hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07081.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta) | 5 | UniProt NCBI |
| IRS2 | Insulin receptor substrate 2 (IRS-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9027276 | 4.78453290596e-05 | 1.0 | IRS2 PIK3CD | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) |
| KEGG:04930 | 0.000133307149468 | 1.0 | IRS2 PIK3CD | Type II diabetes mellitus |
| KEGG:04923 | 0.000146800434109 | 1.0 | IRS2 PIK3CD | Regulation of lipolysis in adipocytes |
| KEGG:04213 | 0.000232637232791 | 1.0 | IRS2 PIK3CD | Longevity regulating pathway - multiple species |
| REAC:R-HSA-9006335 | 0.000292198259614 | 1.0 | IRS2 PIK3CD | Signaling by Erythropoietin |
| WP:WP395 | 0.000460113616736 | 1.0 | IRS2 PIK3CD | IL 4 signaling pathway |
| KEGG:04211 | 0.000526725810094 | 1.0 | IRS2 PIK3CD | Longevity regulating pathway |
| WP:WP585 | 0.000542687198278 | 1.0 | IRS2 PIK3CD | Interferon type I signaling pathways |
| REAC:R-HSA-8853659 | 0.000743311362176 | 1.0 | IRS2 PIK3CD | RET signaling |
| KEGG:04931 | 0.000772693757832 | 1.0 | IRS2 PIK3CD | Insulin resistance |
| KEGG:04935 | 0.000804719987643 | 1.0 | IRS2 PIK3CD | Growth hormone synthesis, secretion and action |
| KEGG:04152 | 0.00102874102663 | 1.0 | IRS2 PIK3CD | AMPK signaling pathway |
| KEGG:04068 | 0.00102874102663 | 1.0 | IRS2 PIK3CD | FoxO signaling pathway |
| KEGG:04910 | 0.00128023634398 | 1.0 | IRS2 PIK3CD | Insulin signaling pathway |
| KEGG:04932 | 0.00155920593969 | 1.0 | IRS2 PIK3CD | Non-alcoholic fatty liver disease |
| KEGG:05206 | 0.00176843313648 | 1.0 | IRS2 PIK3CD | MicroRNAs in cancer |
| KEGG:04140 | 0.00196546760618 | 1.0 | IRS2 PIK3CD | Autophagy - animal |
| REAC:R-HSA-2219530 | 0.00209323314636 | 1.0 | IRS2 PIK3CD | Constitutive Signaling by Aberrant PI3K in Cancer |
| WP:WP3915 | 0.0027415280346 | 1.0 | IRS2 PIK3CD | Angiopoietin like protein 8 regulatory pathway |
| WP:WP4396 | 0.00396523446209 | 1.0 | IRS2 PIK3CD | Nonalcoholic fatty liver disease |
| WP:WP481 | 0.00432149264637 | 1.0 | IRS2 PIK3CD | Insulin signaling |
| REAC:R-HSA-6811558 | 0.0046153654925 | 1.0 | IRS2 PIK3CD | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-2219528 | 0.00486997099357 | 1.0 | IRS2 PIK3CD | PI3K/AKT Signaling in Cancer |
| REAC:R-HSA-199418 | 0.0055363880769 | 1.0 | IRS2 PIK3CD | Negative regulation of the PI3K/AKT network |
| KEGG:05010 | 0.0093688914925 | 1.0 | IRS2 PIK3CD | Alzheimer disease |
| WP:WP5124 | 0.01130704739 | 1.0 | IRS2 PIK3CD | Alzheimer 39 s disease |
| WP:WP2059 | 0.01130704739 | 1.0 | IRS2 PIK3CD | Alzheimer 39 s disease and miRNA effects |
| WP:WP3932 | 0.0130364105952 | 1.0 | IRS2 PIK3CD | Focal adhesion PI3K Akt mTOR signaling pathway |
| REAC:R-HSA-1257604 | 0.0450002407423 | 1.0 | IRS2 PIK3CD | PIP3 activates AKT signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IRS2 | PIK3CD | 0.979 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes