hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_07100.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| COL5A2 | Collagen alpha-2(V) chain | 5 | UniProt NCBI |
| COL5A1 | Collagen alpha-1(V) chain | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0025014 | 1.02525705128e-05 | 1.0 | COL5A2 COL5A1 | Subcutaneous spheroids |
| HP:0025509 | 1.02525705128e-05 | 1.0 | COL5A2 COL5A1 | Piezogenic pedal papules |
| HP:0030009 | 2.05051410255e-05 | 1.0 | COL5A2 COL5A1 | Cervical insufficiency |
| HP:0004872 | 2.05051410255e-05 | 1.0 | COL5A2 COL5A1 | Incisional hernia |
| HP:0003771 | 3.41752350426e-05 | 1.0 | COL5A2 COL5A1 | Pulp calcification |
| HP:0000993 | 3.41752350426e-05 | 1.0 | COL5A2 COL5A1 | Molluscoid pseudotumors |
| HP:0006243 | 5.12628525639e-05 | 1.0 | COL5A2 COL5A1 | Phalangeal dislocation |
| HP:0000139 | 5.12628525639e-05 | 1.0 | COL5A2 COL5A1 | Uterine prolapse |
| HP:0100823 | 5.12628525639e-05 | 1.0 | COL5A2 COL5A1 | Genital hernia |
| HP:0010749 | 5.12628525639e-05 | 1.0 | COL5A2 COL5A1 | Blepharochalasis |
| WP:WP2911 | 6.51224637934e-05 | 1.0 | COL5A2 COL5A1 | miRNA targets in ECM and membrane receptors |
| HP:0010750 | 7.17679935894e-05 | 1.0 | COL5A2 COL5A1 | Dermatochalasis |
| HP:0025019 | 9.56906581192e-05 | 1.0 | COL5A2 COL5A1 | Arterial rupture |
| HP:0004947 | 0.000123030846153 | 1.0 | COL5A2 COL5A1 | Arteriovenous fistula |
| HP:0001073 | 0.000153788557692 | 1.0 | COL5A2 COL5A1 | Cigarette-paper scars |
| HP:0001027 | 0.000225556551281 | 1.0 | COL5A2 COL5A1 | Soft, doughy skin |
| HP:0012888 | 0.000225556551281 | 1.0 | COL5A2 COL5A1 | Abnormal uterine cervix morphology |
| HP:0005294 | 0.000225556551281 | 1.0 | COL5A2 COL5A1 | Arterial dissection |
| HP:0001704 | 0.000266566833332 | 1.0 | COL5A2 COL5A1 | Tricuspid valve prolapse |
| HP:0010754 | 0.000310994638887 | 1.0 | COL5A2 COL5A1 | Abnormality of the temporomandibular joint |
| HP:0003834 | 0.000358839967947 | 1.0 | COL5A2 COL5A1 | Shoulder dislocation |
| KEGG:04974 | 0.000381388503235 | 1.0 | COL5A2 COL5A1 | Protein digestion and absorption |
| REAC:R-HSA-3000170 | 0.000394723964742 | 1.0 | COL5A2 COL5A1 | Syndecan interactions |
| HP:0001788 | 0.000410102820511 | 1.0 | COL5A2 COL5A1 | Premature rupture of membranes |
| GO:1903225 | 0.000468200720083 | 1.0 | COL5A2 COL5A1 | negative regulation of endodermal cell differentiation |
| GO:0005588 | 0.000468200720083 | 1.0 | COL5A2 COL5A1 | collagen type V trimer |
| REAC:R-HSA-8874081 | 0.000471618243588 | 1.0 | COL5A2 COL5A1 | MET activates PTK2 signaling |
| REAC:R-HSA-419037 | 0.000599775374997 | 1.0 | COL5A2 COL5A1 | NCAM1 interactions |
| REAC:R-HSA-8948216 | 0.000743311362176 | 1.0 | COL5A2 COL5A1 | Collagen chain trimerization |
| REAC:R-HSA-8875878 | 0.000958615342944 | 1.0 | COL5A2 COL5A1 | MET promotes cell motility |
| REAC:R-HSA-375165 | 0.00147124386858 | 1.0 | COL5A2 COL5A1 | NCAM signaling for neurite out-growth |
| HP:0001063 | 0.00158914842948 | 1.0 | COL5A2 COL5A1 | Acrocyanosis |
| HP:0001030 | 0.00158914842948 | 1.0 | COL5A2 COL5A1 | Fragile skin |
| HP:0001065 | 0.00169509165811 | 1.0 | COL5A2 COL5A1 | Striae distensae |
| HP:0002036 | 0.00169509165811 | 1.0 | COL5A2 COL5A1 | Hiatus hernia |
| HP:0034033 | 0.00180445241025 | 1.0 | COL5A2 COL5A1 | Peripheral cyanosis |
| HP:0000015 | 0.00180445241025 | 1.0 | COL5A2 COL5A1 | Bladder diverticulum |
| HP:0001075 | 0.00180445241025 | 1.0 | COL5A2 COL5A1 | Atrophic scars |
| REAC:R-HSA-2022090 | 0.00184717145405 | 1.0 | COL5A2 COL5A1 | Assembly of collagen fibrils and other multimeric structures |
| HP:0001278 | 0.00191723068589 | 1.0 | COL5A2 COL5A1 | Orthostatic hypotension |
| HP:0000977 | 0.00191723068589 | 1.0 | COL5A2 COL5A1 | Soft skin |
| REAC:R-HSA-186797 | 0.0019274832564 | 1.0 | COL5A2 COL5A1 | Signaling by PDGF |
| REAC:R-HSA-3000171 | 0.0019274832564 | 1.0 | COL5A2 COL5A1 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-1442490 | 0.0020095038205 | 1.0 | COL5A2 COL5A1 | Collagen degradation |
| HP:0100540 | 0.00203342648503 | 1.0 | COL5A2 COL5A1 | Palpebral edema |
| REAC:R-HSA-1650814 | 0.00226581808332 | 1.0 | COL5A2 COL5A1 | Collagen biosynthesis and modifying enzymes |
| HP:0001058 | 0.00227607065384 | 1.0 | COL5A2 COL5A1 | Poor wound healing |
| HP:0002761 | 0.00227607065384 | 1.0 | COL5A2 COL5A1 | Generalized joint hypermobility |
| HP:0003010 | 0.00240251902349 | 1.0 | COL5A2 COL5A1 | Prolonged bleeding time |
| HP:0001702 | 0.00266566833332 | 1.0 | COL5A2 COL5A1 | Abnormal tricuspid valve morphology |
| HP:0001386 | 0.00266566833332 | 1.0 | COL5A2 COL5A1 | Joint swelling |
| HP:0003083 | 0.00280236927349 | 1.0 | COL5A2 COL5A1 | Dislocated radial head |
| GO:1903224 | 0.0028092043205 | 1.0 | COL5A2 COL5A1 | regulation of endodermal cell differentiation |
| REAC:R-HSA-3000178 | 0.00282458317627 | 1.0 | COL5A2 COL5A1 | ECM proteoglycans |
| HP:0003995 | 0.00323297723503 | 1.0 | COL5A2 COL5A1 | Abnormality of the radial head |
| REAC:R-HSA-216083 | 0.00333721170191 | 1.0 | COL5A2 COL5A1 | Integrin cell surface interactions |
| HP:0004944 | 0.00338334826922 | 1.0 | COL5A2 COL5A1 | Dilatation of the cerebral artery |
| HP:0002758 | 0.00338334826922 | 1.0 | COL5A2 COL5A1 | Osteoarthritis |
| HP:0006479 | 0.0036943429081 | 1.0 | COL5A2 COL5A1 | Abnormal dental pulp morphology |
| REAC:R-HSA-6806834 | 0.00400875507049 | 1.0 | COL5A2 COL5A1 | Signaling by MET |
| HP:0009763 | 0.00401900764101 | 1.0 | COL5A2 COL5A1 | Limb pain |
| HP:0100744 | 0.00401900764101 | 1.0 | COL5A2 COL5A1 | Abnormality of the humeroradial joint |
| HP:0031364 | 0.00401900764101 | 1.0 | COL5A2 COL5A1 | Ecchymosis |
| HP:0100026 | 0.00401900764101 | 1.0 | COL5A2 COL5A1 | Arteriovenous malformation |
| HP:0002035 | 0.00401900764101 | 1.0 | COL5A2 COL5A1 | Rectal prolapse |
| HP:0100679 | 0.00435734246793 | 1.0 | COL5A2 COL5A1 | Lack of skin elasticity |
| REAC:R-HSA-1474290 | 0.00436759503844 | 1.0 | COL5A2 COL5A1 | Collagen formation |
| HP:0011108 | 0.00526298619656 | 1.0 | COL5A2 COL5A1 | Recurrent sinusitis |
| HP:0002616 | 0.00564916635254 | 1.0 | COL5A2 COL5A1 | Aortic root aneurysm |
| HP:0000974 | 0.00604901660254 | 1.0 | COL5A2 COL5A1 | Hyperextensible skin |
| HP:0002999 | 0.00667442340382 | 1.0 | COL5A2 COL5A1 | Patellar dislocation |
| HP:0000987 | 0.00755614446791 | 1.0 | COL5A2 COL5A1 | Atypical scarring of skin |
| HP:0002105 | 0.00755614446791 | 1.0 | COL5A2 COL5A1 | Hemoptysis |
| HP:0025487 | 0.0077851185427 | 1.0 | COL5A2 COL5A1 | Abnormal bladder morphology |
| HP:0031365 | 0.00801751014099 | 1.0 | COL5A2 COL5A1 | Macular purpura |
| HP:0003042 | 0.00801751014099 | 1.0 | COL5A2 COL5A1 | Elbow dislocation |
| HP:0009145 | 0.00825331926278 | 1.0 | COL5A2 COL5A1 | Abnormal cerebral artery morphology |
| HP:0003043 | 0.009230730985 | 1.0 | COL5A2 COL5A1 | Abnormal shoulder morphology |
| REAC:R-HSA-1474228 | 0.00932983916662 | 1.0 | COL5A2 COL5A1 | Degradation of the extracellular matrix |
| GO:0098643 | 0.00983221512175 | 1.0 | COL5A2 COL5A1 | banded collagen fibril |
| GO:0005583 | 0.00983221512175 | 1.0 | COL5A2 COL5A1 | fibrillar collagen trimer |
| HP:0030310 | 0.0102628230833 | 1.0 | COL5A2 COL5A1 | Upper extremity joint dislocation |
| HP:0001482 | 0.0105293899166 | 1.0 | COL5A2 COL5A1 | Subcutaneous nodule |
| HP:0002018 | 0.0105293899166 | 1.0 | COL5A2 COL5A1 | Nausea |
| HP:0200034 | 0.0105293899166 | 1.0 | COL5A2 COL5A1 | Papule |
| HP:0001787 | 0.0107993742735 | 1.0 | COL5A2 COL5A1 | Abnormal delivery |
| HP:0002615 | 0.0113495955576 | 1.0 | COL5A2 COL5A1 | Hypotension |
| WP:WP3932 | 0.0130364105952 | 1.0 | COL5A2 COL5A1 | Focal adhesion PI3K Akt mTOR signaling pathway |
| HP:0100699 | 0.0133830220427 | 1.0 | COL5A2 COL5A1 | Scarring |
| HP:0000961 | 0.0133830220427 | 1.0 | COL5A2 COL5A1 | Cyanosis |
| HP:0100539 | 0.0146201655512 | 1.0 | COL5A2 COL5A1 | Periorbital edema |
| HP:0003045 | 0.0149379952371 | 1.0 | COL5A2 COL5A1 | Abnormal patella morphology |
| HP:0004334 | 0.0149379952371 | 1.0 | COL5A2 COL5A1 | Dermal atrophy |
| HP:0012450 | 0.0149379952371 | 1.0 | COL5A2 COL5A1 | Chronic constipation |
| HP:0032016 | 0.0159119894358 | 1.0 | COL5A2 COL5A1 | Abnormal sputum |
| HP:0012727 | 0.0172584936965 | 1.0 | COL5A2 COL5A1 | Thoracic aortic aneurysm |
| HP:0200036 | 0.0176036635704 | 1.0 | COL5A2 COL5A1 | Skin nodule |
| HP:0012332 | 0.0183042558888 | 1.0 | COL5A2 COL5A1 | Abnormal autonomic nervous system physiology |
| HP:0000979 | 0.0190185183012 | 1.0 | COL5A2 COL5A1 | Purpura |
| HP:0001634 | 0.0201155433461 | 1.0 | COL5A2 COL5A1 | Mitral valve prolapse |
| HP:0000282 | 0.020488053408 | 1.0 | COL5A2 COL5A1 | Facial edema |
| HP:0002034 | 0.0260620342435 | 1.0 | COL5A2 COL5A1 | Abnormal rectum morphology |
| HP:0000246 | 0.0291002126388 | 1.0 | COL5A2 COL5A1 | Sinusitis |
| HP:0031105 | 0.0299990213204 | 1.0 | COL5A2 COL5A1 | Abnormal uterus morphology |
| HP:0001653 | 0.0318376489657 | 1.0 | COL5A2 COL5A1 | Mitral regurgitation |
| HP:0001633 | 0.0323058496858 | 1.0 | COL5A2 COL5A1 | Abnormal mitral valve morphology |
| HP:0004942 | 0.0327774679293 | 1.0 | COL5A2 COL5A1 | Aortic aneurysm |
| HP:0001622 | 0.0346981161387 | 1.0 | COL5A2 COL5A1 | Premature birth |
| HP:0002788 | 0.0351868219998 | 1.0 | COL5A2 COL5A1 | Recurrent upper respiratory tract infections |
| HP:0003394 | 0.0361744862926 | 1.0 | COL5A2 COL5A1 | Muscle spasm |
| HP:0000245 | 0.0366734447242 | 1.0 | COL5A2 COL5A1 | Abnormal paranasal sinus morphology |
| HP:0025323 | 0.0371758206793 | 1.0 | COL5A2 COL5A1 | Abnormal arterial physiology |
| HP:0031481 | 0.0371758206793 | 1.0 | COL5A2 COL5A1 | Abnormal mitral valve physiology |
| HP:0000978 | 0.0371758206793 | 1.0 | COL5A2 COL5A1 | Bruising susceptibility |
| HP:0012732 | 0.0387034536857 | 1.0 | COL5A2 COL5A1 | Anorectal anomaly |
| HP:0007495 | 0.0397389633075 | 1.0 | COL5A2 COL5A1 | Prematurely aged appearance |
| HP:0001739 | 0.0397389633075 | 1.0 | COL5A2 COL5A1 | Abnormal nasopharynx morphology |
| HP:0006705 | 0.0418509928331 | 1.0 | COL5A2 COL5A1 | Abnormal atrioventricular valve morphology |
| GO:0098644 | 0.0426062655276 | 1.0 | COL5A2 COL5A1 | complex of collagen trimers |
| HP:0008067 | 0.0434708989742 | 1.0 | COL5A2 COL5A1 | Abnormally lax or hyperextensible skin |
| REAC:R-HSA-1474244 | 0.0442193366216 | 1.0 | COL5A2 COL5A1 | Extracellular matrix organization |
| HP:0002829 | 0.0456786191579 | 1.0 | COL5A2 COL5A1 | Arthralgia |
| HP:0033151 | 0.0468029843908 | 1.0 | COL5A2 COL5A1 | Abnormal pharynx morphology |
| HP:0034376 | 0.0473702932925 | 1.0 | COL5A2 COL5A1 | Atrioventricular valve regurgitation |
| HP:0033982 | 0.0499436884913 | 0.5 | COL5A1 | Celiac artery dissection |
| HP:0012326 | 0.0499436884913 | 0.5 | COL5A1 | Abnormal celiac artery morphology |
| HP:0005100 | 0.0499436884913 | 0.5 | COL5A1 | Premature birth following premature rupture of fetal membranes |
| HP:0005313 | 0.0499436884913 | 0.5 | COL5A1 | Arterial fibromuscular dysplasia |
| HP:0006316 | 0.0499436884913 | 0.5 | COL5A1 | Irregularly spaced teeth |
| HP:0100858 | 0.0499436884913 | 0.5 | COL5A1 | Dilatation of celiac artery |
| HP:0033981 | 0.0499436884913 | 0.5 | COL5A1 | Vertebral artery tortuosity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| COL5A2 | COL5A1 | 0.991 | 0.444 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes