874605e-05 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Oxidative phosphorylation |
| KEGG:04932 | 2.28801742777e-05 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Non-alcoholic fatty liver disease |
| WP:WP4396 | 3.24963255001e-05 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Nonalcoholic fatty liver disease |
| KEGG:05415 | 5.16258651055e-05 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Diabetic cardiomyopathy |
| KEGG:05208 | 7.07004693439e-05 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Chemical carcinogenesis - reactive oxygen species |
| REAC:R-HSA-611105 | 7.31860792369e-05 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Respiratory electron transport |
| KEGG:04714 | 7.39136996301e-05 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Thermogenesis |
| KEGG:05012 | 0.00011589966492 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Parkinson disease |
| KEGG:05020 | 0.000126475690353 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Prion disease |
| REAC:R-HSA-163200 | 0.000134372084608 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| KEGG:05016 | 0.000171368189864 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Huntington disease |
| KEGG:05014 | 0.00029339200738 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Amyotrophic lateral sclerosis |
| KEGG:05010 | 0.000339187774081 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Alzheimer disease |
| REAC:R-HSA-1428517 | 0.000368729542429 | 1.0 | NDUFB8 NDUFS5 UQCRQ | The citric acid (TCA) cycle and respiratory electron transport |
| KEGG:05022 | 0.000613327564103 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Pathways of neurodegeneration - multiple diseases |
| WP:WP4324 | 0.00167805708824 | 0.666666666667 | NDUFB8 NDUFS5 | Mitochondrial complex I assembly model OXPHOS system |
| WP:WP623 | 0.00193308448658 | 0.666666666667 | NDUFB8 NDUFS5 | Oxidative phosphorylation |
| CORUM:178 | 0.00308025137677 | 0.666666666667 | NDUFB8 NDUFS5 | Respiratory chain complex I (holoenzyme), mitochondrial |
| KEGG:04723 | 0.00533101781525 | 0.666666666667 | NDUFB8 NDUFS5 | Retrograde endocannabinoid signaling |
| GO:0019646 | 0.00675723888767 | 1.0 | NDUFB8 NDUFS5 UQCRQ | aerobic electron transport chain |
| GO:0098803 | 0.00760107672828 | 1.0 | NDUFB8 NDUFS5 UQCRQ | respiratory chain complex |
| GO:0042775 | 0.00851239083773 | 1.0 | NDUFB8 NDUFS5 UQCRQ | mitochondrial ATP synthesis coupled electron transport |
| GO:0042773 | 0.00851239083773 | 1.0 | NDUFB8 NDUFS5 UQCRQ | ATP synthesis coupled electron transport |
| GO:0005746 | 0.00949377645712 | 1.0 | NDUFB8 NDUFS5 UQCRQ | mitochondrial respirasome |
| GO:0070469 | 0.00949377645712 | 1.0 | NDUFB8 NDUFS5 UQCRQ | respirasome |
| HPA:0090923 | 0.00953401580159 | 0.666666666667 | NDUFB8 NDUFS5 | cerebellum; GLUC cells - cytoplasm/membrane[High] |
| REAC:R-HSA-6799198 | 0.0108549519561 | 0.666666666667 | NDUFB8 NDUFS5 | Complex I biogenesis |
| GO:0022904 | 0.0116771431902 | 1.0 | NDUFB8 NDUFS5 UQCRQ | respiratory electron transport chain |
| GO:0022900 | 0.0150763323228 | 1.0 | NDUFB8 NDUFS5 UQCRQ | electron transport chain |
| HPA:0460673 | 0.0169594584426 | 1.0 | NDUFB8 NDUFS5 UQCRQ | skin 1; melanocytes[High] |
| KEGG:01100 | 0.0189521995452 | 1.0 | NDUFB8 NDUFS5 UQCRQ | Metabolic pathways |
| GO:1990204 | 0.0219076797621 | 1.0 | NDUFB8 NDUFS5 UQCRQ | oxidoreductase complex |
| HPA:0091003 | 0.0235249667108 | 0.666666666667 | NDUFB8 NDUFS5 | cerebellum; molecular layer cells - cytoplasm/membrane[High] |
| HPA:0090922 | 0.0244321680476 | 0.666666666667 | NDUFB8 NDUFS5 | cerebellum; GLUC cells - cytoplasm/membrane[>=Medium] |
| GO:0006119 | 0.025655976884 | 1.0 | NDUFB8 NDUFS5 UQCRQ | oxidative phosphorylation |
| HPA:0241103 | 0.0256905205202 | 1.0 | NDUFB8 NDUFS5 UQCRQ | heart muscle; cardiomyocytes[High] |
| HPA:0090921 | 0.0292235343026 | 0.666666666667 | NDUFB8 NDUFS5 | cerebellum; GLUC cells - cytoplasm/membrane[>=Low] |
| HPA:0090952 | 0.0316049848456 | 0.666666666667 | NDUFB8 NDUFS5 | cerebellum; Purkinje cells - dendrites[>=Medium] |
| HPA:0091072 | 0.0333626298265 | 0.666666666667 | NDUFB8 NDUFS5 | cerebellum; white matter cells - cytoplasm/membrane[>=Medium] |
| HPA:0091062 | 0.0344398444789 | 0.666666666667 | NDUFB8 NDUFS5 | cerebellum; synaptic glomeruli - core[>=Medium] |
| HPA:0090951 | 0.0377732318968 | 0.666666666667 | NDUFB8 NDUFS5 | cerebellum; Purkinje cells - dendrites[>=Low] |
| GO:0098800 | 0.0498541011049 | 1.0 | NDUFB8 NDUFS5 UQCRQ | inner mitochondrial membrane protein complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NDUFB8 | NDUFS5 | 0.998 | 0.988 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| NDUFB8 | UQCRQ | 0.972 | 0.83 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| NDUFS5 | UQCRQ | 0.067 | 0.64 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes