hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07089.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SUV39H2 | Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2) | 5 | UniProt NCBI |
| ADNP2 | Activity-dependent neuroprotector homeobox protein 2 (ADNP homeobox protein 2) (Zinc finger protein 508) | 4 | UniProt NCBI |
| CBX5 | Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha) | 5 | UniProt NCBI |
| ZNF280C | Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633) | 4 | UniProt NCBI |
| CBX1 | Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) | 5 | UniProt NCBI |
| CBX3 | Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4320 | 2.13184989952e-05 | 0.5 | CBX1 CBX5 CBX3 | Effect of progerin on genes involved in Hutchinson Gilford progeria syndrome |
| GO:0005721 | 0.00254971303757 | 0.5 | CBX1 CBX5 CBX3 | pericentric heterochromatin |
| HPA:0380203 | 0.00705997843226 | 0.5 | CBX1 CBX5 CBX3 | placenta; endothelial cells[High] |
| HPA:0381193 | 0.011956299923 | 0.5 | CBX1 CBX5 CBX3 | placenta; cytotrophoblasts[High] |
| HPA:0381203 | 0.011956299923 | 0.5 | CBX1 CBX5 CBX3 | placenta; hofbauer cells[High] |
| REAC:R-HSA-8953750 | 0.0144005758041 | 0.333333333333 | CBX3 CBX5 | Transcriptional Regulation by E2F6 |
| HPA:0380202 | 0.0171409770739 | 0.5 | CBX1 CBX5 CBX3 | placenta; endothelial cells[>=Medium] |
| HPA:0381213 | 0.0195685735088 | 0.5 | CBX1 CBX5 CBX3 | placenta; syncytiotrophoblasts - cell body[High] |
| HPA:0381202 | 0.026375700343 | 0.5 | CBX1 CBX5 CBX3 | placenta; hofbauer cells[>=Medium] |
| HPA:0380201 | 0.0295751498494 | 0.5 | CBX1 CBX5 CBX3 | placenta; endothelial cells[>=Low] |
| HPA:0381192 | 0.0325110236602 | 0.5 | CBX1 CBX5 CBX3 | placenta; cytotrophoblasts[>=Medium] |
| HPA:0381201 | 0.0375378760272 | 0.5 | CBX1 CBX5 CBX3 | placenta; hofbauer cells[>=Low] |
| GO:0000792 | 0.0397388592171 | 0.5 | CBX1 CBX5 CBX3 | heterochromatin |
| HPA:0381212 | 0.0427439754553 | 0.5 | CBX1 CBX5 CBX3 | placenta; syncytiotrophoblasts - cell body[>=Medium] |
| HPA:0381191 | 0.0445783024132 | 0.5 | CBX1 CBX5 CBX3 | placenta; cytotrophoblasts[>=Low] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CBX5 | CBX3 | 0.999 | 0.482 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CBX3 | CBX1 | 0.999 | 0.294 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| CBX5 | CBX1 | 0.998 | 0.104 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| SUV39H2 | CBX5 | 0.998 | 0.198 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ADNP2 | CBX3 | 0.997 | 0.2 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only |
| SUV39H2 | CBX3 | 0.994 | 0.23 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SUV39H2 | CBX1 | 0.989 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ADNP2 | CBX1 | 0.986 | 0.058 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () |
| ZNF280C | CBX3 | 0.965 | 0.094 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| ZNF280C | CBX1 | 0.955 | 0.058 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () gupta_WMM |
| ZNF280C | CBX5 | 0.94 | 0.104 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| ADNP2 | CBX5 | 0.905 | 0.172 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only |
| ADNP2 | ZNF280C | 0.887 | 0.154 | hein_WMM bioplex3_WMM WMM_only |
| ZNF280C | SUV39H2 | 0.415 | 0.158 | bioplex3_WMM WMM_only |
| ADNP2 | SUV39H2 | 0.25 | 0.152 | bioplex3_WMM WMM_only |
Related Complexes